LOCUS       NM_014361               6499 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens contactin 5 (CNTN5), transcript variant 1, mRNA.
ACCESSION   NM_014361
VERSION     NM_014361.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6499)
  AUTHORS   Dauar,M.T., Labonte,A., Picard,C., Miron,J., Rosa-Neto,P.,
            Zetterberg,H., Blennow,K., Villeneuve,S. and Poirier,J.
  TITLE     Characterization of the contactin 5 protein and its risk-associated
            polymorphic variant throughout the Alzheimer's disease spectrum
  JOURNAL   Alzheimers Dement 19 (7), 2816-2830 (2023)
   PUBMED   36583624
  REMARK    GeneRIF: Characterization of the contactin 5 protein and its
            risk-associated polymorphic variant throughout the Alzheimer's
            disease spectrum.
REFERENCE   2  (bases 1 to 6499)
  AUTHORS   Kawamura,Y., Nakaoka,H., Nakayama,A., Okada,Y., Yamamoto,K.,
            Higashino,T., Sakiyama,M., Shimizu,T., Ooyama,H., Ooyama,K.,
            Nagase,M., Hidaka,Y., Shirahama,Y., Hosomichi,K., Nishida,Y.,
            Shimoshikiryo,I., Hishida,A., Katsuura-Kamano,S., Shimizu,S.,
            Kawaguchi,M., Uemura,H., Ibusuki,R., Hara,M., Naito,M., Takao,M.,
            Nakajima,M., Iwasawa,S., Nakashima,H., Ohnaka,K., Nakamura,T.,
            Stiburkova,B., Merriman,T.R., Nakatochi,M., Ichihara,S., Yokota,M.,
            Takada,T., Saitoh,T., Kamatani,Y., Takahashi,A., Arisawa,K.,
            Takezaki,T., Tanaka,K., Wakai,K., Kubo,M., Hosoya,T., Ichida,K.,
            Inoue,I., Shinomiya,N. and Matsuo,H.
  TITLE     Genome-wide association study revealed novel loci which aggravate
            asymptomatic hyperuricaemia into gout
  JOURNAL   Ann Rheum Dis 78 (10), 1430-1437 (2019)
   PUBMED   31289104
  REMARK    GeneRIF: The present study revealed three gout specific loci,
            CNTN5, MIR302F, ZNF724, to be clearly associated with mechanisms of
            gout development, which distinctly differ from the known gout risk
            loci that basically elevate serum uric acid level. This
            meta-analysis is the first to reveal the loci associated with
            crystal-induced inflammation, the last step in gout development
            that aggravates asymptomatic hyperuricaemia into gout.
REFERENCE   3  (bases 1 to 6499)
  AUTHORS   Deneault,E., Faheem,M., White,S.H., Rodrigues,D.C., Sun,S., Wei,W.,
            Piekna,A., Thompson,T., Howe,J.L., Chalil,L., Kwan,V., Walker,S.,
            Pasceri,P., Roth,F.P., Yuen,R.K., Singh,K.K., Ellis,J. and
            Scherer,S.W.
  TITLE     CNTN5-/+or EHMT2-/+human iPSC-derived neurons from individuals with
            autism develop hyperactive neuronal networks
  JOURNAL   Elife 8, e40092 (2019)
   PUBMED   30747104
  REMARK    GeneRIF: The most compelling new results revealed a consistent
            spontaneous network hyperactivity in neurons deficient for CNTN5 or
            EHMT2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6499)
  AUTHORS   Thomas,D., Gazouli,M., Karantanos,T., Rigoglou,S., Karamanolis,G.,
            Bramis,K., Zografos,G. and Theodoropoulos,G.E.
  TITLE     Association of rs1568885, rs1813443 and rs4411591 polymorphisms
            with anti-TNF medication response in Greek patients with Crohn's
            disease
  JOURNAL   World J Gastroenterol 20 (13), 3609-3614 (2014)
   PUBMED   24707144
  REMARK    GeneRIF: rs1568885 and rs1813443, but not rs4411591 polymorphisms
            are associated with clinical and biochemical response to infliximab
            in Greek patients with Crohn's disease
REFERENCE   5  (bases 1 to 6499)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 6499)
  AUTHORS   Larson,M.G., Atwood,L.D., Benjamin,E.J., Cupples,L.A.,
            D'Agostino,R.B. Sr., Fox,C.S., Govindaraju,D.R., Guo,C.Y.,
            Heard-Costa,N.L., Hwang,S.J., Murabito,J.M., Newton-Cheh,C.,
            O'Donnell,C.J., Seshadri,S., Vasan,R.S., Wang,T.J., Wolf,P.A. and
            Levy,D.
