LOCUS       NM_001367498           11219 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens contactin associated protein family member 5
            (CNTNAP5), transcript variant 3, mRNA.
ACCESSION   NM_001367498 XM_006712258
VERSION     NM_001367498.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11219)
  AUTHORS   Chakraborty,S., Sharma,A., Sharma,A., Sihota,R., Bhattacharjee,S.
            and Acharya,M.
  TITLE     Haplotype-based genomic analysis reveals novel association of
            CNTNAP5 genic region with primary angle closure glaucoma
  JOURNAL   J Biosci 46 (2021)
   PUBMED   33737499
  REMARK    GeneRIF: Haplotype-based genomic analysis reveals novel association
            of CNTNAP5 genic region with primary angle closure glaucoma.
REFERENCE   2  (bases 1 to 11219)
  AUTHORS   Ludington,E.G., Yu,S., Bae,H.A. and Barnett,C.P.
  TITLE     Novel de novo 2q14.3 deletion disrupting CNTNAP5 in a girl with
            intellectual impairment, thin corpus callosum, and microcephaly
  JOURNAL   Am J Med Genet A 182 (7), 1824-1828 (2020)
   PUBMED   32329157
  REMARK    GeneRIF: Novel de novo 2q14.3 deletion disrupting CNTNAP5 in a girl
            with intellectual impairment, thin corpus callosum, and
            microcephaly.
REFERENCE   3  (bases 1 to 11219)
  AUTHORS   Zhang,Y., Li,M., Wang,Q., Hsu,J.S., Deng,W., Ma,X., Ni,P., Zhao,L.,
            Tian,Y., Sham,P.C. and Li,T.
  TITLE     A joint study of whole exome sequencing and structural MRI analysis
            in major depressive disorder
  JOURNAL   Psychol Med 50 (3), 384-395 (2020)
   PUBMED   30722798
  REMARK    GeneRIF: A joint study of whole exome sequencing and structural MRI
            analysis in major depressive disorder.
REFERENCE   4  (bases 1 to 11219)
  AUTHORS   Schott,J.M., Crutch,S.J., Carrasquillo,M.M., Uphill,J.,
            Shakespeare,T.J., Ryan,N.S., Yong,K.X., Lehmann,M.,
            Ertekin-Taner,N., Graff-Radford,N.R., Boeve,B.F., Murray,M.E.,
            Khan,Q.U., Petersen,R.C., Dickson,D.W., Knopman,D.S.,
            Rabinovici,G.D., Miller,B.L., Gonzalez,A.S., Gil-Neciga,E.,
            Snowden,J.S., Harris,J., Pickering-Brown,S.M., Louwersheimer,E.,
            van der Flier,W.M., Scheltens,P., Pijnenburg,Y.A., Galasko,D.,
            Sarazin,M., Dubois,B., Magnin,E., Galimberti,D., Scarpini,E.,
            Cappa,S.F., Hodges,J.R., Halliday,G.M., Bartley,L., Carrillo,M.C.,
            Bras,J.T., Hardy,J., Rossor,M.N., Collinge,J., Fox,N.C. and Mead,S.
  TITLE     Genetic risk factors for the posterior cortical atrophy variant of
            Alzheimer's disease
  JOURNAL   Alzheimers Dement 12 (8), 862-871 (2016)
   PUBMED   26993346
  REMARK    GeneRIF: This exploratory genome-wide association studies confirmed
            APOE and identified three novel loci: rs76854344 near CNTNAP5 (P =
            8 x 10(-10) OR = 1.9 [1.5-2.3]).
REFERENCE   5  (bases 1 to 11219)
  AUTHORS   Levinson,D.F., Shi,J., Wang,K., Oh,S., Riley,B., Pulver,A.E.,
            Wildenauer,D.B., Laurent,C., Mowry,B.J., Gejman,P.V., Owen,M.J.,
            Kendler,K.S., Nestadt,G., Schwab,S.G., Mallet,J., Nertney,D.,
            Sanders,A.R., Williams,N.M., Wormley,B., Lasseter,V.K., Albus,M.,
            Godard-Bauche,S., Alexander,M., Duan,J., O'Donovan,M.C., Walsh,D.,
            O'Neill,A., Papadimitriou,G.N., Dikeos,D., Maier,W., Lerer,B.,
            Campion,D., Cohen,D., Jay,M., Fanous,A., Eichhammer,P.,
            Silverman,J.M., Norton,N., Zhang,N., Hakonarson,H., Gao,C.,
            Citri,A., Hansen,M., Ripke,S., Dudbridge,F. and Holmans,P.A.
