LOCUS       NM_033655              13150 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens contactin associated protein family member 3
            (CNTNAP3), transcript variant 1, mRNA.
ACCESSION   NM_033655 XM_936404
VERSION     NM_033655.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13150)
  AUTHORS   Wang,H., Song,X., Wang,Y., Yin,X., Liang,Y., Zhang,T., Xu,L.,
            Jiang,F. and Dong,G.
  TITLE     CircCNTNAP3-TP53-positive feedback loop suppresses malignant
            progression of esophageal squamous cell carcinoma
  JOURNAL   Cell Death Dis 11 (11), 1010 (2020)
   PUBMED   33239613
  REMARK    GeneRIF: CircCNTNAP3-TP53-positive feedback loop suppresses
            malignant progression of esophageal squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13150)
  AUTHORS   Tong,D.L., Chen,R.G., Lu,Y.L., Li,W.K., Zhang,Y.F., Lin,J.K.,
            He,L.J., Dang,T., Shan,S.F., Xu,X.H., Zhang,Y., Zhang,C., Du,Y.S.,
            Zhou,W.H., Wang,X. and Qiu,Z.
  TITLE     The critical role of ASD-related gene CNTNAP3 in regulating
            synaptic development and social behavior in mice
  JOURNAL   Neurobiol Dis 130, 104486 (2019)
   PUBMED   31150793
  REMARK    GeneRIF: there are 5 mutations of CNTNAP3 (G410S, P614A, R786C/H,
            R1219X) which were reported to be found in autism spectrum
            disorders patients yet, which caused 4 amino acid changed and one
            stop-gain de novo mutation
REFERENCE   3  (bases 1 to 13150)
  AUTHORS   Okita,M., Yoshino,Y., Iga,J.I. and Ueno,S.I.
  TITLE     Elevated mRNA expression of CASPR3 in patients with schizophrenia
  JOURNAL   Nord J Psychiatry 71 (4), 312-314 (2017)
   PUBMED   28413940
  REMARK    GeneRIF: Considering that CASPR3 is involved in building the brain
            neural network and autophagy in circulating leukocytes, abnormal
            CASPR3 expression in SCZ subjects may be associated with the
            pathogenesis of SCZ.
REFERENCE   4  (bases 1 to 13150)
  AUTHORS   Qiao,Y.Q., Huang,M.L., Zheng,Q., Wang,T.R., Xu,A.T., Cao,Y.,
            Zhao,D., Ran,Z.H. and Shen,J.
  TITLE     CNTNAP3 associated ATG16L1 expression and Crohn's disease
  JOURNAL   Mediators Inflamm 2015, 404185 (2015)
   PUBMED   25883416
  REMARK    GeneRIF: CNTNAP3 could upregulate the expression of ATG16L1 and
            increase autophagy vacuoles
REFERENCE   5  (bases 1 to 13150)
  AUTHORS   Silveira,S.M., da Cunha,I.W., Marchi,F.A., Busso,A.F., Lopes,A. and
            Rogatto,S.R.
  TITLE     Genomic screening of testicular germ cell tumors from monozygotic
            twins
  JOURNAL   Orphanet J Rare Dis 9, 181 (2014)
   PUBMED   25424124
  REMARK    GeneRIF: Loss of 9p13.1-p12 was the novel copy number variant
            shared by twins with testicular germ cell tumors, confirming the
            involvement of CNTNAP3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 13150)
  AUTHORS   Spiegel,I., Salomon,D., Erne,B., Schaeren-Wiemers,N. and Peles,E.
  TITLE     Caspr3 and caspr4, two novel members of the caspr family are
            expressed in the nervous system and interact with PDZ domains
  JOURNAL   Mol Cell Neurosci 20 (2), 283-297 (2002)
   PUBMED   12093160
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162501.11 and AL353729.17.
            
            On Feb 12, 2020 this sequence version replaced NM_033655.4.
