LOCUS       NM_152609               5127 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens consortin, connexin sorting protein (CNST), transcript
            variant 1, mRNA.
ACCESSION   NM_152609
VERSION     NM_152609.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5127)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5127)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5127)
  AUTHORS   Wang,J.H., Wu,X.J., Duan,Y.Z. and Li,F.
  TITLE     Circular RNA_CNST Promotes the Tumorigenesis of Osteosarcoma Cells
            by Sponging miR-421
  JOURNAL   Cell Transplant 29, 963689720926147 (2020)
   PUBMED   32693639
  REMARK    GeneRIF: Circular RNA_CNST Promotes the Tumorigenesis of
            Osteosarcoma Cells by Sponging miR-421.
REFERENCE   4  (bases 1 to 5127)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5127)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 5127)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   7  (bases 1 to 5127)
  AUTHORS   del Castillo,F.J., Cohen-Salmon,M., Charollais,A., Caille,D.,
            Lampe,P.D., Chavrier,P., Meda,P. and Petit,C.
  TITLE     Consortin, a trans-Golgi network cargo receptor for the plasma
            membrane targeting and recycling of connexins
  JOURNAL   Hum Mol Genet 19 (2), 262-275 (2010)
   PUBMED   19864490
  REMARK    GeneRIF: Consortin is a trans-Golgi network cargo receptor for the
            plasma membrane targeting and recycling of connexins.
REFERENCE   8  (bases 1 to 5127)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 5127)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   10 (bases 1 to 5127)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA461531.1, DA994539.1, BX647629.1, AL646019.4 and AL591848.13.
            
            On Nov 23, 2018 this sequence version replaced NM_152609.2.
            
            Summary: Targeting of numerous transmembrane proteins to the cell
            surface is thought to depend on their recognition by cargo
            receptors that interact with the adaptor machinery for anterograde
            traffic at the distal end of the Golgi complex. Consortin (CNST) is
            an integral membrane protein that acts as a binding partner of
            connexins, the building blocks of gap junctions, and acts as a
            trans-Golgi network (TGN) receptor involved in connexin targeting
            to the plasma membrane and recycling from the cell surface (del
            Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun
            2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.11767.1,
                                           SRR1803612.258463.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366513.9/ ENSP00000355470.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DA461531.1         120-150
            32-582              DA994539.1         1-551
            583-2354            BX647629.1         487-2258
            2355-4510           AL646019.4         9798-11953
            4511-5114           AL591848.13        2001-2604
            5115-5127           AL591848.13        2605-2617
FEATURES             Location/Qualifiers
     source          1..5127
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..5127
                     /gene="CNST"
                     /gene_synonym="C1orf71; PPP1R64"
                     /note="consortin, connexin sorting protein"
                     /db_xref="GeneID:163882"
