LOCUS       NM_001370472            6219 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens CCR4-NOT transcription complex subunit 6 (CNOT6),
            transcript variant 1, mRNA.
ACCESSION   NM_001370472 XM_011534606
VERSION     NM_001370472.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6219)
  AUTHORS   Chen,Y., Khazina,E., Izaurralde,E. and Weichenrieder,O.
  TITLE     Crystal structure and functional properties of the human CCR4-CAF1
            deadenylase complex
  JOURNAL   Nucleic Acids Res 49 (11), 6489-6510 (2021)
   PUBMED   34038562
  REMARK    GeneRIF: Crystal structure and functional properties of the human
            CCR4-CAF1 deadenylase complex.
REFERENCE   2  (bases 1 to 6219)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6219)
  AUTHORS   Raisch,T., Chang,C.T., Levdansky,Y., Muthukumar,S., Raunser,S. and
            Valkov,E.
  TITLE     Reconstitution of recombinant human CCR4-NOT reveals molecular
            insights into regulated deadenylation
  JOURNAL   Nat Commun 10 (1), 3173 (2019)
   PUBMED   31320642
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6219)
  AUTHORS   Morita,M., Siddiqui,N., Katsumura,S., Rouya,C., Larsson,O.,
            Nagashima,T., Hekmatnejad,B., Takahashi,A., Kiyonari,H., Zang,M.,
            St-Arnaud,R., Oike,Y., Giguere,V., Topisirovic,I.,
            Okada-Hatakeyama,M., Yamamoto,T. and Sonenberg,N.
  TITLE     Hepatic posttranscriptional network comprised of CCR4-NOT
            deadenylase and FGF21 maintains systemic metabolic homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 116 (16), 7973-7981 (2019)
   PUBMED   30926667
  REMARK    GeneRIF: Studied hepatic role in metabolic homeostasis of
            fibroblast growth factor 21(FGF21) and the 'CCR4-NOT complex' (a
            multisubunit protein complex composed of 'CCR4-NOT transcription
            complex subunit 6 like' (CNOT6L) and 'CCR4-NOT transcription
            complex subunit 6' (CNOT6). Results show CNOT6L plays a major role
            in regulation FGF21 levels.
REFERENCE   5  (bases 1 to 6219)
  AUTHORS   Zhou,F., Wang,Y., Liu,H., Ready,N., Han,Y., Hung,R.J., Brhane,Y.,
            McLaughlin,J., Brennan,P., Bickeboller,H., Rosenberger,A.,
            Houlston,R.S., Caporaso,N., Landi,M.T., Bruske,I., Risch,A., Ye,Y.,
            Wu,X., Christiani,D.C., Goodman,G., Chen,C., Amos,C.I. and Wei,Q.
  CONSRTM   Transdisciplinary Research in Cancer of the Lung (TRICL) Research
            Team
  TITLE     Susceptibility loci of CNOT6 in the general mRNA degradation
            pathway and lung cancer risk-A re-analysis of eight GWASs
  JOURNAL   Mol Carcinog 56 (4), 1227-1238 (2017)
   PUBMED   27805284
  REMARK    GeneRIF: The CNOT6 rs2453176 Single Nucleotide Polymorphism may be
            a new functional susceptible locus for lung cancer risk.
REFERENCE   6  (bases 1 to 6219)
  AUTHORS   Morel,A.P., Sentis,S., Bianchin,C., Le Romancer,M., Jonard,L.,
            Rostan,M.C., Rimokh,R. and Corbo,L.
  TITLE     BTG2 antiproliferative protein interacts with the human CCR4
            complex existing in vivo in three cell-cycle-regulated forms
  JOURNAL   J Cell Sci 116 (Pt 14), 2929-2936 (2003)
   PUBMED   12771185
  REMARK    GeneRIF: CCR4 and BTG2 interact and have a role in cell-cycle
            regulation
REFERENCE   7  (bases 1 to 6219)
  AUTHORS   Chen,J., Chiang,Y.C. and Denis,C.L.