            
            Summary: The protein encoded by this gene belongs to the NCP family
            of cell-recognition molecules. This family represents a distinct
            subgroup of the neurexins. NCP proteins mediate neuron-glial
            interactions in vertebrates and glial-glial contact in
            invertebrates. The protein encoded by this gene may play a role in
            cell recognition within the nervous system. Alternatively spliced
            transcript variants encoding different isoforms have been described
            but their biological nature has not been determined. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF333769.2, SRR14372079.3708582.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297668.11/ ENSP00000297668.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AL162501.11        16043-16230
            189-299             AL162501.11        37204-37314
            300-493             AL162501.11        65024-65217
            494-641             AL162501.11        110935-111082
            642-845             AL353729.17        9286-9489
            846-1030            AL353729.17        10144-10328
            1031-1174           AL353729.17        11554-11697
            1175-1436           AL353729.17        16016-16277
            1437-1580           AL353729.17        21570-21713
            1581-1752           AL353729.17        37669-37840
            1753-1859           AL353729.17        43300-43406
            1860-1979           AL353729.17        47008-47127
            1980-2183           AL353729.17        54511-54714
            2184-2340           AL353729.17        69387-69543
            2341-2468           AL353729.17        78359-78486
            2469-2639           AL353729.17        83732-83902
            2640-2858           AL353729.17        84931-85149
            2859-3098           AL353729.17        87496-87735
            3099-3323           AL353729.17        98999-99223
            3324-3457           AL353729.17        100797-100930
            3458-3545           AL353729.17        101823-101910
            3546-3776           AL353729.17        108726-108956
            3777-3848           AL353729.17        109190-109261
            3849-13150          AL353729.17        113635-122936
FEATURES             Location/Qualifiers
     source          1..13150
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p12"
     gene            1..13150
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /note="contactin associated protein family member 3"
                     /db_xref="GeneID:79937"
                     /db_xref="HGNC:HGNC:13834"
                     /db_xref="MIM:610517"
     exon            1..188
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..3970
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cell recognition molecule Caspr3; contactin
                     associated protein like 3"
                     /codon_start=1
                     /product="contactin-associated protein-like 3 isoform 1
                     precursor"
                     /protein_id="NP_387504.2"
                     /db_xref="CCDS:CCDS6616.1"
                     /db_xref="GeneID:79937"
                     /db_xref="HGNC:HGNC:13834"
                     /db_xref="MIM:610517"
                     /translation="MASVAWAVLKVLLLLPTQTWSPVGAGNPPDCDAPLASALPRSSF
                     SSSSELSSSHGPGFSRLNRRDGAGGWTPLVSNKYQWLQIDLGERMEVTAVATQGGYGS
