LOCUS       NM_033401               6263 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens contactin associated protein family member 4
            (CNTNAP4), transcript variant 1, mRNA.
ACCESSION   NM_033401
VERSION     NM_033401.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6263)
  AUTHORS   Hu,W., Wang,M., Sun,G., Zhang,L. and Lu,H.
  TITLE     Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through
            directly regulating contactin-associated protein-like 4 (CNTNAP4)
            transcription: An experimental study
  JOURNAL   Cell Signal 118, 111139 (2024)
   PUBMED   38479556
  REMARK    GeneRIF: Early B Cell Factor 3 (EBF3) attenuates Parkinson's
            disease through directly regulating contactin-associated
            protein-like 4 (CNTNAP4) transcription: An experimental study.
REFERENCE   2  (bases 1 to 6263)
  AUTHORS   Zhang,W., Zhou,M., Lu,W., Gong,J., Gao,F., Li,Y., Xu,X., Lin,Y.,
            Zhang,X., Ding,L., Zhang,Z., Li,G., Chen,X., Sun,X., Zhu,X., Xu,P.
            and Zhang,Y.
  TITLE     CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian
            phenotypes
  JOURNAL   Theranostics 10 (7), 3000-3021 (2020)
   PUBMED   32194851
  REMARK    GeneRIF: CNTNAP4 deficiency in dopaminergic neurons initiates
            parkinsonian phenotypes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6263)
  AUTHORS   Shangguan,Y., Xu,X., Ganbat,B., Li,Y., Wang,W., Yang,Y., Lu,X.,
            Du,C., Tian,X. and Wang,X.
  TITLE     CNTNAP4 Impacts Epilepsy Through GABAA Receptors Regulation:
            Evidence From Temporal Lobe Epilepsy Patients and Mouse Models
  JOURNAL   Cereb Cortex 28 (10), 3491-3504 (2018)
   PUBMED   28968899
  REMARK    GeneRIF: we demonstrated that the expression of
            contactin-associated protein-like 4 (CNTNAP4) was decreased in the
            temporal neocortex of epileptic patients
REFERENCE   4  (bases 1 to 6263)
  AUTHORS   Kennedy,R.B., Ovsyannikova,I.G., Haralambieva,I.H., Lambert,N.D.,
            Pankratz,V.S. and Poland,G.A.
  TITLE     Genome-wide SNP associations with rubella-specific cytokine
            responses in measles-mumps-rubella vaccine recipients
  JOURNAL   Immunogenetics 66 (7-8), 493-499 (2014)
   PUBMED   24811271
REFERENCE   5  (bases 1 to 6263)
  AUTHORS   Iakoubov,L., Mossakowska,M., Szwed,M., Duan,Z., Sesti,F. and
            Puzianowska-Kuznicka,M.
  TITLE     A common copy number variation (CNV) polymorphism in the CNTNAP4
            gene: association with aging in females
  JOURNAL   PLoS One 8 (11), e79790 (2013)
   PUBMED   24223195
  REMARK    GeneRIF: This study is the first demonstration for association of
            the CNTNAP4 gene and one of its intronic CNV polymorphisms with
            aging.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6263)
  AUTHORS   Dastani,Z., Pajukanta,P., Marcil,M., Rudzicz,N., Ruel,I.,
            Bailey,S.D., Lee,J.C., Lemire,M., Faith,J., Platko,J., Rioux,J.,
            Hudson,T.J., Gaudet,D., Engert,J.C. and Genest,J.
  TITLE     Fine mapping and association studies of a high-density lipoprotein
            cholesterol linkage region on chromosome 16 in French-Canadian
            subjects
  JOURNAL   Eur J Hum Genet 18 (3), 342-347 (2010)
   PUBMED   19844255
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6263)
  AUTHORS   Nordgard,S.H., Johansen,F.E., Alnaes,G.I., Bucher,E., Syvanen,A.C.,
            Naume,B., Borresen-Dale,A.L. and Kristensen,V.N.
  TITLE     Genome-wide analysis identifies 16q deletion associated with
            survival, molecular subtypes, mRNA expression, and germline
            haplotypes in breast cancer patients
  JOURNAL   Genes Chromosomes Cancer 47 (8), 680-696 (2008)
   PUBMED   18398821
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 6263)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   9  (bases 1 to 6263)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   10 (bases 1 to 6263)
  AUTHORS   Spiegel,I., Salomon,D., Erne,B., Schaeren-Wiemers,N. and Peles,E.
