LOCUS       NM_033133               5172 bp    mRNA    linear   PRI 19-MAR-2025
DEFINITION  Homo sapiens 2'',3''-cyclic nucleotide 3'' phosphodiesterase (CNP),
            transcript variant 1, mRNA.
ACCESSION   NM_033133
VERSION     NM_033133.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5172)
  AUTHORS   Qu,W., Jiang,L. and Hou,G.
  TITLE     Circ-AFF2/miR-650/CNP axis promotes proliferation, inflammatory
            response, migration, and invasion of rheumatoid arthritis synovial
            fibroblasts
  JOURNAL   J Orthop Surg Res 16 (1), 165 (2021)
   PUBMED   33653372
  REMARK    GeneRIF: Circ-AFF2/miR-650/CNP axis promotes proliferation,
            inflammatory response, migration, and invasion of rheumatoid
            arthritis synovial fibroblasts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5172)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5172)
  AUTHORS   Al-Abdi,L., Al Murshedi,F., Elmanzalawy,A., Al Habsi,A., Helaby,R.,
            Ganesh,A., Ibrahim,N., Patel,N. and Alkuraya,F.S.
  TITLE     CNP deficiency causes severe hypomyelinating leukodystrophy in
            humans
  JOURNAL   Hum Genet 139 (5), 615-622 (2020)
   PUBMED   32128616
  REMARK    GeneRIF: CNP deficiency causes severe hypomyelinating
            leukodystrophy.
REFERENCE   4  (bases 1 to 5172)
  AUTHORS   Li,Y., Zhao,Y. and Wang,Y.
  TITLE     2',3'-Cyclic-nucleotide 3'-phosphodiesterase contributes to
            epithelial-mesenchymal transition of lens epithelial cells through
            the notch signalling pathway
  JOURNAL   Cell Prolif 52 (6), e12707 (2019)
   PUBMED   31617266
  REMARK    GeneRIF: 2',3'-Cyclic-nucleotide 3'-phosphodiesterase contributes
            to epithelial-mesenchymal transition of lens epithelial cells
            through the notch signalling pathway
REFERENCE   5  (bases 1 to 5172)
  AUTHORS   Garcia-Agudo,L.F., Janova,H., Sendler,L.E., Arinrad,S.,
            Steixner,A.A., Hassouna,I., Balmuth,E., Ronnenberg,A., Schopf,N.,
            van der Flier,F.J., Begemann,M., Martens,H., Weber,M.S.,
            Boretius,S., Nave,K.A. and Ehrenreich,H.
  TITLE     Genetically induced brain inflammation by Cnp deletion transiently
            benefits from microglia depletion
  JOURNAL   FASEB J 33 (7), 8634-8647 (2019)
   PUBMED   31090455
  REMARK    GeneRIF: Catatonia-related executive dysfunction and brain atrophy
            of Cnp(-/-) mice fail to improve under PLX5622.
REFERENCE   6  (bases 1 to 5172)
  AUTHORS   Thompson,R.J.
  TITLE     2',3'-cyclic nucleotide-3'-phosphohydrolase and signal transduction
            in central nervous system myelin
  JOURNAL   Biochem Soc Trans 20 (3), 621-626 (1992)
   PUBMED   1385234
  REMARK    Review article
REFERENCE   7  (bases 1 to 5172)
  AUTHORS   Douglas,A.J., Fox,M.F., Abbott,C.M., Hinks,L.J., Sharpe,G.,
            Povey,S. and Thompson,R.J.
  TITLE     Structure and chromosomal localization of the human 2',3'-cyclic
            nucleotide 3'-phosphodiesterase gene
  JOURNAL   Ann Hum Genet 56 (3), 243-254 (1992)
   PUBMED   1360194
REFERENCE   8  (bases 1 to 5172)
  AUTHORS   Sprinkle,T.J., Lanclos,K.D. and Lapp,D.F.
  TITLE     Assignment of the human 2',3'-cyclic nucleotide 3'-phosphohydrolase
            gene to chromosome 17
  JOURNAL   Genomics 13 (3), 877-880 (1992)
   PUBMED   1322358
REFERENCE   9  (bases 1 to 5172)
  AUTHORS   Leroy,M.J., Dumler,I., Lugnier,C., Shushakova,N.D. and Ferre,F.
  TITLE     A new peptide (1150Da) selectively activates the calcium-calmodulin
            sensitive isoform of cyclic nucleotide phosphodiesterase from human
            myometrium
  JOURNAL   Biochem Biophys Res Commun 184 (2), 700-705 (1992)
   PUBMED   1315529
REFERENCE   10 (bases 1 to 5172)
  AUTHORS   Staugaitis,S.M., Bernier,L., Smith,P.R. and Colman,D.R.
