LOCUS       NM_005076               7916 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens contactin 2 (CNTN2), transcript variant 1, mRNA.
ACCESSION   NM_005076 XM_005245467
VERSION     NM_005076.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7916)
  AUTHORS   Lin,Z.J., He,J.W., Zhu,S.Y., Xue,L.H., Zheng,J.F., Zheng,L.Q.,
            Huang,B.X., Chen,G.Z. and Lin,P.X.
  TITLE     Gene-gene interaction network analysis indicates CNTN2 is a
            candidate gene for idiopathic generalized epilepsy
  JOURNAL   Neurogenetics 25 (2), 131-139 (2024)
   PUBMED   38460076
  REMARK    GeneRIF: Gene-gene interaction network analysis indicates CNTN2 is
            a candidate gene for idiopathic generalized epilepsy.
            Erratum:[Neurogenetics. 2025 Jan 28;26(1):24. doi:
            10.1007/s10048-025-00802-1.. PMID: 39873752]
REFERENCE   2  (bases 1 to 7916)
  AUTHORS   Fajami,Z., Akbarin,M.M., Rafatpanah,H., Ramezani,S., Rahimi,H. and
            Rezaee,S.A.
  TITLE     Assessment of Bcl-xL, TAX, and HBZ Gene Expression in Adult T cell
            Leukemia/Lymphoma Patients
  JOURNAL   AIDS Res Hum Retroviruses 40 (3), 141-147 (2024)
   PUBMED   37565279
  REMARK    GeneRIF: Assessment of Bcl-xL, TAX, and HBZ Gene Expression in
            Adult T cell Leukemia/Lymphoma Patients.
REFERENCE   3  (bases 1 to 7916)
  AUTHORS   Meng,N., Pan,P., Hu,S., Miao,C., Hu,Y., Wang,F., Zhang,J. and An,L.
  TITLE     The molecular mechanism of gamma-aminobutyric acid against AD: the
            role of CEBPalpha/circAPLP2/miR-671-5p in regulating CNTN1/2
            expression
  JOURNAL   Food Funct 14 (4), 2082-2095 (2023)
   PUBMED   36734072
  REMARK    GeneRIF: The molecular mechanism of gamma-aminobutyric acid against
            AD: the role of CEBPalpha/circAPLP2/miR-671-5p in regulating
            CNTN1/2 expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7916)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 7916)
  AUTHORS   Chatterjee,M., van Steenoven,I., Huisman,E., Oosterveld,L.,
            Berendse,H., van der Flier,W.M., Del Campo,M., Lemstra,A.W., van de
            Berg,W.D.J. and Teunissen,C.E.
  TITLE     Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson's
            Disease Patients and Is Present within Lewy Bodies
  JOURNAL   Biomolecules 10 (8), 1177 (2020)
   PUBMED   32806791
  REMARK    GeneRIF: Contactin-1 Is Reduced in Cerebrospinal Fluid of
            Parkinson's Disease Patients and Is Present within Lewy Bodies.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7916)
  AUTHORS   Tsiotra,P.C., Karagogeos,D., Theodorakis,K., Michaelidis,T.M.,
            Modi,W.S., Furley,A.J., Jessell,T.M. and Papamatheakis,J.
  TITLE     Isolation of the cDNA and chromosomal localization of the gene
            (TAX1) encoding the human axonal glycoprotein TAG-1
  JOURNAL   Genomics 18 (3), 562-567 (1993)
   PUBMED   8307567
REFERENCE   7  (bases 1 to 7916)
  AUTHORS   Kenwrick,S., Leversha,M., Rooke,L., Hasler,T. and Sonderegger,P.
  TITLE     Localization of the human TAX-1 gene to 1q32.1: a region implicated
            in microcephaly and Van der Woude syndrome
  JOURNAL   Hum Mol Genet 2 (9), 1461-1462 (1993)
   PUBMED   8242070
REFERENCE   8  (bases 1 to 7916)
  AUTHORS   Walsh,F.S. and Doherty,P.
