LOCUS       NM_001843               5667 bp    mRNA    linear   PRI 18-JUL-2024
DEFINITION  Homo sapiens contactin 1 (CNTN1), transcript variant 1, mRNA.
ACCESSION   NM_001843
VERSION     NM_001843.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5667)
  AUTHORS   Zhou,T., Chen,H., Wang,Y., Wen,S., Dao,P. and Chen,M.
  TITLE     Key Molecules in Bladder Cancer Affect Patient Prognosis and
            Immunotherapy Efficacy: Further Exploration for CNTN1 and EMP1
  JOURNAL   JCO Precis Oncol 7, e2200630 (2023)
   PUBMED   37437228
  REMARK    GeneRIF: Key Molecules in Bladder Cancer Affect Patient Prognosis
            and Immunotherapy Efficacy: Further Exploration for CNTN1 and EMP1.
REFERENCE   2  (bases 1 to 5667)
  AUTHORS   Fehmi,J., Davies,A.J., Antonelou,M., Keddie,S., Pikkupeura,S.,
            Querol,L., Delmont,E., Cortese,A., Franciotta,D., Persson,S.,
            Barratt,J., Pepper,R., Farinha,F., Rahman,A., Canetti,D.,
            Gilbertson,J.A., Rendell,N.B., Radunovic,A., Minton,T., Fuller,G.,
            Murphy,S.M., Carr,A.S., Reilly,M.R., Eftimov,F., Wieske,L.,
            Teunissen,C.E., Roberts,I.S.D., Ashman,N., Salama,A.D. and
            Rinaldi,S.
  TITLE     Contactin-1 links autoimmune neuropathy and membranous
            glomerulonephritis
  JOURNAL   PLoS One 18 (3), e0281156 (2023)
   PUBMED   36893151
  REMARK    GeneRIF: Contactin-1 links autoimmune neuropathy and membranous
            glomerulonephritis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5667)
  AUTHORS   Meng,N., Pan,P., Hu,S., Miao,C., Hu,Y., Wang,F., Zhang,J. and An,L.
  TITLE     The molecular mechanism of gamma-aminobutyric acid against AD: the
            role of CEBPalpha/circAPLP2/miR-671-5p in regulating CNTN1/2
            expression
  JOURNAL   Food Funct 14 (4), 2082-2095 (2023)
   PUBMED   36734072
  REMARK    GeneRIF: The molecular mechanism of gamma-aminobutyric acid against
            AD: the role of CEBPalpha/circAPLP2/miR-671-5p in regulating
            CNTN1/2 expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5667)
  AUTHORS   Loonstra,F.C., de Ruiter,L.R.J., Koel-Simmelink,M.J.A.,
            Schoonheim,M.M., Strijbis,E.M.M., Moraal,B., Barkhof,F.,
            Uitdehaag,B.M.J., Teunissen,C. and Killestein,J.
  TITLE     Neuroaxonal and Glial Markers in Patients of the Same Age With
            Multiple Sclerosis
  JOURNAL   Neurol Neuroimmunol Neuroinflamm 10 (2), e200078 (2022)
   PUBMED   36543540
  REMARK    GeneRIF: Neuroaxonal and Glial Markers in Patients of the Same Age
            With Multiple Sclerosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5667)
  AUTHORS   van Lierop,Z.Y., Noteboom,S., Steenwijk,M.D., van Dam,M.,
            Toorop,A.A., van Kempen,Z.L., Moraal,B., Barkhof,F.,
            Uitdehaag,B.M., Schoonheim,M.M., Teunissen,C.E. and Killestein,J.
  TITLE     Neurofilament-light and contactin-1 association with long-term
            brain atrophy in natalizumab-treated relapsing-remitting multiple
            sclerosis
  JOURNAL   Mult Scler 28 (14), 2231-2242 (2022)
   PUBMED   36062492
  REMARK    GeneRIF: Neurofilament-light and contactin-1 association with
            long-term brain atrophy in natalizumab-treated relapsing-remitting
            multiple sclerosis.
