LOCUS       NM_001201380            7652 bp    mRNA    linear   PRI 15-FEB-2024
DEFINITION  Homo sapiens contactin associated protein family member 3B
            (CNTNAP3B), mRNA.
ACCESSION   NM_001201380 XM_003119167 XM_003119168 XM_006726476
VERSION     NM_001201380.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7652)
  AUTHORS   Boyadjiev,S.A., South,S.T., Radford,C.L., Patel,A., Zhang,G.,
            Hur,D.J., Thomas,G.H., Gearhart,J.P. and Stetten,G.
  TITLE     A reciprocal translocation 46,XY,t(8;9)(p11.2;q13) in a bladder
            exstrophy patient disrupts CNTNAP3 and presents evidence of a
            pericentromeric duplication on chromosome 9
  JOURNAL   Genomics 85 (5), 622-629 (2005)
   PUBMED   15820314
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX649569.5, CR788268.5 and AL953854.21.
            
            On Nov 27, 2019 this sequence version replaced NM_001201380.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377561.7/ ENSP00000478671.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               BX649569.5         121127-121543       c
            418-528             BX649569.5         96746-96856         c
            529-722             BX649569.5         68986-69179         c
            723-870             CR788268.5         18321-18468
            871-1074            CR788268.5         33242-33445
            1075-1259           CR788268.5         34094-34278
            1260-1403           CR788268.5         35498-35641
            1404-1665           CR788268.5         39975-40236
            1666-1809           CR788268.5         45535-45678
            1810-1981           CR788268.5         61601-61772
            1982-2088           CR788268.5         67202-67308
            2089-2208           CR788268.5         70954-71073
            2209-2412           CR788268.5         78460-78663
            2413-2569           CR788268.5         93446-93602
            2570-2697           CR788268.5         102402-102529
            2698-2868           CR788268.5         107753-107923
            2869-3087           CR788268.5         108951-109169
            3088-3327           CR788268.5         111537-111776
            3328-3552           AL953854.21        153965-154189       c
            3553-3686           AL953854.21        152262-152395       c
            3687-3774           AL953854.21        151276-151363       c
            3775-4005           AL953854.21        144177-144407       c
            4006-4077           AL953854.21        143870-143941       c
            4078-7652           AL953854.21        135944-139518       c
FEATURES             Location/Qualifiers
     source          1..7652
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p11.2"
     gene            1..7652
                     /gene="CNTNAP3B"
                     /note="contactin associated protein family member 3B"
                     /db_xref="GeneID:728577"
                     /db_xref="HGNC:HGNC:32035"
     exon            1..417
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..4199
                     /gene="CNTNAP3B"
                     /note="cell recognition molecule Caspr3b; contactin
                     associated protein like 3B"
                     /codon_start=1
                     /product="contactin-associated protein-like 3B precursor"
                     /protein_id="NP_001188309.2"