  TITLE     Framingham Heart Study 100K project: genome-wide associations for
            cardiovascular disease outcomes
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S5 (2007)
   PUBMED   17903304
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6499)
  AUTHORS   Seshadri,S., DeStefano,A.L., Au,R., Massaro,J.M., Beiser,A.S.,
            Kelly-Hayes,M., Kase,C.S., D'Agostino,R.B. Sr., Decarli,C.,
            Atwood,L.D. and Wolf,P.A.
  TITLE     Genetic correlates of brain aging on MRI and cognitive test
            measures: a genome-wide association and linkage analysis in the
            Framingham Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S15 (2007)
   PUBMED   17903297
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6499)
  AUTHORS   Rios,J.C., Melendez-Vasquez,C.V., Einheber,S., Lustig,M.,
            Grumet,M., Hemperly,J., Peles,E. and Salzer,J.L.
  TITLE     Contactin-associated protein (Caspr) and contactin form a complex
            that is targeted to the paranodal junctions during myelination
  JOURNAL   J Neurosci 20 (22), 8354-8364 (2000)
   PUBMED   11069942
REFERENCE   9  (bases 1 to 6499)
  AUTHORS   Kamei,Y., Takeda,Y., Teramoto,K., Tsutsumi,O., Taketani,Y. and
            Watanabe,K.
  TITLE     Human NB-2 of the contactin subgroup molecules: chromosomal
            localization of the gene (CNTN5) and distinct expression pattern
            from other subgroup members
  JOURNAL   Genomics 69 (1), 113-119 (2000)
   PUBMED   11013081
REFERENCE   10 (bases 1 to 6499)
  AUTHORS   Walsh,F.S. and Doherty,P.
  TITLE     Glycosylphosphatidylinositol anchored recognition molecules that
            function in axonal fasciculation, growth and guidance in the
            nervous system
  JOURNAL   Cell Biol Int Rep 15 (11), 1151-1166 (1991)
   PUBMED   1838307
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002428.3, AK308788.1,
            BC130619.1, AB013802.2, AP001892.4, BX090703.1, BM697855.1,
            BU737133.1 and R26700.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014361.3.
            
            Summary: The protein encoded by this gene is a member of the
            immunoglobulin superfamily, and contactin family, which mediate
            cell surface interactions during nervous system development. This
            protein is a glycosylphosphatidylinositol (GPI)-anchored neuronal
            membrane protein that functions as a cell adhesion molecule. It may
            play a role in the formation of axon connections in the developing
            nervous system. Alternatively spliced transcript variants encoding
            different isoforms have been described for this gene. [provided by
            RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript, and encodes the longest isoform (1, also known as long
            isoform). Variants 1 and 2 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.5129.1, BC144186.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000524871.6/ ENSP00000435637.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AP002428.3         84245-84271
            28-1346             AK308788.1         1-1319
            1347-3765           BC130619.1         967-3385
            3766-4356           AB013802.2         3314-3904
            4357-4729           AP001892.4         119518-119890
            4730-5407           BX090703.1         1-678
            5408-5594           AP001892.4         120569-120755
            5595-6058           BM697855.1         1-464
            6059-6479           BU737133.1         37-457              c
            6480-6499           R26700.1           1-20                c
FEATURES             Location/Qualifiers
     source          1..6499
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.1"
     gene            1..6499
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /note="contactin 5"
                     /db_xref="GeneID:53942"
                     /db_xref="HGNC:HGNC:2175"
                     /db_xref="MIM:607219"
     exon            1..322
