LOCUS       NP_689822                725 aa            linear   PRI 19-SEP-2024
DEFINITION  consortin isoform 1 [Homo sapiens].
ACCESSION   NP_689822
VERSION     NP_689822.2
DBSOURCE    REFSEQ: accession NM_152609.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 725)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 725)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (residues 1 to 725)
  AUTHORS   Wang,J.H., Wu,X.J., Duan,Y.Z. and Li,F.
  TITLE     Circular RNA_CNST Promotes the Tumorigenesis of Osteosarcoma Cells
            by Sponging miR-421
  JOURNAL   Cell Transplant 29, 963689720926147 (2020)
   PUBMED   32693639
  REMARK    GeneRIF: Circular RNA_CNST Promotes the Tumorigenesis of
            Osteosarcoma Cells by Sponging miR-421.
REFERENCE   4  (residues 1 to 725)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 725)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (residues 1 to 725)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   7  (residues 1 to 725)
  AUTHORS   del Castillo,F.J., Cohen-Salmon,M., Charollais,A., Caille,D.,
            Lampe,P.D., Chavrier,P., Meda,P. and Petit,C.
  TITLE     Consortin, a trans-Golgi network cargo receptor for the plasma
            membrane targeting and recycling of connexins
  JOURNAL   Hum Mol Genet 19 (2), 262-275 (2010)
   PUBMED   19864490
  REMARK    GeneRIF: Consortin is a trans-Golgi network cargo receptor for the
            plasma membrane targeting and recycling of connexins.
REFERENCE   8  (residues 1 to 725)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (residues 1 to 725)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   10 (residues 1 to 725)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA461531.1, DA994539.1, BX647629.1, AL646019.4 and AL591848.13.
            
            On Nov 15, 2008 this sequence version replaced NP_689822.1.
            
            Summary: Targeting of numerous transmembrane proteins to the cell
            surface is thought to depend on their recognition by cargo
            receptors that interact with the adaptor machinery for anterograde
            traffic at the distal end of the Golgi complex. Consortin (CNST) is
            an integral membrane protein that acts as a binding partner of
            connexins, the building blocks of gap junctions, and acts as a
            trans-Golgi network (TGN) receptor involved in connexin targeting
            to the plasma membrane and recycling from the cell surface (del
            Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun
            2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.11767.1,
                                           SRR1803612.258463.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366513.9/ ENSP00000355470.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..725
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     Protein         1..725
                     /product="consortin isoform 1"
                     /note="protein phosphatase 1, regulatory subunit 64"
                     /calculated_mol_wt=79466
     Region          1..72
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PJW8.3)"
     Region          103..124
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PJW8.3)"
     Region          296..353
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PJW8.3)"
     Region          375..397
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PJW8.3)"
     Region          485..510
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PJW8.3)"
     Region          612..723
                     /region_name="Consortin_C"
                     /note="Consortin C-terminus; pfam15281"
                     /db_xref="CDD:464611"
     Site            665..685
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PJW8.3)"
     CDS             1..725
                     /gene="CNST"
                     /gene_synonym="C1orf71; PPP1R64"
                     /coded_by="NM_152609.3:260..2437"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS1628.1"
                     /db_xref="GeneID:163882"
                     /db_xref="HGNC:HGNC:26486"
                     /db_xref="MIM:613439"
ORIGIN      
        1 mddsdtptyy lqiepqdgch pgdsversvt clpsasdene nqldgdgheh ltssdsamgk
       61 pqvseqdsln nnesctlsce vaagenlqnt lceasrdeqa flgkdkkipg krsprskkgt
      121 akkippglfs gdiaplmqek vlsavtyavd deeaaevnan eqpeapklvl qslfslirge
      181 veqldsralp lclhqiaesy fqeedyekam kfiqlerlyh eqllanlsai qeqwetkwkt
      241 vqphtvtalr nsekgfnged ferltkicat hqdpllskhk iaaveksqer kcstqllvse
      301 dpkeggattk esesktclgt esskesqhtv eplgsspcch qmdvqtdsps lsvtagkdhm
      361 eellcsaeat lalhtqsset agspsgpdss edaceddsrl qlaqteacqd variegiaed
      421 pkvflssksk teplispgcd rippaliseg kysqaqrkel rlplrdasea lptdqlenne
      481 lnelqqpdlt dsdgkspqaq adsdgsenvl cgnnqisdlg illpevcmap eekgdkddql
      541 nketedylns llegclkdte dslsyednqd ddsdllqdls peeasyslqe nlpsdescls
      601 lddlakriei aevvpteglv silkkrndtv gdhpaqmqhk pskrrvrfqe iddsldqdev
      661 gggscillvl lciatvflsv ggtalyctfg dmespvctdf adnmdfyytk llqgvaelkh
      721 wiyls
//