                     /db_xref="CCDS:CCDS75836.1"
                     /db_xref="GeneID:728577"
                     /db_xref="HGNC:HGNC:32035"
                     /translation="MASVAWAVLKVLLLLPTQTWSPVGAGNPPDCDSPLASALPRSSF
                     SSSSELSSSHGPGFSRLNRRDGAGGWTPLVSNKYQWLQIDLGERMEVTAVATQGGYGS
                     SDWVTSYLLMFSDGGRNWKQYRREESIWGFPGNTNADSVVHYRLQPPFEARFLRFLPL
                     AWNPRGRIGMRIEVYGCAYKSEVVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSN
                     GILLHREGQHGNHITLELIKGKLVFFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSVL
                     IELLDTQVNFTVDKHTHHFQAKGDSSNLDLNFEISFGGILSPGRSRAFTRKSFHGCLE
                     NLYYNGVDVTELAKKHKPQILMMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKV
                     SVTFQFRTWNRAGHLLFGELQRGSGSFVLFLKDGKLKLSLFQAGQSPRNVTAGAGLND
                     GQWHSVSFSAKWSHMNVVVDDDTAVQPLVAVLIDSGDTYYFGGCLGNSSGSGCKSPLG
                     GFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSW
                     DTFSCDCLGTGYTGETCHSSLYEQSCEAHKHRGNPSGLYYIDADGSGPLGPFLVYCNM
                     TADSAWTVVRHGGPDAVTLRGAPSGHPLSAVSFAYAAGAGQLRAAVNLAERCEQRLAL
                     RCGTARRPDSRDGTPLSWWVGRTNETHTSWGGSLPDAQKCTCGLEGNCIDSQYYCNCD
                     AGQNEWTSDTIVLSQKEHLPVTQIVMTDTGQPHSEADYTLGPLLCRGDKSFWNSASFN
                     TETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGITDFIRIELRAPTEVTFSFDV
                     GNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNS
                     QLFIGGTATRQRGFLGCIRSLQLNGVALDLEERATVTPGVEPGCAGHCSTYGHLCRNG
                     GRCREKRRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSS
                     LHRDVTLTREMITLSFRTTRTPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNP
                     DAFTFDFKNMADGQLHQVKINREEAVVMVEVNQSAKKQVILSSGTEFNAVKSLILGKV
                     LEAAGADPDTRRAATSGFTGCLSAVRFGCAAPLKAALRPSGPSRVTVRGHVAPMARCA
                     AGAASGSPARELAPRLAGGAGRSGPVDEGEPLVNADRRDSAVIGGVIAVEIFILLCIT
                     AIAIRIYQQRKLRKENESKVSKKEEC"
     exon            418..528
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            529..722
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            723..870
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1074
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1259
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1403
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1665
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1809
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1981
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2088
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2208
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2412
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2569
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2697
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2868
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..3087
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3327
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..3552
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3686
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3687..3774
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3775..4005
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            4006..4077
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..7652