  CONSRTM   Schizophrenia Psychiatric GWAS Consortium
  TITLE     Genome-wide association study of multiplex schizophrenia pedigrees
  JOURNAL   Am J Psychiatry 169 (9), 963-973 (2012)
   PUBMED   22885689
REFERENCE   6  (bases 1 to 11219)
  AUTHORS   McClay,J.L., Adkins,D.E., Aberg,K., Stroup,S., Perkins,D.O.,
            Vladimirov,V.I., Lieberman,J.A., Sullivan,P.F. and van den
            Oord,E.J.
  TITLE     Genome-wide pharmacogenomic analysis of response to treatment with
            antipsychotics
  JOURNAL   Mol Psychiatry 16 (1), 76-85 (2011)
   PUBMED   19721433
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 11219)
  AUTHORS   Pagnamenta,A.T., Bacchelli,E., de Jonge,M.V., Mirza,G.,
            Scerri,T.S., Minopoli,F., Chiocchetti,A., Ludwig,K.U., Hoffmann,P.,
            Paracchini,S., Lowy,E., Harold,D.H., Chapman,J.A., Klauck,S.M.,
            Poustka,F., Houben,R.H., Staal,W.G., Ophoff,R.A., O'Donovan,M.C.,
            Williams,J., Nothen,M.M., Schulte-Korne,G., Deloukas,P.,
            Ragoussis,J., Bailey,A.J., Maestrini,E. and Monaco,A.P.
  CONSRTM   International Molecular Genetic Study Of Autism Consortium
  TITLE     Characterization of a family with rare deletions in CNTNAP5 and
            DOCK4 suggests novel risk loci for autism and dyslexia
  JOURNAL   Biol Psychiatry 68 (4), 320-328 (2010)
   PUBMED   20346443
  REMARK    GeneRIF: Data suggest that rare variants in CNTNAP5 may confer
            autism spectrum disorder (ASD) susceptibility. Genomic disruption
            of both DOCK4 and CNTNAP5 genes may have an additive effect and may
            result in a more severe ASD phenotype.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 11219)
  AUTHORS   Barber,M.J., Mangravite,L.M., Hyde,C.L., Chasman,D.I., Smith,J.D.,
            McCarty,C.A., Li,X., Wilke,R.A., Rieder,M.J., Williams,P.T.,
            Ridker,P.M., Chatterjee,A., Rotter,J.I., Nickerson,D.A.,
            Stephens,M. and Krauss,R.M.
  TITLE     Genome-wide association of lipid-lowering response to statins in
            combined study populations
  JOURNAL   PLoS One 5 (3), e9763 (2010)
   PUBMED   20339536
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 11219)
  AUTHORS   Levy,D., Larson,M.G., Benjamin,E.J., Newton-Cheh,C., Wang,T.J.,
            Hwang,S.J., Vasan,R.S. and Mitchell,G.F.
  TITLE     Framingham Heart Study 100K Project: genome-wide associations for
            blood pressure and arterial stiffness
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S3 (2007)
   PUBMED   17903302
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 11219)
  AUTHORS   Traut,W., Weichenhan,D., Himmelbauer,H. and Winking,H.
  TITLE     New members of the neurexin superfamily: multiple rodent homologues
            of the human CASPR5 gene
  JOURNAL   Mamm Genome 17 (7), 723-731 (2006)
   PUBMED   16845472
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079154.5, AC074362.5,
            AC104648.2, AC097715.3, AC019159.8 and AC019105.7.
            
            On Dec 4, 2018 this sequence version replaced XM_006712258.1.
