LOCUS       NM_001841               5265 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens cannabinoid receptor 2 (CNR2), mRNA.
ACCESSION   NM_001841
VERSION     NM_001841.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5265)
  AUTHORS   Zhou,S., Ling,X., Liang,Y., Feng,Q., Xie,C., Li,J., Chen,Q.,
            Miao,J., Zhang,M., Li,Z., Shen,W., Li,X., Wu,Q., Wang,X., Hou,F.F.,
            Liu,Y., Kong,Y. and Zhou,L.
  TITLE     Cannabinoid receptor 2 plays a key role in renal fibrosis through
            inhibiting lipid metabolism in renal tubular cells
  JOURNAL   Metabolism 159, 155978 (2024)
   PUBMED   39097161
  REMARK    GeneRIF: Cannabinoid receptor 2 plays a key role in renal fibrosis
            through inhibiting lipid metabolism in renal tubular cells.
REFERENCE   2  (bases 1 to 5265)
  AUTHORS   Foyzun,T., Whiting,M., Velasco,K.K., Jacobsen,J.C., Connor,M. and
            Grimsey,N.L.
  TITLE     Single nucleotide polymorphisms in the cannabinoid CB2 receptor:
            Molecular pharmacology and disease associations
  JOURNAL   Br J Pharmacol 181 (15), 2391-2412 (2024)
   PUBMED   38802979
  REMARK    GeneRIF: Single nucleotide polymorphisms in the cannabinoid CB2
            receptor: Molecular pharmacology and disease associations.
            Review article
REFERENCE   3  (bases 1 to 5265)
  AUTHORS   Kwon,E.K., Choi,Y., Sim,S., Ye,Y.M., Shin,Y.S., Park,H.S. and
            Ban,G.Y.
  TITLE     Cannabinoid receptor 2 as a regulator of inflammation induced
            oleoylethanolamide in eosinophilic asthma
  JOURNAL   J Allergy Clin Immunol 153 (4), 998-1009 (2024)
   PUBMED   38061443
  REMARK    GeneRIF: Cannabinoid receptor 2 as a regulator of inflammation
            induced oleoylethanolamide in eosinophilic asthma.
REFERENCE   4  (bases 1 to 5265)
  AUTHORS   More,S.A., Deore,R.S., Pawar,H.D., Sharma,C., Nakhate,K.T.,
            Rathod,S.S., Ojha,S. and Goyal,S.N.
  TITLE     CB2 Cannabinoid Receptor as a Potential Target in Myocardial
            Infarction: Exploration of Molecular Pathogenesis and Therapeutic
            Strategies
  JOURNAL   Int J Mol Sci 25 (3), 1683 (2024)
   PUBMED   38338960
  REMARK    GeneRIF: CB2 Cannabinoid Receptor as a Potential Target in
            Myocardial Infarction: Exploration of Molecular Pathogenesis and
            Therapeutic Strategies.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5265)
  AUTHORS   Bietar,B., Tanner,S. and Lehmann,C.
  TITLE     Neuroprotection and Beyond: The Central Role of CB1 and CB2
            Receptors in Stroke Recovery
  JOURNAL   Int J Mol Sci 24 (23), 16728 (2023)
   PUBMED   38069049
  REMARK    GeneRIF: Neuroprotection and Beyond: The Central Role of CB1 and
            CB2 Receptors in Stroke Recovery.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5265)
  AUTHORS   Nong,L., Newton,C., Friedman,H. and Klein,T.W.
  TITLE     CB1 and CB2 receptor mRNA expression in human peripheral blood
            mononuclear cells (PBMC) from various donor types
  JOURNAL   Adv Exp Med Biol 493, 229-233 (2001)
   PUBMED   11727770
  REMARK    GeneRIF: CB1 and CB2 receptor mRNA expression in human peripheral
            blood mononuclear cells (PBMC) from various donor types.
REFERENCE   7  (bases 1 to 5265)
  AUTHORS   Tao,Q., McAllister,S.D., Andreassi,J., Nowell,K.W., Cabral,G.A.,
            Hurst,D.P., Bachtel,K., Ekman,M.C., Reggio,P.H. and Abood,M.E.
  TITLE     Role of a conserved lysine residue in the peripheral cannabinoid
            receptor (CB2): evidence for subtype specificity
  JOURNAL   Mol Pharmacol 55 (3), 605-613 (1999)
   PUBMED   10051546
REFERENCE   8  (bases 1 to 5265)
  AUTHORS   Shire,D., Calandra,B., Rinaldi-Carmona,M., Oustric,D., Pessegue,B.,
            Bonnin-Cabanne,O., Le Fur,G., Caput,D. and Ferrara,P.
