LOCUS       NM_020872               5269 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens contactin 3 (CNTN3), transcript variant 1, mRNA.
ACCESSION   NM_020872 XM_005264757 XM_039627
VERSION     NM_020872.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5269)
  AUTHORS   Korotkov,A., Luinenburg,M.J., Romagnolo,A., Zimmer,T.S., van
            Scheppingen,J., Bongaarts,A., Broekaart,D.W.M., Anink,J.J.,
            Mijnsbergen,C., Jansen,F.E., van Hecke,W., Spliet,W.G., van
            Rijen,P.C., Feucht,M., Hainfellner,J.A., Krsek,P., Zamecnik,J.,
            Crino,P.B., Kotulska,K., Lagae,L., Jansen,A.C., Kwiatkowski,D.J.,
            Jozwiak,S., Curatolo,P., Muhlebner,A., van Vliet,E.A., Mills,J.D.
            and Aronica,E.
  TITLE     Down-regulation of the brain-specific cell-adhesion molecule
            contactin-3 in tuberous sclerosis complex during the early
            postnatal period
  JOURNAL   J Neurodev Disord 14 (1), 8 (2022)
   PUBMED   35030990
  REMARK    GeneRIF: Down-regulation of the brain-specific cell-adhesion
            molecule contactin-3 in tuberous sclerosis complex during the early
            postnatal period.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5269)
  AUTHORS   Zhou,J., Xie,Z., Cui,P., Su,Q., Zhang,Y., Luo,L., Li,Z., Ye,L.,
            Liang,H. and Huang,J.
  TITLE     SLC1A1, SLC16A9, and CNTN3 Are Potential Biomarkers for the
            Occurrence of Colorectal Cancer
  JOURNAL   Biomed Res Int 2020, 1204605 (2020)
   PUBMED   32566650
  REMARK    GeneRIF: SLC1A1, SLC16A9, and CNTN3 Are Potential Biomarkers for
            the Occurrence of Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5269)
  AUTHORS   Argos,M., Tong,L., Pierce,B.L., Rakibuz-Zaman,M., Ahmed,A.,
            Islam,T., Rahman,M., Paul-Brutus,R., Rahaman,R., Roy,S.,
            Jasmine,F., Kibriya,M.G. and Ahsan,H.
  TITLE     Genome-wide association study of smoking behaviours among
            Bangladeshi adults
  JOURNAL   J Med Genet 51 (5), 327-333 (2014)
   PUBMED   24665060
REFERENCE   4  (bases 1 to 5269)
  AUTHORS   Benjamin,D.J., Cesarini,D., van der Loos,M.J., Dawes,C.T.,
            Koellinger,P.D., Magnusson,P.K., Chabris,C.F., Conley,D.,
            Laibson,D., Johannesson,M. and Visscher,P.M.
  TITLE     The genetic architecture of economic and political preferences
  JOURNAL   Proc Natl Acad Sci U S A 109 (21), 8026-8031 (2012)
   PUBMED   22566634
REFERENCE   5  (bases 1 to 5269)
  AUTHORS   Boal,F. and Stephens,D.J.
  TITLE     Specific functions of BIG1 and BIG2 in endomembrane organization
  JOURNAL   PLoS One 5 (3), e9898 (2010)
   PUBMED   20360857
  REMARK    GeneRIF: BIG1 and BIG2 have roles in endomembrane organization
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5269)
  AUTHORS   Liu,T., Qian,W.J., Gritsenko,M.A., Camp,D.G. 2nd, Monroe,M.E.,
            Moore,R.J. and Smith,R.D.
  TITLE     Human plasma N-glycoproteome analysis by immunoaffinity
            subtraction, hydrazide chemistry, and mass spectrometry
  JOURNAL   J Proteome Res 4 (6), 2070-2080 (2005)
   PUBMED   16335952
REFERENCE   7  (bases 1 to 5269)
  AUTHORS   Kamei,Y., Takeda,Y., Teramoto,K., Tsutsumi,O., Taketani,Y. and
            Watanabe,K.
