LOCUS       NM_007018               7719 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens centriolin (CNTRL), transcript variant 1, mRNA.
ACCESSION   NM_007018 XM_005251679 XM_352972
VERSION     NM_007018.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7719)
  AUTHORS   Brown,L.M., Bartolo,R.C., Davidson,N.M., Schmidt,B., Brooks,I.,
            Challis,J., Petrovic,V., Khuong-Quang,D.A., Mechinaud,F.,
            Khaw,S.L., Majewski,I.J., Oshlack,A. and Ekert,P.G.
  TITLE     Targeted therapy and disease monitoring in CNTRL-FGFR1-driven
            leukaemia
  JOURNAL   Pediatr Blood Cancer 66 (10), e27897 (2019)
   PUBMED   31250523
  REMARK    GeneRIF: In this study, we present two new cases of CNTRL-FGFR1
            fusion
REFERENCE   2  (bases 1 to 7719)
  AUTHORS   Ren,M., Qin,H., Kitamura,E. and Cowell,J.K.
  TITLE     Dysregulated signaling pathways in the development of
            CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated
            with FGFR1 in human and mouse models
  JOURNAL   Blood 122 (6), 1007-1016 (2013)
   PUBMED   23777766
  REMARK    GeneRIF: CNTRL and FGFR1 have roles in myeloid and lymphoid
            malignancies in both human and mouse models
REFERENCE   3  (bases 1 to 7719)
  AUTHORS   Sonnen,K.F., Schermelleh,L., Leonhardt,H. and Nigg,E.A.
  TITLE     3D-structured illumination microscopy provides novel insight into
            architecture of human centrosomes
  JOURNAL   Biol Open 1 (10), 965-976 (2012)
   PUBMED   23213374
REFERENCE   4  (bases 1 to 7719)
  AUTHORS   Kennedy,R.B., Ovsyannikova,I.G., Pankratz,V.S., Haralambieva,I.H.,
            Vierkant,R.A. and Poland,G.A.
  TITLE     Genome-wide analysis of polymorphisms associated with cytokine
            responses in smallpox vaccine recipients
  JOURNAL   Hum Genet 131 (9), 1403-1421 (2012)
   PUBMED   22610502
REFERENCE   5  (bases 1 to 7719)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 7719)
  AUTHORS   Mayor,T., Stierhof,Y.D., Tanaka,K., Fry,A.M. and Nigg,E.A.
  TITLE     The centrosomal protein C-Nap1 is required for cell cycle-regulated
            centrosome cohesion
  JOURNAL   J Cell Biol 151 (4), 837-846 (2000)
   PUBMED   11076968
REFERENCE   7  (bases 1 to 7719)
  AUTHORS   Guasch,G., Mack,G.J., Popovici,C., Dastugue,N., Birnbaum,D.,
            Rattner,J.B. and Pebusque,M.J.
  TITLE     FGFR1 is fused to the centrosome-associated protein CEP110 in the
            8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)
  JOURNAL   Blood 95 (5), 1788-1796 (2000)
   PUBMED   10688839
REFERENCE   8  (bases 1 to 7719)
  AUTHORS   Osaki,E., Nishina,Y., Inazawa,J., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Ohsugi,M., Tezuka,T., Yoshida,M. and Semba,K.
  TITLE     Identification of a novel Sry-related gene and its germ
            cell-specific expression
  JOURNAL   Nucleic Acids Res 27 (12), 2503-2510 (1999)
   PUBMED   10359848
REFERENCE   9  (bases 1 to 7719)
  AUTHORS   Schutze,S., Machleidt,T., Adam,D., Schwandner,R., Wiegmann,K.,
            Kruse,M.L., Heinrich,M., Wickel,M. and Kronke,M.
  TITLE     Inhibition of receptor internalization by monodansylcadaverine
            selectively blocks p55 tumor necrosis factor receptor death domain
            signaling
  JOURNAL   J Biol Chem 274 (15), 10203-10212 (1999)
   PUBMED   10187805
REFERENCE   10 (bases 1 to 7719)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006430.22 and AL137068.10.
            
            On or before Jun 17, 2020 this sequence version replaced
            XM_005251679.4, NM_007018.5.
