LOCUS       NM_173478               3252 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens cyclin N-terminal domain containing 1 (CNTD1),
            transcript variant 1, mRNA.
ACCESSION   NM_173478
VERSION     NM_173478.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3252)
  AUTHORS   Holloway,J.K., Sun,X., Yokoo,R., Villeneuve,A.M. and Cohen,P.E.
  TITLE     Mammalian CNTD1 is critical for meiotic crossover maturation and
            deselection of excess precrossover sites
  JOURNAL   J Cell Biol 205 (5), 633-641 (2014)
   PUBMED   24891606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC026187.2, AK097456.1 and AL833052.1.
            
            On May 17, 2019 this sequence version replaced NM_173478.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK097456.1, SRR5189667.323589.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000588408.6/ ENSP00000465204.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BC026187.2         70-128
            60-216              AK097456.1         1-157
            217-1309            BC026187.2         286-1378
            1310-2300           AK097456.1         1251-2241
            2301-3252           AL833052.1         1706-2657
FEATURES             Location/Qualifiers
     source          1..3252
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2-q21.31"
     gene            1..3252
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
                     /note="cyclin N-terminal domain containing 1"
                     /db_xref="GeneID:124817"
                     /db_xref="HGNC:HGNC:26847"
                     /db_xref="MIM:618166"
     exon            1..376
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1200
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclin N-terminal domain-containing protein 1"
                     /codon_start=1
                     /product="cyclin N-terminal domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_775749.2"
                     /db_xref="CCDS:CCDS11440.1"
                     /db_xref="GeneID:124817"
                     /db_xref="HGNC:HGNC:26847"
                     /db_xref="MIM:618166"
                     /translation="MDGPMRPRSASLVDFQFGVVATETIEDALLHLAQQNEQAVREAS
                     GRLGRFREPQIVEFVFLLSEQWCLEKSVSYQAVEILERFMVKQAENICRQATIQPRDN
                     KRESQNWRALKQQLVNKFTLRLVSCVQLASKLSFRNKIISNITVLNFLQALGYLHTKE
                     ELLESELDVLKSLNFRINLPTPLAYVETLLEVLGYNGCLVPAMRLHATCLTLLDLVYL
                     LHEPIYESLLRASIENSTPSQLQGEKFTSVKEDFMLLAVGIIAASAFIQNHECWSQVV
                     GHLQSITGIALASIAEFSYAILTHGVGANTPGRQQSIPPHLAARALKTVASSNT"
     exon            377..452
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..624
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..787
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..932
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1029
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..3252
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1221..1226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
                     /note="hexamer: TATAAA"
     polyA_site      1244
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
                     /note="major polyA site"
     regulatory      2282..2287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
                     /note="hexamer: AATAAA"
     polyA_site      2301
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
                     /note="major polyA site"
     polyA_site      2346
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
     regulatory      2373..2378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
                     /note="hexamer: AACAAA"
     regulatory      2384..2389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
                     /note="hexamer: ATTAAA"
     polyA_site      2390
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
     polyA_site      2423
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
     regulatory      2693..2698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
                     /note="hexamer: ATTAAA"
     polyA_site      2715
                     /gene="CNTD1"
