LOCUS       NM_015442               2772 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens CCR4-NOT transcription complex subunit 10 (CNOT10),
            transcript variant 1, mRNA.
ACCESSION   NM_015442
VERSION     NM_015442.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2772)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   2  (bases 1 to 2772)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2772)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2772)
  AUTHORS   Raisch,T., Chang,C.T., Levdansky,Y., Muthukumar,S., Raunser,S. and
            Valkov,E.
  TITLE     Reconstitution of recombinant human CCR4-NOT reveals molecular
            insights into regulated deadenylation
  JOURNAL   Nat Commun 10 (1), 3173 (2019)
   PUBMED   31320642
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2772)
  AUTHORS   Hosp,F., Vossfeldt,H., Heinig,M., Vasiljevic,D., Arumughan,A.,
            Wyler,E., Landthaler,M., Hubner,N., Wanker,E.E., Lannfelt,L.,
            Ingelsson,M., Lalowski,M., Voigt,A. and Selbach,M.
  CONSRTM   Genetic and Environmental Risk for Alzheimer's Disease GERAD1
            Consortium
  TITLE     Quantitative interaction proteomics of neurodegenerative disease
            proteins
  JOURNAL   Cell Rep 11 (7), 1134-1146 (2015)
   PUBMED   25959826
REFERENCE   6  (bases 1 to 2772)
  AUTHORS   Miyasaka,T., Morita,M., Ito,K., Suzuki,T., Fukuda,H., Takeda,S.,
            Inoue,J., Semba,K. and Yamamoto,T.
  TITLE     Interaction of antiproliferative protein Tob with the CCR4-NOT
            deadenylase complex
  JOURNAL   Cancer Sci 99 (4), 755-761 (2008)
   PUBMED   18377426
REFERENCE   7  (bases 1 to 2772)
  AUTHORS   Morita,M., Suzuki,T., Nakamura,T., Yokoyama,K., Miyasaka,T. and
            Yamamoto,T.
  TITLE     Depletion of mammalian CCR4b deadenylase triggers elevation of the
            p27Kip1 mRNA level and impairs cell growth
  JOURNAL   Mol Cell Biol 27 (13), 4980-4990 (2007)
   PUBMED   17452450
REFERENCE   8  (bases 1 to 2772)
  AUTHORS   Tsang,H.T., Connell,J.W., Brown,S.E., Thompson,A., Reid,E. and
            Sanderson,C.M.
  TITLE     A systematic analysis of human CHMP protein interactions:
            additional MIT domain-containing proteins bind to multiple
            components of the human ESCRT III complex
  JOURNAL   Genomics 88 (3), 333-346 (2006)
   PUBMED   16730941
REFERENCE   9  (bases 1 to 2772)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   10 (bases 1 to 2772)
  AUTHORS   Weng,N.P., Snyder,J.G., Yu-Lee,L.Y. and Marcus,D.M.
  TITLE     Polymorphism of human immunoglobulin VH4 germ-line genes
  JOURNAL   Eur J Immunol 22 (4), 1075-1082 (1992)
   PUBMED   1348029
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138972.8 and AC139452.4.
