LOCUS       NM_000614               1902 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ciliary neurotrophic factor (CNTF), mRNA.
ACCESSION   NM_000614
VERSION     NM_000614.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1902)
  AUTHORS   Sirkisoon,S.R., Wong,G.L., Aguayo,N.R., Doheny,D.L., Zhu,D.,
            Regua,A.T., Arrigo,A., Manore,S.G., Wagner,C., Thomas,A., Singh,R.,
            Xing,F., Jin,G., Watabe,K. and Lo,H.W.
  TITLE     Breast cancer extracellular vesicles-derived miR-1290 activates
            astrocytes in the brain metastatic microenvironment via the
            FOXA2-->CNTF axis to promote progression of brain metastases
  JOURNAL   Cancer Lett 540, 215726 (2022)
   PUBMED   35589002
  REMARK    GeneRIF: Breast cancer extracellular vesicles-derived miR-1290
            activates astrocytes in the brain metastatic microenvironment via
            the FOXA2-->CNTF axis to promote progression of brain metastases.
REFERENCE   2  (bases 1 to 1902)
  AUTHORS   Perugini,J., Di Mercurio,E., Giuliani,A., Sabbatinelli,J.,
            Bonfigli,A.R., Tortato,E., Severi,I., Cinti,S., Olivieri,F., le
            Roux,C.W., Gesuita,R. and Giordano,A.
  TITLE     Ciliary neurotrophic factor is increased in the plasma of patients
            with obesity and its levels correlate with diabetes and
            inflammation indices
  JOURNAL   Sci Rep 12 (1), 8331 (2022)
   PUBMED   35585213
  REMARK    GeneRIF: Ciliary neurotrophic factor is increased in the plasma of
            patients with obesity and its levels correlate with diabetes and
            inflammation indices.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1902)
  AUTHORS   Fantone,S., Tossetta,G., Montironi,R., Senzacqua,M., Marzioni,D.
            and Mazzucchelli,R.
  TITLE     Ciliary neurotrophic factor (CNTF) and its receptor (CNTFRalpha)
            signal through MAPK/ERK pathway in human prostate tissues: a
            morphological and biomolecular study
  JOURNAL   Eur J Histochem 64 (4), 3147 (2020)
   PUBMED   33131268
  REMARK    GeneRIF: Ciliary neurotrophic factor (CNTF) and its receptor
            (CNTFRalpha) signal through MAPK/ERK pathway in human prostate
            tissues: a morphological and biomolecular study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1902)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1902)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1902)
  AUTHORS   Schooltink,H., Stoyan,T., Roeb,E., Heinrich,P.C. and Rose-John,S.
  TITLE     Ciliary neurotrophic factor induces acute-phase protein expression
            in hepatocytes
  JOURNAL   FEBS Lett 314 (3), 280-284 (1992)
   PUBMED   1281789
REFERENCE   7  (bases 1 to 1902)
  AUTHORS   Masiakowski,P., Liu,H.X., Radziejewski,C., Lottspeich,F.,
            Oberthuer,W., Wong,V., Lindsay,R.M., Furth,M.E. and Panayotatos,N.
  TITLE     Recombinant human and rat ciliary neurotrophic factors
  JOURNAL   J Neurochem 57 (3), 1003-1012 (1991)
   PUBMED   1861138
REFERENCE   8  (bases 1 to 1902)
  AUTHORS   McDonald,J.R., Ko,C., Mismer,D., Smith,D.J. and Collins,F.
  TITLE     Expression and characterization of recombinant human ciliary
            neurotrophic factor from Escherichia coli
  JOURNAL   Biochim Biophys Acta 1090 (1), 70-80 (1991)
   PUBMED   1883844
REFERENCE   9  (bases 1 to 1902)
  AUTHORS   Bazan,J.F.
  TITLE     Neuropoietic cytokines in the hematopoietic fold
  JOURNAL   Neuron 7 (2), 197-208 (1991)
   PUBMED   1714745
REFERENCE   10 (bases 1 to 1902)
  AUTHORS   Lam,A., Fuller,F., Miller,J., Kloss,J., Manthorpe,M., Varon,S. and
            Cordell,B.
  TITLE     Sequence and structural organization of the human gene encoding
            ciliary neurotrophic factor
  JOURNAL   Gene 102 (2), 271-276 (1991)
   PUBMED   1840538
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001350.4, DB241497.1,
            BC068030.1 and DB341875.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000614.3.
            
            Summary: The protein encoded by this gene is a polypeptide hormone
            whose actions appear to be restricted to the nervous system where
            it promotes neurotransmitter synthesis and neurite outgrowth in
            certain neuronal populations. The protein is a potent survival
            factor for neurons and oligodendrocytes and may be relevant in
            reducing tissue destruction during inflammatory attacks. A mutation
            in this gene, which results in aberrant splicing, leads to ciliary
            neurotrophic factor deficiency, but this phenotype is not causally
            related to neurologic disease. A read-through transcript variant
            composed of the upstream ZFP91 gene and CNTF sequence has been
            identified, but it is thought to be non-coding. Read-through
            transcription of ZFP91 and CNTF has also been observed in mouse.
