LOCUS       NM_015463               1896 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens cannabinoid receptor interacting protein 1 (CNRIP1),
            transcript variant 1, mRNA.
ACCESSION   NM_015463
VERSION     NM_015463.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1896)
  AUTHORS   Petgrave,M., Ramgoolam,S.D. and Ganesan,A.
  TITLE     Deciphering the Molecular Association of Human CRIP1a with an
            Agonist-Bound Cannabinoid Receptor 1
  JOURNAL   J Chem Inf Model 64 (2), 499-517 (2024)
   PUBMED   38159053
  REMARK    GeneRIF: Deciphering the Molecular Association of Human CRIP1a with
            an Agonist-Bound Cannabinoid Receptor 1.
REFERENCE   2  (bases 1 to 1896)
  AUTHORS   Gu,S.M., Seo,S., Park,D., Kim,S., Lamichhane,S., Han,K.M.,
            Kim,Y.H., Lee,S., Hong,J.T., Cha,H.J. and Yun,J.
  TITLE     Cannabinoid Receptor Type 1 Regulates Drug Reward Behavior via
            Glutamate Decarboxylase 67 Transcription
  JOURNAL   Int J Mol Sci 22 (19), 10486 (2021)
   PUBMED   34638827
  REMARK    GeneRIF: Cannabinoid Receptor Type 1 Regulates Drug Reward Behavior
            via Glutamate Decarboxylase 67 Transcription.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1896)
  AUTHORS   Chen,D., Wu,H., Feng,X., Chen,Y., Lv,Z., Kota,V.G., Chen,J., Wu,W.,
            Lu,Y., Liu,H., Zhang,Y., Zheng,S. and Wu,J.
  TITLE     DNA Methylation of Cannabinoid Receptor Interacting Protein 1
            Promotes Pathogenesis of Intrahepatic Cholangiocarcinoma Through
            Suppressing Parkin-Dependent Pyruvate Kinase M2 Ubiquitination
  JOURNAL   Hepatology 73 (5), 1816-1835 (2021)
   PUBMED   32955740
  REMARK    GeneRIF: DNA Methylation of Cannabinoid Receptor Interacting
            Protein 1 Promotes Pathogenesis of Intrahepatic Cholangiocarcinoma
            Through Suppressing Parkin-Dependent Pyruvate Kinase M2
            Ubiquitination.
REFERENCE   4  (bases 1 to 1896)
  AUTHORS   Oliver,E.E., Hughes,E.K., Puckett,M.K., Chen,R., Lowther,W.T. and
            Howlett,A.C.
  TITLE     Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and
            Disease
  JOURNAL   Biomolecules 10 (12), 1609 (2020)
   PUBMED   33261012
  REMARK    GeneRIF: Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in
            Health and Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1896)
  AUTHORS   Kwon,H.J., Kim,D.S., Kim,W., Jung,H.Y., Yu,Y.H., Ju,Y.I.,
            Park,D.K., Hwang,I.K., Kim,D.W. and Yoo,D.Y.
  TITLE     Tat-Cannabinoid Receptor Interacting Protein Reduces
            Ischemia-Induced Neuronal Damage and Its Possible Relationship with
            14-3-3eta
  JOURNAL   Cells 9 (8), 1827 (2020)
   PUBMED   32756411
  REMARK    GeneRIF: Tat-Cannabinoid Receptor Interacting Protein Reduces
            Ischemia-Induced Neuronal Damage and Its Possible Relationship with
            14-3-3eta.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1896)
  AUTHORS   Singh,P., Ganjiwale,A., Howlett,A.C. and Cowsik,S.M.
  TITLE     In silico interaction analysis of cannabinoid receptor interacting
            protein 1b (CRIP1b) - CB1 cannabinoid receptor
  JOURNAL   J Mol Graph Model 77, 311-321 (2017)
   PUBMED   28918320
  REMARK    GeneRIF: The Arg82 and Cys126 of CRIP1b are involved in the
            majority of hydrogen bond interactions with the CB1 receptor and
            are possible key residues required for interactions between the CB1
            receptor and CRIP1b
REFERENCE   7  (bases 1 to 1896)
  AUTHORS   Blume,L.C., Patten,T., Eldeeb,K., Leone-Kabler,S., Ilyasov,A.A.,
            Keegan,B.M., O'Neal,J.E., Bass,C.E., Hantgan,R.R., Lowther,W.T.,
            Selley,D.E. and Howlett,A.L.
