LOCUS       NM_001393663            2522 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens canopy FGF signaling regulator 1 (CNPY1), transcript
            variant 20, mRNA.
ACCESSION   NM_001393663
VERSION     NM_001393663.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2522)
  AUTHORS   Hirate,Y. and Okamoto,H.
  TITLE     Canopy1, a novel regulator of FGF signaling around the
            midbrain-hindbrain boundary in zebrafish
  JOURNAL   Curr Biol 16 (4), 421-427 (2006)
   PUBMED   16488878
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009403.5 and AC008060.5.
            
            Summary: Cnpy1 is expressed in the midbrain-hindbrain (MHB)
            boundary in zebrafish, binds FGFR1 (MIM 136350), and plays a role
            in FGF signaling (Hirate and Okamoto, 2006 [PubMed
            16488878]).[supplied by OMIM, Dec 2008].
            
            Transcript Variant: This variant (20) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.139597.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2148874,
                                           SAMEA2151405 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            MANE Ensembl match               :: ENST00000636446.2/
                                                ENSP00000490477.3
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AC009403.5         15907-16037         c
            132-244             AC009403.5         15309-15421         c
            245-448             AC008060.5         139738-139941       c
            449-545             AC008060.5         137864-137960       c
            546-2522            AC008060.5         131973-133949       c
FEATURES             Location/Qualifiers
     source          1..2522
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.3"
     gene            1..2522
                     /gene="CNPY1"
                     /note="canopy FGF signaling regulator 1"
                     /db_xref="GeneID:285888"
                     /db_xref="HGNC:HGNC:27786"
                     /db_xref="MIM:612493"
     exon            1..131
                     /gene="CNPY1"
                     /inference="alignment:Splign:2.1.0"
     exon            132..244
                     /gene="CNPY1"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..583
                     /gene="CNPY1"
                     /note="isoform a is encoded by transcript variant 20;
                     protein canopy homolog 1; canopy 1 homolog"
                     /codon_start=1
                     /product="protein canopy homolog 1 isoform a"
                     /protein_id="NP_001380592.1"
                     /db_xref="CCDS:CCDS94241.1"
                     /db_xref="GeneID:285888"
                     /db_xref="HGNC:HGNC:27786"
                     /db_xref="MIM:612493"
                     /translation="MDEIEHDITKARQKKTKVGSFRINPDGTQERRKIPLAQSEAFLT
                     DLLEKVCERMNDYKLEEDPVTKERTFKRFAPRKGDKIYQEFKKLYFYSDAYRPLKFAC
                     ETIIEEYEDEISSLIAQETHYLADKLCSEKSDLCETSANHTEL"
     exon            245..448
                     /gene="CNPY1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..545
                     /gene="CNPY1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..2522
                     /gene="CNPY1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      673..678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNPY1"
                     /note="hexamer: AAGAAA"
     polyA_site      696
                     /gene="CNPY1"