            [provided by RefSeq, Oct 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068030.1, SRR1660807.25441.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361987.6/ ENSP00000355370.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AP001350.4         58335-58342
            9-13                DB241497.1         199-203
            14-1646             BC068030.1         1-1633
            1647-1647           DB341875.1         254-254             c
            1648-1902           BC068030.1         1635-1889
FEATURES             Location/Qualifiers
     source          1..1902
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..1902
                     /gene="CNTF"
                     /gene_synonym="HCNTF"
                     /note="ciliary neurotrophic factor"
                     /db_xref="GeneID:1270"
                     /db_xref="HGNC:HGNC:2169"
                     /db_xref="MIM:118945"
     exon            1..202
                     /gene="CNTF"
                     /gene_synonym="HCNTF"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..691
                     /gene="CNTF"
                     /gene_synonym="HCNTF"
                     /note="Ciliary Neuronotrophic Factor"
                     /codon_start=1
                     /product="ciliary neurotrophic factor"
                     /protein_id="NP_000605.1"
                     /db_xref="CCDS:CCDS31554.1"
                     /db_xref="GeneID:1270"
                     /db_xref="HGNC:HGNC:2169"
                     /db_xref="MIM:118945"
                     /translation="MAFTEHSPLTPHRRDLCSRSIWLARKIRSDLTALTESYVKHQGL
                     NKNINLDSADGMPVASTDQWSELTEAERLQENLQAYRTFHVLLARLLEDQQVHFTPTE
                     GDFHQAIHTLLLQVAAFAYQIEELMILLEYKIPRNEADGMPINVGDGGLFEKKLWGLK
                     VLQELSQWTVRSIHDLRFISSHQTGIPARGSHYIANNKKM"
     exon            203..1902
                     /gene="CNTF"
                     /gene_synonym="HCNTF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1876..1881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTF"
                     /gene_synonym="HCNTF"
                     /note="hexamer: AATAAA"
     polyA_site      1902
                     /gene="CNTF"
                     /gene_synonym="HCNTF"
                     /note="major polyA site"
ORIGIN      
        1 agtctttgag agtcacatct cttatttgga ccagtataga cagaagtaaa cccagctgac
       61 ttgtttcctg ggacagttga gttaagggat ggctttcaca gagcattcac cgctgacccc
      121 tcaccgtcgg gacctctgta gccgctctat ctggctagca aggaagattc gttcagacct
      181 gactgctctt acggaatcct atgtgaagca tcagggcctg aacaagaaca tcaacctgga
      241 ctctgcggat gggatgccag tggcaagcac tgatcagtgg agtgagctga ccgaggcaga
      301 gcgactccaa gagaaccttc aagcttatcg taccttccat gttttgttgg ccaggctctt
      361 agaagaccag caggtgcatt ttaccccaac cgaaggtgac ttccatcaag ctatacatac
      421 ccttcttctc caagtcgctg cctttgcata ccagatagag gagttaatga tactcctgga
      481 atacaagatc ccccgcaatg aggctgatgg gatgcctatt aatgttggag atggtggtct
      541 ctttgagaag aagctgtggg gcctaaaggt gctgcaggag ctttcacagt ggacagtaag
      601 gtccatccat gaccttcgtt tcatttcttc tcatcagact gggatcccag cacgtgggag
      661 ccattatatt gctaacaaca agaaaatgta gcagttagtc ccttctctct tccttgcttt
      721 ctcttctaat ggaatatgcg tagttccctg gggcctcgct ttcccatctt aaatttctaa
      781 aaacagttaa gacaacaggc attttctttc ttttttctct gaccacctgc agcctgttga
      841 aggactacag gtattttcat caagtagcgt tggagacata cacaaatggg catacaagtt
      901 tagcctgggg ggtgtgattt gtgtgcgtgc ttgcatgtgc tgcaggtgta agagagtggg
      961 agcagggaca acgtccttcc acttcagggt tctaaccttt ctaacccact aagtaacctc
     1021 tacaggcatt taactgcctt acagacagaa tatacatatg ttaattctag tcctggatga
     1081 ctcggtctga gaagattcaa tttaaaatca gactctttag ttgatttaaa ctcttagaga
     1141 ataagaataa taatggctaa cttttattat cttctatatt aaggcagtat gccaagggtc
     1201 tttatgtata ttatgtacag cgtttacaac cttgtgagca aggtggtgtt actcccatta
     1261 ggtagatgag aaaacaggct cacagagatt tggttaagct cacacagcta acaagtagca
     1321 cactgagttt gaacacagat cattctcctt gtaaaagcct atgtgccttt cactttagag
     1381 gcttgatcat gaatcactgc acctctttgt cacagggtgt tggaagatgc atccatgtaa
     1441 tctattccca tcgctggaaa acagctgctg ttagatgtcc tcagaagtca gttgcaaatt
     1501 ttagcgttaa agtcaggatt tattgttcat acttggcggt gaggagggca gctggagatc
     1561 ttaagattcc attttggaaa atgattaggc ccgccaaact tctgaacttt ggaagctggg
     1621 gatgtttagt aatacagcct ggtttttaag tactcactaa aagttctcaa atattgggtt
     1681 gggcacggct tataccaggt tacctcactt ttaattagtg atgcaggcag tgtaacccaa
     1741 gcatttgtgg acaatgagtg gaatactaaa gttaaaaagt caaactttca cctcagattt
     1801 tctggactta gtcatgagga gagggtgagg cccactctgt tcctactgga gataccagag
     1861 actctgaaac tatagaataa agcctctgtg ctgcacaaca aa
//