  TITLE     Caspr3 and caspr4, two novel members of the caspr family are
            expressed in the nervous system and interact with PDZ domains
  JOURNAL   Mol Cell Neurosci 20 (2), 283-297 (2002)
   PUBMED   12093160
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB051550.2, AC106741.3,
            BM544789.1, Z44514.1 and AC108125.4.
            
            On Nov 22, 2018 this sequence version replaced NM_033401.4.
            
            Summary: This gene encodes a member of the neurexin protein family.
            Members of this family function in the vertebrate nervous system as
            cell adhesion molecules and receptors. This protein contains
            epidermal growth factor repeats and laminin G domains. In addition,
            it includes an F5/8 type C domain, discoidin/neuropilin- and
            fibrinogen-like domains, and thrombospondin N-terminal-like
            domains. This protein may also play a role in proper
            neurotransmission in the dopaminergic and GABAergic systems and
            mutations in this gene may be associated with certain psychiatric
            illnesses. A polymorphism in an intron of this gene may be
            associated with longevity. [provided by RefSeq, Apr 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.58095.1,
                                           SRR1803615.200799.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000611870.5/ ENSP00000479811.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2615              AB051550.2         124-2738
            2616-2622           AC106741.3         114984-114990
            2623-3723           AB051550.2         2746-3846
            3724-4347           BM544789.1         28-651
            4348-4569           AB051550.2         4471-4692
            4570-4744           Z44514.1           141-315
            4745-5629           AC106741.3         175540-176424
            5630-6263           AC108125.4         29841-30474
FEATURES             Location/Qualifiers
     source          1..6263
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..6263
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /note="contactin associated protein family member 4"
                     /db_xref="GeneID:85445"
                     /db_xref="HGNC:HGNC:18747"
                     /db_xref="MIM:610518"
     exon            1..347
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..4189
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cell recognition molecule Caspr4; contactin
                     associated protein like 4"
                     /codon_start=1
                     /product="contactin-associated protein-like 4 isoform 1
                     precursor"
                     /protein_id="NP_207837.2"
                     /db_xref="CCDS:CCDS73915.1"
                     /db_xref="GeneID:85445"
                     /db_xref="HGNC:HGNC:18747"
                     /db_xref="MIM:610518"
                     /translation="MGSVTGAVLKTLLLLSTQNWNRVEAGNSYDCDDPLVSALPQASF
                     SSSSELSSSHGPGFARLNRRDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYGS
                     SNWVTSYLLMFSDSGWNWKQYRQEDSIWGFSGNANADSVVYYRLQPSIKARFLRFIPL
                     EWNPKGRIGMRIEVFGCAYRSEVVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSD
                     GILLHREGPNGDHITLQLRRARLFLLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVL
                     IQRLGKQVNFTVDEHRHHFHARGEFNLMNLDYEISFGGIPAPGKSVSFPHRNFHGCLE
                     NLYYNGVDIIDLAKQQKPQIIAMGNVSFSCSQPQSMPVTFLSSRSYLALPDFSGEEEV
                     SATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELND
