LOCUS       NM_017546               2515 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens CCR4-NOT transcription complex subunit 11 (CNOT11),
            mRNA.
ACCESSION   NM_017546
VERSION     NM_017546.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2515)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2515)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2515)
  AUTHORS   Raisch,T., Chang,C.T., Levdansky,Y., Muthukumar,S., Raunser,S. and
            Valkov,E.
  TITLE     Reconstitution of recombinant human CCR4-NOT reveals molecular
            insights into regulated deadenylation
  JOURNAL   Nat Commun 10 (1), 3173 (2019)
   PUBMED   31320642
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2515)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2515)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   6  (bases 1 to 2515)
  AUTHORS   Bawankar,P., Loh,B., Wohlbold,L., Schmidt,S. and Izaurralde,E.
  TITLE     NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT
            complex that docks onto the NOT1 N-terminal domain
  JOURNAL   RNA Biol 10 (2), 228-244 (2013)
   PUBMED   23303381
  REMARK    GeneRIF: Human CNOT10 and CNOT11 form a complex that interacts with
            the CNOT1 N-terminal domain.
REFERENCE   7  (bases 1 to 2515)
  AUTHORS   Mauxion,F., Preve,B. and Seraphin,B.
  TITLE     C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex
  JOURNAL   RNA Biol 10 (2), 267-276 (2013)
   PUBMED   23232451
  REMARK    GeneRIF: CNOT11 interacts with the first amino acids of CNOT1 and
            with CNOT10 and is required for the association of CNOT10 with the
            CCR4-NOT complex.
REFERENCE   8  (bases 1 to 2515)
  AUTHORS   Lau,N.C., Kolkman,A., van Schaik,F.M., Mulder,K.W., Pijnappel,W.W.,
            Heck,A.J. and Timmers,H.T.
  TITLE     Human Ccr4-Not complexes contain variable deadenylase subunits
  JOURNAL   Biochem J 422 (3), 443-453 (2009)
   PUBMED   19558367
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2515)
  AUTHORS   Oh,J.J., Grosshans,D.R., Wong,S.G. and Slamon,D.J.
  TITLE     Identification of differentially expressed genes associated with
            HER-2/neu overexpression in human breast cancer cells
  JOURNAL   Nucleic Acids Res 27 (20), 4008-4017 (1999)
   PUBMED   10497265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX394182.2, BM923954.1 and BC018664.2.
            
            On Nov 22, 2018 this sequence version replaced NM_017546.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.177936.1,
                                           SRR1660803.192531.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289382.8/ ENSP00000289382.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BX394182.2         85-95
            12-803              BM923954.1         1-792
            804-2515            BC018664.2         716-2427
FEATURES             Location/Qualifiers
     source          1..2515
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..2515
                     /gene="CNOT11"
                     /gene_synonym="C2orf29; C40"
                     /note="CCR4-NOT transcription complex subunit 11"
                     /db_xref="GeneID:55571"
                     /db_xref="HGNC:HGNC:25217"
                     /db_xref="MIM:620509"
     exon            1..593
                     /gene="CNOT11"
                     /gene_synonym="C2orf29; C40"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1612
                     /gene="CNOT11"
                     /gene_synonym="C2orf29; C40"
                     /note="UPF0760 protein C2orf29"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 11"
                     /protein_id="NP_060016.3"
                     /db_xref="CCDS:CCDS2050.1"
                     /db_xref="GeneID:55571"
                     /db_xref="HGNC:HGNC:25217"
                     /db_xref="MIM:620509"
                     /translation="MPGGGASAASGRLLTAAEQRGSREAAGSASRSGFGGSGGGRGGA
                     SGPGSGSGGPGGPAGRMSLTPKELSSLLSIISEEAGGGSTFEGLSTAFHHYFSKADHF
                     RLGSVLVMLLQQPDLLPSAAQRLTALYLLWEMYRTEPLAANPFAASFAHLLNPAPPAR
                     GGQEPDRPPLSGFLPPITPPEKFFLSQLMLAPPRELFKKTPRQIALMDVGNMGQSVDI
                     SGLQLALAERQSELPTQSKASFPSILSDPDPDSSNSGFDSSVASQITEALVSGPKPPI
                     ESHFRPEFIRPPPPLHICEDELAWLNPTEPDHAIQWDKSMCVKNSTGVEIKRIMAKAF
                     KSPLSSPQQTQLLGELEKDPKLVYHIGLTPAKLPDLVENNPLVAIEMLLKLMQSSQIT
                     EYFSVLVNMDMSLHSMEVVNRLTTAVDLPPEFIHLYISNCISTCEQIKDKYMQNRLVR
