LOCUS       NM_006586               1431 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens canopy FGF signaling regulator 3 (CNPY3), transcript
            variant 1, mRNA.
ACCESSION   NM_006586
VERSION     NM_006586.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1431)
  AUTHORS   Mo,Y., Wang,S., Chang,Y., Sun,X., Liu,Z., Sun,P., Xu,Y., Zhong,X.
            and Peng,L.
  TITLE     A novel rare variant of CNPY3 from familial NMOSD impairs the
            TLR-mediated immune response
  JOURNAL   J Neuroimmunol 377, 578065 (2023)
   PUBMED   36931208
  REMARK    GeneRIF: A novel rare variant of CNPY3 from familial NMOSD impairs
            the TLR-mediated immune response.
REFERENCE   2  (bases 1 to 1431)
  AUTHORS   Ghait,M., Husain,R.A., Duduskar,S.N., Haack,T.B., Rooney,M.,
            Gohrig,B., Bauer,M., Rubio,I. and Deshmukh,S.D.
  TITLE     The TLR-chaperone CNPY3 is a critical regulator of
            NLRP3-inflammasome activation
  JOURNAL   Eur J Immunol 52 (6), 907-923 (2022)
   PUBMED   35334124
  REMARK    GeneRIF: The TLR-chaperone CNPY3 is a critical regulator of
            NLRP3-inflammasome activation.
REFERENCE   3  (bases 1 to 1431)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1431)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1431)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1431)
  AUTHORS   Kiyokawa,T., Akashi-Takamura,S., Shibata,T., Matsumoto,F.,
            Nishitani,C., Kuroki,Y., Seto,Y. and Miyake,K.
  TITLE     A single base mutation in the PRAT4A gene reveals differential
            interaction of PRAT4A with Toll-like receptors
  JOURNAL   Int Immunol 20 (11), 1407-1415 (2008)
   PUBMED   18780723
REFERENCE   7  (bases 1 to 1431)
  AUTHORS   Takahashi,K., Shibata,T., Akashi-Takamura,S., Kiyokawa,T.,
            Wakabayashi,Y., Tanimura,N., Kobayashi,T., Matsumoto,F., Fukui,R.,
            Kouro,T., Nagai,Y., Takatsu,K., Saitoh,S. and Miyake,K.
  TITLE     A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is
            required for TLR-dependent immune responses
  JOURNAL   J Exp Med 204 (12), 2963-2976 (2007)
   PUBMED   17998391
REFERENCE   8  (bases 1 to 1431)
  AUTHORS   Wakabayashi,Y., Kobayashi,M., Akashi-Takamura,S., Tanimura,N.,
            Konno,K., Takahashi,K., Ishii,T., Mizutani,T., Iba,H., Kouro,T.,
            Takaki,S., Takatsu,K., Oda,Y., Ishihama,Y., Saitoh,S. and Miyake,K.
  TITLE     A protein associated with toll-like receptor 4 (PRAT4A) regulates
            cell surface expression of TLR4
  JOURNAL   J Immunol 177 (3), 1772-1779 (2006)
   PUBMED   16849487
REFERENCE   9  (bases 1 to 1431)
  AUTHORS   Ozyildirim,A.M., Wistow,G.J., Gao,J., Wang,J., Dickinson,D.P.,
            Frierson,H.F. Jr. and Laurie,G.W.
  TITLE     The lacrimal gland transcriptome is an unusually rich source of
            rare and poorly characterized gene transcripts
  JOURNAL   Invest Ophthalmol Vis Sci 46 (5), 1572-1580 (2005)
   PUBMED   15851553
REFERENCE   10 (bases 1 to 1431)
  AUTHORS   Margolis,R.L., Abraham,M.R., Gatchell,S.B., Li,S.H., Kidwai,A.S.,
            Breschel,T.S., Stine,O.C., Callahan,C., McInnis,M.G. and Ross,C.A.
  TITLE     cDNAs with long CAG trinucleotide repeats from human brain
  JOURNAL   Hum Genet 100 (1), 114-122 (1997)
   PUBMED   9225980
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC004423.1, AI202110.1 and
            AL035587.5.
            
            On May 17, 2019 this sequence version replaced NM_006586.4.
