LOCUS       NM_175607               5159 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens contactin 4 (CNTN4), transcript variant 1, mRNA.
ACCESSION   NM_175607
VERSION     NM_175607.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5159)
  AUTHORS   Bamford,R.A., Zuko,A., Eve,M., Sprengers,J.J., Post,H.,
            Taggenbrock,R.L.R.E., Fabetaler,D., Mehr,A., Jones,O.J.R.,
            Kudzinskas,A., Gandawijaya,J., Muller,U.C., Kas,M.J.H.,
            Burbach,J.P.H. and Oguro-Ando,A.
  TITLE     CNTN4 modulates neural elongation through interplay with APP
  JOURNAL   Open Biol 14 (5), 240018 (2024)
   PUBMED   38745463
  REMARK    GeneRIF: CNTN4 modulates neural elongation through interplay with
            APP.
REFERENCE   2  (bases 1 to 5159)
  AUTHORS   McCarthy,N.S., Vangjeli,C., Surendran,P., Treumann,A., Rooney,C.,
            Ho,E., Sever,P., Thom,S., Hughes,A.D., Munroe,P.B., Howard,P.,
            Johnson,T., Caulfield,M., Shields,D.C., O'Brien,E., Fitzgerald,D.J.
            and Stanton,A.V.
  TITLE     Genetic variants in PPARGC1B and CNTN4 are associated with
            thromboxane A2 formation and with cardiovascular event free
            survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)
  JOURNAL   Atherosclerosis 269, 42-49 (2018)
   PUBMED   29258006
  REMARK    GeneRIF: PPARGC1B and CNTN4 genotypes are associated with elevated
            thromboxane A2 formation and with an excess of cardiovascular
            events. Aspirin appears to blunt these associations.
REFERENCE   3  (bases 1 to 5159)
  AUTHORS   Evenepoel,L., van Nederveen,F.H., Oudijk,L., Papathomas,T.G.,
            Restuccia,D.F., Belt,E.J.T., de Herder,W.W., Feelders,R.A.,
            Franssen,G.J.H., Hamoir,M., Maiter,D., Ghayee,H.K., Shay,J.W.,
            Perren,A., Timmers,H.J.L.M., van Eeden,S., Vroonen,L., Aydin,S.,
            Robledo,M., Vikkula,M., de Krijger,R.R., Dinjens,W.N.M., Persu,A.
            and Korpershoek,E.
  TITLE     Expression of Contactin 4 Is Associated With Malignant Behavior in
            Pheochromocytomas and Paragangliomas
  JOURNAL   J Clin Endocrinol Metab 103 (1), 46-55 (2018)
   PUBMED   28938490
  REMARK    GeneRIF: High CNTN4 expression is associated with Pheochromocytomas
            and Paragangliomas.
REFERENCE   4  (bases 1 to 5159)
  AUTHORS   Roohi,J., Montagna,C., Tegay,D.H., Palmer,L.E., DeVincent,C.,
            Pomeroy,J.C., Christian,S.L., Nowak,N. and Hatchwell,E.
  TITLE     Disruption of contactin 4 in three subjects with autism spectrum
            disorder
  JOURNAL   J Med Genet 46 (3), 176-182 (2009)
   PUBMED   18349135
  REMARK    GeneRIF: This report suggests that mutations affecting CNTN4
            function may be relevant to Autism spectrum disorder pathogenesis.
REFERENCE   5  (bases 1 to 5159)
  AUTHORS   Tanaka,E., Maruyama,H., Morino,H., Nakajima,E. and Kawakami,H.