REFERENCE   6  (bases 1 to 5667)
  AUTHORS   Olive,S., Dubois,C., Schachner,M. and Rougon,G.
  TITLE     The F3 neuronal glycosylphosphatidylinositol-linked molecule is
            localized to glycolipid-enriched membrane subdomains and interacts
            with L1 and fyn kinase in cerebellum
  JOURNAL   J Neurochem 65 (5), 2307-2317 (1995)
   PUBMED   7595520
REFERENCE   7  (bases 1 to 5667)
  AUTHORS   Peles,E., Nativ,M., Campbell,P.L., Sakurai,T., Martinez,R., Lev,S.,
            Clary,D.O., Schilling,J., Barnea,G., Plowman,G.D., Grumet,M. and
            Schlessinger,J.
  TITLE     The carbonic anhydrase domain of receptor tyrosine phosphatase beta
            is a functional ligand for the axonal cell recognition molecule
            contactin
  JOURNAL   Cell 82 (2), 251-260 (1995)
   PUBMED   7628014
REFERENCE   8  (bases 1 to 5667)
  AUTHORS   Berglund,E.O. and Ranscht,B.
  TITLE     Molecular cloning and in situ localization of the human contactin
            gene (CNTN1) on chromosome 12q11-q12
  JOURNAL   Genomics 21 (3), 571-582 (1994)
   PUBMED   7959734
REFERENCE   9  (bases 1 to 5667)
  AUTHORS   Reid,R.A., Bronson,D.D., Young,K.M. and Hemperly,J.J.
  TITLE     Identification and characterization of the human cell adhesion
            molecule contactin
  JOURNAL   Brain Res Mol Brain Res 21 (1-2), 1-8 (1994)
   PUBMED   8164510
REFERENCE   10 (bases 1 to 5667)
  AUTHORS   Walsh,F.S. and Doherty,P.
  TITLE     Glycosylphosphatidylinositol anchored recognition molecules that
            function in axonal fasciculation, growth and guidance in the
            nervous system
  JOURNAL   Cell Biol Int Rep 15 (11), 1151-1166 (1991)
   PUBMED   1838307
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC074030.17, DQ442054.1,
            AK289698.1, Z21488.1, U07819.1, BX648591.1, BY799936.2, BM717031.1,
            AI473107.1 and AC024900.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001843.3.
            
            Summary: The protein encoded by this gene is a member of the
            immunoglobulin superfamily. It is a glycosylphosphatidylinositol
            (GPI)-anchored neuronal membrane protein that functions as a cell
            adhesion molecule. It may play a role in the formation of axon
            connections in the developing nervous system. Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Dec
            2011].
            
            Transcript Variant: This variant (1) is the longest transcript and
            encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.178003.1,
                                           SRR1660803.56450.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000551295.7/ ENSP00000447006.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC074030.17        30781-30783         c
            4-113               DQ442054.1         1-110
            114-1645            AK289698.1         53-1584
            1646-2621           Z21488.1           1537-2512
            2622-3452           U07819.1           2392-3222
            3453-4601           BX648591.1         164-1312
            4602-5098           BY799936.2         55-551
            5099-5624           BM717031.1         124-649
            5625-5664           AI473107.1         4-43                c
            5665-5667           AC024900.20        80666-80668         c
FEATURES             Location/Qualifiers
     source          1..5667
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12"
     gene            1..5667
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /note="contactin 1"
                     /db_xref="GeneID:1272"
                     /db_xref="HGNC:HGNC:2171"