  TITLE     Human NB-2 of the contactin subgroup molecules: chromosomal
            localization of the gene (CNTN5) and distinct expression pattern
            from other subgroup members
  JOURNAL   Genomics 69 (1), 113-119 (2000)
   PUBMED   11013081
REFERENCE   8  (bases 1 to 5269)
  AUTHORS   Mock,B.A., Connelly,M.A., McBride,O.W., Kozak,C.A. and Marcu,K.B.
  TITLE     Plasmacytoma-associated neuronal glycoprotein, Pang, maps to mouse
            chromosome 6 and human chromosome 3
  JOURNAL   Genomics 34 (2), 226-228 (1996)
   PUBMED   8661054
REFERENCE   9  (bases 1 to 5269)
  AUTHORS   Yoshihara,Y., Kawasaki,M., Tamada,A., Nagata,S., Kagamiyama,H. and
            Mori,K.
  TITLE     Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and
            F3: four members of an axon-associated cell adhesion molecule
            subgroup of the immunoglobulin superfamily
  JOURNAL   J Neurobiol 28 (1), 51-69 (1995)
   PUBMED   8586965
REFERENCE   10 (bases 1 to 5269)
  AUTHORS   Connelly,M.A., Grady,R.C., Mushinski,J.F. and Marcu,K.B.
  TITLE     PANG, a gene encoding a neuronal glycoprotein, is ectopically
            activated by intracisternal A-type particle long terminal repeats
            in murine plasmacytomas
  JOURNAL   Proc Natl Acad Sci U S A 91 (4), 1337-1341 (1994)
   PUBMED   8108413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016945.22, AC128653.5, AC128656.9, AC024222.16 and AC016950.8.
            
            On or before Feb 5, 2021 this sequence version replaced
            XM_005264757.3, NM_020872.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.13686.1,
                                           SRR14372079.1598365.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263665.7/ ENSP00000263665.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               AC016945.22        65685-65953
            270-404             AC128653.5         95164-95298         c
            405-531             AC128653.5         73765-73891         c
            532-707             AC128653.5         60562-60737         c
            708-803             AC128656.9         31956-32051         c
            804-1007            AC024222.16        23495-23698
            1008-1110           AC024222.16        24903-25005
            1111-1295           AC024222.16        25521-25705
            1296-1432           AC024222.16        29192-29328
            1433-1562           AC024222.16        30298-30427
            1563-1713           AC024222.16        32854-33004
            1714-1841           AC016950.8         135045-135172       c
            1842-2017           AC016950.8         133249-133424       c
            2018-2135           AC016950.8         101204-101321       c
            2136-2294           AC016950.8         100161-100319       c
            2295-2444           AC016950.8         99912-100061        c
            2445-2515           AC016950.8         98382-98452         c
            2516-2750           AC016950.8         96471-96705         c
            2751-2866           AC016950.8         93635-93750         c
            2867-3053           AC016950.8         83819-84005         c
            3054-3166           AC016950.8         65780-65892         c
            3167-3335           AC016950.8         64995-65163         c
            3336-5269           AC016950.8         61082-63015         c
FEATURES             Location/Qualifiers
     source          1..5269
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p12.3"
     gene            1..5269
