LOCUS       NM_003632               5537 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens contactin associated protein 1 (CNTNAP1), mRNA.
ACCESSION   NM_003632
VERSION     NM_003632.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5537)
  AUTHORS   Chang,C., Sell,L.B., Shi,Q. and Bhat,M.A.
  TITLE     Mouse models of human CNTNAP1-associated congenital hypomyelinating
            neuropathy and genetic restoration of murine neurological deficits
  JOURNAL   Cell Rep 42 (10), 113274 (2023)
   PUBMED   37862170
  REMARK    GeneRIF: Mouse models of human CNTNAP1-associated congenital
            hypomyelinating neuropathy and genetic restoration of murine
            neurological deficits.
REFERENCE   2  (bases 1 to 5537)
  AUTHORS   Li,W., Meng,X., Yuan,H., Xiao,W. and Zhang,X.
  TITLE     M2-polarization-related CNTNAP1 gene might be a novel
            immunotherapeutic target and biomarker for clear cell renal cell
            carcinoma
  JOURNAL   IUBMB Life 74 (5), 391-407 (2022)
   PUBMED   35023290
  REMARK    GeneRIF: M2-polarization-related CNTNAP1 gene might be a novel
            immunotherapeutic target and biomarker for clear cell renal cell
            carcinoma.
REFERENCE   3  (bases 1 to 5537)
  AUTHORS   Garel,P., Lesca,G., Ville,D., Poulat,A.L., Chatron,N.,
            Sanlaville,D., Des Portes,V., Arzimanoglou,A. and Lion-Francois,L.
  TITLE     CNTNAP1-encephalopathy: Six novel patients surviving the neonatal
            period
  JOURNAL   Eur J Paediatr Neurol 37, 98-104 (2022)
   PUBMED   35182943
  REMARK    GeneRIF: CNTNAP1-encephalopathy: Six novel patients surviving the
            neonatal period.
REFERENCE   4  (bases 1 to 5537)
  AUTHORS   Li,W., Yang,L., Tang,C., Liu,K., Lu,Y., Wang,H., Yan,K., Qiu,Z. and
            Zhou,W.
  TITLE     Mutations of CNTNAP1 led to defects in neuronal development
  JOURNAL   JCI Insight 5 (21), 135697 (2020)
   PUBMED   33148880
  REMARK    GeneRIF: Mutations of CNTNAP1 led to defects in neuronal
            development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5537)
  AUTHORS   Zhang,S.H., Liu,D.X., Wang,L., Li,Y.H., Wang,Y.H., Zhang,H.,
            Su,Z.K., Fang,W.G., Qin,X.X., Shang,D.S., Li,B., Han,X.N.,
            Zhao,W.D. and Chen,Y.H.
  TITLE     A CASPR1-ATP1B3 protein interaction modulates plasma membrane
            localization of Na+/K+-ATPase in brain microvascular endothelial
            cells
  JOURNAL   J Biol Chem 294 (16), 6375-6386 (2019)
   PUBMED   30792309
  REMARK    GeneRIF: These results demonstrate that CASPR1 binds with ATP1B3
            and thereby contributes to the regulation of Na(+)/K(+)-ATPase
            maturation and trafficking to the plasma membrane in brain
            microvascular endothelial cells.
REFERENCE   6  (bases 1 to 5537)
  AUTHORS   Nie,D.Y., Zhou,Z.H., Ang,B.T., Teng,F.Y., Xu,G., Xiang,T.,
            Wang,C.Y., Zeng,L., Takeda,Y., Xu,T.L., Ng,Y.K.,
            Faivre-Sarrailh,C., Popko,B., Ling,E.A., Schachner,M., Watanabe,K.,
            Pallen,C.J., Tang,B.L. and Xiao,Z.C.
  TITLE     Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation
            of K(+) channel localization
  JOURNAL   EMBO J 22 (21), 5666-5678 (2003)
   PUBMED   14592966
REFERENCE   7  (bases 1 to 5537)
  AUTHORS   Charles,P., Tait,S., Faivre-Sarrailh,C., Barbin,G., Gunn-Moore,F.,
            Denisenko-Nehrbass,N., Guennoc,A.M., Girault,J.A., Brophy,P.J. and
            Lubetzki,C.