  TITLE     Expression of the oligodendrocyte marker 2'3'-cyclic nucleotide
            3'-phosphodiesterase in non-glial cells
  JOURNAL   J Neurosci Res 25 (4), 556-560 (1990)
   PUBMED   2161933
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125257.4.
            
            On Nov 23, 2018 this sequence version replaced NM_033133.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.132563.1,
                                           SRR1660809.82549.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393892.8/ ENSP00000377470.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC125257.4         131484-131576
            94-766              AC125257.4         132757-133429
            767-906             AC125257.4         136581-136720
            907-5168            AC125257.4         138164-142425
            5169-5172           AC125257.4         142426-142429
FEATURES             Location/Qualifiers
     source          1..5172
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..5172
                     /gene="CNP"
                     /gene_synonym="CN37; CNP1; HLD20"
                     /note="2'',3''-cyclic nucleotide 3'' phosphodiesterase"
                     /db_xref="GeneID:1267"
                     /db_xref="HGNC:HGNC:2158"
                     /db_xref="MIM:123830"
     exon            1..93
                     /gene="CNP"
                     /gene_synonym="CN37; CNP1; HLD20"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1356
                     /gene="CNP"
                     /gene_synonym="CN37; CNP1; HLD20"
                     /EC_number="3.1.4.37"
                     /note="isoform 1 is encoded by transcript variant 1; 2',
                     3' cyclic nucleotide 3' phosphohydrolase; CNPase;
                     2',3'-cyclic nucleotide 3' phosphodiesterase"
                     /codon_start=1
                     /product="2',3'-cyclic-nucleotide 3'-phosphodiesterase
                     isoform 1"
                     /protein_id="NP_149124.3"
                     /db_xref="CCDS:CCDS11414.2"
                     /db_xref="GeneID:1267"
                     /db_xref="HGNC:HGNC:2158"
                     /db_xref="MIM:123830"
                     /translation="MNRGFSRKSHTFLPKIFFRKMSSSGAKDKPELQFPFLQDEDTVA
                     TLLECKTLFILRGLPGSGKSTLARVIVDKYRDGTKMVSADAYKITPGARGAFSEEYKR
                     LDEDLAAYCRRRDIRILVLDDTNHERERLEQLFEMADQYQYQVVLVEPKTAWRLDCAQ
                     LKEKNQWQLSADDLKKLKPGLEKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKA
                     FKKELRQFVPGDEPREKMDLVTYFGKRPPGVLHCTTKFCDYGKAPGAEEYAQQDVLKK
                     SYSKAFTLTISALFVTPKTTGARVELSEQQLQLWPSDVDKLSPTDNLPRGSRAHITLG
                     CAADVEAVQTGLDLLEILRQEKGGSRGEEVGELSRGKLYSLGNGRWMLTLAKNMEVRA
                     IFTGYYGKGKPVPTQGSRKGGALQSCTII"
     exon            94..766
                     /gene="CNP"
                     /gene_synonym="CN37; CNP1; HLD20"
                     /inference="alignment:Splign:2.1.0"
     exon            767..906
                     /gene="CNP"
                     /gene_synonym="CN37; CNP1; HLD20"
                     /inference="alignment:Splign:2.1.0"
     exon            907..5172
                     /gene="CNP"
                     /gene_synonym="CN37; CNP1; HLD20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2587..2592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNP"
                     /gene_synonym="CN37; CNP1; HLD20"
                     /note="hexamer: AATAAA"
     polyA_site      2606
                     /gene="CNP"
                     /gene_synonym="CN37; CNP1; HLD20"
                     /note="major polyA site"
