LOCUS       NM_017738               5518 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens centlein (CNTLN), transcript variant 1, mRNA.
ACCESSION   NM_017738
VERSION     NM_017738.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5518)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5518)
  AUTHORS   Jing,Z., Yin,H., Wang,P., Gao,J. and Yuan,L.
  TITLE     Centlein, a novel microtubule-associated protein stabilizing
            microtubules and involved in neurite formation
  JOURNAL   Biochem Biophys Res Commun 472 (2), 360-365 (2016)
   PUBMED   26915804
  REMARK    GeneRIF: Taken together, we propose that centlein is involved in MT
            stability and neuritogenesis in vivo.
REFERENCE   3  (bases 1 to 5518)
  AUTHORS   Fang,G., Zhang,D., Yin,H., Zheng,L., Bi,X. and Yuan,L.
  TITLE     Centlein mediates an interaction between C-Nap1 and Cep68 to
            maintain centrosome cohesion
  JOURNAL   J Cell Sci 127 (Pt 8), 1631-1639 (2014)
   PUBMED   24554434
  REMARK    GeneRIF: Centlein complexes with C-Nap1 and Cep68 at the proximal
            ends of centrioles during interphase.
REFERENCE   4  (bases 1 to 5518)
  AUTHORS   Menni,C., Boffi,L., Cesana,F., Viviani Anselmi,C., Nava,S.,
            Bertola,F., Blasio,A.M., Roncarati,R., Trimarco,V., Marino,M.,
            Trimarco,B., Grassi,G., Giannattasio,C. and Mancia,G.
  TITLE     Variant on chromosome 9p is associated with left ventricular mass:
            results from two cohorts of essential hypertensive individuals
  JOURNAL   J Hypertens 30 (11), 2144-2150 (2012)
   PUBMED   22940680
  REMARK    GeneRIF: identified a SNP (rs894379) in the intronic region of the
            centlein, centrosomal protein (CNTLN) gene on chromosome 9p22,
            whose minor allele G is associated with an increased left
            ventricular mass
REFERENCE   5  (bases 1 to 5518)
  AUTHORS   Imboden,M., Bouzigon,E., Curjuric,I., Ramasamy,A., Kumar,A.,
            Hancock,D.B., Wilk,J.B., Vonk,J.M., Thun,G.A., Siroux,V., Nadif,R.,
            Monier,F., Gonzalez,J.R., Wjst,M., Heinrich,J., Loehr,L.R.,
            Franceschini,N., North,K.E., Altmuller,J., Koppelman,G.H.,
            Guerra,S., Kronenberg,F., Lathrop,M., Moffatt,M.F., O'Connor,G.T.,
            Strachan,D.P., Postma,D.S., London,S.J., Schindler,C.,
            Kogevinas,M., Kauffmann,F., Jarvis,D.L., Demenais,F. and
            Probst-Hensch,N.M.
  TITLE     Genome-wide association study of lung function decline in adults
            with and without asthma
  JOURNAL   J Allergy Clin Immunol 129 (5), 1218-1228 (2012)
   PUBMED   22424883
REFERENCE   6  (bases 1 to 5518)
  AUTHORS   Hart,A.B., Engelhardt,B.E., Wardle,M.C., Sokoloff,G., Stephens,M.,
            de Wit,H. and Palmer,A.A.