            
            Summary: This gene encodes a centrosomal protein required for the
            centrosome to function as a microtubule organizing center. The gene
            product is also associated with centrosome maturation. One version
            of stem cell myeloproliferative disorder is the result of a
            reciprocal translocation between chromosomes 8 and 9, with the
            breakpoint associated with fibroblast growth factor receptor 1 and
            centrosomal protein 1. [provided by RefSeq, Jul 2008].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1221516.1,
                                           SRR14038197.1307433.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373855.7/ ENSP00000362962.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC006430.22        189037-189149
            114-286             AC006430.22        194388-194560
            287-534             AL137068.10        7679-7926
            535-665             AL137068.10        9658-9788
            666-796             AL137068.10        14271-14401
            797-938             AL137068.10        15805-15946
            939-1125            AL137068.10        17769-17955
            1126-1319           AL137068.10        27185-27378
            1320-1439           AL137068.10        31842-31961
            1440-1662           AL137068.10        32885-33107
            1663-1772           AL137068.10        34474-34583
            1773-1967           AL137068.10        37729-37923
            1968-2121           AL137068.10        43314-43467
            2122-2342           AL137068.10        45099-45319
            2343-2519           AL137068.10        55189-55365
            2520-2654           AL137068.10        57928-58062
            2655-2800           AL137068.10        60024-60169
            2801-3008           AL137068.10        60764-60971
            3009-3188           AL137068.10        61474-61653
            3189-3368           AL137068.10        63286-63465
            3369-3485           AL137068.10        64226-64342
            3486-3627           AL137068.10        64627-64768
            3628-3776           AL137068.10        65491-65639
            3777-3966           AL137068.10        68055-68244
            3967-4280           AL137068.10        69553-69866
            4281-4489           AL137068.10        71868-72076
            4490-4682           AL137068.10        74104-74296
            4683-4813           AL137068.10        76853-76983
            4814-4954           AL137068.10        77123-77263
            4955-5081           AL137068.10        77366-77492
            5082-5246           AL137068.10        78238-78402
            5247-5406           AL137068.10        79526-79685
            5407-5522           AL137068.10        81239-81354
            5523-5740           AL137068.10        81437-81654
            5741-5898           AL137068.10        84326-84483
            5899-5972           AL137068.10        85490-85563
            5973-6161           AL137068.10        86872-87060
            6162-6387           AL137068.10        87479-87704
            6388-6593           AL137068.10        88994-89199
            6594-6734           AL137068.10        90791-90931
            6735-7001           AL137068.10        92626-92892
            7002-7064           AL137068.10        93058-93120
            7065-7271           AL137068.10        94401-94607
            7272-7719           AL137068.10        96546-96993
FEATURES             Location/Qualifiers
     source          1..7719
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..7719
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /note="centriolin"
                     /db_xref="GeneID:11064"
                     /db_xref="HGNC:HGNC:1858"
                     /db_xref="MIM:605496"
     exon            1..113
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            114..286
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            287..534
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..7295
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centriole associated protein; centrosomal protein 110kDa;