     regulatory      3911..3916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNP"
                     /gene_synonym="CN37; CNP1; HLD20"
                     /note="hexamer: AATAAA"
     polyA_site      3936
                     /gene="CNP"
                     /gene_synonym="CN37; CNP1; HLD20"
     regulatory      5117..5122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNP"
                     /gene_synonym="CN37; CNP1; HLD20"
                     /note="hexamer: GATAAA"
     regulatory      5147..5152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNP"
                     /gene_synonym="CN37; CNP1; HLD20"
                     /note="hexamer: AATAAA"
     polyA_site      5148
                     /gene="CNP"
                     /gene_synonym="CN37; CNP1; HLD20"
     polyA_site      5172
                     /gene="CNP"
                     /gene_synonym="CN37; CNP1; HLD20"
ORIGIN      
        1 accgctggac tcccgtgtcc ctccgcgcag gcgggcggcc ccggagcgct ggtgccggca
       61 gaggcggcga cggtggcgcc cctcctcatc atgaacagag gcttctcccg aaaaagccac
      121 acattcctgc ccaagatctt cttccgcaag atgtcatcct caggggccaa ggacaagcct
      181 gagctgcagt ttcccttcct tcaggatgag gacacagtgg ccacgctgct agagtgcaag
      241 acgctcttca tcttgcgcgg cctgccagga agcggcaagt ccacgctggc acgggtcatc
      301 gtggacaagt accgtgatgg caccaagatg gtgtcggctg acgcttacaa gatcaccccc
      361 ggcgctcgag gagccttctc cgaggagtac aagcggctcg atgaggacct ggctgcctac
      421 tgccgccgcc gggacatcag aattcttgtg cttgatgaca ccaaccacga acgggaacgg
      481 ctggagcagc tctttgaaat ggccgaccag taccagtacc aggtggtgct ggtggagccc
      541 aagacggcgt ggcggctgga ctgtgcccag ctcaaggaga agaaccagtg gcagctgtcg
      601 gctgatgacc tgaagaagct gaagcctggg ctggagaagg acttcctgcc gctctacttc
      661 ggctggttcc tgaccaagaa gagctctgag accctccgca aagccggcca ggtcttcctg
      721 gaagagctgg ggaaccacaa ggccttcaag aaggagctgc gacaattcgt ccctggggat
      781 gagcccaggg agaagatgga cttggtcacc tactttggaa agagaccccc aggcgtgctg
      841 cattgcacaa ccaagttttg tgactacggg aaggctcccg gggcagagga gtacgctcaa
      901 caagatgtgt taaagaaatc ttactccaag gccttcacgc tgaccatctc tgccctcttt
      961 gtgacaccca agacgactgg ggcccgggtg gagttaagcg agcagcaact gcagttgtgg
     1021 ccgagtgatg tggacaagct gtcacccact gacaacctgc cgcgggggag ccgcgcccac
     1081 atcaccctcg gctgtgcagc tgacgtagag gccgtgcaga cgggccttga cctcttagag
     1141 attctgcggc aggagaaggg gggcagccga ggcgaggagg tgggcgagct aagccggggc
     1201 aagctctatt ccttgggcaa tgggcgctgg atgctgaccc tggccaagaa catggaggtc
     1261 agggccatct tcacggggta ctacgggaaa ggcaaacctg tgcccacgca aggtagccgg
     1321 aaggggggcg ccttgcagtc ctgcaccatc atatgagtgt tctcaccacc acttatgccc
     1381 ctagaaggga aggggagagg gaaacgtgcc ctctgtttga tccttgtttt gtgacatttt
     1441 tttttttttt ttttttactc aaagttaacc tacctgtaac tttttaaaaa cttgtaaaat
     1501 aactgaccct cccttcctgt ccgccctctt cccctctaat gctcacgctc ccaacacaag
     1561 gtgggcaggg aggcaccatt caggaacctg gaccaaagct gacgaggctg ggccaagcca
     1621 gggatggggc cacagccaga accccgagcc ctacttccag gttctggtta gctcagcccc
     1681 agcccagccc agctgctctg cccagagctg ggtgagtggg gagacacctc agagccccgc
     1741 aaaacccact gaccggaggc aaaaggcagt ggggctgggg gtagttttcc atggtcacag
     1801 agaactagtg gtggctctga gaaggggagg acctctgggc tttgattcca tctccttgtc
     1861 ttttttcttt gtttttagag acagggtcct gctatttccc aagctggagt gcagtggtgc
     1921 gatcatggct cactgcagcc tcgaactcct gggctcaagc aatcctcctg agtgatccca
     1981 tttcttaatc agtgtagccc caagaaggct ggggctattt accagggtag aaaaaggagc
     2041 ttacctccca cctttggtcc taagtccctg ccccctcccc ttcacaccat aactaggtaa
     2101 cagtttgata actagggaag aaagcagaac agttaagcag ccgccacatc cccgctggct
     2161 gggggcctca ctccaggaag gggctggact ggctgtcctt tccagtggcc tggctccgct