                     SDWVTSYLLMFSDGGRNWKQYRREESIWGFPGNTNADSVVHYRLQPPFEARFLRFLPL
                     AWNPRGRIGMRIEVYGCAYKSEVVYFDGQSALLYRLDKKPLKPIRDVISLKFKAMQSN
                     GILLHREGQHGNHITLELIKGKLVFFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSVL
                     IELLDTQVNFTVDKHTHHFQAKGDSSYLDLNFEISFGGIPTPGRSRAFRRKSFHGCLE
                     NLYYNGVDVTELAKKHKPQILMMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKV
                     SVTFQFRTWNRAGHLLFGELRRGSGSFVLFLKDGKLKLSLFQPGQSPRNVTAGAGLND
                     GQWHSVSFSAKWSHMNVVVDDDTAVQPLVAVLIDSGDTYYFGGCLDNSSGSGCKSPLG
                     GFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSW
                     DTFSCDCLGTGYTGETCHSSLYEQSCEAHKHRGNPSGLYYIDADGSGPLGPFLVYCNM
                     TADAAWTVVQHGGPDAVTLRGAPSGHPRSAVSFAYAAGAGQLRSAVNLAERCEQRLAL
                     RCGTARRPDSRDGTPLSWWVGRTNETHTSWGGSLPDAQKCTCGLEGNCIDSQYYCNCD
                     AGRNEWTSDTIVLSQKEHLPVTQIVMTDAGRPHSEAAYTLGPLLCRGDQSFWNSASFN
                     TETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGITDFIRIELRAPTEVTFSFDV
                     GNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNS
                     QLFIGGTATRQRGFLGCIRSLQLNGVALDLEERATVTPGVEPGCAGHCSTYGHLCRNG
                     GRCREKRRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSS
                     LHRDVTLTREMITLSFRTTRTPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNP
                     DAFTFDFKNMADGQLHQVKINREEAVVMVEVNQSTKKQVILSSGTEFNAVKSLILGKV
                     LEAAGADPDTRRAATSGFTGCLSAVRFGRAAPLKAALRPSGPSRVTVRGHVAPMARCA
                     AGAASGSPARELAPRLAGGAGRSGPADEGEPLVNADRRDSAVIGGVIAVVIFILLCIT
                     AIAIRIYQQRKLRKENESKVSKKEEC"
     exon            189..299
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            300..493
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            494..641
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            642..845
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1030
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1174
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1436
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1580
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1752
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1859
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1979
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2183
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2340
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2468
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2639
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2858
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..3098
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3323
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3324..3457
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..3545
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..3776
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3777..3848
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3849..13150
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4849..4854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /note="hexamer: ACTAAA"
     polyA_site      4877
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /note="major polyA site"
     regulatory      5071..5076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /note="hexamer: ATTAAA"
     polyA_site      5093