                     bA165P4.1 (ortholog of mouse Ma2a8); bA165P4.2
                     (centrosomal protein 1); 110 kDa centrosomal protein;
                     centrosomal protein of 110 kDa"
                     /codon_start=1
                     /product="centriolin isoform 1"
                     /protein_id="NP_008949.4"
                     /db_xref="CCDS:CCDS35118.1"
                     /db_xref="GeneID:11064"
                     /db_xref="HGNC:HGNC:1858"
                     /db_xref="MIM:605496"
                     /translation="MKKGSQQKIFSKAKIPSSSHSPIPSSMSNMRSRSLSPLIGSETL
                     PFHSGGQWCEQVEIADENNMLLDYQDHKGADSHAGVRYITEALIKKLTKQDNLALIKS
                     LNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKIS
                     KIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQ
                     DLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLE
                     RDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNEL
                     LKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSR
                     YKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQ
                     TRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKL
                     RQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDI
                     MNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEY
                     LGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELES
                     ALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSAL
                     QAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNH
                     VVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKW
                     ERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMEN
                     EIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGL
                     DKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAA
                     QAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQR
                     TEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKRRGYWYFM
                     PPPPSSKVSSHSSQATKDSGVGLKYSASTPVRKPRPGQQDGKEGSQPPPASGYWVYSP
                     IRSGLHKLFPSRDADSGGDSQEESELDDQEEPPFVPPPGYMMYTVLPDGSPVPQGMAL
                     YAPPPPLPNNSRPLTPGTVVYGPPPAGAPMVYGPPPPNFSIPFIPMGVLHCNVPEHHN
                     LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVE
                     ELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELR
                     EADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKA
                     DQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQK
                     DIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEEL
                     HLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKT
                     QLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSEL
                     EKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVEC
                     LSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLN
                     RDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE
                     QTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERE
                     SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESL
                     EKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA
                     SLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYE
                     YTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAIL
                     ERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRL
                     KAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLES
                     SLTEDSQLGQNQEKNASAR"
     exon            535..665
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            666..796
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            797..938
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1125
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1319
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1439
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1662