  TITLE     Genome-wide association study of d-amphetamine response in healthy
            volunteers identifies putative associations, including cadherin 13
            (CDH13)
  JOURNAL   PLoS One 7 (8), e42646 (2012)
   PUBMED   22952603
REFERENCE   7  (bases 1 to 5518)
  AUTHORS   Song,H., Ramus,S.J., Tyrer,J., Bolton,K.L., Gentry-Maharaj,A.,
            Wozniak,E., Anton-Culver,H., Chang-Claude,J., Cramer,D.W.,
            DiCioccio,R., Dork,T., Goode,E.L., Goodman,M.T., Schildkraut,J.M.,
            Sellers,T., Baglietto,L., Beckmann,M.W., Beesley,J., Blaakaer,J.,
            Carney,M.E., Chanock,S., Chen,Z., Cunningham,J.M., Dicks,E.,
            Doherty,J.A., Durst,M., Ekici,A.B., Fenstermacher,D., Fridley,B.L.,
            Giles,G., Gore,M.E., De Vivo,I., Hillemanns,P., Hogdall,C.,
            Hogdall,E., Iversen,E.S., Jacobs,I.J., Jakubowska,A., Li,D.,
            Lissowska,J., Lubinski,J., Lurie,G., McGuire,V., McLaughlin,J.,
            Medrek,K., Moorman,P.G., Moysich,K., Narod,S., Phelan,C., Pye,C.,
            Risch,H., Runnebaum,I.B., Severi,G., Southey,M., Stram,D.O.,
            Thiel,F.C., Terry,K.L., Tsai,Y.Y., Tworoger,S.S., Van Den
            Berg,D.J., Vierkant,R.A., Wang-Gohrke,S., Webb,P.M., Wilkens,L.R.,
            Wu,A.H., Yang,H., Brewster,W., Ziogas,A., Houlston,R.,
            Tomlinson,I., Whittemore,A.S., Rossing,M.A., Ponder,B.A.,
            Pearce,C.L., Ness,R.B., Menon,U., Kjaer,S.K., Gronwald,J.,
            Garcia-Closas,M., Fasching,P.A., Easton,D.F., Chenevix-Trench,G.,
            Berchuck,A., Pharoah,P.D. and Gayther,S.A.
  CONSRTM   Australian Cancer (Ovarian) Study; Australian Ovarian Cancer Study
            Group; Ovarian Cancer Association Consortium
  TITLE     A genome-wide association study identifies a new ovarian cancer
            susceptibility locus on 9p22.2
  JOURNAL   Nat Genet 41 (9), 996-1000 (2009)
   PUBMED   19648919
REFERENCE   8  (bases 1 to 5518)
  AUTHORS   Kim,Y.C., Wu,Q., Chen,J., Xuan,Z., Jung,Y.C., Zhang,M.Q.,
            Rowley,J.D. and Wang,S.M.
  TITLE     The transcriptome of human CD34+ hematopoietic stem-progenitor
            cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (20), 8278-8283 (2009)
   PUBMED   19416867
REFERENCE   9  (bases 1 to 5518)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   10 (bases 1 to 5518)
  AUTHORS   Makino,K., Umeda,K., Uezu,A., Hiragami,Y., Sakamoto,T., Ihn,H. and
            Nakanishi,H.
  TITLE     Identification and characterization of the novel centrosomal
            protein centlein
  JOURNAL   Biochem Biophys Res Commun 366 (4), 958-962 (2008)
   PUBMED   18086554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK308837.1, BX647069.1, AL354738.13, AK021596.1, AK000283.1,
            AL590377.4, CX786573.1, AL133214.12 and CA428767.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017738.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647069.1, SRR1803614.6769.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380647.8/ ENSP00000370021.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AK308837.1         5-82
            79-1525             BX647069.1         86-1532
            1526-1852           BX647069.1         1534-1860
            1853-1853           AL354738.13        35889-35889
            1854-2109           BX647069.1         1862-2117
            2110-2124           AK021596.1         171-185
            2125-2569           AK000283.1         1269-1713
            2570-2570           AL590377.4         25521-25521
            2571-2716           BX647069.1         2579-2724
            2717-2717           AL590377.4         39891-39891
            2718-4009           BX647069.1         2726-4017
            4010-4010           AL590377.4         114946-114946
            4011-4694           BX647069.1         4019-4702
            4695-4958           CX786573.1         358-621
            4959-5004           AL133214.12        6277-6322