  TITLE     CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic
            component of the cytoplasmic deadenylase
  JOURNAL   EMBO J 21 (6), 1414-1426 (2002)
   PUBMED   11889047
REFERENCE   8  (bases 1 to 6219)
  AUTHORS   Dupressoir,A., Morel,A.P., Barbot,W., Loireau,M.P., Corbo,L. and
            Heidmann,T.
  TITLE     Identification of four families of yCCR4- and Mg2+-dependent
            endonuclease-related proteins in higher eukaryotes, and
            characterization of orthologs of yCCR4 with a conserved
            leucine-rich repeat essential for hCAF1/hPOP2 binding
  JOURNAL   BMC Genomics 2, 9 (2001)
   PUBMED   11747467
REFERENCE   9  (bases 1 to 6219)
  AUTHORS   Albert,T.K., Lemaire,M., van Berkum,N.L., Gentz,R., Collart,M.A.
            and Timmers,H.T.
  TITLE     Isolation and characterization of human orthologs of yeast CCR4-NOT
            complex subunits
  JOURNAL   Nucleic Acids Res 28 (3), 809-817 (2000)
   PUBMED   10637334
REFERENCE   10 (bases 1 to 6219)
  AUTHORS   Okubo,K., Itoh,K., Fukushima,A., Yoshii,J. and Matsubara,K.
  TITLE     Monitoring cell physiology by expression profiles and discovering
            cell type-specific genes by compiled expression profiles
  JOURNAL   Genomics 30 (2), 178-186 (1995)
   PUBMED   8586417
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC034213.5 and AC122714.2.
            
            On May 8, 2019 this sequence version replaced XM_011534606.1.
            
            Summary: This gene encodes the catalytic component of the CCR4-NOT
            core transcriptional regulation complex. The encoded protein has a
            3'-5' RNase activity and prefers polyadenylated substrates. The
            CCR4-NOT complex plays a role in many cellular processes, including
            miRNA-mediated repression, mRNA degradation, and transcriptional
            regulation. [provided by RefSeq, Dec 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.239524.1,
                                           SRR1803613.200998.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261951.9/ ENSP00000261951.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-385               AC034213.5         97443-97827
            386-499             AC122714.2         18750-18863
            500-686             AC122714.2         39406-39592
            687-772             AC122714.2         42861-42946
            773-877             AC122714.2         53964-54068
            878-946             AC122714.2         54150-54218
            947-1104            AC122714.2         55295-55452
            1105-1259           AC122714.2         56563-56717
            1260-1414           AC122714.2         57324-57478
            1415-1645           AC122714.2         58585-58815
            1646-1848           AC122714.2         60705-60907
            1849-6219           AC122714.2         63463-67833
FEATURES             Location/Qualifiers
     source          1..6219
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..6219
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /note="CCR4-NOT transcription complex subunit 6"
                     /db_xref="GeneID:57472"
                     /db_xref="HGNC:HGNC:14099"
                     /db_xref="MIM:608951"
     exon            1..385
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /inference="alignment:Splign:2.1.0"
     exon            386..499
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..2061