                     GQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKCKSP
                     LGGFQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDSCGISDRCLPNYCEHGGECSQ
                     SWSTFHCNCTNTGYRGATCHNSIYEQSCEAYKHRGNTSGFYYIDSDGSGPLEPFLLYC
                     NMTETAWTIIQHNGSDLTRVRNTNPENPYAGFFEYVASMEQLQATINRAEHCEQEFTY
                     YCKKSRLVNKQDGTPLSWWVGRTNETQTYWGGSSPDLQKCTCGLEGNCIDSQYYCNCD
                     ADRNEWTNDTGLLAYKEHLPVTKIVITDTGRLHSEAAYKLGPLLCQGDRSFWNSASFD
                     TEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIADFIRIELRSPTVVTFSFDV
                     GNGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNS
                     QLFVGGTATRQRGFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGHCSSYGKLCRNG
                     GKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAAS
                     FHGDMKLSREMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIRYKLNKYQEP
                     DVVNFDFKNMADGQLHHIMINREEGVVFIEIDDNRRRQVHLSSGTEFSAVKSLVLGRI
                     LEHSDVDQDTALAGAQGFTGCLSAVQLSHVAPLKAALHPSHPDPVTVTGHVTESSCMA
                     QPGTDATSRERTHSFADHSGTIDDREPLANAIKSDSAVIGGLIAVVIFILLCITAIAV
                     RIYQQKRLYKRSEAKRSENVDSAEAVLKSELNIQNAVNENQKEYFF"
     exon            348..458
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            459..652
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            653..800
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1004
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1189
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1333
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1595
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1745
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1917
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2024
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2144
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2342
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2499
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2627
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2798
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..3017
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3257
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..3482
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3483..3616
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..3704
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..3923
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3924..3995
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3996..6263
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4720..4725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /note="hexamer: AATACA"
     polyA_site      4744
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /note="major polyA site"
     regulatory      6239..6244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
                     /note="hexamer: AATAAA"
     polyA_site      6263
                     /gene="CNTNAP4"
                     /gene_synonym="CASPR4"
ORIGIN      
        1 gcttttcagt gaggagtcag ggaggtgtgt gtgagagaga gagagaaaag agagagacag
       61 agacggggag agagagaggg agagagaaga gagggaggag ggaagaagaa aagacggagg
      121 gaggtgagga ggaagggagg gggagagaca gagacctaga ggggctgaag acccagacag
      181 agctggcaga gctactgaga agaggactgg agcgctctga gagcctctca agatcttttg
      241 ggggagccca ataaatgtga acatgggatc tgtcacggga gctgtcctca agacgctact
      301 tctgttatct actcaaaatt ggaacagagt cgaagctggg aattcctatg actgtgatga
      361 tcctcttgtg tctgccttgc ctcaggcatc cttcagcagt tcttccgagc tctccagcag