            
            Summary: This gene product belongs to the neurexin family, members
            of which function in the vertebrate nervous system as cell adhesion
            molecules and receptors. This protein, like other neurexin
            proteins, contains epidermal growth factor repeats and laminin G
            domains. In addition, it includes an F5/8 type C domain,
            discoidin/neuropilin- and fibrinogen-like domains, and
            thrombospondin N-terminal-like domains. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.118514.1,
                                           SRR1660805.59244.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682447.1/ ENSP00000508115.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-446               AC079154.5         123966-124411
            447-551             AC074362.5         72671-72775
            552-745             AC074362.5         93166-93359
            746-893             AC104648.2         44513-44660
            894-1097            AC104648.2         61554-61757
            1098-1282           AC104648.2         73823-74007
            1283-1426           AC104648.2         101809-101952
            1427-1691           AC097715.3         21278-21542
            1692-1841           AC097715.3         41289-41438
            1842-2013           AC097715.3         44271-44442
            2014-2120           AC097715.3         80203-80309
            2121-2240           AC097715.3         126787-126906
            2241-2441           AC019159.8         23102-23302
            2442-2598           AC019159.8         122573-122729
            2599-2726           AC019159.8         139016-139143
            2727-2897           AC019159.8         139321-139491
            2898-3116           AC019159.8         148143-148361
            3117-3356           AC019105.7         155-394
            3357-3581           AC019105.7         8349-8573
            3582-3712           AC019105.7         75559-75689
            3713-3800           AC019105.7         79928-80015
            3801-4019           AC019105.7         113135-113353
            4020-4091           AC019105.7         121720-121791
            4092-11219          AC019105.7         124345-131472
FEATURES             Location/Qualifiers
     source          1..11219
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.3"
     gene            1..11219
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /note="contactin associated protein family member 5"
                     /db_xref="GeneID:129684"
                     /db_xref="HGNC:HGNC:18748"
                     /db_xref="MIM:610519"
     exon            1..446
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..4288
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; cell recognition molecule Caspr5; contactin
                     associated protein like 5"
                     /codon_start=1
                     /product="contactin-associated protein-like 5 isoform 3
                     precursor"
                     /protein_id="NP_001354427.1"
                     /db_xref="CCDS:CCDS92855.1"
                     /db_xref="GeneID:129684"
                     /db_xref="HGNC:HGNC:18748"
                     /db_xref="MIM:610519"
                     /translation="MDSLPRLTSVLTLLFSGLWHLGLTATNYNCDDPLASLLSPMAFS
                     SSSDLTGTHSPAQLNWRVGTGGWSPADSNAQQWLQMDLGNRVEITAVATQGRYGSSDW
                     VTSYSLMFSDTGRNWKQYKQEDSIWTFAGNMNADSVVHHKLLHSVRARFVRFVPLEWN