            5005-5518           CA428767.1         16-529              c
FEATURES             Location/Qualifiers
     source          1..5518
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p22.2"
     gene            1..5518
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /note="centlein"
                     /db_xref="GeneID:54875"
                     /db_xref="HGNC:HGNC:23432"
                     /db_xref="MIM:611870"
     exon            1..386
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..4247
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centrosomal protein; centlein, centrosomal protein"
                     /codon_start=1
                     /product="centlein isoform 1"
                     /protein_id="NP_060208.2"
                     /db_xref="CCDS:CCDS43789.1"
                     /db_xref="GeneID:54875"
                     /db_xref="HGNC:HGNC:23432"
                     /db_xref="MIM:611870"
                     /translation="MAARSPPSPHPSPPARQLGPRSPRVGRGAEVHAMRSEASGFAGA
                     AREVVADESDKIWVGEEGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRT
                     QLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDR
                     KVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDK
                     SQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKY
                     STDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQEL
                     QNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFE
                     TTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPH
                     RPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEP
                     PVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERL
                     QMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQE
                     LMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKN
                     GKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETRE
                     KELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKS
                     HQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNV
                     FENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQT
                     QGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNI
                     TAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRF
                     QTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSR
                     SMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMK
                     RHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVK
                     EKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQV
                     LEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTH
                     KAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAENDKEWMLYIQKLLEGQLPFAS
                     YLLEAVLEKINEKKKLVEGYFTIMKDIR"
     exon            387..475
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            476..560
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            561..695
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            696..875
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1009
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1172
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1367
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1544
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1670
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1792
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1912
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2013
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2105
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2641
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2822
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2916
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3140
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3332