                     /gene="CNTNAP3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5295..5300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTNAP3B"
                     /note="hexamer: ATTAAA"
     polyA_site      5318
                     /gene="CNTNAP3B"
     regulatory      7633..7638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTNAP3B"
                     /note="hexamer: AATAAA"
     polyA_site      7652
                     /gene="CNTNAP3B"
                     /note="major polyA site"
ORIGIN      
        1 gactcgcgtt ggtgccggcc gcctcccgcg cctagtgtcc gggacgcgcc tgaacctgcc
       61 gcctccgtgc ctggggcggc gccgcgcggc ccccaggctc ccgcggggcc gacctcggag
      121 acgcagctgg ggccgggcgc ggcttggcgg gagggtctgc agcgccgagg gaggctgcca
      181 gtgcgtgagg aagagagcta gagactggac aggggagaca gagcagcgtc ggagccgcgc
      241 aggggacggg agtgagagcg ggagtgagag caggaacgac gcagagcggc cgtcgccgtg
      301 cccgggtctc agggcgcctg gctgaagtga gcatggcttc agtggcctgg gccgtcctca
      361 aggtgctgct gcttctcccc actcagactt ggagccccgt aggagcagga aatccacctg
      421 actgtgattc cccactggcc tctgccttgc ctaggtcatc cttcagcagc tcctcagagc
      481 tgtccagcag ccacggcccg gggttttcaa ggcttaatcg aagagatgga gctggtggct
      541 ggaccccact tgtgtcaaat aaataccaat ggctgcaaat tgaccttgga gagagaatgg
      601 aggtcactgc tgtcgccacc caaggaggat atgggagctc tgactgggtg accagctacc
      661 tcctgatgtt cagtgatggt gggagaaact ggaagcagta tcgccgagaa gaaagcatct
      721 ggggttttcc aggaaacaca aacgcagaca gtgtggtgca ctacagactc cagcctccct
      781 ttgaagccag gttcctgcgc tttctccctt tagcctggaa ccccaggggc aggattggga
      841 tgcggatcga agtgtacgga tgtgcatata aatctgaggt ggtttatttt gatggacaaa
      901 gtgctctgct gtatacactt gataaaaaac ctttaaaacc aataagagat gttatttctt
      961 tgaaatttaa agccatgcag agcaatggaa ttctacttca cagagaagga caacatggaa
     1021 atcacattac tctggaatta attaaaggaa agcttgtctt ttttcttaat tcaggcaatg
     1081 ctaagctgcc ttctactatt gctcctgtga ccctcaccct gggcagcctg ctggatgacc
     1141 agcactggca ttccgtcctc atcgagctcc tcgacacgca ggtcaacttc accgtggaca
     1201 aacacactca tcatttccaa gcaaagggag attccagtaa cttggatctt aattttgaga
     1261 tcagctttgg gggaattctg tcacccggaa gatcacgggc attcacacgt aaaagctttc
     1321 atgggtgttt agaaaatctt tattataatg gagtggatgt taccgaatta gccaagaaac
     1381 acaaaccaca gatcctcatg atgggaaatg tgtccttctc atgtccacag ccacagactg
     1441 tccctgtgac ttttctgagc tccaggagtt atctggctct gccaggcaac tctggggagg
     1501 acaaagtgtc tgtcactttt caatttcgaa cgtggaacag agcaggacat ttgcttttcg
     1561 gcgaacttca acgtggttca gggagtttcg tcctctttct taaggatggc aagctcaaac
     1621 tgagtctctt ccaggcggga cagtcaccaa ggaatgtcac agcaggtgct ggattaaacg
     1681 atgggcagtg gcactctgta tccttctctg ccaagtggag ccatatgaat gtggtggtgg
     1741 atgatgacac agctgttcag cccctggtgg ctgtgctcat tgattcaggt gacacctatt
     1801 attttggagg ctgcctgggc aacagctctg gctctggatg taaaagcccc ctgggagggt
     1861 ttcagggctg cctaaggctc atcaccattg gtgacaaagc ggtggatccc atcttagtac
     1921 agcagggggc gctggggagt ttcagggacc tccagataga ctcctgcggc atcacagaca
     1981 ggtgcttgcc cagctactgt gagcatgggg gcgagtgttc ccagtcgtgg gacaccttct
     2041 cctgtgactg tctaggcaca ggctatacgg gcgagacctg ccattcctct ctctacgagc
     2101 agtcttgtga agcccacaag caccgaggga acccatccgg gctttactat attgatgcag
     2161 atggaagtgg ccccctggga ccatttcttg tgtactgcaa tatgacagca gactccgcgt
     2221 ggacggtggt gcggcacggt ggccccgacg cggtgaccct ccgaggtgcc cccagcgggc