  TITLE     The CNTN4 c.4256C>T mutation is rare in Japanese with inherited
            spinocerebellar ataxia
  JOURNAL   J Neurol Sci 266 (1-2), 180-181 (2008)
   PUBMED   17915252
  REMARK    GeneRIF: pathological examinations and molecular biological
            examinations are needed to confirm that this mutation is a true
            cause of SCA16
            GeneRIF: Observational study of genotype prevalence. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 5159)
  AUTHORS   Dijkhuizen,T., van Essen,T., van der Vlies,P., Verheij,J.B.,
            Sikkema-Raddatz,B., van der Veen,A.Y., Gerssen-Schoorl,K.B.,
            Buys,C.H. and Kok,K.
  TITLE     FISH and array-CGH analysis of a complex chromosome 3 aberration
            suggests that loss of CNTN4 and CRBN contributes to mental
            retardation in 3pter deletions
  JOURNAL   Am J Med Genet A 140 (22), 2482-2487 (2006)
   PUBMED   17036314
REFERENCE   7  (bases 1 to 5159)
  AUTHORS   Miura,S., Shibata,H., Furuya,H., Ohyagi,Y., Osoegawa,M.,
            Miyoshi,Y., Matsunaga,H., Shibata,A., Matsumoto,N., Iwaki,A.,
            Taniwaki,T., Kikuchi,H., Kira,J. and Fukumaki,Y.
  TITLE     The contactin 4 gene locus at 3p26 is a candidate gene of SCA16
  JOURNAL   Neurology 67 (7), 1236-1241 (2006)
   PUBMED   17030759
  REMARK    GeneRIF: The contactin 4 gene (CNTN4) is associated with cerebellar
            degeneration in spinocerebellar ataxia type 16. Additional studies
            are necessary to prove 4,256C-->T to be a causative mutation.
REFERENCE   8  (bases 1 to 5159)
  AUTHORS   Fernandez,T., Morgan,T., Davis,N., Klin,A., Morris,A., Farhi,A.,
            Lifton,R.P. and State,M.W.
  TITLE     Disruption of contactin 4 (CNTN4) results in developmental delay
            and other features of 3p deletion syndrome
  JOURNAL   Am J Hum Genet 74 (6), 1286-1293 (2004)
   PUBMED   15106122
  REMARK    GeneRIF: Our results demonstrate the association of CNTN4
            disruption with the 3p deletion syndrome phenotype and strongly
            suggest a causal relationship
REFERENCE   9  (bases 1 to 5159)
  AUTHORS   Hansford,L.M., Smith,S.A., Haber,M., Norris,M.D., Cheung,B. and
            Marshall,G.M.
  TITLE     Cloning and characterization of the human neural cell adhesion
            molecule, CNTN4 (alias BIG-2)
  JOURNAL   Cytogenet Genome Res 101 (1), 17-23 (2003)
   PUBMED   14571131
REFERENCE   10 (bases 1 to 5159)
  AUTHORS   Zeng,L., Zhang,C., Xu,J., Ye,X., Wu,Q., Dai,J., Ji,C., Gu,S.,
            Xie,Y. and Mao,Y.
  TITLE     A novel splice variant of the cell adhesion molecule contactin 4
            (CNTN4) is mainly expressed in human brain
  JOURNAL   J Hum Genet 47 (9), 497-499 (2002)
   PUBMED   12202991
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA796385.1, DA063654.1,
            AY090737.1, AF549455.1, AC022002.5, AF464063.1 and R42166.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_175607.2.