  TITLE     Glycosylphosphatidylinositol anchored recognition molecules that
            function in axonal fasciculation, growth and guidance in the
            nervous system
  JOURNAL   Cell Biol Int Rep 15 (11), 1151-1166 (1991)
   PUBMED   1838307
  REMARK    Review article
REFERENCE   9  (bases 1 to 7916)
  AUTHORS   Kuhn,T.B., Stoeckli,E.T., Condrau,M.A., Rathjen,F.G. and
            Sonderegger,P.
  TITLE     Neurite outgrowth on immobilized axonin-1 is mediated by a
            heterophilic interaction with L1(G4)
  JOURNAL   J Cell Biol 115 (4), 1113-1126 (1991)
   PUBMED   1720120
REFERENCE   10 (bases 1 to 7916)
  AUTHORS   Dodd,J., Morton,S.B., Karagogeos,D., Yamamoto,M. and Jessell,T.M.
  TITLE     Spatial regulation of axonal glycoprotein expression on subsets of
            embryonic spinal neurons
  JOURNAL   Neuron 1 (2), 105-116 (1988)
   PUBMED   3272160
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN289415.1, X67734.1,
            BC129986.1 and AL583832.14.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_005076.4.
            
            Summary: This gene encodes a member of the contactin family of
            proteins, part of the immunoglobulin superfamily of cell adhesion
            molecules. The encoded glycosylphosphatidylinositol (GPI)-anchored
            neuronal membrane protein plays a role in the proliferation,
            migration, and axon guidance of neurons of the developing
            cerebellum. A mutation in this gene may be associated with adult
            myoclonic epilepsy. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.157351.1,
                                           SRR1803616.154918.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331830.7/ ENSP00000330633.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                CN289415.1         15-102
            89-2896             X67734.1           1-2808
            2897-3748           BC129986.1         2663-3514
            3749-7916           AL583832.14        49616-53783
FEATURES             Location/Qualifiers
     source          1..7916
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..7916
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /note="contactin 2"
                     /db_xref="GeneID:6900"
                     /db_xref="HGNC:HGNC:2172"
                     /db_xref="MIM:190197"
     exon            1..183
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            184..339
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..3392
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /note="contactin 2 (transiently expressed); axonin-1 cell
                     adhesion molecule; transient axonal glycoprotein 1; axonal
                     glycoprotein TAG-1; contactin 2 (axonal)"
                     /codon_start=1
                     /product="contactin-2 precursor"
                     /protein_id="NP_005067.1"
                     /db_xref="CCDS:CCDS1449.1"
                     /db_xref="GeneID:6900"
                     /db_xref="HGNC:HGNC:2172"
                     /db_xref="MIM:190197"
                     /translation="MGTATRRKPHLLLVAAVALVSSSAWSSALGSQTTFGPVFEDQPL
                     SVLFPEESTEEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTK
                     AQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAH
                     YPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTK
                     SVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKV
                     DGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVIS
                     DTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLRFSKLSLEDSGM
                     YQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVV
                     LWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDA
                     TKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVK
                     ETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTI
                     QLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYE
                     FRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQN
                     GDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGP
                     ESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGD
                     KEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRR
                     PPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQNDLHLTPTLHLTGKNWIEIP
                     VPEDIGHALVQIRTTGPGGDGIPAEVHIVRNGGTSMMVENMAVRPAPHPGTVISHSVA
                     MLILIGSLEL"
     exon            340..484
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..660
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..756
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..966
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1066
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1242
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1379
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1509
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1660
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1788
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1964
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2085
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2244
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2394
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2465
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2700
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2813
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..3000
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3113
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3282
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..7916
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7607..7612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /note="hexamer: AATAAA"
     polyA_site      7637
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /note="major polyA site"
     polyA_site      7678
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
     regulatory      7745..7750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /note="hexamer: AATATA"
     polyA_site      7764
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
     regulatory      7881..7886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /note="hexamer: AATACA"
     regulatory      7892..7897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
                     /note="hexamer: AGTAAA"
     polyA_site      7902
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
     polyA_site      7916
                     /gene="CNTN2"
                     /gene_synonym="AXT; EPEO5; FAME5; TAG-1; TAX; TAX1"
ORIGIN      
        1 acacacacgc gccctcaccc gccaccgccg ccgcggccgc cgccgcaccc ggacagcgag
       61 cggctgaggc cgccagggcc caaaggacag cggcccagac aggggctggc ggcccggccg
      121 gccccggctc accgactcgg gcagcatcca cctgccccag ccaacaccct tctctcgccc
      181 caggtccttt ctcagcctcc agctgggctg tccccaagct gagctgaggc tcttctcctc
      241 cgatccccac ctctgcccgg acatccacca tggggacagc caccaggagg aagccacacc
      301 tgctgctggt agctgctgtg gcccttgtct cctcttcagc ttggagttca gccctgggat
      361 cccaaaccac cttcgggcct gtctttgaag accagcccct cagtgtgcta ttcccagagg
      421 agtccacgga ggagcaggtg ttgctggcat gccgcgcccg ggccagccct ccagccacct
      481 atcggtggaa gatgaatggt accgagatga agctggagcc aggttcccgt caccagctgg
      541 tggggggcaa cctggtcatc atgaacccca ccaaggcaca ggatgccggg gtctaccagt
      601 gcctggcctc caacccagtg ggcaccgttg tcagcaggga ggccatcctc cgcttcggct
      661 ttctgcagga attctccaag gaggagcgag acccagtgaa agctcatgaa ggctgggggg
      721 tgatgttgcc ctgtaaccca cctgcccact acccaggctt gtcctaccgc tggctcctca
      781 acgagttccc caacttcatc ccgacggacg ggcgtcactt cgtgtcccag accacaggga
      841 acctgtacat tgcccgaacc aatgcctcag acctgggcaa ctactcctgt ttggccacca
      901 gccacatgga cttctccacc aagagcgtct tcagcaagtt tgctcagctc aacctggctg
      961 ctgaagatac ccggctcttt gcacccagca tcaaggcccg gttcccagca gagacctatg
     1021 cactggtggg gcagcaggtc accctggagt gcttcgcctt tgggaaccct gtcccccgga
     1081 tcaagtggcg caaagtggac ggctccctgt ccccgcagtg gaccacagct gagcccaccc
     1141 tgcagatccc cagcgtcagc tttgaggatg agggcaccta cgagtgtgag gcggagaact
     1201 ccaagggccg agacaccgtg cagggccgca tcatcgtgca ggctcagcct gagtggctaa
     1261 aagtgatctc ggacacagag gctgacattg gctccaacct gcgttggggc tgtgcagccg
     1321 ccggcaagcc ccggcctaca gtgcgctggc tgcggaacgg ggagcctctg gcctcccaga
     1381 accgggtgga ggtgttggct ggggacctgc ggttctccaa gctgagcctg gaagactcgg
     1441 gcatgtacca gtgtgtggca gagaataagc acggtaccat ctacgccagc gccgagctag
     1501 ccgtgcaagc actcgcccct gacttcaggc tgaatcccgt gaggcgtctg atccccgcgg
     1561 cccgcggggg agagatcctt atcccctgcc agccccgggc agctccaaag gccgtggtgc
     1621 tctggagcaa aggcacggag attttggtca acagcagcag agtgactgta actccagatg
     1681 gcaccttgat cataagaaac atcagccggt cagatgaagg caaatacacc tgctttgctg
     1741 agaacttcat gggcaaagcc aacagcactg gaatcctatc tgtgcgagat gcaaccaaaa
     1801 tcactctagc cccctcaagt gccgacatca acttgggtga caacctgacc ctacagtgcc
     1861 atgcctccca cgaccccacc atggacctca ccttcacctg gaccctggac gacttcccca
     1921 tcgactttga taagcctgga gggcactacc ggagaactaa tgtgaaggag accattgggg
     1981 atctgaccat cctgaacgcc cagctgcgcc atggggggaa gtacacgtgc atggcccaga
     2041 cggtggtgga cagcgcgtcc aaggaggcca cagtcctggt ccgaggtccg ccaggtcccc
     2101 caggaggtgt ggtggtgagg gacattggcg acaccaccat ccagctcagc tggagccgtg
     2161 gcttcgacaa ccacagcccc atcgctaagt acaccctgca agctcgcact ccacctgcag
     2221 ggaagtggaa gcaggttcgg accaatcctg caaacatcga gggcaatgcc gagactgcac
     2281 aggtgctggg cctcaccccc tggatggact atgagttccg ggtcatagcc agcaacattc
     2341 tgggcactgg ggagcctagt gggccctcca gcaaaatccg gaccagggaa gcagccccct
     2401 cggtggcacc ctcaggactc agcggaggag gtggagcccc cggagagctc atcgtcaact
     2461 ggacgcccat gtcacgggag taccagaacg gagacggctt cggctacctg ctgtccttcc
     2521 gcaggcaggg cagcactcac tggcagaccg cccgggtgcc tggcgccgat gcccagtact