                     PSGKIGMRVEVYGCSYKSDVADFDGRSSLLYRFNQKLMSTLKDVISLKFKSMQGDGVL
                     FHGEGQRGDHITLELQKGRLALHLNLGDSKARLSSSLPSATLGSLLDDQHWHSVLIER
                     VGKQVNFTVDKHTQHFRTKGETDALDIDYELSFGGIPVPGKPGTFLKKNFHGCIENLY
                     YNGVNIIDLAKRRKHQIYTVGNVTFSCSEPQIVPITFVNSSGSYLLLPGTPQIDGLSV
                     SFQFRTWNKDGLLLSTELSEGSGTLLLSLEGGILRLVIQKMTERVAEILTGSNLNDGL
                     WHSVSINARRNRITLTLDDEAAPPAPDSTWVQIYSGNSYYFGGCPDNLTDSQCLNPIK
                     AFQGCMRLIFIDNQPKDLISVQQGSLGNFSDLHIDLCSIKDRCLPNYCEHGGSCSQSW
                     TTFYCNCSDTSYTGATCHNSIYEQSCEVYRHQGNTAGFFYIDSDGSGPLGPLQVYCNI
                     TEDKIWTSVQHNNTELTRVRGANPEKPYAMALDYGGSMEQLEAVIDGSEHCEQEVAYH
                     CRRSRLLNTPDGTPFTWWIGRSNERHPYWGGSPPGVQQCECGLDESCLDIQHFCNCDA
                     DKDEWTNDTGFLSFKDHLPVTQIVITDTDRSNSEAAWRIGPLRCYGDRRFWNAVSFYT
                     EASYLHFPTFHAEFSADISFFFKTTALSGVFLENLGIKDFIRLEISSPSEITFAIDVG
                     NGPVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEGHFRLQLNSQ
                     LFVGGTSSRQKGFLGCIRSLHLNGQKMDLEERAKVTSGVRPGCPGHCSSYGSICHNGG
                     KCVEKHNGYLCDCTNSPYEGPFCKKEVSAVFEAGTSVTYMFQEPYPVTKNISLSSSAI
                     YTDSAPSKENIALSFVTTQAPSLLLFINSSSQDFVVVLLCKNGSLQVRYHLNKEETHV
                     FTIDADNFANRRMHHLKINREGRELTIQMDQQLRLSYNFSPEVEFRVIRSLTLGKVTE
                     NLGLDSEVAKANAMGFAGCMSSVQYNHIAPLKAALRHATVAPVTVHGTLTESSCGFMV
                     DSDVNAVTTVHSSSDPFGKTDEREPLTNAVRSDSAVIGGVIAVVIFIIFCIIGIMTRF
                     LYQHKQSHRTSQMKEKEYPENLDSSFRNEIDLQNTVSECKREYFI"
     exon            447..551
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            552..745
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            746..893
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1097
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1282
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1426
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1691
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1841
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..2013
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2120
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2240
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2441
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2598
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2726
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2897
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3116
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3356
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3581
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            3582..3712
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            3713..3800
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            3801..4019
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            4020..4091
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     exon            4092..11219
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11179..11184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /note="hexamer: AATAAA"
     polyA_site      11219
                     /gene="CNTNAP5"
                     /gene_synonym="caspr5"
                     /note="major polyA site"
ORIGIN      
        1 gattccagct ctcgcgcccg acgaggtgga tttggctgtc caccgagctc cggcgcctgt
       61 cgttctaatt gggtttggat ttgcaccgtt aaggaggggg gaagagaagg aagaggcggg