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /note="contactin 3"
                     /db_xref="GeneID:5067"
                     /db_xref="HGNC:HGNC:2173"
                     /db_xref="MIM:601325"
     exon            1..269
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            270..404
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..3436
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /note="plasmacytoma-associated neuronal glycoprotein;
                     brain-derived immunoglobulin superfamily protein 1;
                     contactin 3 (plasmacytoma associated)"
                     /codon_start=1
                     /product="contactin-3 precursor"
                     /protein_id="NP_065923.1"
                     /db_xref="CCDS:CCDS33790.1"
                     /db_xref="GeneID:5067"
                     /db_xref="HGNC:HGNC:2173"
                     /db_xref="MIM:601325"
                     /translation="MMFPWKQLILLSFIGCLGGELLLQGPVFIKEPSNSIFPVGSEDK
                     KITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCFA
                     TNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFN
                     EYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRS
                     DGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLR
                     KFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDS
                     LYWECRASGKPKPSYRWLKNGAALVLEERTQIENGALTISNLSVTDSGMFQCIAENKH
                     GLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWKKGDVSV
                     QEHERISLLNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSN
                     MDVSVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRN
                     IQLKHSGKYVCMVQTGVDSVSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKDN
                     HSPVISYSIQARTPFSVGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIG
                     GGEPSLPSEKVRTEEAVPEVPPSEVNGGGGSRSELVITWDPVPEELQNGEGFGYVVAF
                     RPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSA
                     EEEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMK
                     VAGNETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTKKTPPSQPPGNVVWNA
                     TDTKVLLNWEQVKAMENESEVTGYKVFYRTSSQNNVQVLNTNKTSAELVLPIKEDYII
                     EVKATTDGGDGTSSEQIRIPRITSMDARGSTSAISNVHPMSSYMPIVLFLIVYVLW"
     exon            405..531
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            532..707
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            708..803
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            804..1007
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1110
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1295
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1432
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1562
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1713
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1841
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..2017
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2135
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2294
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2444
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2515
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2750
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2866
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..3053
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..3166