                     /db_xref="MIM:600016"
     exon            1..154
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            155..291
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..3287
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; glycoprotein gP135; neural cell surface protein
                     F3"
                     /codon_start=1
                     /product="contactin-1 isoform 1 precursor"
                     /protein_id="NP_001834.2"
                     /db_xref="CCDS:CCDS8737.1"
                     /db_xref="GeneID:1272"
                     /db_xref="HGNC:HGNC:2171"
                     /db_xref="MIM:600016"
                     /translation="MKMWLLVSHLVIISITTCLAEFTWYRRYGHGVSEEDKGFGPIFE
                     EQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINN
                     PDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDP
                     PYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSI
                     TKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWR
                     KVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWV
                     EHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHKGELRLYDVTFENAGMYQCI
                     AENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSK
                     GTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRII
                     LAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNG
                     ELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTW
                     SRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVV
                     ATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNF
                     GYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLV
                     AVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKEEAANR
                     VQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISS
                     VRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEY
                     VVEVRAHSDGGDGVVSQVKISGAPTLSPSLLGLLLPAFGILVYLEF"
     exon            292..324
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            325..457
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            458..630
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            631..726
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            727..933
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1033
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1215
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1340
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1458
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1609
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1737
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1913
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2034
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2193
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2343
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2414
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2649
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2753
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..2940
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3053
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..3210
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..5667
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5160..5165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /note="hexamer: ACTAAA"
     polyA_site      5181
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
     regulatory      5638..5643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /note="hexamer: AATAAA"
