LOCUS       NM_016083               6019 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens cannabinoid receptor 1 (CNR1), transcript variant 1,
            mRNA.
ACCESSION   NM_016083 NM_001840
VERSION     NM_016083.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6019)
  AUTHORS   Luo,L., Yan,W.H., Zhang,F.Q. and Fan,Z.P.
  TITLE     CB1 Promotes Osteogenic Differentiation Potential of Periodontal
            Ligament Stem Cells by Enhancing Mitochondrial Transfer of Bone
            Marrow Mesenchymal Stem Cells
  JOURNAL   Chin J Dent Res 27 (3), 225-234 (2024)
   PUBMED   39221983
  REMARK    GeneRIF: CB1 Promotes Osteogenic Differentiation Potential of
            Periodontal Ligament Stem Cells by Enhancing Mitochondrial Transfer
            of Bone Marrow Mesenchymal Stem Cells.
REFERENCE   2  (bases 1 to 6019)
  AUTHORS   Ludwiczak,S., Reinhard,J., Reinach,P.S., Li,A., Oronowicz,J.,
            Yousf,A., Kakkassery,V. and Mergler,S.
  TITLE     Joint CB1 and NGF Receptor Activation Suppresses TRPM8 Activation
            in Etoposide-Resistant Retinoblastoma Cells
  JOURNAL   Int J Mol Sci 25 (3), 1733 (2024)
   PUBMED   38339011
  REMARK    GeneRIF: Joint CB1 and NGF Receptor Activation Suppresses TRPM8
            Activation in Etoposide-Resistant Retinoblastoma Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6019)
  AUTHORS   Petgrave,M., Ramgoolam,S.D. and Ganesan,A.
  TITLE     Deciphering the Molecular Association of Human CRIP1a with an
            Agonist-Bound Cannabinoid Receptor 1
  JOURNAL   J Chem Inf Model 64 (2), 499-517 (2024)
   PUBMED   38159053
  REMARK    GeneRIF: Deciphering the Molecular Association of Human CRIP1a with
            an Agonist-Bound Cannabinoid Receptor 1.
REFERENCE   4  (bases 1 to 6019)
  AUTHORS   Bietar,B., Tanner,S. and Lehmann,C.
  TITLE     Neuroprotection and Beyond: The Central Role of CB1 and CB2
            Receptors in Stroke Recovery
  JOURNAL   Int J Mol Sci 24 (23), 16728 (2023)
   PUBMED   38069049
  REMARK    GeneRIF: Neuroprotection and Beyond: The Central Role of CB1 and
            CB2 Receptors in Stroke Recovery.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6019)
  AUTHORS   Aljorani,R.H., Saleh,E.S. and Al Mohammadawi,K.G.
  TITLE     Association between CNR1 gene polymorphisms and susceptibility to
            diabetic nephropathy in Iraqi patients with T2DM
  JOURNAL   J Med Life 16 (11), 1663-1669 (2023)
   PUBMED   38406790
  REMARK    GeneRIF: Association between CNR1 gene polymorphisms and
            susceptibility to diabetic nephropathy in Iraqi patients with T2DM.
REFERENCE   6  (bases 1 to 6019)
  AUTHORS   Ryberg,E., Vu,H.K., Larsson,N., Groblewski,T., Hjorth,S.,
            Elebring,T., Sjogren,S. and Greasley,P.J.
  TITLE     Identification and characterisation of a novel splice variant of
            the human CB1 receptor
  JOURNAL   FEBS Lett 579 (1), 259-264 (2005)
   PUBMED   15620723
  REMARK    GeneRIF: Identification of a splice variant of the human CB1
            receptor.
REFERENCE   7  (bases 1 to 6019)
  AUTHORS   Gerard,C.M., Mollereau,C., Vassart,G. and Parmentier,M.