  TITLE     Cannabinoid Receptor Interacting Protein 1a Competition with
            beta-Arrestin for CB1 Receptor Binding Sites
  JOURNAL   Mol Pharmacol 91 (2), 75-86 (2017)
   PUBMED   27895162
  REMARK    GeneRIF: CRIP1a can compete with beta-arrestins for interaction
            with C-terminal CB1R domains that could affect agonist-driven,
            beta-arrestin-mediated internalization of the CB1R.
REFERENCE   8  (bases 1 to 1896)
  AUTHORS   Smith,T.H., Sim-Selley,L.J. and Selley,D.E.
  TITLE     Cannabinoid CB1 receptor-interacting proteins: novel targets for
            central nervous system drug discovery?
  JOURNAL   Br J Pharmacol 160 (3), 454-466 (2010)
   PUBMED   20590557
  REMARK    Review article
REFERENCE   9  (bases 1 to 1896)
  AUTHORS   Niehaus,J.L., Liu,Y., Wallis,K.T., Egertova,M., Bhartur,S.G.,
            Mukhopadhyay,S., Shi,S., He,H., Selley,D.E., Howlett,A.C.,
            Elphick,M.R. and Lewis,D.L.
  TITLE     CB1 cannabinoid receptor activity is modulated by the cannabinoid
            receptor interacting protein CRIP 1a
  JOURNAL   Mol Pharmacol 72 (6), 1557-1566 (2007)
   PUBMED   17895407
REFERENCE   10 (bases 1 to 1896)
  AUTHORS   Swick,L. and Kapatos,G.
  TITLE     A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein
            interactions
  JOURNAL   J Neurochem 97 (5), 1447-1455 (2006)
   PUBMED   16696853
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC015969.9.
            
            On Jul 19, 2019 this sequence version replaced NM_015463.2.
            
            Summary: This gene encodes a protein that interacts with the
            C-terminal tail of cannabinoid receptor 1. Two transcript variants
            encoding different isoforms have been described for this gene.
            [provided by RefSeq, Jul 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011535.1, AL110235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263655.4/ ENSP00000263655.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-728               AC015969.9         42455-43182         c
            729-879             AC015969.9         40390-40540         c
            880-1896            AC015969.9         16243-17259         c
FEATURES             Location/Qualifiers
     source          1..1896
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p14"
     gene            1..1896
                     /gene="CNRIP1"
                     /gene_synonym="C2orf32; CRIP-1; CRIP1"
                     /note="cannabinoid receptor interacting protein 1"
                     /db_xref="GeneID:25927"
                     /db_xref="HGNC:HGNC:24546"
                     /db_xref="MIM:618538"
     exon            1..728
                     /gene="CNRIP1"
                     /gene_synonym="C2orf32; CRIP-1; CRIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             550..1044
                     /gene="CNRIP1"
                     /gene_synonym="C2orf32; CRIP-1; CRIP1"
                     /note="isoform CRIP1a is encoded by transcript variant 1;
                     CB1 cannabinoid receptor-interacting protein 1;
                     cannabinoid receptor CB1-interacting protein 1"
                     /codon_start=1
                     /product="CB1 cannabinoid receptor-interacting protein 1
                     isoform CRIP1a"
                     /protein_id="NP_056278.1"
                     /db_xref="CCDS:CCDS1886.1"
                     /db_xref="GeneID:25927"