                     /gene_synonym="CNTD; COSA1"
ORIGIN      
        1 gaggagtccg tggccgttgg ggcgggaaaa agctgtggag ggttcgaggc tgtggtggta
       61 attgggtttt cctcagactt gaggcgacga cacactcatt ggaaggggac gaggaatcca
      121 gggtgtggca gaagactgga gaggagctaa gggggtcggt atgtggatcc agtgaacccg
      181 tccaggtgcc ccaagaggct cgtgaatatg gacggaccca tgaggccacg atcggcctcc
      241 ctcgttgact ttcagtttgg agttgtcgcc acagagacga ttgaagacgc cctgcttcac
      301 ttggcccagc agaatgagca agcagtgagg gaggcttcgg ggcggctggg ccgcttcagg
      361 gagccccaga tcgtggagtt tgtttttctc ctgtctgaac aatggtgtct ggagaaatct
      421 gtgagctacc aggctgtaga aatcctagaa aggtttatgg taaaacaggc agagaacatc
      481 tgcaggcaag ccacaatcca gccaagagat aataagagag agtctcagaa ttggagggct
      541 ctgaaacagc agcttgtcaa caagtttact ctccgtcttg tgtcatgtgt tcagctggcc
      601 agcaaacttt ccttccgaaa caaaataatc agcaacatta cagtcttgaa tttcctccag
      661 gctctaggct atctacacac taaagaagaa ctgctggaat cagagcttga tgttttgaag
      721 tccttgaact tccgaattaa tctgcccact cccctggcat atgtggagac gctcctagag
      781 gttttaggat acaatggctg tttggttcca gccatgaggc tgcatgcaac ctgcctgaca
      841 ctgctcgacc tggtctatct tctgcatgaa cccatatatg agagcctgtt gagggcttca
      901 attgagaact ccactcccag tcagctgcaa ggggaaaagt ttacttcagt gaaggaagac
      961 ttcatgctgt tggcagtagg aatcattgca gcaagtgctt tcatccaaaa ccatgagtgt
     1021 tggagccagg ttgtggggca tttgcagagc atcactggta ttgccttggc aagcattgct
     1081 gagttctctt atgcaatcct gactcacgga gtgggagcca acactccggg gagacagcag
     1141 tctattcctc cccacctggc agccagagct ctgaagactg ttgcttcctc taacacatga
     1201 gggaggctga atccaccaaa tataaacagc catccgtcac tgcactcatg cctccctctg
     1261 tttactttca tactaagggt acaaaaattc caagtctctt ttgaactgta ttttgtatgc
     1321 caatttcatg cttatttttc ctttatcaga gagagttaag gtggacgagc atgccctttt
     1381 tgtcatatca gcctgaaaat gttaaaaagc taggtggaga cagattagtt gtttcatttt
     1441 tgtttaacaa ggtatttata cttttagctt aatttcatta agaggaacat caggcattgc
     1501 aatcagtatt aatcaggggc tcaaatacag actatctggg tgaccttgac taagcatcaa
     1561 ggaggtagcc tttatttccc cttaaaatta gtttaacatc tctgttccat tattcagatc
     1621 tacacaaaca aggcttcctc aacagctatc tatttttact agagtctttt tttaaaacta
     1681 aaactaactc taaagaagtt tcaacagaat ttccacatac ctgcattcat tagaacttga
     1741 ttctcccaga atacaaagta ctctatttta aagaaaaacc caacagtgca cccctgggca
     1801 gttttcagac tgcagcaaat cttttattac aaataattaa atctctccat aatgtctcaa
     1861 acagtatcaa acaccatttc atatctctaa cacagagcag agtcggcatt cagtataaga
     1921 accaagtgaa aagtgttaaa tttcaagcat ctgatcacat cacatggtga ccaggtaaag
     1981 cttagatgtc attttcccac attatccaac tgtgcatctc aaacatatcc tcatctcagt
     2041 aaagacaaaa gtttctattt catattgtta agtgcaggaa gttgagagag ataaaaatcc
     2101 agtgaaaaca catcaatctc aattcaactc agttaaaaaa aagaaaagca aatttaaatt
     2161 agtttttttc agagaagaaa gggaaaggag tccatggggt taagaatcaa aactgaccag
     2221 ggctggcaac tatagatggc atgttgtagc tctggaaagt atctgtcaca tgatatttta
     2281 aaataaagtg gcttttgtgg attttttctt ttttggtatt gtaaacatgt actgtttaat
     2341 attacccgaa tttaatttaa aacatgtttg caaacaaaac aaaattaaaa gcctttaagg
     2401 caaacctccc cctaaggaaa aaagtcattt gttataaaat tgtgaggaca cccaagcaag
     2461 accccactta agattcgtca gcatgaactt gagagctttt gtccactgct cctcagagtt
     2521 aaactgggtt ttgatggaat aggagccgcc actgcctcct gtgtcttcaa tcttgccttt
     2581 ctccacatcc atcctgcaga tggacagagc aaaactcatt agtaactgag atctgagtta
     2641 agtaagttcg gggcagggac ttgatcatgg gaccattcac gtcattttat ctattaaaga
     2701 acacttggtg aggaatgata gtgtattttg gatttgcttg aaagccaaaa atcaagaaga
     2761 ctgtcacaag agcctcattg tcattgcaga gtacagggac aggacacaca cccaaagaga
     2821 agagaagcct ggagtagggg tgagtgaggg ttacagtact tcttgctgtt ttcctaggca
     2881 tccctgaact tggcggggga gaaaggaggc agaagaaaag aaatgctttg ttttggggtg
     2941 atagaagcag ccttactcta agtaaaaact agagtttcca tccatcaatg ggatcctaga
     3001 aaaatcaaaa gaagcattcc tgtgtatttc caagggcttc agggaaaaac cttcttgaaa
     3061 ctggagagga ggcttgagct ctatgccaag aaaaccccct aaaccatcta aggcaacatt
     3121 cttctactcc aaggactagg tggtcacatt ctgtcctgct tgcagtactg ggtcagtctc
     3181 tgcccatcaa tgtcatgtga ttctgtgcca tttttttgct ttcccaccat ttatactgtt
     3241 ttgcctccat ta
//