  TITLE     Molecular cloning of a human cannabinoid receptor which is also
            expressed in testis
  JOURNAL   Biochem J 279 (Pt 1) (Pt 1), 129-134 (1991)
   PUBMED   1718258
REFERENCE   8  (bases 1 to 6019)
  AUTHORS   Hoehe,M.R., Caenazzo,L., Martinez,M.M., Hsieh,W.T., Modi,W.S.,
            Gershon,E.S. and Bonner,T.I.
  TITLE     Genetic and physical mapping of the human cannabinoid receptor gene
            to chromosome 6q14-q15
  JOURNAL   New Biol 3 (9), 880-885 (1991)
   PUBMED   1931832
REFERENCE   9  (bases 1 to 6019)
  AUTHORS   Gerard,C., Mollereau,C., Vassart,G. and Parmentier,M.
  TITLE     Nucleotide sequence of a human cannabinoid receptor cDNA
  JOURNAL   Nucleic Acids Res 18 (23), 7142 (1990)
   PUBMED   2263478
REFERENCE   10 (bases 1 to 6019)
  AUTHORS   Matsuda,L.A., Lolait,S.J., Brownstein,M.J., Young,A.C. and
            Bonner,T.I.
  TITLE     Structure of a cannabinoid receptor and functional expression of
            the cloned cDNA
  JOURNAL   Nature 346 (6284), 561-564 (1990)
   PUBMED   2165569
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121835.18 and AL136096.7.
            
            On May 10, 2019 this sequence version replaced NM_016083.5.
            
            Summary: This gene encodes one of two cannabinoid receptors. The
            cannabinoids, principally delta-9-tetrahydrocannabinol and
            synthetic analogs, are psychoactive ingredients of marijuana. The
            cannabinoid receptors are members of the guanine-nucleotide-binding
            protein (G-protein) coupled receptor family, which inhibit
            adenylate cyclase activity in a dose-dependent, stereoselective and
            pertussis toxin-sensitive manner. The two receptors have been found
            to be involved in the cannabinoid-induced CNS effects (including
            alterations in mood and cognition) experienced by users of
            marijuana. Multiple transcript variants encoding two different
            protein isoforms have been described for this gene. [provided by
            RefSeq, May 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.123962.1,
                                           SRR1660809.219825.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369501.3/ ENSP00000358513.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-545               AL121835.18        9116-9660           c
            546-6019            AL136096.7         95289-100762        c
FEATURES             Location/Qualifiers
     source          1..6019
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q15"
     gene            1..6019
                     /gene="CNR1"
                     /gene_synonym="CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR"
                     /note="cannabinoid receptor 1"
                     /db_xref="GeneID:1268"
                     /db_xref="HGNC:HGNC:2159"
                     /db_xref="MIM:114610"
     exon            1..545
                     /gene="CNR1"
                     /gene_synonym="CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR"
                     /inference="alignment:Splign:2.1.0"
     exon            546..6019