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /note="major polyA site"
     regulatory      7416..7421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /note="hexamer: AATAAA"
     polyA_site      7435
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /note="major polyA site"
     regulatory      8375..8380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /note="hexamer: AATAAA"
     polyA_site      8397
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
     regulatory      13131..13136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
                     /note="hexamer: AATAAA"
     polyA_site      13150
                     /gene="CNTNAP3"
                     /gene_synonym="CASPR3; CNTNAP3A"
ORIGIN      
        1 gcagagcagc gtcagagccg cgcaggggac gggagtgaga gcaggagcga cgcagagcgg
       61 ccgtcgccgt gcccgggtct cagggcgcct ggctgaagtg agcatggctt cagtggcctg
      121 ggccgtcctc aaggtgctgc tgcttctccc cactcagact tggagccccg tgggagcagg
      181 aaatccacct gactgtgatg ccccactggc ctctgccttg cctaggtcat ccttcagcag
      241 ctcctcagag ctgtccagca gccacggccc ggggttttca aggcttaatc gaagagatgg
      301 agctggtggc tggactccac ttgtgtcaaa taaataccaa tggctgcaaa ttgaccttgg
      361 agagagaatg gaggtcactg ctgtcgccac ccaaggagga tatgggagct ctgactgggt
      421 gaccagctac ctcctgatgt tcagtgatgg tgggagaaac tggaagcagt atcgccgaga
      481 agaaagcatc tggggttttc caggaaacac aaacgcagac agtgtggtgc actacagact
      541 ccagcctccc tttgaagcca ggttcctgcg ctttctccct ttagcctgga accctagggg
      601 caggattggg atgcggatcg aagtgtacgg atgtgcatat aaatctgagg tggtttattt
      661 tgatggacaa agtgctctgc tgtatagact tgataaaaaa cctttaaaac caataagaga
      721 cgttatttct ttgaaattta aagccatgca gagcaatgga attctacttc acagagaagg
      781 acaacatgga aatcacatta ctctggaatt aattaaagga aagcttgtct tttttcttaa
      841 ttcaggcaat gctaagctgc cttccactat tgctcctgtg accctcaccc tgggcagcct
      901 gctggacgac cagcactggc attccgtcct catcgagctc ctcgacacgc aggtcaactt
      961 caccgtggac aaacacactc atcatttcca agcaaaggga gattccagtt acttggatct
     1021 taattttgag atcagctttg ggggaattcc gacacccgga agatcgcggg cattcagacg
     1081 taaaagcttt catgggtgtt tagaaaatct ttattataat ggagtggatg ttaccgaatt
     1141 agccaagaaa cacaaaccac agatcctcat gatgggaaat gtgtccttct catgtccaca
     1201 gccacagact gtccctgtga cttttctgag ctccaggagt tatctggctc tgccaggcaa
     1261 ctctggggag gacaaagtgt ctgtcacttt tcaatttcga acgtggaaca gagcaggaca
     1321 tttgcttttc ggcgaacttc gacgtggttc agggagtttc gtcctctttc ttaaggatgg
     1381 caagctcaaa ctgagtctct tccagccggg acagtcacca aggaatgtca cagcaggtgc
     1441 tggattaaac gatgggcagt ggcactctgt gtccttctct gccaagtgga gccatatgaa
     1501 tgtggtggtg gacgatgaca cagctgttca gcccctggtg gctgtgctca ttgattcagg
     1561 tgacacctat tattttggag gctgcctgga caacagctct ggctctggat gtaaaagccc
     1621 cctgggaggg tttcagggct gcctaaggct catcaccatt ggtgacaaag cggtggatcc
     1681 catcttagta cagcaggggg cgctggggag tttcagggac ctccagatag actcctgcgg
     1741 catcacagac aggtgcttgc ccagctactg tgagcatggg ggcgagtgtt cccagtcgtg
     1801 ggacaccttc tcctgtgact gtctaggcac aggctatacg ggcgagacct gccattcctc
     1861 tctctacgag cagtcttgtg aagcccacaa gcaccgaggg aacccgtctg ggctttacta
     1921 tattgatgca gatggaagtg gccccctggg accatttctt gtgtactgca atatgacagc
     1981 agacgccgcg tggacggtgg tgcagcacgg tggccccgac gcggtgaccc tccgaggtgc
     2041 ccccagcggg cacccgcgct cggctgtgtc cttcgcgtac gcagcgggcg cggggcagct
     2101 gcggtccgcg gtgaacctgg cggagcgctg cgagcagcgg ctggctctgc gctgcgggac