     2581 ttgtctacag caacgagagc gtccggccct acacgccctt tgaggtcaag atccgcagct
     2641 acaaccgccg cggggatggg cccgagagcc tcactgcact cgtgtactca gctgaggaag
     2701 agcccagggt ggcccctacc aaggtgtggg ccaaaggggt ctcatcctca gagatgaacg
     2761 tgacctggga acccgtgcag caggacatga atggtatcct cctggggtat gagatccgct
     2821 actggaaagc tggggacaaa gaagcagctg cggaccgagt gaggacagca gggctggaca
     2881 ccagtgcccg agtcagcggc ctgcatccca acaccaagta ccatgtgacc gtgagggcct
     2941 acaaccgggc tggcactggg cctgccagcc cttctgccaa cgccacgacc atgaagcccc
     3001 ctccgcggcg acctcctggc aacatctcct ggactttctc aagctctagt cttagcatta
     3061 agtgggaccc tgtggtccct ttccgaaatg agtctgcagt caccggctat aagatgctgt
     3121 accagaatga cttacacctg actcccacgc tccacctcac cggcaagaac tggatagaaa
     3181 tcccagtgcc tgaagacatt ggccatgccc tggtacaaat tcggaccaca gggcccggag
     3241 gggatgggat ccctgcagaa gtccacatcg tgaggaatgg aggcacaagc atgatggtgg
     3301 agaacatggc agtccgccca gcaccacacc ctggcaccgt catttcccac tccgtggcga
     3361 tgctgatcct cataggctcc ctggagctct gatcctggaa cccctccctc tgcgccgcag
     3421 ctggacgcca cctccgacgg acacagccag ccccttcctg ctgccaaggt ggcctgacac
     3481 tgtgccagag agtggctggt tttaaatacc tactttaaac agtgcccttt ttgtaggagg
     3541 taggatattt tatattctgc cgcaggatag aacccacgca aggattttct ttaaattgag
     3601 aggcaccagg cagtaacttc catgatgaca ctgacgccta tacctgagct ctaggctgcc
     3661 tggagggaag gaacaggccc atgggaagaa gggggtttta aaaacatgtc ttcaactcag
     3721 cagagatggc cctctgggac cctatacgga ctccgccact tgagagcagt cctaggcccg
     3781 gcaggaacac cagacatgaa caggttgaag aactggagcg aagtgcacac ctcaccatcc
     3841 ttcagtctaa ggaagaaggg caagccctgg gaccaagagc tctcccgcct tctccctcga
     3901 gcagcagcaa ggaccctgac gctgtccccg ataactccct aggggctcct gcctgcccaa
     3961 gcggctgaga accagcgccc cgatgcctga ggctgggagc ctgagcccct tcagctttga
     4021 ggggggtgat actccaggct gtttggggtg ggagccaaaa agagttgaga ggccagggcc
     4081 cttggtggaa aggggcacca gccttggtct gagatagtca caacccaggt gacgatgccc
     4141 tctcagccaa cactgccaac ctgaccctgt catcccgatt gacagcgcca cttcaggtgg
     4201 ctgggtgact aaagggcttg tcttggtggg gtctcccacc cctccaagac ccattctgca
     4261 cagtccctcc agggtttggg caggagatgg ccaatcatgc gcccacctct ccagtgctgc
     4321 ctgcagtcag ctcggcctcc ccgacctgca gccccagact ctgctctccc agcactgact
     4381 cactcctgcc tgggagggga atgcagcatt catgctgtgt gtcctggtat tgggaggttt
     4441 ctgggaaggg cagaggataa atgtggccct gcctgctccc aggtatacct aggaccacct
     4501 ggccagatcc gctcccagac ggccttggac tgcttgcatt tccccggaga aaaaggggtt
     4561 aataaatggg ccatcctttc ctgagctctg ggtatactac cagtcacaga acgtcagagc
     4621 tggaagaagc cttagagctc aacttcttca agcccctcac tttacagatg aggaaatgga
     4681 ggtggtccag agagggtctg ggattcccaa ggtcacacag cccagaagag atggggctgg
     4741 gttaagaact cgagtcttcc acctttctgt tcaaggctgt ttgtctaccc agaggaagga
     4801 ggcactgctg aatggctatg gcctggctaa gaaggtgatt agtcagtagg gtgtgaaaat
     4861 tctacttcaa ggggttcgga ttggtgatca tggggattgg catggctggg ttcccgtcca
     4921 aggtgtgggc agagcttcta ccaaacttca acatggaggg ctgacttgaa gctccctgtc
     4981 cccctcactc ttgccccaag aaaagaggcc aaagcaagag cagattccct aggcaagagc
     5041 agcagcacaa ctaggaaacc ccaaagccca tgctccgaca ggtggccctt cacagggggc
     5101 agcgggacag gcatcttgaa gggcatatgt cctcggaagc tccgagcctg ttttctgtag
     5161 tttatagtta gagctctatt ttgttatggt tttttaaact tttaagtcct gctctatttt
     5221 cctgggcagg tttatgttga tgtttaccca ctacaatttt ttaaaaatat aagctcacat