                     /gene="CNR1"
                     /gene_synonym="CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR"
                     /inference="alignment:Splign:2.1.0"
     CDS             609..2027
                     /gene="CNR1"
                     /gene_synonym="CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR"
                     /note="isoform a is encoded by transcript variant 1;
                     central cannabinoid receptor; cannabinoid receptor 1
                     (brain)"
                     /codon_start=1
                     /product="cannabinoid receptor 1 isoform a"
                     /protein_id="NP_057167.2"
                     /db_xref="CCDS:CCDS5015.1"
                     /db_xref="GeneID:1268"
                     /db_xref="HGNC:HGNC:2159"
                     /db_xref="MIM:114610"
                     /translation="MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYF
                     PQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENF
                     MDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLA
                     VADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISI
                     HRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYL
                     MFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQ
                     ARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTV
                     NPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCI
                     KSTVKIAKVTMSVSTDTSAEAL"
     regulatory      5985..5990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNR1"
                     /gene_synonym="CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR"
                     /note="hexamer: AATAAA"
     polyA_site      6019
                     /gene="CNR1"
                     /gene_synonym="CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR"
                     /note="major polyA site"
ORIGIN      
        1 agagacagcg cgagcggagg gagcggcagg gactgcgcga gcgggacgag gcgacgggcg
       61 cccgggctgg cggagacggg cggccccacg ccgggccagg cggggctcgc gggaggaccc
      121 agtgaagagc ctgggaaggg gcgaggctcg ccggcggtcg gagcagcggg gcgccagtcc
      181 cggtcgctgt cgcgggcggg cgctggagac cgggacgccg gcgctcggac ggactgactt
      241 gctgaccgcc cgccggaggc acaccccact ccaccccacc ccgcctcgcc agcagcccgg
      301 cgccggcgcc gcctcccgca cgctactccc tctgccaccc cttccttctc cacttctttt
      361 ccgcctccgc ctcttcttgt ctcccgcggc gccagcgcct tcccttggcc cgggcggggg
      421 cctcggctcc ctgcagagct ctccgtagtc agtgggggat atttcgttct agcggacaac
      481 cagcccctga gctgggcgag aggtgccaag ggagcttctg tcccgaggac caggggatgc
      541 gaagggattg ccccctgtgg gtcactttct cagtcatttt gagctcagcc taatcaaaga
      601 ctgaggttat gaagtcgatc ctagatggcc ttgcagatac caccttccgc accatcacca
      661 ctgacctcct gtacgtgggc tcaaatgaca ttcagtacga agacatcaaa ggtgacatgg
      721 catccaaatt agggtacttc ccacagaaat tccctttaac ttcctttagg ggaagtccct
      781 tccaagagaa gatgactgcg ggagacaacc cccagctagt cccagcagac caggtgaaca
      841 ttacagaatt ttacaacaag tctctctcgt ccttcaagga gaatgaggag aacatccagt
      901 gtggggagaa cttcatggac atagagtgtt tcatggtcct gaaccccagc cagcagctgg