     2161 ggcgcggcgc ccggactcac gagatggaac cccactgagc tggtgggttg gaagaaccaa
     2221 tgaaacacac acttcctggg gaggttctct gcctgatgct caaaagtgta cttgtggatt
     2281 agaggggaac tgcattgatt ctcagtatta ctgcaactgt gatgctggcc ggaatgaatg
     2341 gactagtgac acaatagtcc tttcccaaaa ggagcacctg ccagtcactc agattgtgat
     2401 gacagacgca ggccgaccac attccgaagc agcttataca ctggggccac tgctctgccg
     2461 cggagatcag tcattctgga attcagcttc cttcaacact gagacttcat accttcattt
     2521 ccctgctttc cacggagaac tcactgctga cgtgtgcttc ttttttaaga ccacagtttc
     2581 ctccggggtg tttatggaga acctggggat cacagatttc atcaggattg agctgcgtgc
     2641 tcccacagaa gtgacctttt ccttcgatgt ggggaatgga ccttgtgagg tcacggtgca
     2701 gtcacccact ccctttaatg acaatcagtg gcaccacgtg agggcagaga gaaatgttaa
     2761 aggagcgtct cttcaagttg atcagcttcc tcagaagatg cagcctgccc ctgctgatgg
     2821 gcacgttcgt ttacagctca acagccagct cttcattggt ggaacggcca ccagacagag
     2881 aggctttcta ggatgcattc ggtctctgca gttgaacggg gtggccctgg atctggaaga
     2941 aagagccaca gtgacgccag gagtggagcc agggtgtgca ggacactgca gcacctatgg
     3001 acacttgtgt cgcaatggag ggagatgcag agagaaacgc aggggggtca cctgtgactg
     3061 tgccttctca gcctatgatg ggccgttctg ctccaatgag atttccgcat attttgcaac
     3121 tggctcctca atgacatacc attttcaaga acattacact ttaagtgaaa actccagctc
     3181 tctcgtttct tcattacaca gagatgtaac attgaccaga gaaatgatca cactgagctt
     3241 ccgaaccaca cgaactccga gcttattgct gtatgtgagc tctttctatg aggaatacct
     3301 ttcagttatc ctcgccaaca atggaagttt gcagattagg tacaagctag atagacatca
     3361 aaatcctgat gcatttacct ttgattttaa aaacatggct gatgggcaac ttcaccaagt
     3421 gaagattaac agagaagaag ctgtggtcat ggtagaggtt aaccagagca caaagaaaca
     3481 agtcatcttg tcctcaggga cagaattcaa cgccgtcaaa tctctcatat tgggaaaggt
     3541 tttagaggct gccggcgcgg acccggacac aaggcgggcg gcgactagtg gcttcactgg
     3601 ctgcctctcg gcggtgcgct tcggccgcgc tgctcccctg aaggcggcgc tgcgccccag
     3661 cggcccctcc cgggtcaccg tccgcggcca cgtggcccct atggcccgct gcgcagcggg
     3721 ggcggcgtcc ggctccccgg cgcgggaact ggctccccga ctcgcggggg gcgcaggtcg
     3781 ttctggacca gcggatgagg gagagccctt ggttaatgca gacagaagag actctgctgt
     3841 catcggaggt gtgatagcag tggtgatatt tattttgctt tgcatcactg ccatagccat
     3901 acgcatctat caacagagaa agttacgcaa agaaaatgag tcaaaagtct caaaaaaaga
     3961 agagtgctag gacagctcta aacagtgagc tcgatgtgca aaacgcagtc catgaaaacc
     4021 agaaagagcg agtcttctga ttggcagctg tggctgtctc tatcatcgtg actgtggact
     4081 tccctgctgt tgccatcagg gtgcacacaa gcaggtgcag tgctgtcacc tggctgaaga
     4141 cctgcagcct cggagcctct gggaggtccc tttctccctc ggtgaaacac agtcctccac
     4201 atcaatttcc aaacaatgaa ttaggtatgg ccattcatca ctgttcagta gtttccccgt
     4261 ccaaaggctc tcttccaaaa ctgcagtttg atctgtgtta ataattgtgg ggttttagat
     4321 gagaaaatgg ctataaagct gtggccctac tttatttttt aaaaatgaca gaacttttgt
     4381 tcagatgtaa aagacaaaat tgcactttaa tgttttttgt tacttgaaaa catatctggg
     4441 atcccttttt ttggtcctct gctgatattt ataaaacaag aaatgcttct tggactacct
     4501 tcactggcat ttccatagtc ctggaatcca gagccaagtg gcctatctaa aattcacagc
     4561 ccttttattc tcctgtgtga tggttaatac aacacagttg aagcctggaa acactaccat
     4621 tatttttggt gtattgcttt ttctaattga ctgtttttaa tgattttgat acattttaat
     4681 gttgaaatta atattgaatg ttagctatga aattttagta ttgaatttta taatggaaca
     4741 gaacattggt aggtaacaag atgcaagagg atgtcaatac aagattgtct gcctgttttt
     4801 ctttgtaatt tgtaattaca gtttttgtaa cttgtgatta tgtttttaac taaatttacc
     4861 accagataca aacaatactt cttacacaga gttatccttt atttatatca ttaagacgtg