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3335
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..5269
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5248..5253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /note="hexamer: AATAAA"
     polyA_site      5269
                     /gene="CNTN3"
                     /gene_synonym="BIG-1; PANG; PCS"
                     /note="major polyA site"
ORIGIN      
        1 agtgctcgct aggcgccggc agcagccaca gcagcctggc gcttggcggc ggcggcggtg
       61 gcagcggcgg gcgggctggc gccgtggact gggccgggaa ccgtgcggac gagggtgctg
      121 cgcctgcggc ggcggcggct tacgcgggcg cgcacggcgg ccccccgggc ccggactaac
      181 tgcggcggcg gcggtggcgg cggcggcggc ggcggcggcg gcggcgagtg ggccgtcggg
      241 gcgggcgtct ggcgagctgc agagaccaga ttaaaggatt tacctgaaga gaaagcattc
      301 tattcatcag agactggaca agagttactc ttgcatttgg caattaaaga tgatgtttcc
      361 atggaaacag ttgatcctgc tttcattcat tggctgctta ggaggtgagc ttctcttaca
      421 aggccctgta tttatcaaag aacccagcaa cagcattttc cctgttggtt cagaagataa
      481 aaaaataact ttgcattgtg aagcaagagg caatccatca cctcattaca gatggcagct
      541 gaatggaagt gatattgata tgagtatgga acatcgttat aagttgaatg gaggaaatct
      601 tgtggttatt aatcccaaca gaaattggga tacaggaact taccaatgtt ttgcaacaaa
      661 ttcacttgga acaattgtca gcagagaagc caaacttcag tttgcctatc ttgaaaattt
      721 taaaaccaaa atgaggagta cagtgtctgt gcgtgaaggc cagggagttg tgctgctctg
      781 cggcccccca ccacactctg gagaactgtc atatgcttgg atcttcaatg aatacccatc
      841 gtttgttgaa gaagatagtc ggagatttgt ctcccaggag acagggcacc tctacatatc
      901 taaggtggag ccgtctgatg tgggaaatta cacatgtgtg gtgacaagta tggtgacaaa
      961 tgcccgagtg ctgggctctc caactccttt ggtgctacgt tctgatggtg tgatgggtga
     1021 atatgaacct aaaatagaag ttcagtttcc agaaactctt ccagcagcta aaggttcgac
     1081 tgtgaaattg gaatgttttg cccttggaaa tcccatacct cagattaatt ggagaagaag
     1141 tgatgggctg ccattttcca gcaaaattaa attaaggaag ttcagtggtg tgcttgaaat
     1201 ccccaacttc caacaggaag atgcaggttc ctatgaatgc attgctgaga attcacgagg
     1261 aaaaaatgtt gccagagggc gtctcactta ctatgcaaag ccccattggg ttcaactcat
     1321 aaaggatgtg gaaatagccg tggaggacag tctttattgg gaatgcaggg caagcggcaa
     1381 gcccaagcct tcctaccgat ggctgaaaaa tggagcagcc ctggtgctag aggagagaac
     1441 acagatagaa aatggtgccc ttacaatatc aaacctaagt gtgactgatt ctggcatgtt
     1501 ccaatgcata gcagaaaaca aacatggcct tgtttattcc agtgctgagc tcaaagttgt
     1561 tgcttctgct ccagattttt caaagaatcc aatgaagaag ttggttcagg tgcaggtggg
     1621 cagcctggtc agcttggatt gtaaacccag agcctcccca agggcactct cttcctggaa
     1681 gaagggggat gtgagcgtgc aggagcatga aagaatttct ttgttaaacg atggaggact
     1741 caaaatagcc aatgtgacta aagctgatgc tggaacttac acctgcatgg cagaaaacca
     1801 gtttgggaaa gcaaatggca caacacattt ggttgttacg gaaccaacaa gaataacttt
     1861 ggcaccatct aacatggatg tttctgttgg tgaaagcgtc atattgccct gccaggtaca
     1921 acatgacccg ctgttagaca tcatctttac ctggtatttc aatggggccc ttgcagattt
     1981 taagaaagat ggatctcact ttgagaaagt tggtgggagt tcatctggtg atttaatgat
     2041 cagaaacatt cagctgaaac acagtgggaa atatgtttgt atggtgcaaa cgggggtgga
     2101 cagtgtttca tctgctgctg acctcatagt aagaggttca cctggaccac cagaaaatgt
     2161 gaaggtagat gaaattacag acacaacagc ccaactctct tggaaagaag gtaaagacaa
     2221 ccatagccca gttatatcct attctatcca ggctcggaca cctttctccg tgggttggca
     2281 aaccgtcaca acagtgcctg aggtcatcga tgggaagacg cacacagcca ctgtagttga
     2341 gttaaaccca tgggtggaat atgaatttcg ggttgtagcc agtaacaaaa ttggaggtgg
     2401 agaaccaagt ttaccctcag aaaaagtaag aactgaagag gcagttccag aagtgcctcc