      961 ccattgcagt cctgtccctc acgctgggca ccttcacggt cctggagaac ctcctggtgc
     1021 tgtgcgtcat cctccactcc cgcagcctcc gctgcaggcc ttcctaccac ttcatcggca
     1081 gcctggcggt ggcagacctc ctggggagtg tcatttttgt ctacagcttc attgacttcc
     1141 acgtgttcca ccgcaaagat agccgcaacg tgtttctgtt caaactgggt ggggtcacgg
     1201 cctccttcac tgcctccgtg ggcagcctgt tcctcacagc catcgacagg tacatatcca
     1261 ttcacaggcc cctggcctat aagaggattg tcaccaggcc caaggccgtg gtggcgtttt
     1321 gcctgatgtg gaccatagcc attgtgatcg ccgtgctgcc tctcctgggc tggaactgcg
     1381 agaaactgca atctgtttgc tcagacattt tcccacacat tgatgaaacc tacctgatgt
     1441 tctggatcgg ggtcaccagc gtactgcttc tgttcatcgt gtatgcgtac atgtatattc
     1501 tctggaaggc tcacagccac gccgtccgca tgattcagcg tggcacccag aagagcatca
     1561 tcatccacac gtctgaggat gggaaggtac aggtgacccg gccagaccaa gcccgcatgg
     1621 acattaggtt agccaagacc ctggtcctga tcctggtggt gttgatcatc tgctggggcc
     1681 ctctgcttgc aatcatggtg tatgatgtct ttgggaagat gaacaagctc attaagacgg
     1741 tgtttgcatt ctgcagtatg ctctgcctgc tgaactccac cgtgaacccc atcatctatg
     1801 ctctgaggag taaggacctg cgacacgctt tccggagcat gtttccctct tgtgaaggca
     1861 ctgcgcagcc tctggataac agcatggggg actcggactg cctgcacaaa cacgcaaaca
     1921 atgcagccag tgttcacagg gccgcagaaa gctgcatcaa gagcacggtc aagattgcca
     1981 aggtaaccat gtctgtgtcc acagacacgt ctgccgaggc tctgtgagcc tgatgcctcc
     2041 ctggcagcac aggaaaagaa tttttttttt taagctcaaa atctagaaga gtctattgtc
     2101 tccttggtta tattttttta actttaccat gctcaatgaa aaggtgattg tcaccatgat
     2161 cacttatcag tttgctaatg tttccatagt ttaggtactc aaactccatt ctccaggggt
     2221 ttacagtgaa gaaagcctgt tgtttaagtg actgaacgat ccttcaaagt ctcaatgaaa
     2281 taggagggaa acctttggct acacaattgg aagtctaaga acccatggaa aaatgccatc
     2341 aaatgaataa tgcctttgta accacaactt tcactataat gtgaaatgta actgtccgta
     2401 gtatcagaga tgtccatttt tacaagttat agtactagag atattttgta aaatgtatta
     2461 tgtcctgtga gatgtgtatc agtgtttatg tgctattaat atttgtttag ttcagcaaaa
     2521 ctgaaaggta gacttttatg agaacaatgg acaagcagtg gatacgtgtc aatgtgtgca
     2581 ctttttttct atattattgc ccatgatata actttagaaa taaaccttaa tatttcttca
     2641 aatatctcta tttaattttg acactgaaat aaccgtaaag gtttattttt ctgttacctc
     2701 aacaagaaga atttgaagac ttcaaaatat tgagcagaat tcattcatac ttaaaaattt
     2761 attagccctg cattttcata ggaagacaca ttatcttctg gactatagct gttctaatgg
     2821 attataatca gaatggaaga gagaaagcat attgactttt tttgagcgac atctctgact
     2881 ttctttagtc tttagctatt actggatctc ttaagacagc atgtgttaat cttaatgtat
     2941 atcgttatca ctgtgcagtt gctgtttact tgaatagtat tgtgttccta tattccaggt
     3001 ttaagtagat ttcatgcctg ggtggccaaa caacagtctt catttttttt aattgaaaag
     3061 aagtagtgtc tggatcagta aaattatact gtgtgtgagt gtgaatataa atgtgtgtat
     3121 gtgtgtttct gtcctgtaac tgttacagta atgtcataaa gtgagaaaac tgtgaccaag
     3181 tataaacttt taccacttgc tgcactcttg cacatggatt cagtttctaa aattgagttc
     3241 ttcctgtaat cttgttgata aaaatactga ctccaaccat tcaaaaattt caccccatcc
     3301 ctccttaaga gattggatca agtattacta aattgacctt taggtattac acaagaccag
     3361 tgcttagcaa aaaataatga caggcatcca aggaagggat gtatttgtag tgttattgcc
     3421 aggaaaggag agtactttgg tttctgagca ccgaatattg agcaatatgt cagtcactaa