  TITLE     Neurofascin is a glial receptor for the paranodin/Caspr-contactin
            axonal complex at the axoglial junction
  JOURNAL   Curr Biol 12 (3), 217-220 (2002)
   PUBMED   11839274
REFERENCE   8  (bases 1 to 5537)
  AUTHORS   Venken,K., Meuleman,J., Irobi,J., Ceuterick,C., Martini,R., De
            Jonghe,P. and Timmerman,V.
  TITLE     Caspr1/Paranodin/Neurexin IV is most likely not a common
            disease-causing gene for inherited peripheral neuropathies
  JOURNAL   Neuroreport 12 (11), 2609-2614 (2001)
   PUBMED   11496158
REFERENCE   9  (bases 1 to 5537)
  AUTHORS   Li,R., Zhang,B. and Zheng,Y.
  TITLE     Structural determinants required for the interaction between Rho
            GTPase and the GTPase-activating domain of p190
  JOURNAL   J Biol Chem 272 (52), 32830-32835 (1997)
   PUBMED   9407060
REFERENCE   10 (bases 1 to 5537)
  AUTHORS   Peles,E., Nativ,M., Lustig,M., Grumet,M., Schilling,J.,
            Martinez,R., Plowman,G.D. and Schlessinger,J.
  TITLE     Identification of a novel contactin-associated transmembrane
            receptor with multiple domains implicated in protein-protein
            interactions
  JOURNAL   EMBO J 16 (5), 978-988 (1997)
   PUBMED   9118959
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100793.8, U87223.1,
            BC171797.1 and BU729460.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003632.2.
            
            Summary: The gene product was initially identified as a 190-kD
            protein associated with the contactin-PTPRZ1 complex. The
            1,384-amino acid protein, also designated p190 or CASPR for
            'contactin-associated protein,' includes an extracellular domain
            with several putative protein-protein interaction domains, a
            putative transmembrane domain, and a 74-amino acid cytoplasmic
            domain. Northern blot analysis showed that the gene is transcribed
            predominantly in brain as a transcript of 6.2 kb, with weak
            expression in several other tissues tested. The architecture of its
            extracellular domain is similar to that of neurexins, and this
            protein may be the signaling subunit of contactin, enabling
            recruitment and activation of intracellular signaling pathways in
            neurons. [provided by RefSeq, Jan 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U87223.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264638.9/ ENSP00000264638.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC100793.8         20304-20386
            84-449              U87223.1           2-367
            450-2159            BC171797.1         282-1991
            2160-5185           U87223.1           2078-5103
            5186-5537           BU729460.1         18-369              c
FEATURES             Location/Qualifiers
     source          1..5537
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..5537
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /note="contactin associated protein 1"
                     /db_xref="GeneID:8506"
                     /db_xref="HGNC:HGNC:8011"
                     /db_xref="MIM:602346"
     exon            1..366
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..4454
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /note="caspr1; neurexin-4; neurexin IV"
                     /codon_start=1
                     /product="contactin-associated protein 1 precursor"
                     /protein_id="NP_003623.1"
                     /db_xref="CCDS:CCDS11436.1"
                     /db_xref="GeneID:8506"
                     /db_xref="HGNC:HGNC:8011"
                     /db_xref="MIM:602346"