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            3333..3430
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            3431..3557
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..3695
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            3696..3881
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            3882..4067
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            4068..4145
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..5518
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4731..4736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /note="hexamer: AATAAA"
     polyA_site      4754
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /note="major polyA site"
     regulatory      5497..5502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /note="hexamer: AATAAA"
     polyA_site      5518
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /note="major polyA site"
ORIGIN      
        1 aacttgaccc gttagcagcc gcagccatgg cggcgcgttc gcctccctca ccgcaccctt
       61 cgcccccagc gcgacagctg ggccccaggt ccccacgtgt tgggcgggga gctgaagtac
      121 acgcaatgcg cagcgaggcc tcgggttttg ccggcgcagc gcgggaggtg gtcgcggacg
      181 aaagtgataa aatctgggtg ggtgaagaag ggtcaggggg ccggcgaggg cctggggggg
      241 cagctccggc tcatgctccc ctcctcagcg cgcccatggg gtccagacgg ctagagggca
      301 tctcggtaga ggaggcgatg gtgacccgga cgcagctgct ggaggaagag ctgagcagcc
      361 taaaggagga gttggccctg tgtcaggctg ataaagaatt tgtatggtct ttgtggaaac
      421 gtctccaggt tacaaaccca gatctcacac aagtggtcag tttggttgtg gaaagagaaa
      481 aacagaaatc tgaagctaaa gacagaaaag ttctagaaat tctgcaagtc aaggatgcca
      541 aaatacaaga atttgaacag agagagtcag tactgaaaca ggaaataaat gaccttgtaa
      601 aacggaaaat tgcagtagat gaagaaaatg ctttcttaag gaaagaattc agtgacttgg
      661 agaagaaatt taaagataaa agtcaagaaa ttaaggacac taaggagtgt gtacagaaca
      721 aagaagagca aaacagacta gttataaaaa atctggagga ggaaaacaag aaattaagta
      781 cccgctgcac tgacctgcta aatgacctgg agaaattgag gaagcaggaa gcacatttga
      841 gaaaagaaaa atatagcact gatgcaaaaa taaagacctt tgaagacaat ttaattgaag
      901 caaggaaaga agttgaagta tcacagagta aatacaatgc tctatcatta cagttgagta
      961 ataaacagac tgaacttatc cagaaggata tggatattac cctggtcagg aaggaactgc
     1021 aggagctgca gaatctttac aaacagaaca gtacacatac agcccagcaa gcagagctga
     1081 tccagcagct tcaggttctc aatatggaca cacaaaaagt actgagaaat caggaagatg
     1141 ttcacacagc tgaaagtata tcatatcaaa aactttacaa tgagttacat atttgttttg
     1201 aaaccacaaa atcaaatgaa gctatgctcc ggcaaagtgt tactaatctt caggatcagc
     1261 tattacaaaa agagcaagaa aatgctaagt taaaagaaaa acttcaggaa tcacagggag
     1321 cacctcttcc tttacctcaa gaaagtgatc cagactactc agcacaggta cctcatcgcc
     1381 catccttatc aagcttagaa acgttaatgg tttcacagaa gtctgaaatt gagtatttac
     1441 aggagaaact aaagatagca aatgaaaaac tgtcagaaaa catatctgcc aacaagggtt
     1501 tctcccgaaa gagcatcatg acaagtgctg aaggaaaaca taaggaacca cctgtgaaac
     1561 gttcaaggtc tttgtcccca aagagctctt tcacagactc agaagagcta cagaagctga
     1621 gaaaagctga aagaaagatt gaaaacttag agaaggcact acaactaaag agccaagaaa
     1681 atgatgagct aagagatgcc catgaaaaac gcaaggaacg gctacagatg ttacagacca
     1741 actacagagc agtaaaagag caattaaaac agtgggaaga aggcagtggc atgactgaaa
     1801 tcaggaaaat aaagagagca gatccccaac aacttcgaca agaagattct gacgctgtgt
     1861 ggaatgaact ggcatatttc aaaagggaaa accaggagct aatgattcaa aagatgaatc
     1921 ttgaagaaga attagatgaa cttaaagtac atatatctat tgataaggca gcaatacaag
     1981 aattgaatag atgtgtggca gagagaagag aagaacagct ctttagatct ggtgaagatg
     2041 atgaggtcaa gaggagtact ccagagaaga atggaaaaga aatgttggag cagacattac
     2101 agaaggtcac tgagttggaa aatcggctga aatcttttga gaaaaggtcg agaaaattaa
     2161 aagaagggaa taaaaaatta atgaaagaaa atgattttct gaaatccctc ttaaaacagc
     2221 aacaagaaga tacagagacc agagaaaaag agctagaaca gataataaag gggagtaaag
     2281 atgtagaaaa agaaaatact gaacttcaag taaaaatcag tgagctggag acagaagtca
     2341 cttccctgag gagacaagtg gcagaagcta atgcattgag aaatgaaaat gaagagctga