      421 tcatggtcct ggatttgcaa ggctgaatag aagagatgga gctggtggct ggtctccact
      481 tgtgtctaac aaataccagt ggttgcagat tgaccttgga gagagaatgg aggtcaccgc
      541 tgtggccact caagggggat atggtagctc caactgggtg accagctacc tcctgatgtt
      601 cagtgatagt ggctggaact ggaaacaata tcgccaagag gacagcatct ggggtttttc
      661 aggaaatgca aatgcagaca gtgttgtgta ctatagactc cagccttcta tcaaagccag
      721 atttctgcgc ttcatccctt tggaatggaa ccccaagggc agaattggaa tgcgaatcga
      781 agtgttcgga tgtgcataca gatcagaagt ggttgatctt gatggaaaaa gttcccttct
      841 ctacagattt gatcaaaaat ccctgagccc aataaaagac attatttctt tgaaattcaa
      901 aaccatgcag agtgatggga ttctactcca cagggaaggg ccaaatggag atcacatcac
      961 actgcaatta agaagagcaa gactcttttt acttattaat tcaggtgaag ctaaactgcc
     1021 ttccacttcc accctggtca atctcaccct gggcagcctg ctagatgatc agcattggca
     1081 ttcagtgctc atccagcgtt tgggcaaaca agtcaacttc acagtggacg aacacaggca
     1141 tcatttccat gcacggggag aattcaatct catgaatctt gattatgaga tcagctttgg
     1201 agggattcca gcacctggaa aatcagtgtc attcccacat agaaattttc atggatgttt
     1261 agaaaatctc tattataatg gagtggatat cattgatttg gccaagcagc aaaaaccaca
     1321 gatcattgct atgggaaatg tgtcattttc ttgttcacaa ccacaatcta tgcccgtgac
     1381 ttttctgagc tccaggagtt atttagcact gccagacttc tctggagagg aggaggtttc
     1441 tgccactttt caatttcgaa cttggaataa ggcagggctt ctgctgttca gtgaacttca
     1501 gctgatttca gggggtatcc tcctctttct gagtgatgga aaacttaagt cgaatctcta
     1561 ccagccagga aaattaccca gtgacatcac agcaggtgtc gaattaaatg atgggcagtg
     1621 gcattctgtc tctttatctg ctaaaaagaa tcacttgagt gtggcggtgg acggccagat
     1681 ggcttctgct gctcctctgc tggggcctga gcagatttat tcgggtggca cctattattt
     1741 tggaggttgt cctgacaaaa gctttggatc caaatgtaaa agtccacttg gtggatttca
     1801 gggatgtatg aggctcattt ctatcagcgg caaagtggta gatctgattt cagttcagca
     1861 ggggtccctt gggaacttca gtgaccttca gatagactca tgtggcatct cagacaggtg
     1921 tttgcccaac tattgtgaac acggtgggga gtgttcccag tcctggagca cctttcattg
     1981 taactgtacc aacactggtt acagaggagc tacttgccat aactctatct atgagcagtc
     2041 atgtgaagcc tataagcaca gaggaaatac ttcagggttt tactatatag attcagatgg
     2101 aagtggtccc ctggaaccat ttcttctata ttgcaatatg accgaaactg catggaccat
     2161 catacagcac aacggctctg acttaacaag agtcagaaat actaatccag agaacccata
     2221 tgctgggttt ttcgagtatg tggccagcat ggagcaactt caggccacta ttaaccgtgc
     2281 agagcactgt gaacaggagt ttacttatta ctgcaagaag tcacggctgg tcaataagca
     2341 agatggaacc cctctgagtt ggtgggtagg aagaaccaat gaaacgcaaa cctactgggg
     2401 aggttcttcg cctgatcttc aaaaatgtac ttgtggatta gagggaaact gcattgattc
     2461 tcagtattac tgcaattgtg atgctgaccg gaatgaatgg accaatgaca ctggattgct
     2521 tgcttataaa gaacatcttc cagtaactaa gatcgtgatt acagacacag gccgactgca
     2581 ttcagaagca gcttataaac tggggcctct gctctgccag ggagacagat cattttggaa
     2641 ttcagcttcc tttgataccg aggcttcata tcttcatttt cctaccttcc acggagaact
     2701 tagcgcggat gtatctttct tttttaagac aacagcttca tctggggtat ttttagagaa
     2761 cttggggatt gctgatttta tacggataga gcttcgctct ccgacagtag tgactttttc
     2821 atttgatgtg gggaatgggc cttttgaaat ctcagtgcag tcacccaccc acttcaacga
     2881 caaccagtgg caccatgtga gggttgaaag gaacatgaag gaggcctccc ttcaagtgga
     2941 tcagctgaca ccaaagacac agcccgcccc cgctgatggg catgtcctgt tacagctcaa
     3001 cagtcagctc ttcgtgggtg gaacggccac cagacagaga ggctttctgg gctgcattcg
     3061 gtctctgcag ttgaatggga tgaccctgga tttggaagaa agagcccagg tgactccaga
     3121 agtgcagcca ggttgtaggg gacattgcag cagctatggg aagttatgcc gcaatggagg
     3181 gaaatgcaga gaaagaccca ttgggttctt ttgtgactgc actttctctg catacacagg
     3241 gccattctgc tcaaatgaga tttctgcata ttttggatct ggctcatccg tgatatacaa
     3301 ttttcaagaa aattatcttt taagtaaaaa ctccagctcc cacgctgctt catttcatgg