      121 cgaggaaggc gagtccagct agcggctgtt gcggggaccg tagccccagc tgcagctccg
      181 aagaatcccc cgccacggtt tcggtggagc gtctgggcac gggatggagt gaaagagcga
      241 gtgcctctcc aagcgggggt gggagggggt caggctgtgc agaggagaga gacagcgaga
      301 agaagccgcg gctggctact gcgaatttgg gattcgattg ggagggaccg ctcactcggg
      361 ggaaatggat tctttaccac ggctgaccag cgttttgact ttgctgttct ctggcttgtg
      421 gcatttagga ttaacagcga caaactacaa ctgtgatgat ccactagcat ccctgctctc
      481 tccaatggct ttttccagtt cctcagacct cactggcact cacagcccag ctcaactcaa
      541 ctggagagtt ggaactggcg gttggtcccc agcagattcc aatgctcaac agtggctcca
      601 gatggacctg ggaaacagag tagagattac agcagtggcc acgcagggaa gatacggaag
      661 ctctgactgg gtgacgagtt acagcctgat gttcagtgac acaggacgca actggaaaca
      721 gtacaaacaa gaagacagca tctggacctt tgcaggaaac atgaatgctg acagcgtggt
      781 gcaccacaag ctattgcact cagtgagagc ccgatttgtt cgctttgtgc ccctggaatg
      841 gaatcccagt gggaagattg gcatgagagt cgaggtctac ggatgttcct ataaatcaga
      901 tgttgctgac tttgatggcc gaagctcact tctgtacagg ttcaatcaga agttgatgag
      961 tactctcaaa gatgtgatct ccctgaagtt caagagcatg caaggagatg gggtcctgtt
     1021 ccatggagaa ggtcagcgtg gagaccacat caccttggaa ctccagaagg ggaggctcgc
     1081 cctacacctc aatttgggtg acagcaaagc gcggctcagc agcagcttgc cctctgccac
     1141 cctgggcagc ctcctggatg accagcactg gcactcggtc ctcattgagc gggtgggcaa
     1201 gcaggtgaac ttcacggtgg acaagcacac acagcacttc cgcaccaagg gcgagacgga
     1261 tgccttagac attgactatg agcttagttt tggaggaatt ccagtaccag gaaaacctgg
     1321 gaccttttta aagaaaaact tccatggatg catcgaaaac ctttactaca atggagtaaa
     1381 cataattgac ctggctaaga gacgaaagca tcagatctat actgtgggca atgtcacttt
     1441 ttcctgctcc gaaccacaga ttgtgcccat cacatttgtc aactccagcg gcagctattt
     1501 gctgctgccc ggcacccccc aaattgatgg gctctcagtg agtttccagt ttcgaacatg
     1561 gaacaaggat ggtctgcttc tgtccacaga gctgtctgag ggctcgggaa ccctgctgct
     1621 gagcctggag ggtggaatcc tgagactcgt gattcagaaa atgacagaac gcgtagctga
     1681 aatcctcaca ggcagcaact tgaatgatgg cctgtggcac tcggttagca tcaacgccag
     1741 gaggaaccgc atcacgctca ctctggatga tgaagcagca cccccggctc cagacagcac
     1801 ttgggtgcag atttattctg gaaatagcta ctattttgga gggtgccccg acaatctcac
     1861 cgattcccaa tgtttaaatc ccattaaggc tttccaaggc tgcatgaggc tcatctttat
     1921 tgataaccag cccaaggacc tcatttcagt tcagcaaggt tccctgggga attttagtga
     1981 tttacacatt gatctgtgta gcatcaaaga caggtgtttg ccaaactact gtgaacatgg
     2041 aggaagctgc tcccagtcct ggactacctt ctattgtaac tgcagtgaca caagttacac
     2101 tggtgccacc tgccacaact ccatctacga gcaatcctgc gaggtgtaca ggcaccaggg
     2161 gaatacagcc ggcttcttct acatcgactc agatggcagc ggcccactgg gacctctcca
     2221 ggtgtactgc aatatcactg aggacaagat ctggacatca gtgcagcaca acaatacaga
     2281 gctgacccga gtgcggggcg ctaaccctga gaagccctat gccatggcct tggactacgg
     2341 gggcagcatg gaacagctgg aggccgtgat cgacggctct gagcactgtg agcaggaggt
     2401 ggcctaccac tgcaggaggt cccgcctgct caacacgccg gatggaacac catttacctg
     2461 gtggattggg cggtccaatg aaaggcaccc ttactgggga ggttcccctc ctggggtcca
     2521 gcagtgtgag tgtggcctag acgagagctg cctggacatt cagcactttt gcaattgcga
     2581 cgctgacaag gatgaatgga caaatgatac tggctttctt tccttcaaag accacttgcc
     2641 tgtcactcag atagttatca ctgataccga cagatcaaac tcagaagccg cttggagaat
     2701 tggtcccttg cgttgctatg gtgaccgacg cttctggaac gccgtctcat tttatacaga
     2761 agcctcttac ctccactttc ctaccttcca tgcggaattc agtgccgata tttccttctt
     2821 ttttaaaacc acagcattat ccggagtttt cctagaaaat cttggcatta aagacttcat