                     /db_xref="HGNC:HGNC:26486"
                     /db_xref="MIM:613439"
     exon            1..208
                     /gene="CNST"
                     /gene_synonym="C1orf71; PPP1R64"
                     /inference="alignment:Splign:2.1.0"
     exon            209..638
                     /gene="CNST"
                     /gene_synonym="C1orf71; PPP1R64"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..2437
                     /gene="CNST"
                     /gene_synonym="C1orf71; PPP1R64"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein phosphatase 1, regulatory subunit 64"
                     /codon_start=1
                     /product="consortin isoform 1"
                     /protein_id="NP_689822.2"
                     /db_xref="CCDS:CCDS1628.1"
                     /db_xref="GeneID:163882"
                     /db_xref="HGNC:HGNC:26486"
                     /db_xref="MIM:613439"
                     /translation="MDDSDTPTYYLQIEPQDGCHPGDSVERSVTCLPSASDENENQLD
                     GDGHEHLTSSDSAMGKPQVSEQDSLNNNESCTLSCEVAAGENLQNTLCEASRDEQAFL
                     GKDKKIPGKRSPRSKKGTAKKIPPGLFSGDIAPLMQEKVLSAVTYAVDDEEAAEVNAN
                     EQPEAPKLVLQSLFSLIRGEVEQLDSRALPLCLHQIAESYFQEEDYEKAMKFIQLERL
                     YHEQLLANLSAIQEQWETKWKTVQPHTVTALRNSEKGFNGEDFERLTKICATHQDPLL
                     SKHKIAAVEKSQERKCSTQLLVSEDPKEGGATTKESESKTCLGTESSKESQHTVEPLG
                     SSPCCHQMDVQTDSPSLSVTAGKDHMEELLCSAEATLALHTQSSETAGSPSGPDSSED
                     ACEDDSRLQLAQTEACQDVARIEGIAEDPKVFLSSKSKTEPLISPGCDRIPPALISEG
                     KYSQAQRKELRLPLRDASEALPTDQLENNELNELQQPDLTDSDGKSPQAQADSDGSEN
                     VLCGNNQISDLGILLPEVCMAPEEKGDKDDQLNKETEDYLNSLLEGCLKDTEDSLSYE
                     DNQDDDSDLLQDLSPEEASYSLQENLPSDESCLSLDDLAKRIEIAEVVPTEGLVSILK
                     KRNDTVGDHPAQMQHKPSKRRVRFQEIDDSLDQDEVGGGSCILLVLLCIATVFLSVGG
                     TALYCTFGDMESPVCTDFADNMDFYYTKLLQGVAELKHWIYLS"
     exon            639..844
                     /gene="CNST"
                     /gene_synonym="C1orf71; PPP1R64"
                     /inference="alignment:Splign:2.1.0"
     exon            845..875
                     /gene="CNST"
                     /gene_synonym="C1orf71; PPP1R64"
                     /inference="alignment:Splign:2.1.0"
     exon            876..962
                     /gene="CNST"
                     /gene_synonym="C1orf71; PPP1R64"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1077
                     /gene="CNST"
                     /gene_synonym="C1orf71; PPP1R64"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1099
                     /gene="CNST"
                     /gene_synonym="C1orf71; PPP1R64"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1196
                     /gene="CNST"
                     /gene_synonym="C1orf71; PPP1R64"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..2095
                     /gene="CNST"
                     /gene_synonym="C1orf71; PPP1R64"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2231
                     /gene="CNST"
                     /gene_synonym="C1orf71; PPP1R64"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..5127
                     /gene="CNST"
                     /gene_synonym="C1orf71; PPP1R64"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4874
                     /gene="CNST"
                     /gene_synonym="C1orf71; PPP1R64"
