LOCUS       NM_016284               8411 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens CCR4-NOT transcription complex subunit 1 (CNOT1),
            transcript variant 1, mRNA.
ACCESSION   NM_016284
VERSION     NM_016284.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8411)
  AUTHORS   Wu,T., Chen,X. and Zhang,X.
  TITLE     Vissers-Bodmer syndrome caused by a novel de novo CNOT1 frameshift
            variant
  JOURNAL   Am J Med Genet A 194 (2), 363-367 (2024)
   PUBMED   37818768
  REMARK    GeneRIF: Vissers-Bodmer syndrome caused by a novel de novo CNOT1
            frameshift variant.
REFERENCE   2  (bases 1 to 8411)
  AUTHORS   Burgess,H.M., Grande,R., Riccio,S., Dinesh,I., Winkler,G.S.,
            Depledge,D.P. and Mohr,I.
  TITLE     CCR4-NOT differentially controls host versus virus poly(a)-tail
            length and regulates HCMV infection
  JOURNAL   EMBO Rep 24 (12), e56327 (2023)
   PUBMED   37846490
  REMARK    GeneRIF: CCR4-NOT differentially controls host versus virus
            poly(a)-tail length and regulates HCMV infection.
REFERENCE   3  (bases 1 to 8411)
  AUTHORS   Zhang,Q., Pavanello,L., Potapov,A., Bartlam,M. and Winkler,G.S.
  TITLE     Structure of the human Ccr4-Not nuclease module using X-ray
            crystallography and electron paramagnetic resonance spectroscopy
            distance measurements
  JOURNAL   Protein Sci 31 (3), 758-764 (2022)
   PUBMED   34923703
  REMARK    GeneRIF: Structure of the human Ccr4-Not nuclease module using
            X-ray crystallography and electron paramagnetic resonance
            spectroscopy distance measurements.
REFERENCE   4  (bases 1 to 8411)
  AUTHORS   Matkovic,R., Morel,M., Lanciano,S., Larrous,P., Martin,B.,
            Bejjani,F., Vauthier,V., Hansen,M.M.K., Emiliani,S., Cristofari,G.,
            Gallois-Montbrun,S. and Margottin-Goguet,F.
  TITLE     TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation
            pathway to repress HIV
  JOURNAL   Nat Commun 13 (1), 66 (2022)
   PUBMED   35013187
  REMARK    GeneRIF: TASOR epigenetic repressor cooperates with a CNOT1 RNA
            degradation pathway to repress HIV.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8411)
  AUTHORS   Poetz,F., Corbo,J., Levdansky,Y., Spiegelhalter,A., Lindner,D.,
            Magg,V., Lebedeva,S., Schweiggert,J., Schott,J., Valkov,E. and
            Stoecklin,G.
  TITLE     RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT
            complex-mediated deadenylation
  JOURNAL   Nat Commun 12 (1), 7175 (2021)
   PUBMED   34887419
  REMARK    GeneRIF: RNF219 attenuates global mRNA decay through inhibition of
            CCR4-NOT complex-mediated deadenylation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8411)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   7  (bases 1 to 8411)
  AUTHORS   Laveder,P., De Pitta,C., Toppo,S., Valle,G. and Lanfranchi,G.
  TITLE     A two-step strategy for constructing specifically self-subtracted
            cDNA libraries
  JOURNAL   Nucleic Acids Res 30 (9), e38 (2002)
   PUBMED   11972353
REFERENCE   8  (bases 1 to 8411)
  AUTHORS   Chen,J., Rappsilber,J., Chiang,Y.C., Russell,P., Mann,M. and
            Denis,C.L.
  TITLE     Purification and characterization of the 1.0 MDa CCR4-NOT complex
            identifies two novel components of the complex
  JOURNAL   J Mol Biol 314 (4), 683-694 (2001)
   PUBMED   11733989
  REMARK    GeneRIF: purification and characterization of 1.0 MDa yeast
            CCR4-NOT complex identifies two novel components, CAF40 and CAF130:
            yeast CAF40 binds human NOT1
REFERENCE   9  (bases 1 to 8411)
  AUTHORS   Albert,T.K., Lemaire,M., van Berkum,N.L., Gentz,R., Collart,M.A.
            and Timmers,H.T.