            
            Summary: This gene encodes a protein that binds members of the
            toll-like receptor protein family and functions as a chaperone to
            aid in folding and export of these proteins. Alternative splicing
            results in multiple transcript variants. Naturally occuring
            readthrough transcription occurs between this locus and the
            downstream GNMT (glycine N-methyltransferase) gene and is
            represented with GeneID:107080644. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.263217.1,
                                           SRR7346977.284684.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372836.5/ ENSP00000361926.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1400              BC004423.1         297-1696
            1401-1424           AI202110.1         11-34               c
            1425-1431           AL035587.5         12110-12116         c
FEATURES             Location/Qualifiers
     source          1..1431
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..1431
                     /gene="CNPY3"
                     /gene_synonym="CAG4A; DEE60; EIEE60; ERDA5; PRAT4A; TNRC5"
                     /note="canopy FGF signaling regulator 3"
                     /db_xref="GeneID:10695"
                     /db_xref="HGNC:HGNC:11968"
                     /db_xref="MIM:610774"
     exon            1..242
                     /gene="CNPY3"
                     /gene_synonym="CAG4A; DEE60; EIEE60; ERDA5; PRAT4A; TNRC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..928
                     /gene="CNPY3"
                     /gene_synonym="CAG4A; DEE60; EIEE60; ERDA5; PRAT4A; TNRC5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein associated with Toll-like receptor 4A;
                     CAG repeat containing; protein canopy homolog 3; CTG
                     repeat protein 4a; protein associated with TLR4; expanded
                     repeat-domain protein CAG/CTG 5; trinucleotide
                     repeat-containing gene 5 protein"
                     /codon_start=1
                     /product="protein canopy homolog 3 isoform 1 precursor"
                     /protein_id="NP_006577.2"
                     /db_xref="CCDS:CCDS4875.1"
                     /db_xref="GeneID:10695"
                     /db_xref="HGNC:HGNC:11968"
                     /db_xref="MIM:610774"
                     /translation="MDSMPEPASRCLLLLPLLLLLLLLLPAPELGPSQAGAEENDWVR
                     LPSKCEVCKYVAVELKSAFEETGKTKEVIGTGYGILDQKASGVKYTKSDLRLIEVTET
                     ICKRLLDYSLHKERTGSNRFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVA
                     DLKKQCDVLVEEFEEVIEDWYRNHQEEDLTEFLCANHVLKGKDTSCLAEQWSGKKGDT
                     AALGGKKSKKKSSRAKAAGGRSSSSKQRKELGGLEGDPSPEEDEGIQKASPLTHSPPD
                     EL"
     exon            243..366
                     /gene="CNPY3"
                     /gene_synonym="CAG4A; DEE60; EIEE60; ERDA5; PRAT4A; TNRC5"
                     /inference="alignment:Splign:2.1.0"
     exon            367..463
                     /gene="CNPY3"
                     /gene_synonym="CAG4A; DEE60; EIEE60; ERDA5; PRAT4A; TNRC5"
                     /inference="alignment:Splign:2.1.0"
     exon            464..586
                     /gene="CNPY3"
                     /gene_synonym="CAG4A; DEE60; EIEE60; ERDA5; PRAT4A; TNRC5"
                     /inference="alignment:Splign:2.1.0"
     exon            587..704
                     /gene="CNPY3"
                     /gene_synonym="CAG4A; DEE60; EIEE60; ERDA5; PRAT4A; TNRC5"
                     /inference="alignment:Splign:2.1.0"
     exon            705..1431
                     /gene="CNPY3"
                     /gene_synonym="CAG4A; DEE60; EIEE60; ERDA5; PRAT4A; TNRC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1379..1384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNPY3"
                     /gene_synonym="CAG4A; DEE60; EIEE60; ERDA5; PRAT4A; TNRC5"
                     /note="hexamer: AGTAAA"
     polyA_site      1400
                     /gene="CNPY3"
                     /gene_synonym="CAG4A; DEE60; EIEE60; ERDA5; PRAT4A; TNRC5"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcccgg aagcggcgag gggaaactgc tccgcgcgcg ccgcgggagg aggaaccgcc
       61 cggtccttta gggtccgggc ccggccgggc catggattca atgcctgagc ccgcgtcccg
      121 ctgtcttctg cttcttccct tgctgctgct gctgctgctg ctgctgccgg ccccggagct
      181 gggcccgagc caggccggag ctgaggagaa cgactgggtt cgcctgccca gcaaatgcga
      241 agtgtgtaaa tatgttgctg tggagctgaa gtcagccttt gaggaaaccg gcaagaccaa
      301 ggaggtgatt ggcacgggct atggcatcct ggaccagaag gcctctggag tcaaatacac
      361 caagtcggac ttgcggttaa tcgaagtcac tgagaccatt tgcaagaggc tcctggatta
      421 tagcctgcac aaggagagga ccggcagcaa tcgatttgcc aagggcatgt cagagacctt
      481 tgagacatta cacaacctgg tacacaaagg ggtcaaggtg gtgatggaca tcccctatga
      541 gctgtggaac gagacttctg cagaggtggc tgacctcaag aagcagtgtg atgtgctggt
      601 ggaagagttt gaggaggtga tcgaggactg gtacaggaac caccaggagg aagacctgac
      661 tgaattcctc tgcgccaacc acgtgctgaa gggaaaagac accagttgcc tggcagagca
      721 gtggtccggc aagaagggag acacagctgc cctgggaggg aagaagtcca agaagaagag
      781 cagcagggcc aaggcagcag gcggcaggag tagcagcagc aaacaaagga aggagctggg
      841 tggccttgag ggagacccca gccccgagga ggatgagggc atccagaagg catcccctct
      901 cacacacagc ccccctgatg agctctgagc ccacccagca tcctctgtcc tgagacccct
      961 gattttgaag ctgaggagtc aggggcatgg ctctggcagg ccgggatggc cccgcagcct
     1021 tcagcccctc cttgccttgg ctgtgccctc ttctgccaag gaaagacaca agccccagga
     1081 agaactcaga gccgtcatgg gtagcccacg ccgtcctttc ccctccccaa gtgtttctct
     1141 cctgacccag ggttcaggca ggccttgtgg tttcaggact gcaaggactc cagtgtgaac
     1201 tcaggagggg caggtgtcag aactgggcac caggactgga gccccctccg gagaccaaac
     1261 tcaccatccc tcagtcctcc ccaacagggt actaggactg cagccccctg tagctcctct
     1321 ctgcttaccc ctcctgtgga caccttgcac tctgcctggc ccttcccaga gcccaaagag
     1381 taaaaatgtt ctggttctga tttctgagtc ctctgcagcc ctcagaggtg c
//