     3481 aaggaagaca gttctacaga aaaacaatgg taacattttt caatagcgtg tgtagatagt
     3541 atgcactata tacatcacgt taaagtagga ctatcacacc cagcccatgt ggctaaaaaa
     3601 gctgaatcag acagtggatg agacacacaa cggcagtgaa gaaccgatac acttggcatt
     3661 gacgtctagc tatgctgtat ctgtgctttg cccacatgcc cttggtgaca gctgagcacc
     3721 cagctctgtc ttggtaggtt tgggctaagg aacaaatctc tcctttgctc gtggttagca
     3781 agatacactc aagcatgaag ataaacacag ctgctttctt cttacacccc ggtctcatgc
     3841 tccttaatgg cgccatgggt gcttgttggg cctttttcca gtaaggaatg atattgctga
     3901 agaatctact taaccctgac aaattttaat tataatctct tcttatacag ataaaacatg
     3961 actcctacaa ggccccaagg tttacatagt ctgaagtgaa gtacagagct ggcatctatc
     4021 tggtgatttc tagctctcga gatacccaag cagcctgatg gggcagttcc ccttcttacg
     4081 gttcacgctc taaggcagga tgtggcttat gagatacttt gcattgtctg tctgcacacc
     4141 ttgaatctgc ctgctggctc ccttacttta cctctctgtc atgtgcagat gaaggctcag
     4201 ggtgctagag gattagtaag atctctttct aaagacagga gagattattt acaagaagaa
     4261 ctcaccaggg tttagtttgc atttaagaat tgccagtctt ttgtcctgca tcatcttgaa
     4321 cattaatcca catgtttcag agctcaccag gcagtaccaa tgctcttttc acagctatga
     4381 agagctagag aaattcttgt tatggtagaa aaatttcacg attcattttt gaaactgcat
     4441 ttgtgcgtat gcagtgtaga ttttatagtg tgttgtgctt tcaagatcta aatcatatat
     4501 aataaattaa gggacaatgg ggctgacagc actaaacttg gtgcttattg atattctaag
     4561 aaatatctgt gaaatatcat cacgtatgtt atacaacctt catttaaaaa ggtttaaaac
     4621 tagttagatt cactttgaca cttttcatat catttcttaa cccaagtgac gaaaacattg
     4681 tccccaatga atatactcat tagaattacc atttgttaat atcactcatt aattaacccc
     4741 ataattagat ccattaattt aaatgattta aatttaagta agttttataa ggtctgacat
     4801 cagaggtatc ttactttcct ctgaggatga tgtacttgcc ctgaccatgc attttaccat
     4861 cacacatgtt cagaaagggc caaattccca acctgctcat ttttttttta tcagagtcat
     4921 gatgaatcag tcctagaatg tttcatttgc acaagtaggg ctgcctccaa gaggaacctc
     4981 tgatttattt tgtatgaaat atatgtgaaa ggatatgaat ctgagagatg ctgtagacat
     5041 ctgtcctaca cttgagatga tttccaagcc tctctggcac tttgagttaa gtctatctgg
     5101 tattaaatgc caaggacctt ttgctgccta aatccactct gcaggaaata ggcccaacca
     5161 ccagatgaga attaggccct ggatgagtag cgctatagtt actgtcctgt tgattaattt
     5221 ctgccatttc atgtccataa aagagaccac ccatatcatg cacacaatta gatttctcac
     5281 actctaactg tatatttgta tgatatttta aaatctccta aatgctgggc aatggctatt
     5341 aacaattaat tgtcttgcac tggccttctg atgaaatgtt aacaatgcct attgtaatat
     5401 agaaaaaaac attctatcta ctgatttggg ctgaatgtat gtaaataggt ttctaaaaag
     5461 tcagatgttt gagcagtggc ctacaaatca gtaattttcg gatgggagag tttctttaca
     5521 ttgccgtggc atcttaaaag ctatcttcat gtaaattgac tgtactaggc ctactgggga
     5581 tcagagttcc caagaaagga aaccttttct tgtatctgga ttcaaattta tttccaatgt
     5641 ttcaagcggg aaacatgact ctttattgtc tgtaaatcta acattattac ttttcctctt
     5701 agaagaatat tgtattgtta gatgtttgtt gagctggtaa catcgttgca accactgcaa
     5761 tatcttcgtt agtaatctgt ataatacttt gtatacaagt actggtaaga ttgttattaa
     5821 atgtagcttc agtcattaaa ttactatagc aaagtagtac ttcttctgta atatttacaa
     5881 tgtattaagc ccacagtata ttttatttca atgtaattaa actgttaact tattcaaaga
     5941 gaaaacatct catcatgtct attgtccaaa gttacctgga atcaaataaa aattctagat
     6001 taccatgaag aacataaaa
//