  TITLE     Isolation and characterization of human orthologs of yeast CCR4-NOT
            complex subunits
  JOURNAL   Nucleic Acids Res 28 (3), 809-817 (2000)
   PUBMED   10637334
REFERENCE   10 (bases 1 to 8411)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833549.1, AC010287.9, BX537840.1, AL117492.1, AC009118.11 and
            BM023419.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016284.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832769.1, AL833549.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317147.10/ ENSP00000320949.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1805              AL833549.1         21-1825
            1806-1806           AC010287.9         73395-73395         c
            1807-2825           AL833549.1         1827-2845
            2826-3919           BX537840.1         2817-3910
            3920-4988           AL833549.1         3939-5007
            4989-7667           AL117492.1         888-3566
            7668-8317           AC009118.11        27877-28526
            8318-8411           BM023419.1         1-94
FEATURES             Location/Qualifiers
     source          1..8411
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..8411
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /note="CCR4-NOT transcription complex subunit 1"
                     /db_xref="GeneID:23019"
                     /db_xref="HGNC:HGNC:7877"
                     /db_xref="MIM:604917"
     exon            1..99
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            100..375
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..7404
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /note="isoform a is encoded by transcript variant 1; NOT1
                     (negative regulator of transcription 1, yeast) homolog;
                     adrenal gland protein AD-005; CCR4-associated factor 1;
                     negative regulator of transcription subunit 1 homolog"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 1 isoform
                     a"
                     /protein_id="NP_057368.3"
                     /db_xref="CCDS:CCDS10799.1"
                     /db_xref="GeneID:23019"
                     /db_xref="HGNC:HGNC:7877"
                     /db_xref="MIM:604917"
                     /translation="MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEAD
                     RHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECALLITKPNFISTLSYAIDNPLHYQ
                     KSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSSDLRGFAAQFIKQKLPDLLRSY
                     IDADVSGNQEGGFQDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQER
                     CPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVGYGFCASIEECRNI
                     IVQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSDGAQAH
                     TWNVEVLIDVLKELNPSLNFKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPV
                     DLIYRPWKHAEGQLSFIQHSLINPEIFCFADYPCHTVATDILKAPPEDDNREIATWKS
                     LDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMP
                     IFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQD
                     LKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRC
                     PSILGGLAPEKDQPKSAQLPPETLATMLACLQACAGSVSQELSETILTMVANCSNVMN
                     KARQPPPGVMPKGRPPSASSLDAISPVQIDPLAGMTSLSIGGSAAPHTQSMQGFPPNL
                     GSAFSTPQSPAKAFPPLSTPNQTTAFSGIGGLSSQLPVGGLGTGSLTGIGTGALGLPA
                     VNNDPFVQRKLGTSGLNQPTFQQSKMKPSDLSQVWPEANQHFSKEIDDEANSYFQRIY
                     NHPPHPTMSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITA
                     CLFGGIIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYC
                     QHLASISHFMQFPHHLQEYIEYGQQSRDPPVKMQGSITTPGSIALAQAQAQAQVPAKA
                     PLAGQVSTMVTTSTTTTVAKTVTVTRPTGVSFKKDVPPSINTTNIDTLLVATDQTERI
                     VEPPENIQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFH
                     SLYSNFLDTLKNPEFNKMVLNETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITL
                     AKNKPILHTDLDVKSLLLEAYVKGQQELLYVVPFVAKVLESSIRSVVFRPPNPWTMAI
                     MNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDKDRLKNLDEQLSAPK
                     KDVKQPEELPPITTTTTSTTPATNTTCTATVPPQPQYSYHDINVYSLAGLAPHITLNP
                     TIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESR
                     MRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALRTASPQQREMMDQAAAQ
                     LAQDNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQEGRRYCDPVVLTYQAER
                     MPEQIRLKVGGVDPKQLAVYEEFARNVPGFLPTNDLSQPTGFLAQPMKQAWATDDVAQ
                     IYDKCITELEQHLHAIPPTLAMNPQAQALRSLLEVVVLSRNSRDAIAALGLLQKAVEG