            
            Summary: This gene encodes a member of the contactin family of
            immunoglobulins. Contactins are axon-associated cell adhesion
            molecules that function in neuronal network formation and
            plasticity. The encoded protein is a
            glycosylphosphatidylinositol-anchored neuronal membrane protein
            that may play a role in the formation of axon connections in the
            developing nervous system. Deletion or mutation of this gene may
            play a role in 3p deletion syndrome and autism spectrum disorders.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1, 4 and 6 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.170200.1,
                                           SRR1660805.230952.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000418658.6/ ENSP00000396010.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DA796385.1         1-22
            23-118              DA063654.1         1-96
            119-2165            AY090737.1         1-2047
            2166-3556           AF549455.1         2209-3599
            3557-3557           AC022002.5         144861-144861
            3558-5153           AF464063.1         1469-3064
            5154-5159           R42166.1           20-25               c
FEATURES             Location/Qualifiers
     source          1..5159
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p26.3-p26.2"
     gene            1..5159
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /note="contactin 4"
                     /db_xref="GeneID:152330"
                     /db_xref="HGNC:HGNC:2174"
                     /db_xref="MIM:607280"
     exon            1..113
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            114..195
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            196..251
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            252..394
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..3420
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; axonal-associated cell adhesion molecule;
                     neural cell adhesion protein BIG-2; brain-derived
                     immunoglobulin superfamily protein 2"
                     /codon_start=1
                     /product="contactin-4 isoform a precursor"
                     /protein_id="NP_783200.1"
                     /db_xref="CCDS:CCDS43041.1"
                     /db_xref="GeneID:152330"
                     /db_xref="HGNC:HGNC:2174"
                     /db_xref="MIM:607280"
                     /translation="MRLPWELLVLQSFILCLADDSTLHGPIFIQEPSPVMFPLDSEEK
                     KVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTA
                     TNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFN
                     EYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDG
                     VMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKS
                     NGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVF
                     WECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGV
                     IFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKE
                     NERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMD
                     VTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNI
                     QLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNH
                     SPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGI
                     GEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFR
                     PYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAE
                     EEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTV
                     GNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSD
                     SKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEI
                     KPFSDGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL"
     exon            395..521