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1772
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1967
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2121
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2342
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2519
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2654
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2800
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..3008
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3188
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3368
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..3485
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..3627
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            3628..3776
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            3777..3966
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            3967..4280
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            4281..4489
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            4490..4682
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            4683..4813
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            4814..4954
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            4955..5081
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            5082..5246
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            5247..5406
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            5407..5522
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            5523..5740
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            5741..5898
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            5899..5972
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            5973..6161
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            6162..6387
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            6388..6593
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            6594..6734
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            6735..7001
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            7002..7064
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            7065..7271
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     exon            7272..7719
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7701..7706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /note="hexamer: AATAAA"
     polyA_site      7719
                     /gene="CNTRL"
                     /gene_synonym="bA165P4.1; CEP1; CEP110; FAN"
                     /note="major polyA site"
ORIGIN      
        1 aaccggcaca acacaacaaa atggctgccg cgccgctggg cccctgagga aagagcccga
       61 acttctcccg ctctacctca gcctgcggga ctgctcggct cggcttctag gcgagacagg
      121 ggctccctgt gtttcccagg ctgcagtgca gtggccagtc acaaggttga tcatagcaca
      181 ttgtagcctg gagctcctgg gatcaagcaa tcctcctgcc tcatcctctg gagtaactgg
      241 gactgcaagt atacataccg tgcctgacga aatatcacaa tatttggttt tgatgaacac
      301 ctggctttat tcttgcaatg aagaaaggtt ctcaacaaaa aatattctcc aaagcaaaga
      361 taccatcatc atctcactct cctatcccat catctatgtc caatatgaga tctaggtcac
      421 tttcaccttt gattggatca gagactctac cttttcattc tggaggacag tggtgtgagc
      481 aagttgagat tgcagatgaa aacaatatgc ttttggacta tcaagaccat aaaggagctg
      541 attcacatgc aggagttaga tatattacag aggccctcat taaaaaactt actaaacagg
      601 ataatttggc tttgataaaa tctctgaacc tttcactttc taaagacggt ggcaagaaat
      661 ttaagtatat tgagaatttg gaaaaatgtg ttaaacttga agtactgaat ctcagctata
      721 atctaatagg gaagattgaa aagttggaca agctgttaaa attacgtgaa ctcaacttat
      781 catataacaa aatcagcaaa attgaaggca tagaaaatat gtgtaatctg caaaagctta
      841 accttgcagg aaatgaaatt gagcatattc cagtatggtt agggaagaag ttaaaatctt
      901 tgcgagtcct caatttgaaa ggcaacaaga tatcatcgct ccaagatata agcaagttga
      961 aaccgcttca agatttgatt tctctgatcc tagttgaaaa tccagttgtg acccttcctc
     1021 attacctcca gtttaccatt ttccacctcc gttcattgga aagtttggaa ggtcagccag
     1081 taaccactca ggatagacag gaggcttttg agagattcag tttagaagag gtagaaagac