            
            On Jun 2, 2019 this sequence version replaced NM_015442.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.171108.1, AK023227.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328834.10/ ENSP00000330060.5
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               AC138972.8         84706-85000         c
            296-390             AC138972.8         66226-66320         c
            391-552             AC138972.8         65216-65377         c
            553-703             AC138972.8         61368-61518         c
            704-846             AC138972.8         56819-56961         c
            847-933             AC138972.8         53877-53963         c
            934-1017            AC138972.8         52951-53034         c
            1018-1135           AC138972.8         49957-50074         c
            1136-1285           AC138972.8         44589-44738         c
            1286-1488           AC138972.8         42318-42520         c
            1489-1610           AC138972.8         36644-36765         c
            1611-1787           AC138972.8         35212-35388         c
            1788-1868           AC138972.8         32698-32778         c
            1869-1982           AC138972.8         10617-10730         c
            1983-2113           AC138972.8         7325-7455           c
            2114-2149           AC138972.8         5698-5733           c
            2150-2277           AC138972.8         5379-5506           c
            2278-2353           AC138972.8         226-301             c
            2354-2772           AC139452.4         159210-159628       c
FEATURES             Location/Qualifiers
     source          1..2772
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.3"
     gene            1..2772
                     /gene="CNOT10"
                     /note="CCR4-NOT transcription complex subunit 10"
                     /db_xref="GeneID:25904"
                     /db_xref="HGNC:HGNC:23817"
                     /db_xref="MIM:620508"
     exon            1..295
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..2508
                     /gene="CNOT10"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 10
                     isoform 1"
                     /protein_id="NP_056257.1"
                     /db_xref="CCDS:CCDS2655.1"
                     /db_xref="GeneID:25904"
                     /db_xref="HGNC:HGNC:23817"
                     /db_xref="MIM:620508"
                     /translation="MAADKPADQGAEKHEGTGQSSGITDQEKELSTNAFQAFTSGNYD
                     ACLQHLACLQDINKDDYKIILNTAVAEFFKSNQTTTDNLRQTLNQLKNQVHSAVEEMD
                     GLDDVENSMLYYNQAVILYHLRQYTEAISVGEKLYQFIEPFEEKFAQAVCFLLVDLYI
                     LTYQAEKALHLLAVLEKMISQGNNNKNGKNETGNNNNKDGSNHKAESGALIEAAKSKI
                     HQYKVRAYIQMKSLKACKREIKSVMNTAGNSAPSLFLKSNFEYLRGNYRKAVKLLNSS
                     NIAEHPGFMKTGECLRCMFWNNLGCIHFAMSKHNLGIFYFKKALQENDNVCAQLSAGS
                     TDPGKKFSGRPMCTLLTNKRYELLYNCGIQLLHIGRPLAAFECLIEAVQVYHANPRLW
                     LRLAECCIAANKGTSEQETKGLPSKKGIVQSIVGQGYHRKIVLASQSIQNTVYNDGQS
                     SAIPVASMEFAAICLRNALLLLPEEQQDPKQENGAKNSNQLGGNTESSESSETCSSKS
                     HDGDKFIPAPPSSPLRKQELENLKCSILACSAYVALALGDNLMALNHADKLLQQPKLS
                     GSLKFLGHLYAAEALISLDRISDAITHLNPENVTDVSLGISSNEQDQGSDKGENEAME
                     SSGKRAPQCYPSSVNSARTVMLFNLGSAYCLRSEYDKARKCLHQAASMIHPKEVPPEA
                     ILLAVYLELQNGNTQLALQIIKRNQLLPAVKTHSEVRKKPVFQPVHPIQPIQMPAFTT
                     VQRK"
     exon            296..390
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     exon            391..552
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     exon            553..703
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     exon            704..846
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     exon            847..933
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1017
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1135
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1285
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1488
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1610
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1787
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1868