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /EC_number="3.1.13.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     carbon catabolite repression 4 protein; cytoplasmic
                     deadenylase; carbon catabolite repressor protein 4
                     homolog"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 6 isoform
                     1"
                     /protein_id="NP_001357401.1"
                     /db_xref="CCDS:CCDS4455.1"
                     /db_xref="GeneID:57472"
                     /db_xref="HGNC:HGNC:14099"
                     /db_xref="MIM:608951"
                     /translation="MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLS
                     ASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLREL
                     HLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGT
                     AKRITTEQPPPRSWIMLQEPDRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWD
                     YRKKAIIQEILSCNADIVSLQEVETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQE
                     RKHVDGCAIFFKTEKFTLVQKHTVEFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLEL
                     RKESIEMPSGKPHLGTEKQLILVANAHMHWDPEYSDVKLVQTMMFLSEVKNIIDKASR
                     NLKSSVLGEFGTIPLVLCADLNSLPDSGVVEYLSTGGVETNHKDFKELRYNESLTNFS
                     CHGKNGTTNGRITHGFKLQSAYESGLMPYTNYTFDFKGIIDYIFYSKPQLNTLGILGP
                     LDHHWLVENNISGCPHPLIPSDHFSLFAQLELLLPFLPQVNGIHLPGRR"
     exon            500..686
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /inference="alignment:Splign:2.1.0"
     exon            687..772
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /inference="alignment:Splign:2.1.0"
     exon            773..877
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /inference="alignment:Splign:2.1.0"
     exon            878..946
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1104
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1259
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1414
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1645
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1848
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..6219
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4660..4665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /note="hexamer: AATAAA"
     polyA_site      4681
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /note="major polyA site"
     regulatory      5808..5813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /note="hexamer: AATAAA"
     polyA_site      5831
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
     regulatory      6192..6197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /note="hexamer: AATAAA"
     polyA_site      6219
                     /gene="CNOT6"
                     /gene_synonym="CCR4; Ccr4a"
                     /note="major polyA site"
ORIGIN      
        1 gagggacggc ggccgccgcc atgatgcttg tttgctttca atgaaaacga ggggggcgcg
       61 gaggaggagg cggcggcgtc ggtggcggcg gcgacggcgg cgcggaggcg aaggcagcgg
      121 cgggcgcagc gaggagggcg aggccggggg ccgagagggc gggagggcgt agtggcggcc
      181 cgtcggggcg gctgaggcgg gcagccgaag cagtggctct cggaggggga acaaagagca
      241 gcgactaagg cggcagagga gcggcggcgg tggcggcgct gcagcagcgg gcgggactgg
      301 tatggtggtt ccacagggca gaccccgctg cactcacagg gaggaggagg cggcagcggc
      361 ggaggaaggc ggcgcacccc gagaggcatg cccaaagaaa aatacgagcc ccctgaccct
      421 cggaggatgt atacaattat gtcttctgag gaagcagcaa atggaaagaa atcccactgg
      481 gcagagcttg aaataagtgg aaaagtaaga agcttaagcg catctttgtg gtcactaact
      541 cacctgacag ctttgcattt gagtgacaat tccctgtccc gaattccttc agacattgcc