                     /translation="MMHLRLFCILLAAVSGAEGWGYYGCDEELVGPLYARSLGASSYY
                     SLLTAPRFARLHGISGWSPRIGDPNPWLQIDLMKKHRIRAVATQGSFNSWDWVTRYML
                     LYGDRVDSWTPFYQRGHNSTFFGNVNESAVVRHDLHFHFTARYIRIVPLAWNPRGKIG
                     LRLGLYGCPYKADILYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGA
                     QGDYVTLELEGAHLLLHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVN
                     FTLDGYVQRFILNGDFERLNLDTEMFIGGLVGAARKNLAYRHNFRGCIENVIFNRVNI
                     ADLAVRRHSRITFEGKVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTW
                     DLTGLLLFSRLGDGLGHVELTLSEGQVNVSIAQSGRKKLQFAAGYRLNDGFWHEVNFV
                     AQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWDCHSNQTAFHGCME
                     LLKVDGQLVNLTLVEGRRLGFYAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYC
                     ELTGYKGETCHTPLYKESCEAYRLSGKTSGNFTIDPDGSGPLKPFVVYCDIRENRAWT
                     VVRHDRLWTTRVTGSSMERPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRL
                     LNTAGGYPYSFWIGRNEEQHFYWGGSQPGIQRCACGLDRSCVDPALYCNCDADQPQWR
                     TDKGLLTFVDHLPVTQVVIGDTNRSTSEAQFFLRPLRCYGDRNSWNTISFHTGAALRF
                     PPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPYVRVELNTSRDVVFAFDVGN
                     GDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTYIWMEYDQP
                     LYVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANASEGTSPNCTGHCAHPRLPCFHGG
                     RCVERYSYYTCDCDLTAFDGPYCNHDIGGFFEPGTWMRYNLQSALRSAAREFSHMLSR
                     PVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSFSF
                     STSSAPAVLLYVSSFVRDYMAVLIKDDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSI
                     NITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYLGRVMETGVIDPEIQRYNTP
                     GFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEALRVQGELSESNCGAMPRLVSEVPP
                     ELDPWYLPPDFPYYHDEGWVAILLGFLVAFLLLGLVGMLVLFYLQNHRYKGSYHTNEP
                     KAAHEYHPGSKPPLPTSGPAQVPTPTAAPNQAPASAPAPAPTPAPAPGPRDQNLPQIL
                     EESRSE"
     exon            367..468
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            469..662
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            663..810
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1014
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1199
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1343
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1605
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1755
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1927
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2034
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2154
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2358
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2515
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2643
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2829
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..3051
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..3291
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            3292..3645
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            3646..3773
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            3774..3867
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            3868..4113
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            4114..4161
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     exon            4162..5537
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5336..5341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /note="hexamer: TATAAA"