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            323..461
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            462..586
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             532..3834
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; neural adhesion molecule; neural recognition
                     molecule NB-2"
                     /codon_start=1
                     /product="contactin-5 isoform 1 precursor"
                     /protein_id="NP_055176.1"
                     /db_xref="CCDS:CCDS53696.1"
                     /db_xref="GeneID:53942"
                     /db_xref="HGNC:HGNC:2175"
                     /db_xref="MIM:607219"
                     /translation="MASSWKLMLFLSVTMCLSEYSKSLPGLSTSYAALLRIKKSSSSS
                     LFGSKTRPRYSSPSLGTLSASSPSWLGAAQNYYSPINLYHSSDAFKQDESVDYGPVFV
                     QEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIIS
                     NPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCS
                     PPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVT
                     NARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITW
                     MKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHW
                     VEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQ
                     SDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGS
                     PKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASL
                     SVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFE
                     SIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEI
                     TESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNP
                     WVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVS
                     EEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNN
                     KGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYW
                     KDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKS
                     PPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQ
                     AVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKITSAQSTLHSLSTSSSSVT
                     LLLALMIPSTSW"
     exon            587..808
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..932
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1108
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1204
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1408
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1511
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1693
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1830
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1960
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2111
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2239
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2415
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2536
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2695
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2845
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..2916
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3151
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3261
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3448
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3449..3561
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..3730
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3731..6499
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6470..6475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /note="hexamer: AATAAA"
     regulatory      6474..6479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /note="hexamer: AATAAT"
     polyA_site      6493
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
     polyA_site      6499
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /note="major polyA site"
ORIGIN      
        1 acaccagccg caggaggcgc cgcacctact tcccaatata accaactacg gcgtggggga