     4921 aatgaaacat catcctaact tacttcccca agatattgag aggtcatatc tgtttttctt
     4981 tatcattcat ttctttttct aaaagttgtt actgatatgc ttttgatttc ctatgactct
     5041 attatgttgt acagaacatc ttttcaattt attaaaaaaa tagcttaact gaagatcact
     5101 aattcctttt ctaaattttg aactgctcta ggcataaata tcattgtgta ttatcctttc
     5161 atctaatcac ttttggaatg taaactgaag actgttcact ccaagttaag ttagcattta
     5221 catgatgttt attaaatctg ccagtctgat cacaggttta tgaccatggg gccaaattcc
     5281 catagattac ccaaaattga atatgtgcag ttaactggaa catgtctcat taaggtttac
     5341 atacacacta agacagcaaa ggattggaat taactttatg gagacagttc cagggactag
     5401 tattgaagca gtggttattt gataatgcat ggaaccacca tttggattca ataaaccaat
     5461 tacataaaag caatgatgct acactcttca tattccagat accaactgcc taccaaggac
     5521 taatgagatg gtatatttct tccacatcag ggcaagctga aaatatattg attcagcgtt
     5581 actgttacgt aaatgaattt ccatcttgtt atggaaattc gtatgtgtta tttttgaaag
     5641 aatgaataca ctctctgtct taaatccgct cttaacaaat gatctcttct cagaatacta
     5701 catctgtatt gagagtacag acagcccatt ggtcactgca ccttttgcaa gacagcgaaa
     5761 cggatgcatc aaattgcatt gatacatcat caccatcaat cttttgcact gatttttaga
     5821 cttaatcttc ttatttgaaa ataaactcat ttttaaataa aataaaaaat attttaggga
     5881 aagctctata aaattaaaat tacagaatta tatgcttttt aaaatttatg caaaaatgtg
     5941 cagacaaatg tattctgtat tggtttatgt atcactttgc ccttgtatat tttgagatta
     6001 ttaagatttg ttgacttttt tggtttgata tttatcatct gttaaatttt tccttttaaa
     6061 ttattaaatg caaagtgcaa gaaaaagaga taaatattta ctgattgcta gatgtaaaaa
     6121 tatctatgaa tatatatatt taaacttctg ccaaagagca accatctaac agtcaactta
     6181 ctaaaatcta aattgagtac tttttactgt tgcagagaat taagtcacta aacgttattt
     6241 agatacatag atgctagttg caagtaacac ccttttgtaa cataaaagta aaagcataat
     6301 aatttcccaa cttttttctt caaattaaaa aagaaaatag catataatta ccattcttca
     6361 tttgagaaag ctgaagattc tgatgcttaa aaacttcaga attctaatat taaaaataga
     6421 gtggttcatg tgacattgaa ggcttatctc tgtaaaatag tgacactggt gagtggtatt
     6481 atctcaatat ttttgtccaa attcacctta ggaaatcact gtaaatcttc attgtttact
     6541 aaaagtcatt attacggcat aaacttaaca tactttgata gtagttacta ctgatacgtg
     6601 acatattcta ccccgtgtct ctattactct gtctctatta ctgtgaaaag tcacagtaaa
     6661 tttaacattt tcttccagac tgtgtatgat ctttcattgt aatagagaca tggagtagga
     6721 taagtcatgt attaacatgt aagatttttt taacctgctc cctcagtttt atagatgaga
     6781 caaagataag gttgtaagag ctaatctctt caagtaggca gtactagtaa gttgtcatgc
     6841 gtggactgaa ctcctggcac ttctctctct taacttcaat ccatagagaa gcccaccttc
     6901 ctgccttccc agtattattt agcagaggag aaaatcatat taggctgttt gatactgttt
     6961 gcctagactg accaataatt ctggatcttt gttcacatct tctctgaaag aatatttgat
     7021 gggaaatctt ttttattttt taatttttgt gtacatacta ggtgtatata tttatggagt
     7081 acatgaaatg ttttgataca ggcatgcact gtgaaataag cacatcatgg agaatggggt
     7141 atccatcccc tcaacattta tcctttgtgt tacaaacaac ctgattacac tctgtatttt
     7201 aaaatatgca gttaagtttt tattgactat agtcacccta ttgtgctatc atatagtaag
     7261 ttttactcat tctttctact ttttttgtac ccattaacct atccccacct ctgccccacc
     7321 attatctcag ctgtctacta cttttttcag cctttactaa ccatccttct actctatatc
     7381 catgaattcc gttgttttga tttttagatc ccacaaataa atgagaacat ggcaatgttt
     7441 gtctttctat gcctggccta tttcacttaa cataatgacc tccagttcca tccatgctgt
     7501 cgcaagtgac aggatctcat tctcttttat ggctgaagag tactccattt tgtatgtgaa
     7561 ccacattttc ttcattcatc tgttgatgaa cacttagggt gtttccaaat cttagctgtt
     7621 ataaacagta ttgcaacaaa taaaagagtg cagatggaaa attgattttg atggcttttt