     2881 tcgactcgaa ataagctctc cttcagagat cacctttgcc atcgatgttg ggaatggtcc
     2941 tgtggagctt gtagtccagt ctccttctct tctgaatgac aaccaatggc actatgtccg
     3001 ggctgagagg aacctcaagg agacctccct gcaggtggac aaccttccaa ggagcaccag
     3061 ggagacgtcg gaggagggcc attttcgact gcagctgaac agccagttgt ttgtaggggg
     3121 aacgtcatcc agacagaaag gcttcctagg atgcattcgc tccttacact tgaatggaca
     3181 gaaaatggac ctggaagaga gggcaaaggt cacatctgga gtcaggccag gctgccccgg
     3241 ccactgcagc agctacggca gcatctgcca caacgggggc aagtgtgtgg agaagcacaa
     3301 tggctacctg tgtgattgca ccaattcacc ttatgaaggg cccttttgca aaaaagaggt
     3361 ttctgctgtt tttgaggctg gcacgtcggt tacttacatg tttcaagaac cctatcctgt
     3421 gaccaagaat ataagcctct catcctcagc tatttacaca gattcagctc catccaagga
     3481 aaacattgca cttagctttg tgacaaccca ggcacccagt cttttgctct ttatcaattc
     3541 ttcttctcag gacttcgtgg ttgttctgct ctgcaagaat ggaagcttac aggttcgcta
     3601 tcacctaaac aaggaagaaa cccatgtatt caccattgat gcagataact ttgctaacag
     3661 aaggatgcac cacttgaaga ttaaccgaga gggaagagag cttaccattc agatggacca
     3721 gcaacttcga ctcagttata acttctctcc ggaagtagag ttcagggtta taaggtcact
     3781 caccttgggc aaagtcacag agaatcttgg tttggattct gaagttgcta aagcaaatgc
     3841 catgggtttt gctggatgca tgtcttccgt ccagtacaac cacatagcac cactgaaggc
     3901 tgccctgcgc catgccactg tcgcgcctgt gactgtccat gggaccttga cggaatccag
     3961 ctgtggcttc atggtggact cagatgtgaa tgcagtgacc acggtgcatt cttcatcaga
     4021 tccttttggg aagacagatg agcgggaacc actcacaaat gctgttcgaa gtgattcggc
     4081 agtcatcgga ggggtgatag cagtggtgat attcatcatc ttctgtatca tcggcatcat
     4141 gacccggttc ctctaccagc acaagcagtc acatcgtacg agccagatga aggagaagga
     4201 atatccagaa aatttggaca gttccttcag aaatgaaatt gacttgcaaa acacagtgag
     4261 cgagtgtaaa cgggaatatt tcatctgaga aactgcaggg ttcctactac tcttttttct
     4321 tgttgttcaa ttatctcctc cccctcttct ctcctgtctt ttgatttggt cattctcttt
     4381 attttctgct tgccatgtct tttctggaac atacttgcat ccaccacagc atcaattccc
     4441 ttgatccagc ccaagagacc aggcagccat ggccactgcc ttcctctctg atgaacctat
     4501 cgggtgaaaa cgaccactca agagactgac ttcgccattc aagacaagga agagacacat
     4561 gtgtgcactc ctgcatgttc agttctgtac ttccagtttc taaaatgcac tgttcagttt
     4621 tccaaccact tggtggttca ggcttgcttt gaacctgagc tcttaggcac atgacggtca
     4681 ttcctgacat cctccccagc tcaagtctat tcttaccata gaacccaggg cagggagaga
     4741 agaacctaga ggcctggttt gctttggtgg cattgtaaaa agagtaagag aggtttggtt
     4801 tgtggtggtt tgctttcttt accataagca atcccttgcc ttaactcatc accctttttc
     4861 actatgaccc ttagaccctg agtattttca aatatatgat tgctgatagt agtgaccaaa
     4921 actactttgt tcctttctta ccactctctc ctggggccga cacgttggga cagcacacca
     4981 tagcataaag ctaggggatg catggaaata gcagcttgaa actaggaggt aacaagaaag
     5041 cttctaggaa gtagatgttc catatcttca aaatgcctcc tccaattttg taagaatgct
     5101 agctaggtat tcctgggatt attatactga gatatatata tatacacaca cacacacata
     5161 tgtgtatata tgtatatata tatgtgagta tatatacaca cacacacaca cacacacata
     5221 tatatatata cacacacgca cacatatatg ttgctgcagc ataaagaaat tgaaataaaa
     5281 gtttaaaata gtacccggtt caatgaaaga gcctaaacca tcttaactca gctttaaaac
     5341 aaaaattaaa tcaggaaaaa atgaaaaaaa aactgcatga aagaagaaaa ataccaaaca
     5401 gaattcttcc cttccattca ctcactaaag acctggtgaa gatagttaat tcaaatttgc
     5461 aagtttcaca ttttttaaca tcaagctatt ctccaagaag tttaggatgc attaacataa
     5521 gtgaaatggt cacctctagc taactagcat tgcttgattt cagaggagcc cttaggttct
     5581 gtagcatacc acattttcaa atctgctata ccctatatac ataaagaccc ttccaaacat
     5641 ctttttatag gcttaaactc ccaaaagagg tggtgacaaa tttcagggtc tttgtccctt