     2281 acccgctctc ggctgtgtcc ttcgcgtacg cagcgggcgc ggggcagctg cgggccgcgg
     2341 tgaacctggc ggagcgctgc gagcagcggc tggctctgcg ctgcgggaca gcgcggcgcc
     2401 cggactcacg agatggaacc ccactgagct ggtgggttgg aagaaccaat gaaacacaca
     2461 cttcctgggg aggttctctg cctgatgctc aaaagtgtac ttgtggatta gaggggaact
     2521 gcattgattc tcagtattac tgcaactgtg atgctggcca gaatgaatgg actagtgaca
     2581 caatagtcct ttcccaaaag gagcacctcc cagtcactca gattgtgatg acagacacag
     2641 gccaaccaca ttccgaagca gattatacac tggggccact gctctgccgc ggagataagt
     2701 cattttggaa ttcagcttcc ttcaacactg agacttcata ccttcatttc cctgctttcc
     2761 acggagaact cactgctgac gtgtgcttct tttttaagac cacagtttcc tctggggtgt
     2821 ttatggagaa cctggggatc acagacttca tcaggattga gctgcgggct cccacagaag
     2881 tgacattttc cttcgatgtg gggaatggac cttgtgaggt cacggtgcag tcacccactc
     2941 cctttaatga caatcagtgg caccacgtga gggcagagag aaatgttaaa ggagcgtctc
     3001 ttcaagttga tcagcttcct cagaagatgc agcctgcccc tgctgatggg cacgttcgtt
     3061 tacagctcaa cagccagctc ttcattggtg gaacggccac cagacagaga ggctttctag
     3121 gatgcattcg gtctctgcag ttgaacgggg tggccctgga tctggaagaa agagccacag
     3181 tgacgccagg agtggagcca gggtgtgcag gacactgcag cacctatgga cacttgtgtc
     3241 gcaatggagg gagatgcaga gagaaacgca ggggggtcac ctgtgactgt gccttctcag
     3301 cctatgatgg accgttctgc tccaatgaga tttccgcata tttcgcaact ggctcctcaa
     3361 tgacatacca ttttcaagaa cattacactt taagtgaaaa ctccagctct ctcgtttctt
     3421 cattacacag agatgtaaca ttgaccagag aaatgatcac actgagcttc cgaaccacac
     3481 gaactccgag cttattgctg tatgtgagct ctttctatga ggaatacctt tcagttatcc
     3541 tcgccaacaa tggaagtttg cagattaggt acaagctaga tagacatcaa aatcctgatg
     3601 catttacctt tgattttaaa aacatggctg atgggcaact tcaccaagtg aagattaaca
     3661 gagaagaagc cgtggtcatg gtagaggtta accagagcgc aaagaaacaa gtcatcttgt
     3721 cctcagggac agaattcaac gccgtcaaat ctctcatatt gggaaaggtt ttagaggctg
     3781 ccggcgcgga cccggacaca aggcgggcgg cgactagtgg cttcactggc tgcctctcgg
     3841 cggtgcgctt cggctgcgct gctcccctga aggcggcgct gcgccccagc ggcccctccc
     3901 gggtcaccgt ccgcggccac gtggccccta tggcccgctg cgcggcgggg gcggcgtccg
     3961 gctccccggc gcgggaactg gctccccgac tcgcgggggg cgcaggtcgt tctggaccag
     4021 tggatgaggg agagcccttg gttaatgcag acagaagaga ctctgctgtc atcggaggtg
     4081 tgatagcagt ggagatattt attttgcttt gcatcactgc catagccata cgcatctatc
     4141 aacagagaaa gttacgcaaa gaaaatgagt caaaagtctc aaaaaaagaa gagtgctagg
     4201 acagctctaa acagtgagct cgatgtgcaa aacgcagtcc atgaaaacca gaaagagtga
     4261 gtcttctgat tggcagctgt ggctgtctct atcatcgtga ctgtggactt ccctgctgtt
     4321 gccatcaggg tgcacacagc aggtgcagtg ctgtcacctg gctgaagatc tgcagcctca
     4381 gagcctctgg gaggtccctt tctccctcgg tgaaacacag tcctccacat caatttccaa
     4441 acaatgaatt aggtatggcc attcatcact gttcagtagt ttccccgtcc aaaggctctc
     4501 ttccaaaact gcagtttgat ctgtgttaat aattgtgggg ttttagatga gaaaatgact
     4561 ataaagctgt ggccctactt tattttttaa aaatgacaga acttttgttc agatgtaaaa
     4621 gacaaaattg cactttaatg ttttttgtta cttgaaaaca tatctgggat cccttttttt
     4681 ggtcctctgc tgatattata aaacaagaaa tgcttcttgg actaccttca ctggcatttc
     4741 catagtcctg gaatccagag ccaagtggcc tatctaaaat tcacagccct tttattctcc
     4801 tgtgtgatgg ttaatacaac acagttgaag cctggaaaca ctaccattat ttttggtgta
     4861 ttgctttttc taattgactg tttttaatga ttttgataca ttttaatgtt gaaattaata
     4921 ttgaatgtta gctatgaaat tttagtattg aattttataa tggaacagaa cattggtagg