                     /db_xref="HGNC:HGNC:24546"
                     /db_xref="MIM:618538"
                     /translation="MGDLPGLVRLSIALRIQPNDGPVFYKVDGQRFGQNRTIKLLTGS
                     SYKVEVKIKPSTLQVENISIGGVLVPLELKSKEPDGDRVVYTGTYDTEGVTPTKSGER
                     QPIQITMPFTDIGTFETVWQVKFYNYHKRDHCQWGSPFSVIEYECKPNETRSLMWVNK
                     ESFL"
     exon            729..879
                     /gene="CNRIP1"
                     /gene_synonym="C2orf32; CRIP-1; CRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1896
                     /gene="CNRIP1"
                     /gene_synonym="C2orf32; CRIP-1; CRIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1877..1882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNRIP1"
                     /gene_synonym="C2orf32; CRIP-1; CRIP1"
                     /note="hexamer: AATAAA"
     polyA_site      1896
                     /gene="CNRIP1"
                     /gene_synonym="C2orf32; CRIP-1; CRIP1"
                     /note="major polyA site"
ORIGIN      
        1 agtgtccacc tcacgtagct ggccgaggcg gtatccagat tccgggggtc tcgctccttg
       61 gcatagtggt cgcttaactc cagcgccttc ccagtgcctc ccaaacctct cctcctcctg
      121 cccggggctg ttctaggagg agcctaaatg tccgcttccc cagctgaagg ggattgtggt
      181 gcgtaaacag gattaactcc ctcgccccca gctgcgcgga tctgcgcggc ggcctgcggg
      241 ccagagcgag ccttcgggtg cgtggagggc gcagcactgg agcgggggat ggggaagcgc
      301 gcggccttgg agccgtctct tgggcccgct tcctcgccga gtggggaggg gggccacagc
      361 ctaaggagct gctcctcaaa agcccgggcg gacggcggcg acggcgcggg ttcctagcgg
      421 cagcctcagc tccaccacct ccctcaccct ccccgcgctt cctctccgcc cctcgcgctc
      481 cagccactcg gccgcagccg gcgctgtcct ccgccccccg gagccgccgc gccagaccct
      541 cgcccagaca tgggggacct gccgggcctc gtgcgcctct ccatcgcgct gcgcatccag
      601 cctaatgacg gcccggtctt ttacaaggtg gacgggcagc gcttcggcca gaaccgcacc
      661 atcaagctgc tcaccggctc ctcctacaag gttgaggtga agattaaacc cagcacgctg
      721 caggtcgaga atatttccat tggtggtgtg cttgtcccac tggaactgaa gtctaaagag
      781 cctgatgggg acagagttgt ttatacgggt acatatgaca cagaaggtgt gaccccaacg
      841 aagagtggag aacggcaacc catccagatc accatgccgt tcacagacat tgggaccttc
      901 gagacagtgt ggcaagtcaa gttctacaat taccacaagc gggatcactg ccagtgggga
      961 agccccttct ctgtcattga gtatgaatgc aagcccaacg agacacgcag tctgatgtgg
     1021 gtgaacaagg agtccttcct ctgaaagtgg ctctttctga tgctactgga caatcttttc
     1081 agaaatctac ttttagataa accagcgcag gccttaaaca aggcatgcca caccattgct
     1141 gttccccatc tggtactaat gacctactag ccctggttat tttgaaagtg taattcccct
     1201 ctgacacaat atccctcaca tacaagatgg tgatgtacca ctcccgagaa tattcccatc
     1261 tgtattttgt gctgatgttc ctgcatccag ttgttctcgg tcatactttt gaccacttgt
     1321 gactggagtt cagtggccct ggcaggcttg tcctgctctt gaccattcca ctgactaact
     1381 ttggtgtttt gtttccaagt taagtgattc ctcctttttt ttgttcaatg ttaaatttaa
     1441 aaataacaat gtgtatgggt cctcccatgt gtaatatggt aacatgtaac ttgcagtgtt
     1501 tgccagcttt caaagcaggc tttgtgaaaa tgtaatacaa acagcagtga atgggactca
     1561 aatgttgtgc ttcctataaa cagctccgct ctttcaggga aggatggtaa caaactagaa
     1621 ggacaaatat gtacgtattt ataacgtatt aaaactcttt taagtagctt aaggtattgt
     1681 gcaatggcct agcctagtag aaatggggga aaagcattgc tgtggaccat tgttaaagtg
     1741 acaggagttg tagggttacc cctttgacaa gcttccatag tcttcagaca cgcacattga
     1801 tggcatccct acagtcttct tcacttgaac tttgtaaaac tgcatatgga cctgtaatca
     1861 acttttgata tttcttaata aaggcgttga aaatca
//