                     LLDATSGADADLLLRYRECHLLVLKALQDGRAYGSPWCNKQITRCLIECRDEYKYNVE
                     AVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQLVKILLVDERSVAHVTEADL
                     FHTIETLMRINAHSRGNAPEGLPQLMEVVRSNYEAMIDRAHGGPNFMMHSGISQASEY
                     DDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKTDDLITRFFR
                     LCTEMCVEISYRAQAEQQHNPAANPTMIRAKCYHNLDAFVRLIALLVKHSGEATNTVT
                     KINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLLELNAPEHVLETINFQTL
                     TAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLLIDLFKY
                     LAPFLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLI
                     LSAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNFTGVMPPQFKKDLDSYLKTRSPV
                     TFLSDLRSNLQVSNEPGNRYNLQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHM
                     DIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEAIQEQITR
                     VLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLFQSVAQCCMGQK
                     QAQQVMEGTGAS"
     exon            376..483
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            484..582
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            583..651
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            652..706
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            707..910
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1079
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1206
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1317
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1488
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1616
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1857
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1977
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2100
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2252
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2403
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2605
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2752
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2877
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..3164
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3243
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3474
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3615
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3616..3795
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3796..3912
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3913..4023
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4024..4101
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4102..4279
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4280..4410
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4411..4707
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4708..4848
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4849..4953
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4954..5073
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            5074..5265
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            5266..5408
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            5409..5517
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            5518..5687
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            5688..5919
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            5920..6168
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            6169..6332
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            6333..6450
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            6451..6552
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            6553..6726
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            6727..6876
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            6877..7057
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            7058..7190
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            7191..7325
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            7326..8411
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7650..7655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /note="hexamer: AATACA"
     polyA_site      7667
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /note="major polyA site"
     regulatory      8393..8398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /note="hexamer: ATTAAA"
     polyA_site      8411
                     /gene="CNOT1"
                     /gene_synonym="AD-005; CDC39; HPE12; NOT1; NOT1H; VIBOS"
                     /note="major polyA site"