  TITLE     Molecular cloning, expression and function of the murine CB2
            peripheral cannabinoid receptor
  JOURNAL   Biochim Biophys Acta 1307 (2), 132-136 (1996)
   PUBMED   8679694
REFERENCE   9  (bases 1 to 5265)
  AUTHORS   Galiegue,S., Mary,S., Marchand,J., Dussossoy,D., Carriere,D.,
            Carayon,P., Bouaboula,M., Shire,D., Le Fur,G. and Casellas,P.
  TITLE     Expression of central and peripheral cannabinoid receptors in human
            immune tissues and leukocyte subpopulations
  JOURNAL   Eur J Biochem 232 (1), 54-61 (1995)
   PUBMED   7556170
REFERENCE   10 (bases 1 to 5265)
  AUTHORS   Munro,S., Thomas,K.L. and Abu-Shaar,M.
  TITLE     Molecular characterization of a peripheral receptor for
            cannabinoids
  JOURNAL   Nature 365 (6441), 61-65 (1993)
   PUBMED   7689702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590609.15, X74328.1 and
            BC069722.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001841.2.
            
            Summary: The cannabinoid delta-9-tetrahydrocannabinol is the
            principal psychoactive ingredient of marijuana. The proteins
            encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1)
            gene have the characteristics of a guanine nucleotide-binding
            protein (G-protein)-coupled receptor for cannabinoids. They inhibit
            adenylate cyclase activity in a dose-dependent, stereoselective,
            and pertussis toxin-sensitive manner. These proteins have been
            found to be involved in the cannabinoid-induced CNS effects
            (including alterations in mood and cognition) experienced by users
            of marijuana. The cannabinoid receptors are members of family 1 of
            the G-protein-coupled receptors. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X74328.1, BM151899.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374472.5/ ENSP00000363596.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL590609.15        46350-46384         c
            36-66               X74328.1           1-31
            67-67               AL590609.15        46318-46318         c
            68-1484             X74328.1           32-1448
            1485-1767           BC069722.1         1391-1673
            1768-1810           X74328.1           1734-1776
            1811-5265           AL590609.15        3537-6991           c
FEATURES             Location/Qualifiers
     source          1..5265
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..5265
                     /gene="CNR2"
                     /gene_synonym="CB-2; CB2; CX5"
                     /note="cannabinoid receptor 2"
                     /db_xref="GeneID:1269"
                     /db_xref="HGNC:HGNC:2160"
                     /db_xref="MIM:605051"
     exon            1..117
                     /gene="CNR2"
                     /gene_synonym="CB-2; CB2; CX5"
                     /inference="alignment:Splign:2.1.0"
     exon            118..5265
                     /gene="CNR2"
                     /gene_synonym="CB-2; CB2; CX5"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1245
                     /gene="CNR2"
                     /gene_synonym="CB-2; CB2; CX5"
                     /note="cannabinoid receptor 2 (macrophage)"
                     /codon_start=1
                     /product="cannabinoid receptor 2"
                     /protein_id="NP_001832.1"
                     /db_xref="CCDS:CCDS245.1"
                     /db_xref="GeneID:1269"
                     /db_xref="HGNC:HGNC:2160"
                     /db_xref="MIM:605051"
                     /translation="MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLG
                     LLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDS
                     KAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVL
                     SALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQ
                     HVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQ
                     VKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPR
                     SSVTETEADGKITPWPDSRDLDLSDC"
     regulatory      2686..2691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNR2"
                     /gene_synonym="CB-2; CB2; CX5"
                     /note="hexamer: AATGAA"
     polyA_site      2705
                     /gene="CNR2"
                     /gene_synonym="CB-2; CB2; CX5"
                     /note="major polyA site"
     regulatory      5231..5236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNR2"
                     /gene_synonym="CB-2; CB2; CX5"
                     /note="hexamer: ATTAAA"
     polyA_site      5265
                     /gene="CNR2"
                     /gene_synonym="CB-2; CB2; CX5"
                     /note="major polyA site"
ORIGIN      
        1 ggcactcaac aggtgctctg agtggcaccc acggccaggt cctgggagag gacagaaaac
       61 aactgggact cctcagcccc cggcagctcc cagtgcccag ccacccacaa cacaacccaa
      121 agccttctag acaagctcag tggaatctga agggcccacc ccatggagga atgctgggtg
      181 acagagatag ccaatggctc caaggatggc ttggattcca accctatgaa ggattacatg
      241 atcctgagtg gtccccagaa gacagctgtt gctgtgttgt gcactcttct gggcctgcta
      301 agtgccctgg agaacgtggc tgtgctctat ctgatcctgt cctcccacca actccgccgg
      361 aagccctcat acctgttcat tggcagcttg gctggggctg acttcctggc cagtgtggtc
      421 tttgcatgca gctttgtgaa tttccatgtt ttccatggtg tggattccaa ggctgtcttc
      481 ctgctgaaga ttggcagcgt gactatgacc ttcacagcct ctgtgggtag cctcctgctg
      541 accgccattg accgatacct ctgcctgcgc tatccacctt cctacaaagc tctgctcacc
      601 cgtggaaggg cactggtgac cctgggcatc atgtgggtcc tctcagcact agtctcctac
      661 ctgcccctca tgggatggac ttgctgtccc aggccctgct ctgagctttt cccactgatc
      721 cccaatgact acctgctgag ctggctcctg ttcatcgcct tcctcttttc cggaatcatc
      781 tacacctatg ggcatgttct ctggaaggcc catcagcatg tggccagctt gtctggccac
      841 caggacaggc aggtgccagg aatggcccga atgaggctgg atgtgaggtt ggccaagacc
      901 ctagggctag tgttggctgt gctcctcatc tgttggttcc cagtgctggc cctcatggcc
      961 cacagcctgg ccactacgct cagtgaccag gtcaagaagg cctttgcttt ctgctccatg
     1021 ctgtgcctca tcaactccat ggtcaaccct gtcatctatg ctctacggag tggagagatc
     1081 cgctcctctg cccatcactg cctggctcac tggaagaagt gtgtgagggg ccttgggtca
     1141 gaggcaaaag aagaagcccc gagatcctca gtcaccgaga cagaggctga tgggaaaatc
     1201 actccgtggc cagattccag agatctagac ctctctgatt gctgatgagg cctcttccca
     1261 atttaaacaa ctcaagtcag aaatcagttc actccctgga agagagagag gggtcttggc
     1321 actctcttct tacttaaacc agtcccagac acctagacac ggaccccttt ttgctgatga
     1381 gtgttgggac tgactcctgg aagacagcct ggccttgccc acctgcacac agtctgttgg
     1441 ataggtaggg ccacgaggag tagccaggta ggcgagacac aaaaggcctg ggacagggtc
     1501 agtacaagtc aggtcaggct tcatgcctgc atcctccaga gaccacagga gccaaagcga
     1561 gcctccaggc ccagcaatga gggacttggg agaaatctga gaagaatggg ttgttctctt
     1621 gggaagtcag ggtatcagat gggatggaca tccaggtctt ctctctgcct aattgtcaag
     1681 gcctccttgg ctctggagct atgaaaggcc ccactttcaa gtcacccttg ccactgagga
     1741 ccgaggacta tgctatgatg aggattaagg tgttgacttg cctctttcag agataaatga
     1801 caagccttca gtttggggca tcctgttgtt tgggcgagga ccctctctga tattctgata
     1861 atccccacct gtaacctcag gtccctggaa atacagagga ggctgggatc gcctgagaca
     1921 caaaaatctt tggagaattt tcttgaccct ctgaagtcct tccagcagca gtcctggtgg
     1981 tgctgctgga agcaggcaat gtcctagtct aacctaactc gaagaaaaaa aggaagatat
     2041 tcacaaagat tgtataaatc tccaaactgt tcccctatct gcccccaatt cagctccctt
     2101 gcctcctcca cacccctatt acatataata agcagagcaa gtgggaggag gggaaatgtc
     2161 cttcctatat gccaggtatg gggctgacat ttcagtctat tgaccccagc tagaatatag