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1982
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2113
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2149
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2277
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2353
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2772
                     /gene="CNOT10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2587..2592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNOT10"
                     /note="hexamer: AATAAA"
     polyA_site      2611
                     /gene="CNOT10"
     regulatory      2750..2755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNOT10"
                     /note="hexamer: ATTAAA"
     polyA_site      2772
                     /gene="CNOT10"
                     /note="major polyA site"
ORIGIN      
        1 agtgggtacc gggacgccgt gaggcggaag ctgtgtatgg cgggaggctg tggcggtccc
       61 ttggtgggga agctgttgct gttgctagac gacgggaact agctctcgtc acttcctcag
      121 cccgccgtct gcccactcct ctagccggaa cctgggggcc cggagccggg gtaggcacag
      181 agttgtcctc ggaggtccag gacagcggcc agcccggcgg cgggagtcag ggccacgcca
      241 cctgcaggga agaacccgag tcgaagcggg aagatggctg cagacaagcc tgcagatcag
      301 ggagcagaga aacatgaagg cacaggtcag tcctctggga tcactgatca agagaaggag
      361 ttatccacca atgctttcca agctttcaca tctggaaatt atgatgcctg tctacaacac
      421 cttgcctgtc tacaagatat aaacaaagat gattataaaa taattttgaa tacagcagta
      481 gctgagtttt ttaaaagtaa ccaaacaaca acagataatt tgagacaaac acttaaccag
      541 ctgaagaatc aggtccactc agctgttgaa gaaatggatg gattagatga tgttgaaaac
      601 agcatgttgt actataatca agcagtcatt ctttatcatc tgcggcagta tacagaagcc
      661 atatcagttg gtgaaaaact ttatcagttc atagagcctt ttgaagaaaa atttgcccaa
      721 gcagtgtgtt ttttgcttgt agacctgtat atattaacct accaagctga gaaagctttg
      781 catcttcttg ctgtcctaga aaaaatgatt tcacagggta acaataacaa aaatggaaag
      841 aatgagactg gtaataacaa caacaaagat ggatctaatc ataaagctga aagtggagct
      901 ctaatagaag ctgcaaaatc aaagatacat cagtacaaag tacgagctta tatccaaatg
      961 aagtctctga aagcatgtaa aagggaaatc aagtcagtca tgaatacagc tggaaattcc
     1021 gcaccctctc tctttcttaa aagcaatttt gagtacttaa gaggtaatta tcgaaaagcc
     1081 gtgaagctat taaatagttc aaacattgct gagcatccag gattcatgaa aacaggtgaa
     1141 tgcttgagat gcatgttctg gaataacctt ggttgcatcc attttgccat gagcaagcac
     1201 aatttgggaa tattctactt taaaaaggct ctgcaagaga atgacaatgt ctgtgcacag
     1261 ctcagtgcag gtagcactga tccaggtaaa aaattttcag gaagacccat gtgtacgtta
     1321 ctaaccaata agagatatga gttgctgtat aactgtggaa ttcagcttct tcacattgga
     1381 aggcctcttg ctgccttcga atgtctgatt gaagctgttc aggtttatca tgcaaatcct
     1441 cgcctctggc tacggctggc tgaatgctgc attgctgcca ataaggggac ttctgaacaa
     1501 gaaactaaag gccttcccag caaaaaagga attgtacagt ctattgttgg tcaaggctat
     1561 catcgtaaaa tagttttggc atcacagtct atacagaata ctgtttataa tgatgggcag
     1621 tcttcggcca ttcctgtagc cagtatggag tttgcagcca tatgtctcag aaatgccttg
     1681 ttgctgctac ctgaagaaca gcaagatcca aagcaggaaa atggggctaa aaatagtaat
     1741 caattaggtg ggaacacaga gagcagcgaa agcagtgaaa cttgcagcag taaaagccat
     1801 gatggagata aattcattcc agctccacct tcttctccat tgagaaaaca ggaattagaa
     1861 aacttaaagt gctccatact tgcttgcagt gcctacgtgg ctctggcttt gggtgataac
     1921 ctcatggctt tgaatcatgc agataaactt cttcagcagc ccaagctgtc aggatctctt
     1981 aagtttttgg gacatttata tgctgcagaa gccctcatct ctctcgacag aatatctgat
     2041 gccattactc acttgaaccc ggagaatgtc actgatgtct ccttagggat ctcttcaaat
     2101 gagcaggacc aaggatcaga caaaggtgaa aatgaagcaa tggaatcctc tggtaagcgg
     2161 gcccctcagt gctaccccag ttccgtcaac tctgccagga ctgtgatgct gttcaacctt
     2221 ggcagcgctt actgcctgag gagcgaatat gacaaagccc gaaagtgtct ccaccaggcg
     2281 gcttcaatga tccatcctaa agaggtgccc cctgaggcca tcttgctggc agtctacctt
     2341 gaactgcaga atggtaatac tcagctggcc ttacagatca tcaaaaggaa tcagctgctc
     2401 cctgcagtga aaacacactc tgaagtgaga aagaagccag tgtttcagcc tgtccacccg
     2461 atccagccca tccaaatgcc ggctttcacc actgtgcaga gaaagtgata cttcactttt
     2521 ggaaaactgt tacctgagac ccaggggaga atttactggc cattttagtt gtatcacagc
     2581 agaatgaata aaagatggtg aaggctgtta attttgagtc aattctaccc ctgacatttg
     2641 gccaaaagct tacttaaaat taaggattta ctaagtcatc atcagctgtt tttcttaatt
     2701 tcagccagac tattaatttt gagccattat gtaatatatg ccataggcaa ttaaaacata
     2761 attttatcag aa
//