     polyA_site      5667
                     /gene="CNTN1"
                     /gene_synonym="CMYO12; CMYP12; F3; GP135; MYPCN"
                     /note="major polyA site"
ORIGIN      
        1 gggcttctgc tgtcaagtag ccagggtggg ctccgccgag gcgaggaggg gcgccggtgg
       61 ggagatgcgc tcccaggtgt ttgcagcgga agtgggaaac ctgtagggta tggtccagct
      121 gtgccgcacc gaggcgagca ggagcaggga acaggtgttt aaaattatcc aactgccata
      181 gagctaaatt cttttttgga aaattgaacc gaacttctac tgaatacaag atgaaaatgt
      241 ggttgctggt cagtcatctt gtgataatat ctattactac ctgtttagca gagtttacat
      301 ggtatagaag atatggtcat ggagtttctg aggaagacaa aggatttgga ccaatttttg
      361 aagagcagcc aatcaatacc atttatccag aggaatcact ggaaggaaaa gtctcactca
      421 actgtagggc acgagccagc cctttcccgg tttacaaatg gagaatgaat aatggggacg
      481 ttgatctcac aagtgatcga tacagtatgg taggaggaaa ccttgttatc aacaaccctg
      541 acaaacagaa agatgctgga atatactact gtttagcatc taataactac gggatggtca
      601 gaagcactga agcaaccctg agctttggat atcttgatcc tttcccacct gaggaacgtc
      661 ctgaggtcag agtaaaagaa gggaaaggaa tggtgcttct ctgtgacccc ccataccatt
      721 ttccagatga tcttagctat cgctggcttc taaatgaatt tcctgtattt atcacaatgg
      781 ataaacggcg atttgtgtct cagacaaatg gcaatctcta cattgcaaat gttgaggctt
      841 ccgacaaagg caattattcc tgctttgttt ccagtccttc tattacaaag agcgtgttca
      901 gcaaattcat cccactcatt ccaatacctg aacgaacaac aaaaccatat cctgctgata
      961 ttgtagttca gttcaaggat gtatatgcat tgatgggcca aaatgtgacc ttagaatgtt
     1021 ttgcacttgg aaatcctgtt ccggatatcc gatggcggaa ggttctagaa ccaatgccaa
     1081 gcactgctga gattagcacc tctggggctg ttcttaagat cttcaatatt cagctagaag
     1141 atgaaggcat ctatgaatgt gaggctgaga acattagagg aaaggataaa catcaagcaa
     1201 gaatttatgt tcaagcattc cctgagtggg tagaacacat caatgacaca gaggtggaca
     1261 taggcagtga tctctactgg ccttgtgtgg ccacaggaaa gcccatccct acaatccgat
     1321 ggttgaaaaa tggatatgcg tatcataaag gggaattaag actgtatgat gtgacttttg
     1381 aaaatgccgg aatgtatcag tgcatagctg aaaacacata tggagccatt tatgcaaatg
     1441 ctgagttgaa gatcttggcg ttggctccaa cttttgaaat gaatcctatg aagaaaaaga
     1501 tcctggctgc taaaggtgga agggtgataa ttgaatgcaa acctaaagct gcaccgaaac
     1561 caaagttttc atggagtaaa gggacagagt ggcttgtcaa tagcagcaga atactcattt
     1621 gggaagatgg tagcttggaa atcaacaaca ttacaaggaa tgatggaggt atctatacat
     1681 gctttgcaga aaataacaga gggaaagcta atagcactgg aacccttgtt atcacagatc
     1741 ctacgcgaat tatattggcc ccaattaatg ccgatatcac agttggagaa aacgccacca
     1801 tgcagtgtgc tgcgtccttt gatcctgcct tggatctcac atttgtttgg tccttcaatg
     1861 gctatgtgat cgattttaac aaagagaata ttcactacca gaggaatttt atgctggatt
     1921 ccaatgggga attactaatc cgaaatgcgc agctgaaaca tgctggaaga tacacatgca
     1981 ctgcccagac aattgtggac aattcttcag cttcagctga ccttgtagtg agaggccctc
     2041 caggccctcc aggtggtctg agaatagaag acattagagc cacttctgtg gcacttactt
     2101 ggagccgtgg ttcagacaat catagtccta tttctaaata cactatccag accaagacta
     2161 ttctttcaga tgactggaaa gatgcaaaga cagatccccc aattattgaa ggaaatatgg
     2221 aggcagcaag agcagtggac ttaatcccat ggatggagta tgaattccgc gtggtagcaa
     2281 ccaatacact gggtagagga gagcccagta taccatctaa cagaattaaa acagacggtg
     2341 ctgcaccaaa tgtggctcct tcagatgtag gaggtggagg tggaagaaac agagagctga
     2401 ccataacatg ggcgcctttg tcaagagaat accactatgg caacaatttt ggttacatag
     2461 tggcatttaa gccatttgat ggagaagaat ggaaaaaagt cacagttact aatcctgata
     2521 ctggccgata tgtccataaa gatgaaacca tgagcccttc cactgcattt caagttaaag
     2581 tcaaggcctt caacaacaaa ggagatggac cttacagcct agtagcagtc attaattcag
     2641 cacaagacgc tcccagtgaa gccccaacag aagtaggtgt aaaagtctta tcatcttctg
     2701 agatatctgt tcattgggaa catgttttag aaaaaatagt ggaaagctat cagattcggt