     5701 ttggtaacaa agcattgaaa acagtcattc cttcaagaag gcaccttgag ctcatccatg
     5761 gggtggcggt aaagatctta atgatttttc tgtggcaata tgcatcattc tttgtcctgg
     5821 gccatcttgg agaaaaaggt aaggagaaga caatgtaaat gctccaagat agtggaaatg
     5881 ctcatgtaat gattcttagg tgtggaaaat acttgctgat tctctttatg aggcagattc
     5941 aatttagaaa acaatgacca cagctctatt tgccatcctt gacagttagc agacattcca
     6001 acttgtgctt agggtacact gtctctcgcc tctcacaatg aggaacttag ttgcttcatt
     6061 ccatttcaaa cacagctttt ctttcagttt cagagcttat gagttaagga tttagtttgc
     6121 aatcatattt ctctatttta agatgttgtt tcaaatgcat attctctcct cgaaattttc
     6181 tgtggatttg agctcaatcg ctttatcatc tacatgatat cttttggcta gtacatttat
     6241 tttaaagtga ttttaaccat gatatcattt ctctcctttt agttttaata agatgaatga
     6301 ttctttagta agatgaagga tctttaaaca ctgttttccc ctgccctttc ctccctttct
     6361 tcaattttca tttttgaatt ttctatttcc ataaaaaggc tatataaatc agccttttgc
     6421 ttggctatat attcctttgt cccctgaaat aaaagtcacc atgaagtgta gtaggtttag
     6481 cctgaagcag ctccaataat gaaatagaaa ggcaaaggaa ggtatgagta ataaagctgg
     6541 aactcttcat tattcaatct ttgagcagtg aggactatgt tttgctgaca tagtgctaat
     6601 agaagaaatg gagactagca aaggctaact cagagtattt gattttctca tctaagtata
     6661 tatgcttgta gattgtcctg taggatgaag aatctgtgaa gctctatcct gaccacaatg
     6721 gcactacaaa atcaactggc atcttcctca cgtgtgtaga ctccatgcac actacatacc
     6781 acagacctaa atgtagatgc caggacagtg ccgtctacac gtcactccta taagtagtct
     6841 cagggctaaa gcagaattat ttttacaggg ttgaattatt tcataacccc agagaacact
     6901 aactttcact agatatatat gaaatgcaag tgatccgtac cctccaaagt agaatgtaat
     6961 ttacaattag aaatcgtgct aactctgact gtctttcctc agtggtacca agatctatgt
     7021 agttttatgt aattgttcaa ttgtgtgagt gttttaatcc ttctgcaatt atcatctcga
     7081 aggagacttt gaaagcatct taatctctct ttaaccattt tttttttctt tttcctacca
     7141 cattcaggtt tcccaactac atgctctggc caactgggcc accatgatct cttccactta
     7201 aatcctcagc cttcaataac tgctgtttac aaaaagatct tatggaatat ggatcacttt
     7261 acagtaaagc caaaagtact tgtgaaattt cacattttaa tggagctgtt tcattgatat
     7321 ttttttccac caaacaaatc tatttatgta agcaacagta tatttgctta ctctaaaata
     7381 tatttatcct actgcatcat ttattgcata tatagcctca attgccatct ttatgaaaat
     7441 ttgtctggag aaatagacat ttgtcatttc tatagacata tttttatgac taactttgcc
     7501 tcttctattt accctctgct gtatgcagaa gattttaagg atcctagcgg tgatgtttta
     7561 aaacaacttt tttcctctcc ttagtaataa cagagatggt attaacttga cttctacctt
     7621 ttgtcagact catctccacc aacgggtagc aagagcagga tagaacaaaa taaagagatt
     7681 gtttttcttt tttcattcat gaagtattta tggaatgcca atgagtgccg ggctaggcat
     7741 tgggtgaaca tatataaatt acaccttgtt tttgcccttg gggagctcaa agtctagctg
     7801 gcaaggcatg tattgttgca acagggccac acataaagtg tcctagaatg cagcacaagg
     7861 tcccgcacaa ttatttttgt gaagcatctg ccagactgaa agaaatgtaa atttctggga
     7921 aatatctgtt attttttaaa ttactgcttc caccttctgt aagctgtttt gtttctcctc
     7981 ctcaaagtag atatctatca atgcatatag atttctgtag aaaggggtgg attgactttt
     8041 aggaacagta agaatagatg gtctctgtct ctgccataca tttgaggagg ctgaattctc
     8101 tacattcttg tttcgggtca ggttggggga ttccaaaagt cttgcctccc atgagttgga
     8161 cctaagagtg tccactttgg cccctctcct tcccttttct cagttcttcc acagccatgt
     8221 gtttatgacc tattgcatgc cgttgttctt ccagatgttc ctgaaggtgg tttggttgtc
     8281 atccagctct tcctaaaacc ctccttagtc ctgatgagcc attttgactc tacataacat
     8341 ttctgaacct aactgaagtc tacccttcca tcagtaattg actaaaaaaa tgttgtccat
     8401 ttatgtgagg tctcacctct gagcctgagt gagtgtttcc tgtcttgaag gtcatacttg