     polyA_site      5358
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /note="major polyA site"
     regulatory      5513..5518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /note="hexamer: AATAAA"
     polyA_site      5537
                     /gene="CNTNAP1"
                     /gene_synonym="CASPR; CHN3; CNTNAP; NRXN4; P190"
                     /note="major polyA site"
ORIGIN      
        1 gaaaccggcg cgtgccagga gacagaggct ggggaagggg ggaggtgaga ggaaagaggg
       61 tggaaaggag aggatagaga gagaagagcg gaggaccagg aaccagagag agagagagag
      121 aaaagagaga ggagagacag agcgcttggg ggcgaaagga gagagggagg gaagggtggg
      181 taaggaggag agagcggtct gctgcaaacc ccaggaggag agcttggagc ccaagccaga
      241 actcgagccc tagccggagc cgttcacagg gaggcggctg ccgggaccgt cagccctgca
      301 tgatgcatct ccggctcttc tgcatcctgc tcgccgcggt ctcaggagcc gagggctggg
      361 gctactacgg ctgcgacgag gagctggtgg gtcccctgta tgcacgctcc ctgggcgcct
      421 cctcctacta cagtctcctt actgcgccga gattcgccag gctgcacggc ataagcgggt
      481 ggtcaccacg gattggggat ccgaatccct ggctccagat agacttaatg aagaagcacc
      541 ggatccgggc cgtggccaca cagggctcct ttaattcttg ggactgggtc acacgttaca
      601 tgctactcta cggcgaccga gtggacagct ggacaccgtt ctaccagcga gggcacaact
      661 cgaccttctt tggtaacgtg aacgagtcgg cggtggtgcg ccatgacctg cacttccact
      721 tcactgcgcg ctacatccgc atcgtgcccc tggcctggaa cccacgcggc aagatcggcc
      781 tgaggctcgg cctctatggc tgcccataca aggccgacat actctatttc gacggcgacg
      841 atgccatctc ctaccgcttc ccgcgagggg tcagccgaag cctgtgggac gtgttcgcct
      901 tcagcttcaa gaccgaggag aaggacggtc ttctgctgca cgccgagggc gcccagggcg
      961 actacgtgac gctcgagctg gagggggcac acctgctgct gcacatgagc ctgggcagca
     1021 gccctatcca gccaagacca ggtcacacca ccgtgagcgc aggcggagtc ctcaatgacc
     1081 agcactggca ctatgtgcgg gtggaccgat ttggccgcga tgtaaatttc accctggacg
     1141 gctatgtgca gcgctttatt ctcaatggag acttcgagag gctgaacctg gacactgaga
     1201 tgttcatcgg aggtctggtg ggcgccgcgc ggaagaacct ggcctatcgg cataacttcc
     1261 gcggctgcat agaaaacgta atcttcaacc gcgtcaacat cgcagacctg gccgtgcggc
     1321 gccattcccg gatcaccttc gagggtaagg tggcttttcg ttgcctggac ccggtaccgc
     1381 accctatcaa cttcggaggc cctcacaact tcgttcaagt gcccggtttc ccacgccgtg
     1441 gccgcctggc agtctcattt cgcttccgca cctgggacct caccgggctt ctccttttct
     1501 cccgtctggg ggacgggctg ggccacgtgg agctgacgct cagcgaaggg caggtcaacg
     1561 tgtccatcgc gcagagcggc cgaaagaagc ttcagttcgc tgctgggtac cgactgaatg
     1621 acggcttttg gcacgaggtg aattttgtgg cacaggaaaa ccatgcagtt atcagcattg
     1681 atgatgtgga aggggcagag gtcagggtct catacccgtt gctgatccgg acagggacct
     1741 catatttctt tgggggttgt cccaagccag ccagtcgatg ggactgccac tccaaccaga
     1801 cggcattcca tggctgcatg gagctgctca aggtggatgg tcaactggtc aacctgactc
     1861 tggtggaggg ccggcggctt ggattctatg ctgaggtcct ctttgataca tgtggcatca
     1921 ctgataggtg cagccctaac atgtgtgagc atgatggacg ctgctaccag tcttgggatg
     1981 acttcatttg ctactgcgaa ctgacgggct acaagggaga gacctgccac acacctttgt
     2041 ataaggaatc ctgtgaggct tatcggctca gtgggaaaac ttctggaaac ttcaccattg
     2101 atcctgatgg cagtggcccc ctgaagccat ttgtagtgta ctgtgatatc cgagagaacc
     2161 gagcgtggac agttgtgcgg catgacaggc tgtggacaac tcgagtgaca ggttccagca
     2221 tggagcggcc attcctgggg gctatccagt actggaatgc atcctgggag gaagtcagtg
     2281 cccttgccaa tgcttcccag cattgtgaac agtggatcga gttctcctgc tacaattccc
     2341 ggctgctcaa cactgcagga ggctacccct acagcttttg gattggccga aatgaggagc
     2401 agcacttcta ctggggaggc tcccagcctg ggatccagcg ctgtgcctgt ggtctggacc
     2461 ggagctgtgt ggaccctgcc ttgtactgca actgtgacgc tgaccagccc cagtggagaa
     2521 ctgacaaggg actgctgacc tttgtggacc atctgcctgt cactcaggta gtgatagggg