                     /note="major polyA site"
     regulatory      5095..5100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNST"
                     /gene_synonym="C1orf71; PPP1R64"
                     /note="hexamer: AATAAA"
     polyA_site      5127
                     /gene="CNST"
                     /gene_synonym="C1orf71; PPP1R64"
ORIGIN      
        1 gcggtcgcgg gccgccagcc tccagccggc cagccgcgag gggtgcgcag agggaggcgg
       61 ggcggaaagg cgagaggtgt ctcctccacc ggagccaggg gagacccgag caagctccgt
      121 gacagcacgt cggccgccat gtcgccgagt ggggctggaa acagacccgg cgcccagcgg
      181 tagccctcct tgcgcctccg attcccagac atggaaggtc tttaatgtaa ctttaaatgg
      241 ttcaccaaag gatgctctaa tggatgacag cgatactcct acatattatc tgcaaataga
      301 accacaagat ggatgtcatc ctggtgacag cgtggaaagg agtgtgacct gtctgccttc
      361 tgcatcagat gaaaatgaaa atcagcttga cggggacggg catgagcatc tgaccagcag
      421 tgacagtgcg atgggaaagc cccaagtgtc tgagcaggac agtctcaata ataatgaaag
      481 ctgcacattg agctgcgagg tggctgcagg tgagaacttg caaaacaccc tttgtgaagc
      541 ctccagagat gaacaggcct tcttgggaaa ggacaaaaaa attcctggaa aaagaagtcc
      601 aagaagcaaa aaagggactg ctaagaagat accaccagga cttttttcag gagatattgc
      661 acctttaatg caagaaaaag tactaagcgc agtcacatat gctgttgatg atgaagaagc
      721 tgctgaagta aatgctaatg agcagccaga ggcgccaaag cttgttctgc agtctctgtt
      781 ttcacttata cgaggtgaag ttgagcagtt ggattcaaga gcacttcccc tttgccttca
      841 tcagatagca gaatcctatt tccaggagga ggactatgag aaagcaatga aattcattca
      901 gctagaacga ttgtatcatg agcaattgct cgcaaatctt tctgccattc aagaacagtg
      961 ggaaacaaaa tggaaaactg tgcaaccaca tacagttacg gctctaagga attcagaaaa
     1021 gggatttaat ggtgaagatt ttgaacggct tacgaaaatt tgtgcaacac atcaagatcc
     1081 tcttttatcc aaacataaga tagcagctgt ggagaagtcc caggaaagga aatgctccac
     1141 gcagttacta gtgtctgaag atccaaagga aggaggagct accaccaaag agtcagagag
     1201 taaaacttgt ctcggcacag agtcaagtaa agaaagccaa catacagtgg agcccctggg
     1261 gagcagtccc tgctgtcatc agatggacgt gcaaacagat tccccaagcc tttcggtaac
     1321 tgcaggaaag gaccacatgg aggagctgct ctgcagcgct gaagccacgt tagcgctcca
     1381 cacccagtcc tccgagacag cagggagccc gtctgggcca gactcttctg aggatgcttg
     1441 tgaggatgac agtcgcttgc agctggctca aacagaggcc tgccaggatg tggccagaat
     1501 agagggcatt gctgaagacc ctaaggtgtt tctttccagc aagtcaaaga cagagccgtt
     1561 gatttcacca ggctgtgacc gtatacctcc tgcattgatt tctgagggta aatattcaca
     1621 ggctcagagg aaagaactcc gtttgccact tcgggatgct tctgaggcgt tgcccacaga
     1681 ccaacttgag aacaatgaat taaatgagct gcagcagcct gatcttacag acagtgatgg
     1741 aaaatcacca caggcgcagg ctgactcaga cggttctgag aatgtgctct gtggaaataa
     1801 tcaaatatct gacttaggca tactgcttcc agaggtgtgt atggccccag aggaaaaggg
     1861 agataaagac gaccaactca acaaagaaac agaagactat ttgaacagcc ttttagaagg
     1921 atgtttaaaa gatactgaag attccctttc ctatgaagat aaccaagacg acgactccga
     1981 tctccttcaa gatctctctc ctgaagaagc atcctatagt ctccaggaga atctgccttc
     2041 tgatgagagc tgtctttctc ttgatgatct tgccaaaagg atagagattg cagaggttgt
     2101 tcctactgaa ggattggtct ccatattaaa gaagaggaat gatactgtag gagatcatcc
     2161 tgcccaaatg caacacaaac catctaagcg aagagtgaga ttccaagaaa tagacgatag
     2221 cttggatcaa gatgaagttg gaggtggctc ctgtattttg ctggtcttgc tgtgcatagc
     2281 aacggttttc ctcagtgttg gaggaactgc attatactgc actttcggtg acatggagtc
     2341 acctgtttgt actgactttg cagacaacat ggacttctat tacactaagt tacttcaggg