                     LVCVFLQSLIRNKIINVQDLFIEVQAFCIEFSRIREAAGLFRLLKTLDTGETPSETKM
                     SK"
     exon            594..758
                     /gene="CNOT11"
                     /gene_synonym="C2orf29; C40"
                     /inference="alignment:Splign:2.1.0"
     exon            759..911
                     /gene="CNOT11"
                     /gene_synonym="C2orf29; C40"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1114
                     /gene="CNOT11"
                     /gene_synonym="C2orf29; C40"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1317
                     /gene="CNOT11"
                     /gene_synonym="C2orf29; C40"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1414
                     /gene="CNOT11"
                     /gene_synonym="C2orf29; C40"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..2515
                     /gene="CNOT11"
                     /gene_synonym="C2orf29; C40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2490..2495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNOT11"
                     /gene_synonym="C2orf29; C40"
                     /note="hexamer: ATTAAA"
     polyA_site      2515
                     /gene="CNOT11"
                     /gene_synonym="C2orf29; C40"
                     /note="major polyA site"
ORIGIN      
        1 gcgctttacg gccgcgggga cggagcgagc cggcgccagg gcccctcggg ccgggaagag
       61 gggaagggga gcgaggttga tgcccggcgg aggggcgagc gcggcgtctg gccggcttct
      121 caccgccgcg gagcaaagag ggtcccggga agcggcaggg tcggcgtcca ggagcggctt
      181 cgggggctcc ggcggcggca gaggcggagc aagcggcccc gggtccggga gcggaggccc
      241 ggggggcccc gcgggcagga tgagcttgac cccgaaggag ctctcgagcc tgctgagcat
      301 catatcggag gaggcgggcg gcggcagcac cttcgagggc ctgtccaccg ccttccacca
      361 ctacttcagc aaggccgacc acttccgcct gggctcggtg ctcgtcatgc tgctccagca
      421 gcccgacctg ctgcctagcg cggcgcagcg cctcacggcg ctctacctgc tctgggagat
      481 gtaccgcacc gagccgctgg ccgccaaccc cttcgccgcc agcttcgcgc acctgctcaa
      541 ccccgcgccg cccgcccgcg gcggccagga acccgaccgc cctccgctct caggattttt
      601 acctcctata actccaccag aaaagttttt tctttcccag ctgatgctgg cacccccacg
      661 ggaactcttc aaaaagacgc ctcgccagat tgcactgatg gacgttggaa acatgggcca
      721 gtctgtggac attagtgggc ttcagttagc cttggccgaa cgccaatctg aattgccaac
      781 gcaaagcaaa gcgagcttcc ccagtattct cagtgaccca gacccggatt cttctaattc
      841 tggatttgac agctcagttg cctctcagat cacagaagct ttagtcagcg gaccaaagcc
      901 acctattgaa agccattttc gaccagagtt tattcgtcca ccgcctccac tccacatttg
      961 tgaggatgaa cttgcttggc taaaccccac ggagcctgac cacgcgatcc agtgggataa
     1021 atcgatgtgt gttaagaata gcactggtgt ggagatcaaa cgaataatgg ccaaagcctt
     1081 caaaagcccc ttatcctctc cccaacaaac acagctactt ggtgagttgg aaaaagaccc
     1141 caaacttgtc taccatattg gcctcacccc agccaaactt cctgaccttg tggaaaacaa
     1201 ccctttagtc gctatagaaa tgttgctgaa attaatgcag tcaagccaga tcactgagta
     1261 tttctctgtc ctggtcaata tggacatgtc tttacattca atggaagttg taaatcgact
     1321 aactacagct gttgatctac ctcctgaatt tattcacctt tatatatcaa attgcatctc
     1381 tacttgtgaa cagattaagg ataaatatat gcagaatcgg ttggtgcgtc ttgtgtgtgt
     1441 gtttctccaa tccttgatcc gtaacaaaat tattaatgta caggatttgt ttatagaagt
     1501 gcaggcattc tgtattgaat tcagtaggat acgagaagct gctggtcttt tccggttgtt
     1561 gaagacattg gatactgggg aaacaccttc tgagaccaaa atgtcaaaat aatacctcat
     1621 cagaaccatc ccatccattc actgttcagc tgtactgtga tttagttttt acaccgttaa
     1681 aaccctgagt ggattgcttg gtttaatgca tataaacagt actttatcta cttaaagcaa
     1741 agttttgctt tcttgaatga ctttttctgt gagatgaatt tttgataaga actagggaaa
     1801 acatgtcttt taggtgtctt gctgatgact atccatagga ggaatggcta tcccaaaaaa
     1861 agttccgcaa aaaagtagat gagtttcttt tttttttaag cactaaagaa caaaatgcat
     1921 ttttcattaa tacaggcttc tgatgaacca ggaatcctgt tttcgtaaag ttccaatgtt
     1981 gatgagagta aattcttaag catttgtcct agaggtgaaa gcagctgaat gtttctgaac
     2041 catcaagagg caaacaaaca ggagtttgtt tcttgaacct gcttatgcac acagctctta
     2101 actcctcatg aggcacacag ctcttaactc ctgatgaacc aaggatttac tcataacttt
     2161 ctccttgtca tggaggctta atagacaaca gaataaatgc atttcttggg cctcttataa
     2221 acttgggaat tcttagaaag ctgcttctat taccaggctg taatagctgg tatagttttt
     2281 tttttttctc ttaagatgtt ctgttattag tctgagacag ccattttttt gttttaagga
     2341 aaaatatcag tcagtgctcc gggaggtaat ttcctgtggg gtctgcaccc tcctgtctgg
     2401 gtggtggatg tgggtttgag aagtaggaga gcagggtggt accgtgtggg ctcttaccct
     2461 ttatgtgatt ttggacaaca gtgccttcca ttaaagttct ttttatcaac tgtta
//