     2581 atacgaaccg ctccacttct gaggcccagt tcttcctgag gcctctgcgc tgctatggcg
     2641 atcgaaattc ctggaacacc atttccttcc acaccggggc tgcactacgc ttccccccaa
     2701 tccgtgccaa ccacagcctg gatgtctcct tctacttcag gacctctgct ccctcggggg
     2761 tcttcctaga gaatatgggg ggcccttact gccagtggcg ccgaccttat gtgcgggtgg
     2821 aactcaacac atcccgggat gtggtcttcg cctttgatgt ggggaatggg gatgagaacc
     2881 tcacagtaca ctcagacgac tttgagttca atgatgacga gtggcacctg gtccgggctg
     2941 aaatcaacgt gaagcaggcc cggctccgag tggatcaccg gccctgggtt ctgcggccta
     3001 tgccactgca gacctacatc tggatggagt atgaccagcc cctctatgtg ggatctgcag
     3061 agcttaagag acgccccttt gtgggttgct tgagggccat gcgtctgaac ggagtgactc
     3121 tgaacctgga gggccgtgcc aatgcctctg agggtacctc acccaactgc acaggccact
     3181 gtgcccaccc tcggctcccc tgtttccatg gaggccgctg cgtggagcgc tatagctact
     3241 acacgtgtga ctgtgacctc acggcttttg atgggccata ctgcaaccac gatattggtg
     3301 gtttctttga gccgggcacc tggatgcgct ataacctaca gtcagcgctg cgctctgcag
     3361 ccagggagtt ctcccacatg ctgagccggc cagtgccagg ctatgagcct ggctacatcc
     3421 cgggctatga tactccgggc tatgtgcctg gctaccatgg ccccgggtac cgcctgcccg
     3481 actacccccg gcctggtcgg cctgtgcccg gttaccgtgg gcctgtctac aacgttacgg
     3541 gagaggaggt ctccttcagc ttcagcacca gctccgcccc tgctgtcctg ctctacgtca
     3601 gttcctttgt tcgtgactac atggctgtgc tcatcaagga tgatgggacc cttcagctgc
     3661 gatatcagct gggcaccagt ccctacgtgt accagctaac cactcgacca gtgaccgatg
     3721 gccagcccca tagcatcaat atcacccgtg tttaccggaa cctcttcatc caggtggact
     3781 acttcccact gacagagcag aagttctcgc tgttggtgga cagccagttg gactcaccca
     3841 aggccttgta tttagggcgt gtgatggaga caggagtcat tgacccggag atccagcgct
     3901 acaacacccc aggtttctca ggctgcctgt ctggtgttcg attcaacaac gtggctcccc
     3961 tcaagaccca cttccgaacc cctcgaccca tgactgctga gctagctgag gcccttcgag
     4021 ttcagggaga actgtccgaa tctaattgcg gagctatgcc acgtcttgtt tcagaggtgc
     4081 cacctgagct tgatccctgg tatctgcccc cagacttccc ctactaccat gatgaaggat
     4141 gggttgccat acttttaggc tttttggtgg cctttctgct gctggggctg gtgggaatgt
     4201 tggtgctctt ctatctgcaa aatcatcgct ataagggctc ctaccatacc aatgagccca
     4261 aggctgccca cgagtaccat cctggcagca aacctcccct acccacttca ggccctgccc
     4321 aggtccccac ccctacagca gctcccaacc aagctccagc ctcagcccca gccccagccc
     4381 caactccagc cccagcccct ggcccccggg atcagaacct accccagatc ctggaggagt
     4441 ccaggtctga atgagtcaga agggcttctg ggaccaattc cagctcctga cattccccca
     4501 gtcctgcctc tcccccatcc tatcagggac atttggctcc tcttagctgg ctctgctcat
     4561 ccagaggata ttcccccatc ccccccccat caagtttggt gggcagagct acagatggga
     4621 cccaagggag tggccgagcc tcactgccta aaccaatgcc cttctcatcc ctgtttcccc
     4681 aggctcctgg ctgtttatct gccccaaagg agaagcctca tggggttgac ataggtcctt
     4741 tctgccatct ctgttccagc tgctgtcagg gattaacaac agagtgtagg ggagattaac
     4801 tgcctccctt ccaatagaca ctatcagcag ggacagatgt gtgggagtgc agggctgcag
     4861 agggtatggg gggaggaggc tgctaaaccc tatcccccag cctcccccct gccctgaaga
     4921 tcttccattt gcttccactc agctggaggc tcaagagggc ttgatggctg tcccctgccc
     4981 ccctcctttt gttttgtaca cagagaccaa gaggcctcag tttagcacct tagtacctcc
     5041 gctgcttcac ttgctttagc caaagccata aaaaacctgc aacgtagaga aaataatgca
     5101 gataccctga ctagccagcc ctctactcct ccaacctttt ccaagatatg caatggcctt
     5161 tgtgcctgcc caaaggcttc gccccctcca gtgcatgagg aaccctcttt cctccgctca
     5221 gagatgctgc ttcatttacc caggaggtca tattctttat atatattttt tgttgcaaag
     5281 tgtctctcta gagaaactct atatattatt cgaattttta aattatttgt ttatatataa
     5341 aagaaaagct caattggctg tgctgtcctg tgctgtgctg tgcccacagt ctgtagtttg
     5401 cctttcctgt gttggaagtg tcgtgagtcc tgctggtcac ccaccagcct ggtccggcct
     5461 ccactctgaa gcagggttga gcctgctgtg ctctcagacg cggagccgtt ccaataaagc
     5521 agagtggcag agcccca
//