      601 aagcttcaca atctggtgta tttggacctg tcatctaata aaattcgtag cttacccgca
      661 gaactcggaa acatggtatc actcagggag ctccatttaa ataacaacct gttacgagtt
      721 ctaccttttg agctgggaaa actgtttcag ttgcagactt taggcctgaa aggaaatccc
      781 cttacccagg atatattgaa cctttatcag gaaccagatg gaacaagacg gctgctgaac
      841 tatttgcttg ataatttgtc aggtactgca aaaagaatta caacagaaca accacctcca
      901 aggtcttgga ttatgttaca agaaccagat aggacaaggc caactgcctt gttttctgtc
      961 atgtgctata atgttctttg tgataaatat gcgacccggc agttatacgg ctactgtcca
     1021 tcatgggcgc taaactggga ctacaggaaa aaggccatta ttcaagaaat cttgagctgc
     1081 aatgctgata tcgtaagtct tcaggaggtt gaaacggaac agtattacag tttttttctg
     1141 gtagagctga aagaacgtgg ctataatgga ttcttcagtc ctaagtctag agctaggaca
     1201 atgtcagaac aagaaaggaa acatgttgat ggctgtgcaa tattcttcaa gacagaaaaa
     1261 tttactttgg ttcagaaaca cactgttgaa tttaatcagc tagccatggc aaattctgag
     1321 gggtctgaag ctatgctgaa cagagtcatg acaaaagata acattggggt tgcagtactg
     1381 ctagaacttc ggaaggaatc gattgaaatg ccgtccggaa agccacatct tggaacagaa
     1441 aaacaactta ttcttgtggc taacgcccac atgcattggg accctgaata ctctgatgtg
     1501 aagttggtac aaactatgat gttcctctca gaagtgaaga acattattga taaagcctct
     1561 cgcaacctca aatccagtgt tttgggagaa tttggaacta ttccacttgt gttatgtgca
     1621 gatcttaatt ctttgccaga ctctggtgtt gtagaatatt tgagcacagg tggagtagaa
     1681 acaaatcaca aagactttaa ggagttgagg tataatgaaa gtctcacaaa cttcagctgt
     1741 catgggaaga atggaaccac caatggaagg atcactcatg gtttcaagtt acagagtgcc
     1801 tatgagagtg gcctgatgcc ttacacgaat tacacatttg atttcaaggg tataatagac
     1861 tacattttct attctaaacc tcagctgaac accttaggca tcctgggccc tctggaccac
     1921 cactggctgg ttgagaataa catcagtggc tgcccgcacc ccctcatccc ctctgaccac
     1981 ttctcacttt ttgcacaact ggagctctta ctgcctttcc tgccccaagt caacggcatc
     2041 caccttcctg gcaggaggta gtcaagcacc ttcagaggac agccttgatt cacttgtaaa
     2101 cttgtgaaaa tctgaacata ggggagtgag gtatggccac tgaggatttt tgcttgctta
     2161 agaatgattt ggactttcaa tctgattatt tgataaggat atagtatgaa agccaggtgc
     2221 tagcaacaga caaattctga gcccaatatg ctttatactg ctagacaggg attggtgtgt
     2281 ttgcacctgt ctttcatttg tcataagaga ttttcctatt tcttctaccc aatagaatat
     2341 tttcatgcct ggaaatagga aaatgtgtga acagcgtatt ctcttcacac agaaatctgt
     2401 agcactgctt ttttgaggcc agtagcaaca tccagagatc attcttccat actttactcc
     2461 ctcctttttc agacttgttt gtaaagtaca gaatctgaat ttagccttta tgattgtata
     2521 tgatccacag aagacctgat ttatgaaatt ttgtactaaa atcatttgga aatgattgta
     2581 ttgtaaactg aggctaaatt tttttttaaa cctgtttcat gtgttataaa ggccagcttg
     2641 taaaagaagc tgcaacagac tttctctgct catgatttgc actcttaggg ttttgttagc
     2701 ccttttgtac tactttcttt ttaaattgag aacatggttc tttacatata aatctgcttc
     2761 aaccttagga tgttttcaga ccagaggcaa cttattcatg aatttttatg aaaactatct
     2821 actaggacag ataagctgaa cagtgatgat ctgtagacat ttatggactg aatgtaatgg
     2881 ttgatatatg tacattctga tatttttaaa tctttaactt tttaaagtta aaaacctaca
     2941 gctgcttagg tccagcttct taactctttt tgagacactt cctgtcctat ctccactgtg
     3001 cctgcctaaa tttgttctca ccaagcactg cctgtgcatg cagagaaaat ctgtgcatcc
     3061 tcttttatat ttttaaaata ctgtttaaca tttgtgagaa ttttatgaaa atgcttttgt
     3121 atgagctgtg gctttttccc attgtgaagc attgaatatc acattttgga acatgttata
     3181 gggtgagtcc ctggatcttt gctcaccaga tccaagcact gcttctcggt gtcattgcag
     3241 tgtgctgctt gtcacccaga atactactat catgtgaatt ctttttgtcg tcagtgtctt
     3301 ttccttagtc tttttgttgt tgttgttgtt gttgttttaa tcattccttt tttaagaaga
     3361 agtaattttc catttatgaa gcagtatgaa ttagatgtat tttcaaaaca ggtccctaag