       61 gcggaactgc gagaaggcgg cagccaaagt gccattaaag ctcggggcgg agaggatgcg
      121 ttacctgggt cccgtctgct gcgagaggca gggcaagctg gaggattccc tctgaatgat
      181 taagaactcc gcaattcgcc tctgccacag gctgcaaagg acccgaggaa ccgctctctc
      241 tgaactgtgc tgatgggcag gaggatggga gacaggaatt gagagtcaca gaggaaggac
      301 agtggagtct ggcatcttat tggtgtcttt aaaggattgc catttaatgc cattcaagat
      361 ctactaagca tcatttttgc atgactactg caaaaggatt actttacaga taccagttcc
      421 tttgtcaaga gcatactttg gaccctgttt tcagaaagca gggcactctt taatgaagaa
      481 acaccagagc tgttaaacac attgagacac agaagattct agtgactgag gatggcttcc
      541 tcttggaaac taatgctgtt tctgtcagtc accatgtgtc tttcagagta ttcaaaatct
      601 cttcctggtc tctccacttc atatgctgct ttgttaagaa ttaagaagag ttcatcttca
      661 tctctctttg gttccaaaac cagaccacga tacagcagcc cttcattagg aacactgagt
      721 gcttcttcac ccagctggct aggggcagct cagaattatt attcccccat caatctttat
      781 cattcctcag atgccttcaa acaagatgaa agtgtggact atgggccagt ttttgtgcaa
      841 gaaccagatg atattatttt tccaactgat tctgatgaaa agaaggtagc attgaattgt
      901 gaagttcgtg gcaatccagt tcccagttac agatggcttc gaaatggaac agaaatagat
      961 ctggaaagtg attatcgcta cagtttgata gatggcacct tcattataag caatccaagt
     1021 gaagcaaagg attctggtca ttatcagtgt ttagcaacca acactgtggg gagtattctt
     1081 agtagagaag ctacactgca gtttgcctat ctgggaaatt ttagtggccg gacaagaagt
     1141 gcagtctctg tgagggaagg ccagggtgtc gttctgatgt gctctcctcc gccacattca
     1201 ccagagatca tctatagctg ggtatttaat gagttccctt cctttgtggc ggaagacagc
     1261 cggcggttca tctcccagga gacaggcaac ctttatattt ctaaagtcca aacatcagat
     1321 gttggcagct atatttgtct ggtgaaaaac acagtgacga atgctagagt ccttagtcct
     1381 ccaacgccac tcactctgcg taatgatggt gtgatgggag aatatgagcc gaaaattgag
     1441 gtccattttc ctttcacggt tacagctgct aaaggaacaa ctgttaagat ggaatgcttt
     1501 gcacttggca accccgttcc aacaatcaca tggatgaagg ttaatggtta tattcctagt
     1561 aaggcacgtc tgcggaaatc tcaggcggtg ctggaaatac cgaatgtaca gctggatgat
     1621 gcaggcattt atgagtgcag agctgaaaac tcacgtggaa aaaattcctt tcgtggacaa
     1681 ttacaagtat acacctaccc acactgggta gaaaaactga atgatactca gttagacagt
     1741 gggagccctc tccgatggga atgtaaggct actggaaaac ccagacccac gtatcgttgg
     1801 ctgaagaatg gagtacccct ctcacctcag agtagggttg agatggttaa tggagtattg
     1861 atgatccaca atgtgaatca atcagatgct ggaatgtatc agtgtttggc tgaaaataag
     1921 tatggagcca tttacgctag tgctgagctg aagattctag cttcagctcc cacttttgca
     1981 ctgaatcaac tgaagaaaac aataattgtt accaaagacc aagaagttgt catagagtgc
     2041 aaaccccaag gctctccaaa accaaccatc tcttggaaga aaggagacag agcagttaga
     2101 gaaaacaaaa gaatagctat tcttccagac gggagtctac ggatcctaaa tgcttccaaa
     2161 tcagacgagg gaaagtacgt ttgccgaggg gaaaacgtct ttggttctgc tgaaattata
     2221 gcttcgctat ctgtaaaaga acctacaagg atagaactta ctcctaaaag aacagaattg
     2281 acagtgggag aaagcattgt ccttaattgc aaagcaattc acgatgctag tttggatgtc
     2341 actttctact ggactctgaa aggacagcct attgatttcg aggaagaggg tggacatttt
     2401 gaaagcatca gggcccaagc atcctctgca gatttaatga tcaggaacat ccttctgatg
     2461 catgctggga gatatggctg cagggtacag accacagcag acagtgtgtc agatgaggca
     2521 gaacttcttg ttaggggacc cccaggccca cctgggatag taattgttga ggaaataacc
     2581 gaaagtacgg ccacactgtc ctggagccca gcagctgaca accacagccc aatctcctcc
     2641 tacaaccttc aagctcgcag cccattttcc ctgggctggc aaacagtaaa gacagtccca
     2701 gaaatcataa caggggacat ggagtcagcc atggctgtgg acctaaatcc ctgggtggaa
     2761 tatgaatttc gagtggtagc caccaaccct attgggacag gagatccaag caccccatct
     2821 cgaatgatcc gcacaaatga agcagttccg aagacagcac ccaccaatgt aagcggaaga
     2881 agtggaagaa ggcatgagtt agtcattgcc tgggagccag tatctgaaga gtttcagaat
     2941 ggggaaggct tcggctatat tgtggctttc agacccaatg gaacacgtgg ctggaaggaa
     3001 aaaatggtga catcctctga agcttccaaa ttcatttatc gagatgaaag tgtccctcct
     3061 cttactccct ttgaagtgaa agttggcgtt tataacaata aaggagatgg gccttttagt
     3121 caaattgtgg tcatctgttc agctgaagga gaacccagtg ctgctcccac agatgtcaag
     3181 gcgacaagtg tgtctgtgtc agagattctt gttgcatgga aacacattaa agagagtcta
     3241 ggaagaccac agggatttga ggttggttac tggaaagaca tggaacagga agatacagca