     8461 ctccctctct gcaggaagtt aattcagtta gaagagttgc actgggaggg tgcaagcaca
     8521 gccaacttat ccagtccaag atatccaggg agatgaggat gagacctgtt gaattttttc
     8581 ttaggaaagg aaaggtcttg acagactgtt caccaactgc cctagcttcc tttaagcttc
     8641 cccatagcta ccatccatca aaacctcatt gcagctgtag cctaccaaaa ggcctttggg
     8701 atacctgtat ggttctgcca gtcattcttc cttaatgaaa aggcttggac atacttagtc
     8761 ctcaattatc ctacaggtca tgtatcgact aaataaataa actgacttca ttgtttctga
     8821 agatggcaaa ggcgattaat ggaagaagat gcagacaaac tcaaaacttt cagaagtcta
     8881 ggaggataac tgagtgctat tttctgtctc atgcagtttg aacatgtttt ctttaaaata
     8941 cacataatgt aattgaatta tttctatata ctgttcttga gtctttcttg acctcttctt
     9001 ttatcccctc tttcatagtc ttgtttgtgg aaccatctac tctgcagatt tttattgtct
     9061 ctaattatca gctctgcctt cacaaattcc aaatttgaac cacctaaagg ggaaaaaatg
     9121 caacacacac acgcacgctc acatgcacac tttgtacaaa tagggctgtt attcaacttt
     9181 tctcttgaac attctacata catatctgtt tggtagggag agaagcattc ctcttttatg
     9241 ttgacaatta tttgaatcct tcatataagg ttttaataat taaccggttt gctatttttc
     9301 agtgattatt ttatcttatt ttgcactaag gtactctgag gaagaacaga aaagcacatt
     9361 ttctagtgaa atattgtact ttgtaagcta gatgtctgtc ttatgtaatg tttatagtct
     9421 acaaaatggc tgagcagaca tgaacaaagg ttaatgcaaa agttggtttt ggtttcaacc
     9481 acacctgctg cgaacttgac gaggaggaag aggggccagt ggcagtaatt ggtggccatc
     9541 tgaggtgagg aaggaaattg cttccaccat gaatcagtgg tggcagcctt tccactttca
     9601 tggctcctca ctcaggagtc tctttagtgc atttggatca ttgtcttact cattagggaa
     9661 agaggcaata tcatgggctt tgcatgaata attctttact cacatttgca tgattttttt
     9721 taccttccaa cacttcttca gtcacattct tttttttcaa tttttaaatt ttttttcagg
     9781 attttctcag agtgctttag aactattatt ataattatct aacctgccca ggttaagcac
     9841 ccagatgcaa ctttcaggaa atgaaactgt cagaaaactg ccctaggtct attatcaatc
     9901 agagcccctg tgagtggaag tcctcagatt ctggaatcca tccagtgtct ttcttttcct
     9961 tccattcatc ctgacatgaa taagcataac ataactgtaa gaaggagtgt agtgtcccag
    10021 ccctgacaac gagtaccgcc agggacctac catctaacac catctgggaa cactattttt
    10081 tctcagtcct tccagttgac acaaggaaac cctttataaa ataggacaaa attaggagat
    10141 tagtcccaag ccaagaccaa aggtgaagat aattgtgtta gtgattaacg cctggtctta
    10201 ttttaacgag tgtcatagtc ttacatgctt cagatgccag aaatatcttc agagaacgtg
    10261 aacaaagtgc tggatatgaa acaggaataa tgcattcctc tacagactct ttgaaaggct
    10321 ttctctttca agaaaccttg aagggaaaat attaacgggc atcagcctgg gcatactttc
    10381 ccatcagagt cagcctctat cacaaacatt ttacatgaaa tattcaccta gtctattctc
    10441 tttgaaaggt agtatcaacc tgtgtaacct tgtcctgcct taaatactgt tgcaaaaaat
    10501 accaaacttt gcttaaagca gcatagttac attgagaaag agactgcctt tagtgaggac
    10561 aaagaccaag aattttctct ttctgaatct ggcagttgac aggcctcctg atatcctgtg
    10621 ttgccttgga ctaacatttt ccttagtcac tagcctaggg cagaaaggca gccatgtata
    10681 aatgaatacc catggccatg ttccaatata actttattta caaaatctaa tttagttcat
    10741 aggttacggt ttgctgattc ctaagataga gcattacagt gtctgtttca gatgggaagt
    10801 aagtcttcct atggcatgtt caggccctcc ttttcaggga atgagaaaga gtggggaggg
    10861 tatttcaaca agtaataaat tgcagaatac cctccccaca aaaatacaca tatgtcagac
    10921 tctttattat ggtaaaagca caaaacaggt catctttttg tggaaatgct ggagtctacc
    10981 ttttcctttt tatcttctga tttttgttcc taaaataaaa tcccaagtga tgttgcctca
    11041 ttccaagtca gttttgtaga ccatgtaaca tgtcttaata cactgtatgg ggaaaaaata
    11101 aaagttagcc ttagatttct ttgttttcta tggttattgt tgtacagaag aaagacaaac
    11161 tgtaaataat gtatatttaa taaagagaac attttgtatg attttgtgtg gaagacaaa
//