     1141 tggaaagaga cctagaaaaa aagatgatag aaactgaaga gcttaagagc aaacaaacaa
     1201 ggttccttga ggaaattaaa aatcaagata aattgaataa atcattaaaa gaggaggcca
     1261 tgttacagaa acagagctgt gaggaactca agagtgactt aaacacaaaa aatgaattgc
     1321 taaaacagaa gaccatagaa ttaacacgag catgtcagaa gcaatatgag ctggaacagg
     1381 aattggcctt ttataaaatt gatgctaaat ttgagccact aaattattat ccatcagagt
     1441 atgctgaaat tgataaagcc ccagatgaaa gcccttacat tggcaaatcc agatacaaga
     1501 gaaatatgtt tgccacagag agttatatta ttgacagtgc tcaggcagta cagatcaaga
     1561 agatggagcc agatgaacaa cttagaaatg atcacatgaa cttgagaggc cacacaccac
     1621 tggacacgca actggaagac aaagaaaaaa aaataagtgc agcacaaact cgactatcag
     1681 aactgcatga tgaaatagaa aaggcagaac aacaaatttt gagagctact gaagaattta
     1741 aacaactgga agaagctata caactaaaaa agatttcaga agcagggaaa gaccttcttt
     1801 acaagcagtt gagtggtaga ctacaacttg taaataaatt acgccaggaa gctctggatc
     1861 tagaactgca gatggaaaag caaaagcagg aaattgccgg aaagcagaag gagattaagg
     1921 acctgcaaat agccatagat agcctggatt ccaaagaccc aaaacattcc catatgaagg
     1981 ctcaaaagag cggtaaagaa caacagcttg acattatgaa caagcagtac caacaacttg
     2041 aaagtcgttt ggatgagata ctttctagaa ttgctaagga aacggaagag attaaggacc
     2101 ttgaagaaca gcttactgaa ggccagatag cagcaaatga agccctgaag aaggatttag
     2161 aaggtgttat cagtgggttg caagaatacc tggggaccat taaaggccag gcaactcagg
     2221 cccagaatga gtgcaggaag ctgcgggatg agaaagagac attgttgcag agattgacag
     2281 aagtcgagca ggagagagac cagctggaaa tagttgccat ggatgcagaa aatatgagga
     2341 aggagcttgc agagctagaa agtgccctcc aagagcagca tgaggtgaat gcatctttgc
     2401 agcagaccca gggagatctc agtgcctatg aagctgagct agaggctcgg ctaaacctaa
     2461 gggatgctga agccaaccag ctcaaggaag agttggaaaa agtaacaaga cttacccagt
     2521 tagaacaatc agcccttcaa gcagaacttg agaaggaaag gcaagccctc aagaatgccc
     2581 ttggaaaagc ccagttctca gaagaaaagg agcaagagaa cagtgagctc catgcaaaac
     2641 ttaaacactt gcaggatgac aataatctgt taaaacagca acttaaagat ttccagaatc
     2701 accttaacca tgtggttgat ggtttggttc gtccagaaga agtggcagct cgtgtggatg
     2761 agctaagaag aaaactgaaa ttaggaactg gggaaatgaa catccatagt ccttcagatg
     2821 tcttagggaa aagtcttgct gatttacaga aacaattcag tgaaattctt gcacgctcca
     2881 agtgggaaag agatgaagca caagttagag agagaaaact ccaagaagaa atggctctgc
     2941 agcaagagaa actggcaact ggacaagaag agttcaggca ggcctgtgag agagccctgg
     3001 aagcaagaat gaattttgat aagaggcaac atgaagcaag aatccagcaa atggagaatg
     3061 aaattcacta tttgcaagaa aatctaaaaa gtatggagga aatccaaggc cttacagatc
     3121 tccaacttca ggaagctgat gaagagaagg agagaattct ggcccaactc cgagagttag
     3181 agaaaaagaa gaaacttgaa gatgccaaat ctcaggagca agtttttggt ttagataaag
     3241 aactgaagaa actaaagaaa gccgtggcca cctctgataa gctagccaca gctgagctca
     3301 ccattgccaa agaccagctg aagtcccttc atggaactgt tatgaaaatt aaccaggagc
     3361 gagcagagga gttgcaggaa gcagagaggt tcagcagaaa ggcagcacaa gcagccagag
     3421 atctcacccg agcagaagct gagatcgaac tcctgcagaa tctcctcagg cagaaggggg
     3481 agcagtttcg acttgagatg gagaaaacag gtgtaggtac tggagcaaac tcacaggtcc
     3541 tagaaattga gaaactgaat gagacaatgg aacgacaaag gacagagatt gcaaggctgc
     3601 agaatgtact agacctcact ggaagtgaca acaaaggagg ctttgaaaat gttttagaag
     3661 aaattgctga acttcgacgt gaagtttctt atcagaatga ttacataagc agcatggcag
     3721 atcctttcaa aagacgaggc tattggtact ttatgccacc accaccatca tcaaaagttt
     3781 ccagccatag ttcccaggcc accaaggact ctggtgttgg ccttaagtac tcagcctcaa
     3841 ctcctgttag aaaaccacgc cctgggcagc aggatgggaa ggaaggcagt caacctcccc
     3901 ctgcctcagg atactgggtt tattctccca tcaggagtgg gttacataaa ctgtttccaa
     3961 gtagagatgc agacagtgga ggagatagtc aggaagagag tgagctggat gaccaagaag
     4021 aacccccatt tgtgcctcct cctggataca tgatgtatac tgtgcttcct gatggttctc
     4081 ctgtacccca gggcatggcc ctgtatgcac cacctcctcc cttgccaaac aatagccgac
     4141 ctctcacccc tggcactgtt gtttatggcc cacctcctgc tggggccccc atggtgtatg
     4201 ggcctccacc ccccaacttc tccatcccct tcatccctat gggtgtgctg cattgcaacg
     4261 tccctgaaca ccataactta gagaatgaag tttctagatt agaagacata atgcagcatt
     4321 taaaatcaaa gaagcgggaa gaaaggtgga tgagagcatc caagcggcag tcggagaaag
     4381 aaatggaaga actgcatcat aatattgatg atcttttgca agagaagaaa agcttagagt