     7681 tctttaataa aacattaatt tcttcatgta taactggaag gcaaacaaat gatccatttg
     7741 cttagtttat tcttgaatcc ataatataag taacagaaat ggattattaa aatatacttg
     7801 aatttgggga agaatgatat ggacacattt taaatcaaaa catgatgaat tggctgttta
     7861 acctactacc tcattggcca atctggggca agatgaaagt atttgtaaac actgttttgg
     7921 caattatgtg taaagagaga accaattttt taattaaaaa attgaattct aagaattaca
     7981 gagcttttct attggtaaag acattaaata tcatagagtc caacgctttt ctcttccttc
     8041 acatcactcc caatggatgt agctcaggct aagttcattg ctgatgtgtt gtcagaacag
     8101 ccactcacgg tttaagttgg tatacttaag tgcaaatgta accttaagaa ggttacataa
     8161 agttgccatt actaggagta gtagcagaat ttattatgga ttaatcatat cgtcgggaaa
     8221 atgtactgaa gcactacttc ctgtggtatt ttttttacaa aatgataaca tagtttattg
     8281 cctataggtt atgacctaaa attatatttt tgcattttat tgtgccatta tatattttaa
     8341 aatgtgaggt tcacatggtt gcatttgctc tgtgaataaa aatgtttaaa atcataagat
     8401 gaacttttag attttgcgat atgaaaattt ctaacttagc tagcttgtga tggtacctaa
     8461 aaatttaaga aagcccttaa aatagaacct ctgtgactgc atgagcactt tgtatgactc
     8521 atatcacatt ttaactcctt aagcaagcca atgaggtaaa acatataatt gtccccattt
     8581 ttgcaaaatt cacaaaggcc ttcactgctt tgagaaaaca ttacacagat aattactgac
     8641 aaaaatgggt tagaatgcag gtcctgagat gtctagttcc tgaccaattc tacaggttgc
     8701 cttgctccca taatatgctc caatctacaa tgttcatctt aatctgcagt gagtaaacat
     8761 aattgatagc taaatttact tcttgttcca aatctttagg atatgattca tgtgtgttat
     8821 atacatacat atatatatgt gtatgtgtgt ttatacttac atatatttct ttttcttatt
     8881 ttacttctgg ctaagatgga gtaataggga gcatatttac cctctaaccc tcctgcatga
     8941 aacaacctca aaccagacaa aatatatgaa actatggttt tcagtacact ggacatgagg
     9001 cacggaatgt aatccctgaa agacaggaaa cataagatgt gtgctgtgag tatcccagct
     9061 tacaacttga gagaatttga gacagcagtg acaatggaga tagatagctt aaggaagcct
     9121 agcaagtctc tgaatggagt agctgttgct gagagttcag gtacacgaag gtggctagag
     9181 attgcaggat agagtaccgg cgaggaaaga gctgcattgg agaaaacttt gcaaatctgg
     9241 agagggtcgc ccttcagtgt gtaacaaagt gcatgaaact acctgaggca agggaaagaa
     9301 acactcaaaa gaattacagc ggcatttatc aacctttaaa aaattattat tgacctcaag
     9361 gaatcttttt aaacatcttt tctagtcacc tctctatgaa ttttttaatt tttatttaat
     9421 ttaatttaat tttattttat ttttgagacg gagtcttgct ctgtcgctca ggctggagtg
     9481 cagtggcgcg atcctggctc actgcaagct ccgcctccag ggttcatgcc attctcctgc
     9541 ctcagcctcc cgagtagctg ggactacagg cacaagccaa catgcccagc taattttttt
     9601 tttttttttt ttttttgtat ttttagtgga ggcaaggttt caccgtgtta gccaggatgg
     9661 tctcgatctc tggatctcat gatctgccca cctcagcctc ctaaagcgct ggtatcacag
     9721 gcgtaagcca ctgcgcccgc cctgaaattt taatatcgca catgcactgc atatctcttt
     9781 agtactatac gtatatctgg gctttacaca aaaagaatat ttttcttctc ttcacttctc
     9841 ccatcccccc caaaaaaact aatttctgtc gttttgggga caatattact ctcactgaga
     9901 gtgcatgttc acatacaacc atgaatagag gtggttgcca tgggctatac cagaaatccc
     9961 cataattaat agggcattag gtagaatatt cataggggtc ttgcctcagt cctggcaagt
    10021 cctagaccat gtattactat ggcggcccca ctgaacaaat cttcaaagat ttggaaaaaa
    10081 agatcaaacc gtttccaata actaattggc atctctgagc aaagttcaca tgtatttcca
    10141 gtaacataaa actatccaac accaggccgg gcacagtggc tcatgcctgt aatcccagca
    10201 ctttgggagg tcgaggcagg cagatcacga ggtcgggaga tggagaccat cctgctaaca
    10261 aggtggaaac cccgtctcta ctaaacatac aaaaattagc cgggcgtggt gttgggcgcc
    10321 tgaagtccca gctactcggg aggctggggc aggagaatgg catgaacccg ggaggcagag