     3301 gaaacagtca aaactagagg gaatgagtct ttcgtcatcc taacaggatt agaaggaaat
     3361 acgttatatc acttcacagt gagggcttac aatggagctg gatatgggcc acctagcagt
     3421 gaagtgagtg caaccaccaa gaaatcccct cctagtcaag cacctagcaa cctcaggtgg
     3481 gagcagcaag gctctcaggt ttctctgggc tgggaacccg tcataccatt agccaacgaa
     3541 tctgaagttg tgggttacaa ggttttttat aggcaagagg gtcacagcaa cagccaagtt
     3601 attgaaacac agaaacttca agcagtagta ccactcccag atgctggagt ctatattatt
     3661 gaagttcgag catatagtga aggaggagat ggaacagcta gttctcaaat tagggtacca
     3721 tcatattcag gtggaaaaat cacaagtgca cagtcgaccc ttcactctct ctccacatct
     3781 tcgtcatcag tcaccttgct cttggcattg atgattcctt caacttcctg gtgaaaactg
     3841 ctgacttaat ttgcttttgt ttgctttagc ttggtaacag cggtgaatag agtgtagtgt
     3901 aagtggagaa ccaggatcct gagatgagct tgagctttaa aaacttggga ctatacatgg
     3961 tgaacttaca ggaggttagg ggggaaatat tacttatcca tcaggtttct ctttggtttt
     4021 tgtaaacgga gaggacagtt cttagtccag taaaaatatg cagattgtat gtaatgaatt
     4081 tttgtaaaca aaggtaattt ctgtcaaatg tattctttac ttttttaata tgttgggatt
     4141 ttattttata tctgatgact ccgagtgtgt gccatccatt tgttaagtaa ctggccttta
     4201 gcagatctgt ttcaaaaaca aatacaaaaa tgagaatgaa aagtttgctt aagactaagt
     4261 ccagtgtttt tcattttccc tttggctgaa tatttcaatt gacaaaccag caggacatat
     4321 gaaaaatgct tcagtgatgt ggtccattat aagataagta cacaaaaatt ttcttgaaaa
     4381 atattgtatg attgcatagt gaaatagcaa gatttgtcaa tatgctattc tatatgcacc
     4441 cctagagcaa gtcattaggg tagggaataa gccatttaca ttagtgcaag atagaaagcg
     4501 agtccagatg aatttcagtg ctatagtttt tcataaagta ctatgttatc tagcagcaaa
     4561 tataataaat atttattttt aataacaaaa gatggtttaa catcaccaaa aaatatgatc
     4621 actaaaaact gcagacatgc tggcatgggt gctaacttaa aaatgagatg aatatgggac
     4681 agagcgtttc catttcttta cctactgcca aaacagatgt tgaattaggt ccaaggtttt
     4741 cttctaattg caaaattttg caaaaatttt aagggcaatg aaaatttgtt gtgcaaataa
     4801 ttatgcatag tctgtagatt aaaatggttc aagtataaca aataagtttt gatttttaaa
     4861 aacagttcca tgcatcacat accactgata aaatcaacta gtaaaataaa gacagtcttt
     4921 cttggataaa ttgaattttt aattaagctg tggaaacatg gcatcagtac agggattcag
     4981 ctagtctagc cagctatgca ctgtttgatt ctgtggcttg ggaagtaatc cttatttgct
     5041 atttcaaaga gtcatcttga gcctgagaga tcctagagag ttgttggaaa atgagatgaa
     5101 aattttctac ttgatgatat cttaaagaag ttctaacaag cacaagaatg tgccagagtt
     5161 ggcatcatac ccatgaagat gcgtgaaagg atagttattg caaagtcata tgccagagaa
     5221 gagcctggag aaactatggt tttataggcg atgttaacaa gagaacaaaa attggtttta
     5281 taattttata taatttaaac ttgttaactg tatttgcttc attaataaca agcaaaatga
     5341 aacaatatgg agctcaaatt gctagctctc aaggttaatc cttgtagaat cagagaagtg
     5401 attgaagttt ctgttctgaa catcctgaaa gaatagtttc agagccacag taaaagtctg
     5461 tatgtaggtt acatattctc tttggggaaa tgatgtaaga caccctaaac aaacaagaaa
     5521 ttagttaaaa gactcactca atgatattat agtaaatact acagatggta agtatttaag
     5581 cctgtaagta agtaattatg accaagtggc ctttcttgaa cgcctccttt aaagtgggag
     5641 aggctggact ttgcaaaaac agggatgcta attgtttagc tggcaaaaca tgagctctcc
     5701 caagtatagt ttacctttat gaattgtgca tctgaataaa agacagaaag aatattttta
     5761 atgcaaaata attttacgta tttcatgaat caagccattt tcttcatttt ccatggtggt
     5821 gtacaccaga tttagtgaag gactttaaga atcaacttct tacttacact ctcagaaagc
     5881 aaagcccagt aaaatattaa acaaataaaa tggcaaattt aaattaacca atatttttaa
     5941 ttagctgatg gatggtacgt atctgacaga gtatttacac atatagaatg tctgatgtat
     6001 tcttacagga atcagagata tggaatgttt ttacttaaca tacacagaat atgtattttg
     6061 catcataaac ctatttaaaa aacaggtttt caatgtttat gtacttatgt gctgcatatc
     6121 tgttactttg tagaaaccag aagagcattc ttatcaaggt acattatttt tcagctacag
     6181 tactgagttt tttctgctat gggatagtaa ccacagtctt aaatcactaa agagactgta
     6241 tttttgtata atgtccattg aatatgaaga aagcaacagt ccttataatt agaaatttca
     6301 tgaaagcaaa agttttgcat acccaaatga aggtactgtg gaccccatgt caaactgtta
     6361 aatatattgt gtacgatctg tatatatact atatataagg catataccgt gtggaaggca
     6421 cagtcaaata atagttctgt gtactgttct tgtaacatta gatcttttta ataaataatt
     6481 ctctttttat tgactttta
//