     2461 ttctgaagtc aatggaggag gcggaagccg gtctgaactt gtgataacct gggatccagt
     2521 ccctgaagaa ctacagaatg gtgaaggttt tgggtatgtt gttgctttcc gccctcttgg
     2581 ggttaccacc tggatccaga cagtggtgac atcccctgac accccaagat atgtctttag
     2641 gaatgaaagc atcgtgccat attcaccata tgaagttaaa gtgggtgttt ataataacaa
     2701 aggtgaagga ccatttagcc cagtgacaac agtgttctct gcagaagaag agcctacagt
     2761 ggccccatct caagtctctg caaatagcct atcttcctca gaaattgagg tttcatggaa
     2821 caccattcct tggaagttga gcaatggaca tttactgggc tatgaggtgc ggtactggaa
     2881 tgggggtgga aaggaggaat catccagtaa gatgaaagtg gcaggaaatg agacatcagc
     2941 cagactacgg ggcctgaaga gcaacctggc ctattacacg gctgtccggg cttacaacag
     3001 tgccggcgct gggcctttta gcgccacagt taatgtaacc accaagaaaa cgcctcccag
     3061 tcagccacca ggaaatgttg tttggaatgc cacagacact aaagtgttac ttaattggga
     3121 gcaagttaaa gccatggaga atgagtcaga agtaacagga tataaagttt tctataggac
     3181 tagcagtcaa aataacgtac aagtactgaa cacaaataaa acttcagctg aacttgtgct
     3241 gcccattaaa gaggactaca ttattgaagt caaggccaca acagatggag gggatgggac
     3301 cagtagtgaa cagatcagga ttccacgaat aaccagtatg gatgcaagag gatccacttc
     3361 agccatctcg aatgtccacc ctatgtcaag ttatatgcct atagtactgt tcttaattgt
     3421 atatgtcctg tggtgatatt aactcctttt tattatttat tggaaagtta tttggttacc
     3481 aaaaaaagtg ctttcatgaa atgcagtgat tatgcatgtt tttttcaact cttattttta
     3541 actttctact tcattatagg taaatatgaa tataattaaa aaaacagtaa atccttttag
     3601 gggaatctga aatgccttaa tattaacttg ataaaccaaa ggaatttaca tattacatac
     3661 ttcagacttt tgatataaat gttcttaaac tatgagttta agcactgcct atggataaag
     3721 actcacacac tctcacatgt acacacacac gcatgagaat ttctttttac attgaaaaac
     3781 tctttcattt aattcaaatg ctattttccc attataatag cattatttgg aagacttaac
     3841 cagtatcaat ttgaaatgct gatttaagtc cccaaggatg aaaaatacat tttaaaaatt
     3901 attttgttgg agaggagtgg catgtgattc aaaagagcat tgttggaaaa tgctactgtg
     3961 gggcttagaa gaatgatgtt tggtttggta tgctgctaac tagttgtaag actttacaaa
     4021 tcactttgcc atctgtacct ctcaattatt cctctataaa atatggagat aataatacct
     4081 atctgatcag actttgcccc atgaattagt ttttaaaaga taaagactga agtatgaaag
     4141 tgcttttgtc accccaaatg caattgaccc atgcaaaata ttagcatgaa tttatttaat
     4201 cacataaaag tcatgaagac cagccagatt ttcaagcttc attctgtttc attcagttat
     4261 attccaaaat tcaaatgatc acattttatt ctttctcaaa aaaaaaaagt ttttttaaat
     4321 taaaaaagga attgtttcct tcacagctat gaataagctt tcaggtttta ttaaaaccta
     4381 gaggaaaaaa tcaggaatga cctgaatctc aacccaaata ttaaacaaaa tccacataat
     4441 ccctcatttc aatttccaat tccattaagg gaccctctct ttttggatgg cagagatggt
     4501 tttttaatga aatcccacca tctatctgag tgagtctggc aggcttttta gttcctgagt
     4561 taaatttgta atagaaccaa ggcaatgctg ctgactttga tatgtatgac tcagtctttc
     4621 aatatgtggt tttcaaaaaa ttgttgaaga cgtgacttca tagcaatata tagagaataa
     4681 attaaaatca gcagattgag ttttcaacat tgcaaaatca gttttttacc tctttcctac
     4741 caatttcaca ttttgcagaa acttgttcac atttccaaca atatcagaat tagaaaacag
     4801 ttcagataac aagaaagatt aaaaattagg gaaattctga tatcaccata aagcactatt
     4861 ttacatttag agattacatt taagataaag tcatcataca caaaaacaat aaatatttat
     4921 aactttctct ataaggtccg catatactgt atatattgaa acaatctgaa tgactagtag
     4981 atttcatatg accattgtta tttccacttt ctccaatact tgtattttat gctacatgta
     5041 atgaagttgg acctttttat tatttagtaa ttcctatatg ttcctatact tttcattttc
     5101 aagatgattg ctctattgtt tcatgttgtt tctagcaata tatctccatg agatatgcac
     5161 tttgtttcat attgaaaagt ataaaattta tctttcaatt cctgtgtgtg tatcctatgg
     5221 ttatctgtat gtattatttt ctattctaat aaaatttata acaagcaaa
//