                     /note="major polyA site"
     regulatory      2496..2501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNPY1"
                     /note="hexamer: ATTAAA"
     polyA_site      2522
                     /gene="CNPY1"
                     /note="major polyA site"
ORIGIN      
        1 actgcactcc agcctgggtg acagagcaag actctgtctc aaaaaataaa taaatgaata
       61 aataggaaag cacatttgaa ggctgcacat ggtggctgat acttgtaatc ccagcaattc
      121 aggaggccaa gcgtgcaggg cgctgatgga cgagatagag cacgacatca ccaaggctcg
      181 gcagaagaag accaaggtgg gatccttccg aatcaatccc gatgggactc aggagaggag
      241 aaagatcccc ctagctcagt cggaggcgtt cctaacggat cttttggaga aagtctgtga
      301 gcgaatgaac gactacaagc ttgaggaaga ccctgtgacg aaggagagaa ctttcaagag
      361 attcgctcct aggaaaggag acaaaatata ccaagaattt aaaaaattgt atttttattc
      421 tgatgcttac agacctttga aatttgcgtg tgaaactata atagaagagt atgaagatga
      481 aatatcctca cttatcgccc aggagacaca ctatctagct gacaagctgt gcagtgaaaa
      541 atcagatctg tgtgaaactt ctgctaatca tactgagctc taggagtgcc gttctgctgg
      601 tcgtagagag gagtaaagtc acacccaaag gtcaatgtct gcattttatg tttgcatgtt
      661 gtctttcatg ataagaaaaa ttttgtctct tgtttatacc gtgtttgtct ccgtttatga
      721 ttcattttga aaatctgttg gttgacatca tgacaaaccc tgcgtttttt tataggtgaa
      781 gctgaggagt acatgaaact taaattaacc tttgcagatt ttgataaatc aagcttgaca
      841 atagaggatt taattctgta ttgaggaaaa aagcgaagac atttcataaa caaaataggg
      901 atttcataat gtatgctgct tattttataa cagtgtatgt gcacatatgc aagcgcagtg
      961 gctgtctgat aagaactgga tttgaatcct caaatacttg attgcctata aatttaagga
     1021 aatacatggc aacaaattca aaatgtggcc ttctgggtga gatatggcta ttagtgaaag
     1081 aaacccactt tttatcagga atgaaattaa aatttttaga aaccacaagt ttaaaaaccc
     1141 atctctaaaa tttagtggaa tgtgtaaaaa ctaatgaatg ctttaattta tagtaaacaa
     1201 taattatatt ggcctctcaa acaccattct gagtttaagt ggcttagaaa gttgatttat
     1261 tattgcatca ggtgttaaaa gatgacacta gtgattgcgt tttgtttcgc tccaaactct
     1321 tctggcttgt ttgtttttct tctaaacgtt ttttttttgg ctcacattta gtgtgttgag
     1381 tttactacta aataatctac cattcttcta caggaatgga aaaagagttg ggacctggtg
     1441 ggaaattatc ttttggccac acttaatata caaagtctag taacaatcac tcccggaaat
     1501 ttctttatct ctgttacatt tgcattcaat ggaatctgac tttaatgatt aaaaatgtca
     1561 gggtatggtc tacaccagtt tctaaaaaga gattctcatt gtctttggtg acaatcaagt
     1621 gggtaggatg ctacaaatcc cccccccaac ccccccgacc caaaactctt tgccatattg
     1681 ttacttagtt gcttaaaaag cacattatgt gtttaaatca ttctcctgac tcttcagcag
     1741 gaaacaattc ttaaatttag gaaaatttac caaagctaag gggaagggct ttccatgccc
     1801 cctccccacc taaactctga ttaaaagtta gtgagttaat gtcacttaat tacttgggtg
     1861 cttctttttt gtcttgtctg tggctgctta agtctgatgg ctcctacata acccagcgaa
     1921 ctcgcacccg agctgacaca cgatggaaat agaactgaat aataattaac actattttcc
     1981 agtagggtag gacaattgtt atttaaaaca tagtccctat agctttattt aaacgtatct
     2041 agttaaggtt aatttggcat ttaaagtagt aaatcaggaa cattctccta acttggattt
     2101 tcttgggaaa tgcactaaac aggacaatta ttcctgaaaa cctagtgacc ttcacaggaa
     2161 catggcggga cctgtgacac taagtaagct tcagtgaaaa ctgttcacgg tcgtaaccgt
     2221 agaagtgttg ccaaatctgt ttccatactc tctttgatca tcatcaaaca ttctcaaatg
     2281 taggcaatgc taacactaat tatagaaatt aagaaaatgt gggctcctgt ttgtaactaa
     2341 acggacgtgg ggaggtgcac ctcctgtcac tgaggggtgc ctttcatgga cagtgatgct
     2401 ttgctttgaa tggagagggc gaggaacctt gacttacagt gactatctaa ggttgtgata
     2461 aatatggcat ttcaggtttt tttcttggat ttcccattaa aaatagtctt gtatcttgca
     2521 aa
//