     4981 taacaagatg caagaggatg tcaatacaag attgtctgcc tgtttttctt tgtaatttgt
     5041 aattacagtt tttgtaactt gtgattatgt ttttaactaa atttaccacc agatacaaac
     5101 actacttctt acacagagtt atcctttatt tatatcatta agacgtgaat gaaacatcat
     5161 cctaacttac ttccccaaga tattgagagg tcatatctgt ttttcatcat tcatttcttt
     5221 ttctaaaagt tgttactgat atgcttttga tttcctatga ctctattatg ttgtacagaa
     5281 catcttttca atttattaaa aaaaatagct taactgaaga tcactaattc cttttctaaa
     5341 ttttgaactg ctctaggcat aaatatcatt gtgtattatc ctttcatcta atcacttttg
     5401 gaatgtaaac tgaaggctgt tcactccaag ttaagttaac atttacatga tgtttattaa
     5461 atctgccagt ctgatcaaag gtttatgacc atggggccaa attcccatag attacccaaa
     5521 attgaatatg tgcagttaac tggaacatgt ctcattaagg tttacataca cactaagaca
     5581 gcaaaggatt ggaattaact ttatggagac agttccaggg actaatattg aagcagtggt
     5641 tatttgataa tgcatggaac caccatttgg attcaataaa ccaattacat aaaagcaatg
     5701 atgctacgct cttcatattc cagataccaa ctgcctacca aggactaatg agatggtata
     5761 tttcttccac atcagggcaa gctgaaaata tattgattca gcgttactgt tatgtaaatg
     5821 aatttccatc ttctcatatg tgttattttt gaaagaatga atacactctc tgtcttaaat
     5881 ccgctcttaa caaatgatct cttctcagaa tactacatct gtattgagag tacagacagc
     5941 ccattggtca ctgcaccttt tgcaagacag cgaaacggat gcatcaaatt gcattgatac
     6001 atcatcacca tcaatctttt gcactgattt ttagacttaa tcttcttatt tgaaaataaa
     6061 ctcattttta aataaaataa aaaatatttt agggaaagct ctataaaatt aaaattacag
     6121 aattatatgc tttttaaaat ttatgcaaaa atgtgcagac aaatgtattc tgtattggtt
     6181 tatgtatcac tttgcccttg tatattttga gattattaag atttgttgac ttttttggtt
     6241 tgatatttat catctgttaa atttttcctt ttaaattatt aaatgcaaag tgcaagaaaa
     6301 agagataaat atttactgat tgctagatgt aaaaatatct atgaatatat atatttaaac
     6361 ttctgccaga gagcaaccat ctgacagtca acttactaaa atctaaattg agtacttttt
     6421 actgttgcag agaattaagt cactaaacgt tatttagata tatagatgct agttgcaagt
     6481 aacacccttt tgtaatataa aagtaaaagc ataataattt cccaactttt gtcttcaaat
     6541 taaaaaagaa aatagcatat aattaccatt cttcatttga gaaagctgaa gattctgatg
     6601 cttaaaaact tcagaattct aatattaaaa atagagtggt tcatgtgaca ttgaaggctt
     6661 atctctgtaa aatagtgaca ctggtgagtg gtattatctc aatatttttg tccaaattca
     6721 ccttaggaag tcactgtaaa tcttcattgt ttcctaaaag tcattattac ggcataaact
     6781 taacatactt tgatagtagt tagtactgat acgtgacata ttctaccccg tgtctctgtt
     6841 actctgtctc tattactgtg aaaagtcaca gtaaatttaa cattttcttc cagactgtgt
     6901 atgatctttc attgtaatag agacatggag taggataagt catgtattaa catataagat
     6961 ttttttaacc tgctccctca gttttataga tgagacaaag ataaggttgt aagagctaat
     7021 ctcttcaagt aggcagtact agtaagttgt catgcgtgga ctgaactcct ggcacttctt
     7081 tctcttaact tcaatccata gagaagccca ccttcctgcc ttcccagtat tatttagcag
     7141 aggagaaaat catattaggc tgtttgatac tctgtttgcc tagactgatc aataattctg
     7201 gatctttgtt cacatcttct ctgaaagaat atttgatggg aaatcttttt tattttttaa
     7261 tttttgtgta catactaggt gcatatattt atggagtaca tgaaatgttt tgatacaggc
     7321 atgcactgtg aaataagcac atcatggaga atggggtatc catcccctca acatttatcc
     7381 tttgtgttac aaacaacctg attacactct gtattttaaa atatgcagtt aagtttttat
     7441 tgactatagt caccctattg tgctatcata tagtaagttt tactcattct ttctactttt
     7501 tttgtaccca ttaacctatc cccacctctg ccccaccatt atctcagctg tctactactt
     7561 ttttcagcct ttactaacca tccttctact ctatatccat gagttccgtt gttttggttt
     7621 ttagatccca caaataaatg agaacatggc aa
//