     2401 agtggcagaa ctgaagcact ggatctacct ctcctagcag cattccagac acagacatgc
     2461 tggcagtgag agtgaaaggc gggagacttt ctaaacagtt tttctttcag gaattctgta
     2521 gcattccccc ttccctctgt taggaaccaa ggacatcaga aatagcaact ttaagtggca
     2581 agccggagga actctgttag aataatccac acagtgaggc aaatatcaat ctaagcattg
     2641 tggatggaag gaatggtctt tggagagagc atatccatct cctcctcact gcctcctaat
     2701 gtcatgaggt acactgagca gaattaaaca gggtagtctt aaccacacta tttttagcta
     2761 ccttgtcaag ctaatggtta aagaacactt ttggtttaca cttgttgggt catagaagtt
     2821 gctttccgcc atcacgcaat aagtttgtgt gtaatcagaa ggagttacct tatggtttca
     2881 gtgtcattct ttagttaact tgggagctgt gtaatttagg ctttgcgtat tatttcactt
     2941 ctgttctcca cttatgaagt gattgtgtgt ttgcgtgtgt gtgcgtgcgc atgtgcttcc
     3001 ggcagttaac ataagcaaat acccaacatc acaaagatga tctttcttct tttaacttga
     3061 tgatgatgtg caggcacaaa tctttggaga aggcttaact gtggaataga tgaattctag
     3121 aactcttgac cctgcaatga gaaactgtga cagatctgtg tcaattaact tgattagcca
     3181 gaaattaatc acaggcctag agaccaaaga aaaagctccc ctgagtctca ggcaacagtt
     3241 ttgtcacgga tgcaaagctt cctgaaatca tgaatgctgg actcagtttg gcaaacgctt
     3301 acacctatta tgttctgaga ttctgagaac cagaatgcaa acttaagtaa gatacagttc
     3361 ccactgtagg tgttttaatc ctggtcttat atagaataaa ccagtacttt gctgagtgaa
     3421 atcaccatat agaattcagt attaacagat catgcattca gatgcttgaa tgtgcattct
     3481 tgttgtgggc ttgatttaga tcctattgcg gggtcattac gcaaaaattc aatcatacct
     3541 tccatagaca aatgtctgat ttttgtttaa atctgtccgt taggtggcct ttccttatct
     3601 gaggtgtagt ggtctaacat ttaggaagcc ttgctttgac tttatcgggc agcattaaaa
     3661 aaaaaacaac aaagaaaaac caaacatgaa ttatagtttt taacaagtga tctttatttc
     3721 ctgtcttctg ttaggatcat ttgaaagaaa aagggagaac ttactttcta gttgttactg
     3781 gctggcacag tacctccctt tgtgtttctg cttatttatt tagattatgt gaatcttaaa
     3841 gggcttttta tatcagttga aagtgtgtta ctgcgcatgc atttggtgat tccagtgcta
     3901 gatatttaat tactgtgtat ttagtgtttt gattttctat aatttcagtt ccgcgtgttt
     3961 ttacacttgt tcattttaaa ttgatgtttc attttcactt ataatactgt ttgacttgtc
     4021 tctatcatgt caccataaac tgtaatattt tcaagggtta tagatcaaag atatttattt
     4081 agaaatgtac aagataatga aatttagatt ccttatactt aaggctgatt ttattagaag
     4141 attattttaa tgttctatta taaattttaa gaatttgtat tcaaattgta tgtaaaatat
     4201 gtaaaatgtt gacggtacta tattaagtgg ttctataaaa gctattcaca agttctactg
     4261 tgatggacat cctcatcata gacaaacctc ctctgtttta tcctcaattt ctagttacag
     4321 aaatttggtg atgcttattt ttgccaattt tatgtcaaaa taagttaaaa cttccctcct
     4381 gttcacctct tgggtctcta tcctgtgtaa cctctggtgt agtatttgcc cataggcaac
     4441 cagagccact tcctctgaac ccaacatctc ctggggacct tcgcagcaag aggaaagcac
     4501 tgagacaata gcttgctaag caggggccca gtggtgtctc agagaaacca tgggtgtcct
     4561 cgccacttcc cagggagggt gaggtgagct cgggaacata acgatgtttt gacttacaat
     4621 aggcatgaaa tcgcaactag aaaaattagg gcagttttta aaaatgtcat agttatctat
     4681 tgcatgaact ggagtaattc cacctggtgg tgaaaggatt gttatttcac acatgaaaaa
     4741 ttcatccagt tttactaaaa tgtaattttt tctgtcattt gaaagtactg acaactattt
     4801 gtaactaatc ttccttaaga actgtatttg agggtatcaa atcaagcttg taatttaaaa
     4861 tctgtaccaa caaagtgtct cagagagttt atttgaacca ttgggtgctg agaaaaaact
     4921 gctttaaagt gaaactttga tttcagaagt tgatctggcc ctacaagtag acagtcatct
     4981 actttgggaa gactaatagg tccttaggta acggctcttc tgctttaaaa tacctccccc
     5041 atctgctgac agtagctgaa gattattcta aacattcatt cttttagatt taaaaataaa
     5101 aatcttctgg aggatttaag atttgaa
//