     3421 acaattcttc agatcatttt taaaatgact aagtcatttt agtatgtcaa gcaagataaa
     3481 aattacatca taccgtctat tttgcccata gtgccattta gagatgaaaa ccagctttaa
     3541 ctttgcaaag tgaacatgta catggtctgc tctcatttat tcattcttct ctcaaaagtc
     3601 aaatgaatgc agagggagct tggtcaaact gcttttgttt caactgcagg caggggagca
     3661 aaaggacgcc atgtgagcat taggaaaaaa aatactcact cttactaaca atttttatac
     3721 agaaaatgag tcattttgga aatgattctt atgttttttt tttttctcct tttagaaaat
     3781 tctccaaaag gttttgatgt tgaatcttgg tcttggacct gttttttcct ttgagggttt
     3841 tttgtttttt gttttttcta ggatttcatt gtgatgtttt ggttttgttt tttgcttttt
     3901 gtttaagttg tgctgacacc aaacacatcc agtttataat cagtacattg gaaagctggt
     3961 attgatgtag aaccagtgca taacttttta tggggttttg ttattggttt ttttttgtaa
     4021 agtgtgaata aaaggtatgt ttactcattt ttcctgaaca ctgtgttggt aatgtgcatc
     4081 atgacaattt ccagtgaagg tgagctggag ctggttggac taatgagact gaggaagcag
     4141 cttttcctac gatctgcatt atgtaatcac aggtccagag agctttatgg aagcgggaga
     4201 ggaggagcac ttactcatgt tgtatttgtt aatggaggat gtcatctttt catagatgct
     4261 ggaactagag tgcacttgtt agatgctaaa ggtttgagct ttacacaaaa tgtcttcatc
     4321 tgtatttgtt attgtctaca atatatttga atttggggca gcatattaag atgtaatggc
     4381 ctgttatgtc ttgaaaatac ttgttttgcc tcttccaggc atactgcatt ctgtggatca
     4441 gtttgaacag cttctccacc ttatttggac agtgataaat tgaaccaaga gtgtagattt
     4501 acaagtgtaa ccttcaaaag aggaagaact atttggggtc tgtaggtaat gaacagtcac
     4561 accaaaatag actatgatgc ttttgttaag aaaggtttca tgttttagat attttccgtg
     4621 tcctaaataa ttttcaataa tctataatcc ctaaaatgca ataaaaacta gtatgttttc
     4681 acggtgtata ttttttttca aaaattctgt aacaaatata tttaatgtgt tgccataatg
     4741 tcatttcagt atttttgctg gataaatcca ttttagaaat gtcttacaaa aagtttaggg
     4801 catgttttct gttttaaaga ccagaagttt gaaggcaccc aaatccttgt cgccaatctc
     4861 ctgaagtaca gctttaccat attagtggtc attatttatg ctttgagagt ttcaatattg
     4921 ttcgtcaagt taacttatgg cataatttaa gctaaagttg tagaaatgaa ttgttgagtg
     4981 caactttcat agtcccaaag ataggcagag aacatctcca gaaatgtgtg tgtgtgtgtg
     5041 tgtgtgtgtg tgtgtgttta atatgattta gtgacaacca ggaaaactta cttgggatta
     5101 ttagcacttt caaacttagg gacattatta aattggatgg aatgcacttc taaatgttta
     5161 aattaaaatt tcaaagctct ttcgagattc aggttctcaa taataatatt caagttttag
     5221 agtttcactt tgtactattt aaatttatgg aactagtttc catactgact tgtaaggttt
     5281 tggggtcata tataaggact aaagccaagc taggcaaaac aatgacagca ccgttttttc
     5341 agtgaagctc tcagaatgtc cagtacagat gttgcagata attccaagaa ctccttcagc
     5401 aggtgttctt caccattcgt aaacagtatt ttaagatgtt cactttgctc ttctttttgg
     5461 ttacatacat tttaataact ggtatgttga agtagtgtct aaaagtatct agtctttatt
     5521 cacagtacat tatattgtgt gatgcactgg actaactctt gtttaccatt catgtaacaa
     5581 aacccagcac attatctgca ctataagctc aaagaatgtc acatccgccc agacagctct
     5641 ttgatgaggg tgatgggaac tgaataaacc atacggactg gcagtaacaa gggcttttac
     5701 tgttctgttc agtggaacct tcttggtcaa attgtaatta gctagcatta tatttatata
     5761 cagggtcttt tttctttacc gatgtatttt cctactcata gccaaccaat aaattcagta
     5821 tctgtttcaa atattttaga agtgtagttt gtatagctgt agtactgagg tttgaggaaa
     5881 aataaatgtt gatcagcaga ccacgtattt aaaattctga atcttctggg acagggttgt
     5941 aactcagcct tccaaaggga agagtgcagg gggacggggc catgatatgg ggaaatggtg
     6001 taaactaatg tatttcttta ttggctgtta ttctgtataa cactcatatc tttgccaaag
     6061 ttcaatttta tatttaggca actgatggtc cttttgcatt taggattttc gttgttgtta
     6121 ccttatacct catgatataa ggaatgggct catgtgtctt ccgtcttttg gaaggaggtt
     6181 gacatatttt aaataaatgc ttttaaatac agtagcaaa
//