     5281 gccttttccc tgccacagcc aaacccccac tgcaccctac ccacccaccc ctagcccagg
     5341 tcagctttcc tggagctggc taatgaaagc ctcctcacct cttcccaacc cttacaagca
     5401 agggtgctag gggctcagct atacgaccat tctccctgac agggagtcca aacttggcct
     5461 agcatccctc ctggcccccc tctggccacg acttggcctg tgcctggttc tctatcagaa
     5521 aggggatgct gaacaaaacc tccttccaag ttttatccaa ttcgttcctc attgcctcgg
     5581 gctgcgtcag gggaagcagg ggacaggtgt ccagttgctg ggccgaggga ggagctggtt
     5641 tggcatagga cctaaccagt gaagctagag gctacagcca ctaaacttgc ttcaggccaa
     5701 cgatagttac tcacaagtaa gtaccttaat gctaatgagg tccactaaaa aggggaggaa
     5761 ggcagacctc ctgggagacc cacgaagggt ttttagccag ggaaaactga gccccaggaa
     5821 aacctaacca ctgggcaggc agaatttgtt tgagggatag aacgacaaca aaataaatgt
     5881 tcctgcagcc tgagatttca ggtagagtac tgactaaggt ttaataagac aataggtgac
     5941 ctgaggacat gcaagcttgt aaaatgcaac agcctcctgc tagagtgact tgtacatgag
     6001 cttgcttgca gaagactaga ttagatgttt ctcaggatcc cctcctgcgc aggggttctc
     6061 tgattttcgt gttctctgcc cagatgggct gggggagttg agagtgtgct tattttcact
     6121 gcgatcatga gaccacagtt ctgggttatc tcctctcata catcaagccc cagaggaggc
     6181 ggcaagagga acagccacaa acaagtactt taccccacag cttagtggcc agtaaacacc
     6241 ctggggacta ggaaaaggaa ccaactgtag gcacctctcc agggcctagg gagacaagtg
     6301 tcctctcttc tgcatacatt tgggctcccc ttacagagcc ctttgccctg gctctctggt
     6361 ccttgttgct ctaacagtcc agatgtacac ccagcctcag ggggaaggca gctctctcca
     6421 gacagagtct cagggcccag caaggtcagg ttatctgctt tcattcaggg caacaaatga
     6481 tacaaatggt gccagggagt ggcaaggcca tgggggtagg tgggggtgtc tttttctttt
     6541 cataaagtaa caacagacga gactgaggtt aaacatcaga aaaaaacctc tggaatgacc
     6601 ttcctcattc caggaggccc tggaataagg aagaggcttc tttctgaggg agctttgagg
     6661 aattttgaca gctgttgaca tgggatttgg gaaaggtgaa gctgtgactg gaggggcagg
     6721 agatggtcca agtgtccatc cagagatgag actcttagaa tcaaagtgtt cagcccagga
     6781 agtcttggag atcccacctt ctgtggccct gcaccttatg ggaagccatt aagggggctc
     6841 atctaggaat tctggttaca gcccagtgct catcccagcg tatgctgcct ctttagggca
     6901 gccccaaggg ccagccagcc tgtactctgg gcaagagccc aaaatggcta ggaatgtttg
     6961 actcccttaa tctcttcccc agctacagag gaatcttttc tctgcctggt ctcagaatgg
     7021 gactgccaac tggctcattg gtgggagaca cagtatcctc aaacctgtgg ccactggcat
     7081 gacagtggtg ctctgtctcc ctgggtgaca cccaccctag gcttcctcct ggatgtgatg
     7141 gggattgcca gagaggctct tagcataaaa ggcattaggt gggcattttt ctgtgtgccc
     7201 ccaaaaagct ccatggaaac aggcacctgg tagctgcgga acacccgtgg acttgtgtat
     7261 atggtcatag gctttgggaa gacaggacgt aaaggaaaat gagagaaaca aaatgggtca
     7321 gatagctttg gccacagccc caggcagcct ttggggccta tgacacttag tgcccttaga
     7381 tgggatacat cttgcctcgg ccccaagact cctccaactt acccgtccca tccagggcct
     7441 gcacagctta gagaggctca cagcttggca aatgctaggg cttcatcaga ccactgactt
     7501 gactcagtgt ttgttaaaat ggaaccactc ccgttggcct actgtttctc tcctgtactt
     7561 cttgtaatga tagttattta ttgactctgg tagcaggcag ttcttaaata aagatggttt
     7621 ctcaacctgt tggggaagct ggcacgagct gtgggtgtta tcatcaggct aaagcatacc
     7681 tccttgtcct gttcttcact ccagaggctt ttatccaaga atttctttac cccccacaca
     7741 gtgaaatata agtaagttac aacatacagt ctatattgct tcatccagtc ccaggaggag
     7801 ggaaaaatta ggccaagatc ttaaggcagg tccaagcaga gcacaggcag gcatttggct
     7861 agaatcagtt ggctttacct aatacagtgg cagtaaacaa tgcttatgtg atggta
//
