LOCUS       NM_152755               1478 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens canopy FGF signaling regulator 4 (CNPY4), mRNA.
ACCESSION   NM_152755 XM_941945 XM_945568
VERSION     NM_152755.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1478)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1478)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1478)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1478)
  AUTHORS   Hart,B.E. and Tapping,R.I.
  TITLE     Cell surface trafficking of TLR1 is differentially regulated by the
            chaperones PRAT4A and PRAT4B
  JOURNAL   J Biol Chem 287 (20), 16550-16562 (2012)
   PUBMED   22447933
  REMARK    GeneRIF: a mechanism for the differential trafficking of TLR1 I602S
            variants, and highlight the distinct roles for PRAT4A and PRAT4B in
            the regulation of TLR1 surface expression.
REFERENCE   5  (bases 1 to 1478)
  AUTHORS   Konno,K., Wakabayashi,Y., Akashi-Takamura,S., Ishii,T.,
            Kobayashi,M., Takahashi,K., Kusumoto,Y., Saitoh,S., Yoshizawa,Y.
            and Miyake,K.
  TITLE     A molecule that is associated with Toll-like receptor 4 and
            regulates its cell surface expression
  JOURNAL   Biochem Biophys Res Commun 339 (4), 1076-1082 (2006)
   PUBMED   16338228
  REMARK    GeneRIF: A PRotein Associated with Tlr4 (PRAT4B), regulates cell
            surface expression of TLR4. PRAT4B has a signal peptide followed by
            a mature peptide. PRAT4B is associated with the hypoglycosylated,
            immature form of TLR4 but not with MD-2 or TLR2.
REFERENCE   6  (bases 1 to 1478)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073842.5 and BC032339.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152755.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.4587.1,
                                           SRR5189655.197117.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262932.5/ ENSP00000262932.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC073842.5         85053-85060         c
            9-1478              BC032339.1         1-1470
FEATURES             Location/Qualifiers
     source          1..1478
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1478
                     /gene="CNPY4"
                     /gene_synonym="PRAT4B"
                     /note="canopy FGF signaling regulator 4"
                     /db_xref="GeneID:245812"
                     /db_xref="HGNC:HGNC:28631"
                     /db_xref="MIM:610047"
     exon            1..229
                     /gene="CNPY4"
                     /gene_synonym="PRAT4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..858
                     /gene="CNPY4"
                     /gene_synonym="PRAT4B"
                     /note="PRotein Associated with Tlr4; protein canopy
                     homolog 4; canopy 4 homolog"
                     /codon_start=1
                     /product="protein canopy homolog 4 precursor"
                     /protein_id="NP_689968.1"
                     /db_xref="CCDS:CCDS34701.1"
                     /db_xref="GeneID:245812"
                     /db_xref="HGNC:HGNC:28631"
                     /db_xref="MIM:610047"
                     /translation="MGPVRLGILLFLFLAVHEAWAGMLKEEDDDTERLPSKCEVCKLL
                     STELQAELSRTGRSREVLELGQVLDTGKRKRHVPYSVSETRLEEALENLCERILDYSV
                     HAERKGSLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTYLKKQCETML
                     EEFEDIVGDWYFHHQEQPLQNFLCEGHVLPAAETACLQETWTGKEITDGEEKTEGEEE
                     QEEEEEEEEEEGGDKMTKTGSHPKLDREDL"
     exon            230..356
                     /gene="CNPY4"
                     /gene_synonym="PRAT4B"
                     /inference="alignment:Splign:2.1.0"
     exon            357..453
                     /gene="CNPY4"
                     /gene_synonym="PRAT4B"
                     /inference="alignment:Splign:2.1.0"
     exon            454..576
                     /gene="CNPY4"
                     /gene_synonym="PRAT4B"
                     /inference="alignment:Splign:2.1.0"
     exon            577..694
                     /gene="CNPY4"
                     /gene_synonym="PRAT4B"
                     /inference="alignment:Splign:2.1.0"
     exon            695..1478
                     /gene="CNPY4"
                     /gene_synonym="PRAT4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1451..1456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNPY4"
                     /gene_synonym="PRAT4B"
                     /note="hexamer: ATTAAA"
     polyA_site      1478
                     /gene="CNPY4"
                     /gene_synonym="PRAT4B"
                     /note="major polyA site"
ORIGIN      
        1 cttcctcggc tggatttaag gttgccgcta gccgcctggg aatttaaggg acccacacta
       61 ccttcccgaa gttgaaggca agcggtgatt gtttgtagac ggcgctttgt catgggacct
      121 gtgcggttgg gaatattgct tttccttttt ttggccgtgc acgaggcttg ggctgggatg
      181 ttgaaggagg aggacgatga cacagaacgc ttgcccagca aatgcgaagt gtgtaagctg
      241 ctgagcacag agctacaggc ggaactgagt cgcaccggtc gatctcgaga ggtgctggag
      301 ctggggcagg tgctggatac aggcaagagg aagagacacg tgccttacag cgtttcagag
      361 acaaggctgg aagaggcctt agagaattta tgtgagcgga tcctggacta tagtgttcac
      421 gctgagcgca agggctcact gagatatgcc aagggtcaga gtcagaccat ggcaacactg
      481 aaaggcctag tgcagaaggg ggtgaaggtg gatctgggga tccctctgga gctttgggat
      541 gagcccagcg tggaggtcac atacctcaag aagcagtgtg agaccatgtt ggaggagttt
      601 gaagacattg tgggagactg gtacttccac catcaggagc agcccctaca aaattttctc
      661 tgtgaaggtc atgtgctccc agctgctgaa actgcatgtc tacaggaaac ttggactgga
      721 aaggagatca cagatgggga agagaaaaca gaaggggagg aagagcagga ggaggaggag
      781 gaagaggagg aagaggaagg gggagacaag atgaccaaga caggaagcca ccccaaactt
      841 gaccgagaag atctttgacc cttgcctttg agcccccagg aggggaaggg atcatggaga
      901 gccctctaaa gcctgcactc tccctgctcc acagctttca gggtgtgttt atgagtgact
      961 ccacccaagc ttgtagctgt tctctcccat ctaacctcag gcaagatcct ggtgaaacag
     1021 catgacatgg cttctggggt ggagggtggg ggtggaggtc ctgctcctag agatgaactc
     1081 tatccagccc cttaattggc aggtgtatgt gctgacagta ctgaaagctt tcctctttaa
     1141 ctgatcccac ccccacccaa aagtcagcag tggcactgga gctgtgggct ttggggaagt
     1201 cacttagctc cttaaggtct gtttttagac ccttccaagg aagaggccag aacggacatt
     1261 ctctgcgatc tatatacatt gcctgtatcc aggaggctac acaccagcaa accgtgaagg
     1321 agaatgggac actgggtcat ggcctggagt tgctgataat ttaggtggga tagatacttg
     1381 gtctacttaa gctcaatgta acccagagcc caccatatag ttttataggt gctcaatttt
     1441 ctatatcgct attaaacttt tttctttttt tctaaaaa
//