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..697
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..793
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            794..991
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1094
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1279
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1416
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1546
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1697
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1825
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..2001
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2122
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2281
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2431
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2502
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2737
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2850
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..3037
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3150
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3319
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3320..5159
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5136..5141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /note="hexamer: AATAAA"
     polyA_site      5159
                     /gene="CNTN4"
                     /gene_synonym="AXCAM; BIG-2"
                     /note="major polyA site"
ORIGIN      
        1 gttcgacgcc aggattggct gcaagtaggg agctttcgcc gccgccccgg gcccctcgga
       61 ctgtgccggc gccgcacccg aggctctcgc cagcccggcg ccccggtgct gagtgggtga
      121 aaaagaacag tgtgtcatga agacaggcac ctggaggtga tttgggtggc attcatgaga
      181 aaattcacgt tacccgaatc attgacatag agtaactcca cagcatgtgt cttcaagagc
      241 ttccctaaaa gattaaaggt tatacaaaac ttaaaagaag cagcaattct attcgcttgt
      301 tattggactt gaaactccct ttgacctcgg aaactgaaga tgaggttgcc atgggaactg
      361 ctggtactgc aatcattcat tttgtgcctt gcagatgatt ccacactgca tggcccgatt
      421 tttattcaag aaccaagtcc tgtaatgttc cctttggatt ctgaggagaa aaaagtgaag
      481 ctcaattgtg aagttaaagg aaatccaaaa cctcatatca ggtggaagtt aaatggaaca
      541 gatgttgaca ctggtatgga tttccgctac agtgttgttg aagggagctt gttgatcaat
      601 aaccccaata aaacccaaga tgctggaacg taccagtgca cagcgacaaa ctcgtttgga
      661 acaattgtta gcagagaagc aaagcttcag tttgcttatc ttgacaactt taaaacaaga
      721 acaagaagca ctgtgtctgt ccgtcgaggt caaggaatgg tgctactgtg tggcccgcca
      781 ccccattctg gagagctgag ttatgcctgg atcttcaatg aatacccttc ctatcaggat
      841 aatcgccgct ttgtttctca agagactggg aatctgtata ttgccaaagt agaaaaatca
      901 gatgttggga attatacctg tgtggttacc aataccgtga caaaccacaa ggtcctgggg
      961 ccacctacac cactaatatt gagaaatgat ggagtgatgg gtgaatatga gcccaaaata
     1021 gaagtgcagt tcccagaaac agttccgact gcaaaaggag caacggtgaa gctggaatgc
     1081 tttgctttag gaaatccagt accaactatt atctggcgaa gagctgatgg aaagccaata
     1141 gcaaggaaag ccagaagaca caagtcaaat ggaattcttg agatccctaa ttttcagcag
     1201 gaggatgctg gtttatatga atgtgtagct gaaaattcca gagggaaaaa tgtagcaagg
     1261 ggacagctaa ctttctatgc tcaacctaat tggattcaaa aaataaatga tattcacgtg
     1321 gccatggaag aaaatgtctt ttgggaatgt aaagcaaatg gaaggcctaa gcctacatac
     1381 aagtggctaa aaaatggcga acctctgcta actcgggata gaattcaaat tgagcaagga
     1441 acactcaaca taacaatagt gaacctctca gatgctggca tgtatcagtg tttggcagag
     1501 aataaacatg gagttatctt ttccaacgca gagcttagtg ttatagctgt aggtccagat
     1561 ttttcaagaa cactcttgaa aagagtaact cttgtcaaag tgggaggtga agttgtcatt
     1621 gagtgtaagc caaaagcgtc tccaaaacct gtttacacct ggaagaaagg aagggatata
     1681 ttaaaagaaa atgaaagaat taccatttct gaagatggaa acctcagaat catcaacgtt
     1741 actaaatcag acgctgggag ttatacctgt atagccacta accattttgg aactgctagc
     1801 agtactggaa acttggtagt gaaagatcca acaagggtaa tggtaccccc ttccagtatg
     1861 gatgtcactg ttggagagag tattgtttta ccgtgccagg taacgcatga tcactcgcta
     1921 gacatcgtgt ttacttggtc atttaatgga cacctgatag actttgacag agatggggac