     4441 gtgaagtaga agaattacat agaactgtcc agaaacgtca acagcaaaag gacttcattg
     4501 atggaaatgt tgagagtctt atgactgaac tagaaataga aaaatcactc aaacatcatg
     4561 aagatattgt agatgaaatt gagtgcattg agaagactct tctgaaacgt cgctcagagc
     4621 tcagggaagc tgaccgactc ctggcagagg ctgagagtga actttcatgc actaaagaaa
     4681 agacaaaaaa tgctgttgaa aagttcactg atgccaagag aagtttattg caaactgagt
     4741 cagatgctga ggaattagaa aggagagctc aggaaactgc tgttaacctc gtcaaagctg
     4801 atcagcagct aagatcgctc caggctgatg caaaggattt ggagcagcac aaaatcaagc
     4861 aagaagaaat cttgaaagaa ataaacaaaa ttgtagcagc aaaagactca gacttccaat
     4921 gtttaagcaa gaagaaggaa aaactgacag aagagcttca gaaactacag aaagacatag
     4981 agatggcaga acgcaatgag gatcaccacc tgcaggtcct taaagaatct gaggtgcttc
     5041 ttcaggccaa aagagccgag ctggaaaagc tgaaaagcca ggtgacaagt cagcagcagg
     5101 agatggctgt cttggacagg cagttagggc ataaaaagga ggagctgcat ctactccaag
     5161 gaagcatggt ccaggcaaaa gctgacctcc aggaagctct gagactggga gagactgaag
     5221 taactgagaa gtgcaatcac attagggaag taaaatctct tctggaagaa ctgagttttc
     5281 agaaaggaga actaaatgtt cagattagtg aaagaaaaac tcaacttaca cttataaagc
     5341 aggaaattga aaaagaggaa gaaaatcttc aggttgtttt aaggcagatg tctaaacata
     5401 aaaccgaact aaagaatatt ctggacatgt tgcaacttga aaaccatgag ctacaaggtt
     5461 tgaagctaca acatgaccaa agggtatctg aattagagaa gactcaggtg gcagtgctag
     5521 aggagaaact ggagttagag aatttgcagc agatatccca gcagcagaaa ggggaaatag
     5581 agtggcagaa gcagctcctt gagagggata aacgagaaat agaacgaatg actgctgagt
     5641 cccgagcttt acaatcgtgt gttgagtgtt tgagcaaaga aaaggaagat ctccaagaga
     5701 aatgtgacat ttgggaaaaa aagttggcac aaaccaaaag ggttttagca gcagcagaag
     5761 aaaatagcaa aatggagcaa tcaaacttag aaaagttgga attgaatgtc agaaaactgc
     5821 agcaggaact agaccaacta aacagagaca agttgtcact gcataacgac atttcagcaa
     5881 tgcaacagca gctccaagaa aaacgagaag cagtaaactc actgcaggag gaactagcta
     5941 atgtccaaga ccatttgaac ctagcaaaac aggacctgct tcacaccacc aagcatcagg
     6001 atgtgttgct cagtgagcag acccgactcc agaaggacat cagtgaatgg gcaaataggt
     6061 ttgaagactg tcagaaagaa gaggagacaa aacaacaaca acttcaagtg cttcagaatg
     6121 agattgaaga aaacaagctc aaactagtcc aacaagaaat gatgtttcag agactccaga
     6181 aagagagaga aagtgaagaa agcaaattag aaaccagtaa agtgacactg aaggagcaac
     6241 agcaccagct ggaaaaggaa ttaacagacc agaaaagcaa actggaccaa gtgctctcaa
     6301 aggtgctggc agctgaagag cgtgttagga ctctgcagga agaggagagg tggtgtgaga
     6361 gcctggagaa gacactctcc caaactaaac ggcagctttc agaaagggag cagcaattgg
     6421 tggagaaatc aggtgagctg ttggccctcc agaaagaggc agattctatg agggcagact
     6481 tcagccttct gcggaaccag ttcttgacag aaagaaagaa agctgagaag caggtggcca
     6541 gcctgaagga agcacttaag atccagcgga gccagctgga gaaaaacctt cttgagcaaa
     6601 aacaggagaa cagctgcata caaaaggaaa tggcaacaat tgaactggta gcccaggaca
     6661 accatgagcg ggccaggcgc ctgatgaagg agctcaacca gatgcagtat gagtacacgg
     6721 agctcaagaa acagatggca aaccaaaaag atttggagag aagacaaatg gaaatcagtg
     6781 atgcaatgag gacacttaaa tctgaggtga aggatgaaat cagaaccagc ttgaagaatc
     6841 ttaatcagtt tcttccagaa ctaccagcag atctagaagc tattttggaa agaaacgaaa
     6901 acctagaagg agaattggaa agcttgaaag agaaccttcc atttaccatg aatgagggac
     6961 cttttgaaga aaaactgaac ttttcccaag ttcacataat ggatgaacac tggcgtggag
     7021 aagcactccg ggagaaactg cgtcaccggg aagaccgact caaggcccaa ctccgacact
     7081 gtatgtccaa gcaagcagaa gtattaatta aaggaaagcg gcagacagag ggcactttac
     7141 acagtttgag gagacaagta gatgctttag gggaattggt caccagcacc tctgcagatt
     7201 cagcgtcatc acccagtctg tctcagctgg agtcttccct cacagaggac tctcaacttg
     7261 gacaaaatca ggaaaagaat gcctcagcca gatgaggaat actgtcttgt gtaaatatat
     7321 tcaaggaaaa cacctccact acctcactga cttcataatt ggaatgtcac atggtttttt
     7381 taatcaagat gcagtgaact gagattctga aactccactg tagtttactt tgcctgtacc
     7441 attaatgcca atgtttttat aaatcacttg tacatagtac atatgggaat agttgcatat
     7501 gggaatttaa accaacatgt ggctgagcct tttttttttt aatcttcgta acatgtttaa
     7561 aaaaaaacag tgattttaac tgcatatttg aacctacaaa ctggtaaatc ttattaacaa
     7621 aaagaatgta cttaaggccc tctttattta tagtgtcgag ttatttttga attttgctta
     7681 aaatctattt ttcatatgaa aataaaagat aacaatcaa
//