     2401 tcaacccaat ggagaaatca caccagtcag cagacagagc taaatccgag atggccacca
     2461 tgaaagtgag atctggacga tatgattgta agacaactat gaccaaggtt aaatttaaag
     2521 ctgcgaagaa aaattgctct gtgggtcgtc accacactgt tctcaatcat tccatcaagg
     2581 ttatgagcaa tgtgtttgag aacctcagca aggacggctg ggaggatgtg agtgaaagca
     2641 gcagtgattc tgaagcacag acctctcaaa ctttgggaac aattattgta gaaacatccc
     2701 agaaaataag tcctacggaa gatggaaaag accagaaaga aagtgatcca acagaagaca
     2761 gccaaacaca aggaaaagaa atagtacaga catatttaaa tatagatggc aagaccccaa
     2821 aggactattt tcatgataag aatgccaaaa aaccaacttt tcaaaagaag aattgcaaga
     2881 tgcaaaagag ttcacataca gcagttccta ctagagtcaa cagagaaaag tacaaaaata
     2941 taactgccca gaaatcaagt agcaatatta ttttattacg agaacggatt atatccttgc
     3001 aacaacaaaa cagtgtactt cagaatgcca agaaaacagc agaattgtct gttaaagaat
     3061 ataaagaagt taatgaaaag ctcctccatc aacagcaagt atccgatcaa cgatttcaga
     3121 caagcaggca gacaataaag aagctaaatt tggatttggc tgggcttcgg aaagaaaaag
     3181 aagatttact aaagaaattg gagtcctcat ctgaaatcac aagtttggca gaagaaaatt
     3241 cccaggtaac atttccacgg atacaagtta catcacttag tccttcaagg agcatggatt
     3301 tggaaatgaa gcaattgcag tataaactaa agaatgctac taatgaactc actaaacagt
     3361 catcaaatgt gaagactttg aaatttgaac tcctagcaaa agaagaacac ataaaggaaa
     3421 tgcatgaaaa gatatctcga atggagaggg atataactat gaaaagacat ttgatagagg
     3481 acttgaaatt tcgacagaaa gtaaatttgg aaagtaacaa gagttttagt gaaatgttac
     3541 aaaatcttga taaaaaggta aagacattaa ctgaagaatg ttccaacaag aaggtatcaa
     3601 ttgattcact aaagcaaaga cttaacgttg ctgtaaaaga aaagtcacag tatgaacaga
     3661 tgtatcagaa atctaaagag gagttagaaa aaaaggatct caagcttact ctcctagtat
     3721 caagaataag tgagactgaa tctgcaatgg cagaaattga aacagcagca tctaagcagc
     3781 ttcaagaatt agcattgcaa agtgaacagg tcctagaagg tgcacagaag acattgctgt
     3841 tagccaatga aaaagtagaa gagttcacca catttgtgaa ggctttggcc aaagagttgc
     3901 aaaatgatgt ccatgtggta aggcgacaaa taagagagct taaaaaaatg aagaaaaaca
     3961 gggacgcctg taaaacctca acccataaag cccagacctt ggcagcttct atcctgaaca
     4021 tttcacggtc agatttagag gaaatattag acacagaaga tcaagtggaa attgaaaaaa
     4081 caaaaattga tgctgaaaat gacaaggaat ggatgttgta cattcagaaa cttcttgaag
     4141 gacagcttcc ttttgcctca tatttactag aagcagtact ggaaaaaata aatgaaaaaa
     4201 agaaactagt tgaaggatat ttcacaatta tgaaagatat tagatgatat taaaatggag
     4261 agctttattg caaatgtgaa aactttttat gtggtgtgat tggaatacat gcattgcaat
     4321 cctgacacgg tatctgctcc aactatcaat agtcaggttc aataccaaaa taagaagtct
     4381 ctgaaaataa ttaattgctg aacaagtgaa actaattaag tacatagcca tttaaaagga
     4441 aatagtgtag catctgatgg tcgaatacaa atattgccac aaatcagtgc aaacttaaaa
     4501 atgattttcc ttctagtgca ttaaaagaaa ctgagcaggc ttggtacaca caaattggcc
     4561 tgagcataag aagaaaaagt atcaactaag gatttaatgt tttacgtttc atgaagaaac
     4621 tagacttttt acataaaact gctatagatg gccataagtg gtccagggag caacagattt
     4681 gtagtatgag caaatataaa atgaagcatc ataacttgag catttattga aataaattgt
     4741 gtggtccaat tgaatctgtt ctcattgatg tgctggttta tgtaggagat actgtgtatt
     4801 tctacaactc tttggcaaaa acaaaaacat tttcttcttc tctctcttaa cttcacaata
     4861 ctatacgttg tgtagtcata taaatttgca gggaaccaca aacccaatgt ataaaattag
     4921 gctctattta acagaactac tactgtggtc agctaattta agttacattc ttaaccatga
     4981 tgtcatcctt atttagattc ctggacattc ccacctcatt tcacctcttc accgtgttcc
     5041 tgccataccc tttttggttc ctctaattca ccatactggt gcctgcctcc cacatttgcc
     5101 cttggtcttc tctctttcta gaatactctg cactcaactt tcctcatggc tggctccttg
     5161 tcatcattca gctccacctt ccccggtccc tcagagacac attctctgac cagcttacta
     5221 ttttatttcc tcatagcaca aaattatcta tctgttcatg tatttgtttt cttgtttatt
     5281 ttcttctttt ccctctttag tatgtaggtc ccatgagatt aaggcaaggg ttggcagatt
     5341 atagcctgca gggcgaatct ggcctgccac ctgttttgta tggcccacaa gctaagaatg
     5401 gtttttgcct tattaaatgg tttttaaaaa atcaaaagga gaataatatt ttgtagcatg
     5461 tgaaaattat ataaaattca aattttggtg tctgttaata aagttttatt ggaacaca
//