     1981 cactttgaaa gagttggagg gcaggattca gctggtgatt tgatgatccg aaacatccaa
     2041 ctgaagcatg ctgggaaata tgtctgcatg gtccaaacaa gtgtggacag gctatctgct
     2101 gctgcagacc tgattgtaag aggtcctcca ggtcccccag aggctgtgac aatagacgaa
     2161 atcacagata ccactgctca gctctcctgg agacccgggc ctgacaacca cagccccatc
     2221 accatgtatg tcattcaagc caggactcca ttctccgtgg gctggcaagc agtcagtaca
     2281 gtcccagaac tcattgatgg gaagacattc acagcgaccg tggtgggttt gaacccttgg
     2341 gttgaatatg aattccgcac agttgcagcc aacgtgattg ggattgggga gcccagccgc
     2401 ccctcagaga aacggagaac agaagaagct ctccccgaag tcacaccagc gaatgtcagt
     2461 ggtggcggag gcagcaaatc tgaactggtt ataacctggg agacggtccc tgaggaatta
     2521 cagaatggtc gaggctttgg ttatgtggtg gccttccggc cctacggtaa aatgatctgg
     2581 atgctgacag tgctggcctc agctgatgcc tctagatacg tgttcaggaa tgagagcgtg
     2641 caccccttct ctccctttga ggttaaagta ggtgtcttca acaacaaagg agaaggccct
     2701 ttcagtccca ccacggtggt gtattctgca gaagaagaac ccaccaaacc accagccagt
     2761 atctttgcca gaagtctttc tgccacagat attgaagttt tctgggcctc cccactggag
     2821 aagaatagag gacgaataca aggttatgag gttaaatatt ggagacatga agacaaagaa
     2881 gaaaatgcta gaaaaatacg aacagttgga aatcagacat caacaaaaat cacgaactta
     2941 aaaggcagtg tgctgtatca cttagctgtc aaggcatata attctgctgg gacaggcccc
     3001 tctagtgcaa cagtcaatgt gacaacccga aagccaccac caagtcaacc ccccggaaac
     3061 atcatatgga attcatcaga ctccaaaatt atcctgaatt gggatcaagt gaaggccctg
     3121 gataatgagt cggaagtaaa aggatacaaa gtcttgtaca gatggaacag acaaagcagc
     3181 acatctgtca ttgaaacaaa taaaacatcg gtggagcttt ctttgccttt cgatgaagat
     3241 tatataatag aaattaagcc attcagcgac ggaggagatg gcagcagcag tgaacaaatt
     3301 cgaattccaa agatatcaaa tgcctacgcg agaggatctg gggcttccac ttcgaatgca
     3361 tgtacgctgt cagccatcag tacaataatg atttccctca cagctaggtc cagtttatga
     3421 caaaagttat ctgaaggact tgctgtttat aatataagca acatttagct agttgttttg
     3481 aagacaccca gtactaagta atattgttgt tcaagtacat cttattactg gaataaaaat
     3541 gttttttgct tctttaggaa tggcattata cagtacttcc tcaaagcaaa tctagctttg
     3601 tctgaagttt ctttggaaac tctgcaatgc actgaagaca tctgtaatat gatgttacca
     3661 aagcagttta catatgtcct tatatgcata ttttttatta tatatttagt gttttataga
     3721 attttttaaa gttaacatat aatgtagata ttaatttttt cctcggctgt aaaatgctat
     3781 gggcaacaca atcatgcaat tataatttga aaatatttcc tttaaagaca gagtttgaaa
     3841 ctcatcttgg taaataaatt gcaaattact cgtacagttt tacaaggatc tcatggcaga
     3901 acagcggaag acttggtccg taactcaagg ctgttgtatg caaactactc ttctagtggt
     3961 taatgcactt gacatgtaca gtatgtttcc catgccgttg tgattttgac atgtacagta
     4021 tgttttcatg ccgttgtgaa ttttgttgtt caacccaact tgagatggtt tcaggaatgg
     4081 ctgcaatctc aaaagctcaa tgtactgccc aagaggcacc ttgtgcaata ttcccatccc
     4141 tgaatttagc attgtacagg aagattttct tttcactcaa ctgagttagc attgtctttg
     4201 tggtagcatt atcttagaca ttaaatttga agtaacatat atcctgtagt aacatagacc
     4261 caaagttact atagtcaacc aagtctttca aaggataaaa gatcatttta ttatctttaa
     4321 ctgtatctat tttgaatgta aatttaaaaa aagtaattct ctgtcaatgg attcgtaatt
     4381 tctttacaaa atttcttata tataatatgt gtatctctgt aataatagag cccttctttt
     4441 gaatcaaaat tacatatgga ctttggaaga ttgctcctat ttcaacaaat agttgctgca
     4501 agaattttta atatgactct ataaaagctc tttagtacaa ttgtatggtt tcttgatgat
     4561 tctgttttgc aataggtagc ctagttgctt tatatgcttt accttctagg tcttaaaatc
     4621 acacattgga aaatgacaat atcaacaaaa ctgtattctt atgaaaagaa ctatttgtta
     4681 caatgagaaa ggttttgtga gtaaacccta ctggacagtg acataaaagg caatggaatt
     4741 ttctataaac attttctcat gtaaacatgc tgccaccttt tcttctttct cagagaactc
     4801 aaatttgcta tagtttgtca tttttgctta caaataatat aacttttcaa ccttctagtt
     4861 atatttatcc aataaagtca taatcgggat tccatttgtg taaaaactag ggtggtaacc
     4921 ggaaaaaaat attgtcagta tttcaagctg tgttcctttc ttagtttgat atggttactt
     4981 ctatgttgaa ataaaattta aaatcacatg caaaaaaaaa atcagcaaaa taataaaatg
     5041 aacgaaaaaa aatgacaccc agggagttcc caaccccagt gtaaatgata tttaccagtg
     5101 atctagcata tgtaatcttt tttaaaggta ttgttaataa atattctgtc atttgtaaa
//