     2221 gtgtggatgg ggagatcggg gccagaggca gaaccctggt gaggaagctc cagtcctgct
     2281 ctctacccag cccatcttgc ctccatggtg cctctggagg cctctgggcc tcctctaaca
     2341 ggggctggtg ggcaccaaga gccaatggag tagacccctg gctggtaagg gccaagtccc
     2401 accggttgct tctgggaagg ggtttctaac actagtctgt gtgctgtggt tcctggggtg
     2461 ccctccactg ccctctgttc agtaacaggg ccttgctaat cgggttgtca ctcaacaaaa
     2521 gtgctttgga tttaagttac tatcctggct ttgcccaacc tcagcaacct gtaagactga
     2581 taatgaaata aatcatgtta atcctagctg tgtgcagtct ctcttaccct tctgtgccca
     2641 gctcagtctt ccctagggct gggtgtatta ggactggctt tgtcccacag cttggggcca
     2701 tcggtcctgt ctcccctctg ctggccgggc acagctgtgg tgaggttggg cagctgaaca
     2761 gtgttggctt tcatgaggag gcagaaagca gaggctggcc tcagactcat acagaaggtg
     2821 ggggttggct gggtacgagg gatgtggagc acaaaagcct ctcatccccc attaaccagg
     2881 gcaccaagcc cacaggtgtc cccagcccac tggatcagaa agagttcagt aagaccggaa
     2941 gctcctggta tgggtttctc ccagttctct agggaaggcc acctgcaggt cactgaaact
     3001 tcaagcacca gggaagatct aacatttgag tcccttccag gccatcagag gcctagtcag
     3061 ccacatggga aacttccaag acctgactca ggcatcattc caccatggct aaggcaccag
     3121 ccggggaaga cttgaaagaa aggggcagga gctcagatga agagaaatcc taagttacct
     3181 ttctaggtca aggcctgtcc ctggccatct ctgaacttca gctagagctt caagtctgtg
     3241 cctggagctc ctgggaaggc tactcacctt gaacaccacg cttgacagga cagcatggtg
     3301 catgccgctg catccgtgag cagtgtgtct cctgcatgca gaaagggagc agagaaggcc
     3361 aggggctttt gctaaaaata gtggccagac cagagctctg gagccacctg tcccacctca
     3421 aatgggtctg ggggtcagga ggcagggttt tatctctgtc taccatctcc ctcgaaccca
     3481 cactgcaaca ggaactgtga gagtctttgt aagtaaactg ccctgtctag gtcagtaccc
     3541 acctgagctt tggacgcaca cagcttttag tacccacctg agctttggac acacacagct
     3601 tctagtgatt tctggggccc caccgtaaag tgagcatgct ttctgaactc gcttctctgt
     3661 gactgatgtt aggctgggcc cagaggcaca gccggggcct gcctagcact cacatgctgg
     3721 acaggtctgg gagaggcaga gtgccccacc tgccactagg ctgggtgccc acagcccgca
     3781 tgcagcagct tgctgcaccc caagtccagg tcgggctcag ctctggctca cagactggag
     3841 acaatgcaga tgccagagca aagggccagg aagggtcaaa acattttatt ctcttttttt
     3901 tttctttttt aataaagtta aacagtaaaa caaaaattca caagctgcct ccctgtccac
     3961 ccccgcctcc ctcccctgcc ctcggtcttc ggcattggtt ccctttgctc caccccactc
     4021 acagagacac agggcatcca actgagaaaa cgaaactgct ctaagcacac ggagacgtga
     4081 tgaagggagg aggtgaactg tttccacatt caagattaaa ctgagtgaat ctgcattttc
     4141 tgggttctgg gtggttgccc ttcattagcc aaattgaaaa aagaaattcc ctggaccaga
     4201 tgctgaaaga gaaaagaggg gttggtagtt ggctatggat tttctaagga agatcacttt
     4261 gctctgatta tggaaaagtc ttcaagggct gcttcaaact caaacacaga gagaaactct
     4321 atgggtatca aacagctcag gctgtttttg ggtgcaagag ggagcacgtg actgtattat
     4381 acatgggtag cttctgacct cagcattatc tatatagtac ctttgctctt gcagagaagc
     4441 cttggtacta ggcagttaga gatgcctccc tgaccctgca gagatgcggt ggctaaaggt
     4501 cccaaggcaa ggggtgcctg ggaaccttcc tgtcttcatc cttagcaaca gccgagtgga
     4561 tagatgccct gctagatgag aattcagctg cccccgctca tgggcccctc tgactcccaa
     4621 agagctgcct aagaggcaat gagtgtgttg gcttgtgatc tgggaactcc caagaacagc
     4681 aggcccacct accttcaaag ctgaagccgc caggaccgcc aaagaatgcc ttgaagatat
     4741 tgtttggatc aaaatctgta gagcagggca agtaacatgg aagggaagaa aaggtgaaaa
     4801 attagaaatg ttcgaagaga actgatgaca ctgagaacag atctccaaag ctttcctgga
     4861 gagtctcact cccctccttt cccaacactt cagactgcaa gtgagcaaac ctgccccatc
     4921 ccgtgcaaaa catgctacct gatcccactc ctaggacatg ttcccttctc cttccaactg
     4981 ctgccccaaa ggaagctttc tctgcttcag cttgcttcat tgggctgttt tctcaacaaa
     5041 tggaatgcca tttgcactta cacaagactt tccccatact ctgtctccct ataatgctgg
     5101 agcggctact aaaaaggata aaatgtatca cttaaatgtt accaaaaata aatataagag
     5161 caagatctag ga
//