     3361 tgatatgaag ctgagcagag aaatgatcaa atttagtttc cgaacaacac gaacaccaag
     3421 cttgctgctt tttgtgagct ccttttacaa agaatacctt tctgtgatca ttgccaaaaa
     3481 tggaagtttg cagatcaggt acaagttaaa taaatatcaa gagcctgatg ttgttaactt
     3541 tgattttaaa aacatggctg atggacaact tcaccacata atgattaaca gagaagaagg
     3601 agtggtcttt atagagattg acgataatag aaggagacaa gttcacctgt catcaggcac
     3661 agaattcagt gcagtcaaat ctctggtatt gggcaggatt ttagaacaca gtgatgtgga
     3721 ccaggatact gcactggcag gtgcgcaggg cttcacaggc tgcctctctg cagtgcagct
     3781 cagccacgtg gcccctctga aggcagctct gcaccccagc cacccagacc ctgtcactgt
     3841 tacaggacac gtgactgagt ccagctgtat ggcccagcct ggcactgatg ccacatcaag
     3901 ggaaaggaca cactcgtttg cagatcattc tggaacaata gatgacagag agccccttgc
     3961 taatgcaatc aaaagtgact ctgcagtaat tggaggtctg atagctgttg tgatttttat
     4021 cttgctttgc atcactgcca tagctgttcg catttatcag cagaaaaggt tatataaaag
     4081 aagtgaggca aaaaggtcag agaatgtaga cagtgctgag gctgttctga aaagtgagct
     4141 taatatacaa aatgcagtca atgaaaatca gaaagagtac ttcttctgat tggcagctat
     4201 gatttaacat aaaattatga tagtttgttt taatagccag gggttctcaa tggaaaaacg
     4261 aatgctctta cactgaatgt acaggcagtg ggcttgcagc actgccatct tgccatgtac
     4321 aggcttgggg tggctccagg aagcctcgtc cagtgatata tttctcatag cattcattct
     4381 atggaacaag aaattagata ttgctgttaa ttttcaactg ttctggtatg atctaaaaca
     4441 agtttaacct gcttaatggc tacagttttt acatgtgaaa actgtagcct tggtctctta
     4501 accatgtaat acataagttt tgttagaggt aaaaattaaa tttggactat aatgtccttg
     4561 ctttatttga gaacatttgc tgtgtttgct tttgtctcct cgtggtgtta ttcatagacc
     4621 tggaaatgct tctcagatcc tgtgtggccg gtgtttgcat cttcagtggc cacaagcata
     4681 ataaagcccc tttgcctttc tctgtattat attcaataca atacatcaat agtcttgaaa
     4741 aatgttttgc tgtctttgct ttgtttgtat tgctcattat tctatttgtc tcttcttaat
     4801 aatgttgaat acatttggtt ttgagtctca gacttcaact ctgaacatac aagttgtatt
     4861 taacaagact cagaaagtgc agtggttgtt agtatgtaat gtctttcctt ttaaaaaaag
     4921 ttttccaatt aatttgctac cattgtttga tggtgacagt acttaagacc ctgagtaatg
     4981 ccagtttccc aaagaatgta aaatgttttc aactaaactg ttgatatatt aaaaaaaatt
     5041 cttaacacag caaaaaatta ttatttaatt tacaactgta atacctcaaa tgaaatatac
     5101 ttatgagact attttgccca aacctagatc agtcctttat tggtttacat ttctgttttt
     5161 ctgaagttta tcacaaactt cgccttgatc ttcaatgatt atacttcacg aatcatctta
     5221 tatattacca aaaaagagac aaattgaagt atagagcccc atttcccatt ctgaaacata
     5281 taccccttta ggtgtacatt ttgctgtgca tagacttcca gtacatactt tttgaaatat
     5341 gagctgcaac catcagtgat ctacacaatc aataattaaa caatgcacac tctaagggga
     5401 gatagcatat taaatgatct actgtgaatt tgtcattcca gacacttctc gtctgaaacg
     5461 atggggtgaa tttctcaaaa attaccaaga atcaatccaa cttgctgaat ggtacattct
     5521 gattagggtg tattatacac taggagatca aagaatgatc aataacctta tggaactgtt
     5581 acaataatta atcttgagac catgcataca aggaactatc tttgaattct gcaagccaat
     5641 catacaataa aggcactcta ttatacatac tcacaccttc aagtgcctcc caagtaacta
     5701 ttggatttct tagtttgtct acaccagaag aatcgggaaa tatgtaaatt tagcattact
     5761 atcatcttat tttctatatt ttccttgtta actcttctta taaaacctgc ctctcttttc
     5821 tcatagcact atatccatat tgatgtttct gcaaatgcct gactaaatct taagaacctg
     5881 aattaacata gtagtttacg aaggactaag gacctatgtt ggtagatggt atactctttg
     5941 tttgattgga agatctatgg tgacaaggga aggatttaac atagaaatgg cattatttat
     6001 tcgatgcaaa gctgagtgca aacatcatta tatctctgaa tcttttgcag atgttcatgt
     6061 tatttagtag cggtattaac ctcattggta gctgaactct agggaggttt attggtgaag
     6121 cctcacagtc ctctgtggtc tgcactgcta gagactcaac attatggcat ggaaatgcat
     6181 tgacacatcc tatgccatga ctttaatttc ctgatttgta atctcttatt ttatcattaa
     6241 taaaatgcat ttttgaacta aaa
//