     2761 attgggctgc ccatgacaaa gaagaagctg caaacagagt tcaagtcacc agccaagagt
     2821 actcggccag gctcgagaac cttctgccag acacccagta ttttatagaa gtcggggcct
     2881 gcaatagtgc agggtgtgga cctccaagtg acatgattga ggctttcacc aagaaagcac
     2941 ctcctagcca gcctccaagg atcatcagtt cagtaaggtc tggttcacgc tatataatca
     3001 cctgggatca tgtcgttgca ctatcaaatg aatctacagt gacgggatat aaggtactct
     3061 acagacctga tggccagcat gatggcaagc tgtattcaac tcacaaacac tccatagaag
     3121 tcccaatccc cagagatgga gaatacgttg tggaggttcg cgcgcacagt gatggaggag
     3181 atggagtggt gtctcaagtc aaaatttcag gtgcacccac cctatcccca agtcttctcg
     3241 gcttactgct gcctgccttt ggcatccttg tctacttgga attctgaatg tgttgtgaca
     3301 gctgctgttc ccatcccagc tcagaagaca cccttcaacc ctgggatgac cacaattcct
     3361 tccaatttct gcggctccat cctaagccaa ataaattata ctttaacaaa ctattcaact
     3421 gatttacaac acacatgatg actgaggcat tcgggaaccc cttcatccaa aagaataaac
     3481 ttttaaatgg atataaatga tttttaactc gttccaatat gccttataaa ccacttaacc
     3541 tgattctgtg acagttgcat gatttaaccc aatgggacaa gttacagtgt tcaattcaat
     3601 actataggct gtagagtgaa agtcaaatca ccatatacag gtgctttaaa tttaataaca
     3661 agttgtgaaa tataatagag attgaaatgt tggttgtatg tggtaaatgt aagagtaata
     3721 cagtctcttg tactttcctc actgttttgg gtactgcata ttattgaatg gcccctatca
     3781 ttcatgacat cttgagtttt cttgaaaaga caatagagtg taacaaatat tttgtcagaa
     3841 atcccattat caaatcatga gttgaaagat tttgactatt gaaaaccaaa ttctagaact
     3901 tactatcagt attcttattt tcaaaggaaa taattttcta aatatttgat tttcagaatc
     3961 agttttttaa tagtaaagtt aacataccat atagattttt ttttactttt atattctact
     4021 ctgaagttat tttatgcttt tcttatcaat ttcaaatctc aaaaatcaca gctcttatct
     4081 agagtatcat aatattgcta tatttgttca tatgtggagt gacaaatttt gaaaagtaga
     4141 gtgcttcctt ttttattgag atgtgacagt ctttacatgg ttaggaataa gtgacagtta
     4201 agtgaatatc acaattacta gtatgttggt ttttctgctt cattcctaag tattacgttt
     4261 ctttattgca gatgtcagat caaaaagtca cctgtaggtt gaaaaagcta ccgtattcca
     4321 ttttgtaaaa ataacaataa taataataat aataattagt tttaagctca tttcccactt
     4381 caatgcaata ctgaaaactg gctaaaaata ccaaatcaat atactgctaa tggtactttg
     4441 aagagtatgc aaaactggaa ggccaggagg aggcaaataa tatgtctttc cgatggtgtc
     4501 tcccaagtgt tggtgctttg ggtttttata agttgtgaaa aggaagatgc acatttcttc
     4561 attctccatg gtgtgcatgg aaatgtgttt gagtgtggat gtaaaagaaa tcgagtaata
     4621 aagaattagc tggcttgtga aatagtgcag tgttggatgc ttcaagaggt ataatcctat
     4681 tttattagca caaacttgct agctaattag agtttatctt tttagaaagg acaccgtata
     4741 ggttcgtaaa aaatatttac aggaagcaaa atagatctat tactacttta ccgactttac
     4801 cccctttctt taatttgtat aatttttgta ctatatatcg atgtgtaaat gtttagagtc
     4861 ttcattatga aaatatcaat aaatatttca ttagtttaca tttaactctg gtataaaatg
     4921 aaacttttaa aaataagtga aatggatgat ttcccagtgg aagtatgtca acagtcttaa
     4981 gatcattgcc agatttcata aaatatttaa gtatttgaaa aagaaacaaa atgtcttcat
     5041 actttaggga aacgaatacc ctgtatacct tctgtacaaa tgtttgtgtt ttcattgtta
     5101 cactttgggg ttttactttt gcaatgtgac ccatgttggg catttttata taatcaacaa
     5161 ctaaatcttt tgccaaatgc atgcttgcct tttattttct aatatatgat aataacgagc
     5221 aaaactggtt agattttgca tgaaatggtt ctgaaaggta agaggaaaac agactttgga
     5281 ggttgtttag ttttgaattt ctgacagaga taaagtagtt taaaatctct cgtacactga
     5341 taactcaagc ttttcatttt ctcatacagt tgtacagatt taactgggac catcagtttt
     5401 aaactgttgt caagctaact aataatcatc tgctttaaga cgcaagattc tgaattaaac
     5461 tttatatagg tatagataca tctgttgttt ctttgtattt caggaaaggt gatagtagtt
     5521 ttatttgata ctgataaata ttgaattgat tttttagtta ttttttatca ttttttcaat
     5581 ggagtagtat aggactgtgc tttgtccttt ttatgaatga aaaaattagt ataaagtaat
     5641 aaatgtctta tgttacccaa gaaagaa
//