    10381 tttgcagtgg gccgagattg cgccattgca ctccagcctg ggcaacagag ccagactcca
    10441 tcaaaaaaaa atccaacacc caacgaggta aaatcacaat gtctggtata caataaaaaa
    10501 ttaccaagtg tgtgaagagg cagaaaaata ggacctataa tgaggataaa aatcaatcta
    10561 aaatgaccca gcacataccc agatgttaga attactaatg aaaaatatta tgactatatt
    10621 ccgtattttc aaagattagg atgtgacaag aaaaggcttt aattaaactt cgagagatga
    10681 caatgttaat gtataagatt aaaaaataca atggatgtaa ttaatggcag atgagagttt
    10741 tcagaagaaa atattaataa acttgaatat atatagcagt agaaagcatc caaaatgaaa
    10801 cagagacaga aaaaaaacaa agaataatca gagtatcggt gatctgtggg acaacttcag
    10861 ttgcctaatc tgtgtgtatt tggagttctc aaaggagaaa agagagtgga tggatagaaa
    10921 aaaatatttt taaaaattaa tacataagca ttttccacat ttgatgcaaa ctataaaccc
    10981 acagacccag ctcaacatcc ccaagtaggg gtgctattaa gaaaaccaca tcacaacaca
    11041 tcataagcaa atggatcaaa actcagtgtg gtaaagagaa aaagacaagt cttacacaga
    11101 gaagaaaaac aaggatgata ccagacttct ttttggaagc aatgcaaggg gaagggcagt
    11161 ggagcaacat ctttcatgct tccagtgaaa catcttccaa ccaaaagcag aaaactctct
    11221 ctcctaggtt tctataccca gcaaaaccgt ctttcaagaa aggatgaaac aaagatattt
    11281 ttcagacata gaaaagttaa aagtaatata ttatcagcaa acctggacta tgagaacagt
    11341 gtaaaagcct ttcaggaaga aggaaaataa agaataatat ctttgtgcag atagaaacat
    11401 ggatccacac aaagaaatga agagcactgg caatagtaac accataagta aatatacaat
    11461 acctgccctt attacttaaa tatcttttaa agataattgg ctgtttagaa ataatagcag
    11521 tgtcatgtga gttctgcagc atgagtaaaa gtaaaatata tgacaacaat aacctagagt
    11581 aaatggaaat atagtttagt ttgtaaggtt cttagactgt gtgtaaagtc gtataatgcc
    11641 tattaaaagt tggctattac aagttatctt taagttaaaa catctgtatg gtgtaatccc
    11701 taaagcaaat gctagagtaa caaaaacagt gataatatta caatattaca caataatatt
    11761 acaatgcagc gatgaaatag aataaatttt taaatgcttg aaagtagaca aaaaagatga
    11821 gaaagaggac aaagaacaaa tgggacaaat agaaagcaaa tagcaagata taaaataaaa
    11881 atctgataaa tttgacctta agattaacaa ctctcctttt aaaatacatt gttaagagaa
    11941 taagagtcaa gctacagact gggagaaaat atttgcaaca ctttatttga atgctgtaaa
    12001 tttttttcag aatatagttc ataaagaact cttaacaact caataattag caaaaataaa
    12061 atgaaaataa tgaatataag aaaaaatgac gaaaagtgct aggccagtgg acaaaaagca
    12121 cacaaaaatg ttcaatatcg ttttgtcatt aaggaaatgc aaattaaaac cacagtgagt
    12181 tattcttccc actaaaatgg ttatgattaa aaatattgtc agtaccacgt gttgttgaga
    12241 atatggagca attataattc tcatacatta ttgttggaat gtaaaatgct acaaccactt
    12301 aggaaaaatt gtttaacatt gttttatata attaagcata catgaaacct atgacccaac
    12361 aattccaatc ctagattgaa aagaaatgaa aacttatgcc cattataaga cttacacaag
    12421 aacgtttata gcatctttac ttataatatc cccaaactgt aaactgccta aaagaccttc
    12481 aacaagaaaa tggacaaaca atttgtgttg tattaataat gaaatactct tcagctataa
    12541 aatggacaaa actactggta actgcaacaa acatggctga atctaaaaaa ccttgtgttg
    12601 aatgaataaa tctagacact atagggtaca ttctgaagtc ctagaacaag cgaaactaag
    12661 atatagcagt agaaattgta tcagtagtta cctgggttga ggtgggatgg gagttgactg
    12721 cagagaaaca caagggaagt ttctggagtg atggaaatgt tctatgtctt gattgactat
    12781 ggttacattg gtgtggacat ttgtcaaaac tctgaatttc atatttggaa tttgtatatt
    12841 ttgtatataa attatacttc aataaatatg tacatgtata tatatgtgta tatataatac
    12901 attttgatat gtcatgatgt ctatcacttc acagcatatt atatttctat cataccatat
    12961 ttacataatg gaaaaagatg aaaaggatgc tgtattttgg ggaaatcaca agagattatc
    13021 acctttattt attttttata caaatacata taaatctttc acagtacaat acaaatgtca
    13081 aaatgtggta ttttcattgc tctataaatt cttatatgtt ctatgtatgt aataaatgtt
    13141 aaaaacagtg
//