     2221 ctccatgatt ttaaagatct caggggccag gcatggtagc tcatgcctgt aatcccagca
     2281 ctttgggagg ccaaggcagg tggatcacct gaggtcagga gtttgagacc agcctgacca
     2341 atatggtgaa accctgtctc tactaaaaat acaaaaatta gcagggcatg gtggcaggca
     2401 cctgtagtcc cagctactcg ggaggctgag acaggagaat tgcttgaacc ctggaggcag
     2461 aggttgcagt gagccgagat tgcaccactg cactccagcc tgggtgacag agcaagactg
     2521 tctcaaaaaa ataaaataaa atagatccca gggtactcat ttttcatatg agggaggctg
     2581 ggttcctccc agaggagcct aaaacagcca acaagagaaa ttgttggcgg caggaagatt
     2641 gcagaggaat tctaatgcaa ttatttggga cctcaaatgg aataaaatga aagatattgg
     2701 ttaaacatgt cttcgtttaa tactttcaag acaaaatatc cactagctat tcacttattc
     2761 attcatctca taaacatgag ccaggctctg tgcagggtcc tgagtaccca gccataaatg
     2821 agactgtgcc cctgtctcat ggggcttaca gtctatatcc tgcttgcaag acagccaata
     2881 agtcaataaa gaagataatt acaggcagta caacaaagga aatatgcagg ttcatgtcat
     2941 gtaataggga ttaattgagt taactcaata aacggtagga tagacctacc atgtgccggc
     3001 tcacttttat tgagccttta ctatgtgcca ggcagggggc taagtgtttt taaatgcctt
     3061 atttcacttc atgtttccca acaacctaat aagaaggtct tagttatctt cattttacag
     3121 atgtggcaac ctcaaagatg caaagtcact tgtctaaggt caccctgcta agtaccagag
     3181 ctgaggtctc caacctagtt ctgtttgact tcaaagcctg ccctcttaac cactaacctt
     3241 ttgtcctagt tcagtcaaat tctgcttgat tattgctcat tagggataat attagctatc
     3301 tgtagcatca gattgctgca aagttaactc atcgtagatt ctcaatatac tccattttat
     3361 taaatggccc cgtattaatc tcctgtaata aatttcacaa atccagtggc ttatcaacag
     3421 aaatttactg tctcataatt ctggaggcca gaagtcaaaa tcaagatgtg gtagggccct
     3481 gctccctcca aaagtttaag gggagaatta ttccttgact ctttcaactt ctggcagtcc
     3541 ctgtcattcc ttggcttgtg gaaacatcac tcctacctct gactctgtct tcatatggca
     3601 tttcctctgt gtctcttggt gtcttttttt tttttttttt tttttttgag acggaatctc
     3661 attctgttgt ccaggcagga gtgcagtgac atgatcttgg ctcactgcaa cctccacctc
     3721 tcaggttcaa gtgattctcc tgcctcagcc tcccaaatag ctgggactac aggcacccgc
     3781 caccacactc agctaatttt tgtattttta gtagagatgg ggtttcacca tcttgcccag
     3841 gctggtcttg aactcctgac ctcaagtgat ccgcccacct tggcctccta aattgctggg
     3901 attacagacg tgagccacca tacccggcct ggtgtctttt ttaaagaata tcagtcactg
     3961 gatttgggcc caccctaatc ctaatagtat gacttcatct taatttaacc aattatatct
     4021 gtagagaccc tgtttccaaa taaggtcaca ttcacagatt ccaggtggac aagaagttta
     4081 ggcggacact attcaactca gtacagaccc aggaacaaag tccacccact gggctgtgtt
     4141 gagtggcagt cactagttta tcctccctca acaagatgag ctccaggttg acctctgcat
     4201 ccccagtgct cagtcaggac ccagcagagc atctgaaggg atctggtcaa tatgtgtgga
     4261 actgaactgt ttctgaaaag ctctgacgta tgttttggaa aatcaaatct tgttttaatc
     4321 cagacaccaa tctttttgta aggcaaacaa gtagcataaa tgtttaaaag tgaatttgca
     4381 tgtttatata ctgtcattcc ttaaagttga agcatgcctt tctttattca tcggtggaat
     4441 cctttctcat tttggcaaag aaaatgccca agtgcctggc acaaacaagc actgagtaaa
     4501 tacttcttga atgaataaaa ctagattcta aaaatcattt gatcaaacgc aactccacac
     4561 tttctacttc tcttctttta gaaccacact gtatttctgc tttttttttt tttttttttt
     4621 tttttgacat agaatctcac tctgtcaccc aggttggagt gcagtggcat gcaatcttgg
     4681 ctcactgcaa cctctgcctc ctgggttcaa gcagttctcc tgccttagcc tcccatgtag
     4741 ctgggattac aggtacccgc caccatgccc agctaatttt tgtattgtta gtagagatgg
     4801 aatttcacca tattggccag gctggtcttg aactcctgac ttcaagtgat ccacccacct
     4861 tagcctccca aagtgctagg attacaggtg tgagccacca ctcccagccc ctatgtctgc
     4921 tttaagtgga gaagcagagc ttatgaggga ggagaacaag ggtgcaaaag ggacctagat
     4981 atcactgaga actgcccttg ttgtttggtt gaggaaatgg gcccagacag tggacaagac
     5041 ttgctcaggg agacaaacga gatggtgtcc agtgcaacaa acctaggttt cctaacttcc
     5101 agttctgtcc actctacatc agtgcctctc acctgtccct gcaggttcac attttggtta
     5161 tgtggataag gagaaataaa ttgaagatca caatgtccca ttttatcttc cccaagacaa
     5221 gctctgtaac attaaagacc actatgcaaa ccgattacta gaaaa
//