ORIGIN      
        1 gtagagaaac aagcggagtt aaccgaagag ggggtcgagg agagccggag tcggggaccc
       61 aggagtttcc tgtgtccagc gctgccggag ccgcctgagg tgccatgttt cagaacagag
      121 taagacccct ggtaaagaag aactgaagat attatacaga taccagatat agcctaatta
      181 caaagaaagc attaacctgc ctctgaggtg actaaagggg aataatggtg attttgcgcc
      241 gggctcggcc gcctgcttcc gccccaacca gcaatgaatc ttgactcgct ctcgctggcc
      301 ttgtctcaaa tcagctacct ggtggacaat ttaaccaaga aaaattaccg agccagccag
      361 caggaaatac agcatattgt gaatcggcac ggtcctgagg cagacaggca tttattacgc
      421 tgcctatttt cgcatgtgga tttcagtggc gatggtaaaa gcagtggcaa agatttccat
      481 cagactcagt ttctgattca ggagtgtgcg ttgctgatta caaagccaaa ttttatctcg
      541 acgctgtcct atgccattga taatccattg cactatcaga agagtttaaa gcctgcaccc
      601 cacttatttg cccagctgag taaagtgctc aaattaagca aagtacaaga ggtaattttt
      661 ggccttgccc tgttgaattc ttccagctca gatcttagag gtttcgctgc ccagtttatc
      721 aaacagaagc ttccagatct tctgcgttct tacattgacg cagacgtcag tggaaatcaa
      781 gaaggtggct tccaagatat agcaatagag gtcctacacc tcctcctctc ccatctcctc
      841 tttgggcaga agggagcctt tggagttgga caagaacaga tagacgcttt tcttaagacg
      901 ctgcgcagag attttcccca agaacgctgt cccgtggtgc tcgcaccact tttataccct
      961 gaaaaacggg acattctaat ggacaggatc ctgcctgatt ccggaggggt agctaaaacc
     1021 atgatggaga gctctttggc tgatttcatg caagaagtag gctatggctt ttgtgcaagt
     1081 attgaagaat gtcgcaatat aatcgtgcag tttggtgttc gggaggtcac agctgcccag
     1141 gttgcaaggg ttttgggaat gatggctcga actcattcag gattaacaga tggcattcca
     1201 ttacagagta tttctgctcc gggcagtggg atctggagtg atgggaaaga taaaagtgat
     1261 ggagcacagg cacacacatg gaatgtagaa gtcttgattg acgttcttaa agaactgaat
     1321 ccaagtttga atttcaagga agtaacttat gaactggacc atcctggatt tcaaattcgt
     1381 gacagtaaag gacttcataa tgtggtttat ggcattcaga ggggtttggg tatggaagtg
     1441 ttcccagtag acctcatata tagaccttgg aaacatgctg aaggccagct ctccttcatt
     1501 caacattccc ttataaatcc agagatcttc tgttttgctg actatccctg tcatactgtt
     1561 gccactgata ttctgaaagc accaccagag gatgacaatc gagaaattgc cacatggaag
     1621 agcttggatt tgattgaatc tctgctgagg cttgcagagg ttgggcagta tgagcaagtc
     1681 aaacagctct tcagcttccc tatcaaacac tgtccagaca tgctggtatt ggccttacta
     1741 caaattaaca cctcttggca taccttgcgc catgaactta tctccactct gatgccaatt
     1801 ttccttggaa accatcctaa ctcagctatt attttgcact atgcatggca tgggcaggga
     1861 cagtctccct caattcgcca acttatcatg catgcaatgg cagaatggta catgagaggg
     1921 gagcagtatg atcaggccaa attgtctcga atacttgatg tggcccagga cttgaaggcc
     1981 ttgtcaatgc tgctaaatgg tactccattt gcctttgtta ttgaccttgc tgcacttgct
     2041 tcacgtcgtg aatacctcaa acttgataag tggctcacag ataaaattcg agagcatggg
     2101 gagcctttta tccaggcgtg tatgactttt ttaaagagac ggtgtccttc tattttgggc
     2161 ggacttgccc cagaaaaaga ccagcccaaa agtgctcaac ttcctccaga aactttggcg
     2221 acaatgttgg cctgtctgca agcttgtgca gggagtgttt ctcaggagct atcagaaact
     2281 atcctcacca tggtagccaa ttgcagtaat gttatgaata aggccagaca accaccacct
     2341 ggagttatgc caaaaggacg tcctcctagt gctagcagct tagatgccat ttctcctgtt
     2401 cagattgacc ctcttgctgg aatgacatct cttagtatag gtggttcagc tgcccctcac
     2461 acccagagta tgcagggttt tcctccaaat ttgggttctg cattcagtac ccctcagtca
     2521 ccagcaaaag catttccacc cctttcaacc cccaatcaga ccactgcatt cagtggtatt
     2581 ggaggacttt catcacagct tccagtaggt ggtcttggca caggcagcct gactggtata
     2641 ggaactggtg ctcttggact ccctgcagtg aataacgacc cttttgtaca gaggaaactg
     2701 ggcacctctg gactgaatca gcctacattc cagcagagta agatgaaacc ttcggacttg
     2761 tctcaggtgt ggccagaggc aaaccagcac tttagtaaag agatagatga tgaagcaaac
     2821 agctatttcc agcgaatata taatcatcca ccacatccaa ccatgtctgt tgatgaggta
     2881 ttagaaatgc tgcagagatt taaagactct actataaaga gggaacgaga agtatttaac
     2941 tgtatgctaa ggaacttgtt tgaagaatat cgtttttttc cccagtatcc tgataaagag
     3001 ttacatataa cagcctgcct atttggtggt ataattgaga aaggactggt cacttacatg
     3061 gcactaggtc tggctctacg atatgttctt gaagccttac gcaagccttt tggatccaaa
     3121 atgtattatt tcgggattgc tgcactagat agatttaaaa acagattgaa ggactatccc
     3181 cagtattgtc agcatttggc ttctatcagt cactttatgc aatttccaca tcatttacag
     3241 gagtatattg agtatggaca gcagtctaga gatcctcctg tgaaaatgca aggctctatc
     3301 acaacccctg gaagtattgc actggctcag gcccaggctc aggcccaggt tccagcaaaa
     3361 gctcctcttg ctggtcaagt tagcactatg gtaaccacct caacaactac cactgttgct
     3421 aaaacggtta cggtcaccag gccaactgga gtcagcttta agaaagatgt gccaccttct
     3481 attaatacta caaatataga tacgttgctt gtggccacag atcaaactga gagaattgtg
     3541 gagcccccag aaaatatcca ggagaaaatt gcttttattt tcaataatct ctcacagtca
     3601 aatatgacac aaaaggttga agagctaaag gaaacggtga aagaagaatt tatgccttgg
     3661 gtttcacagt atctggttat gaagagagtc agtattgagc caaactttca tagcctgtat
     3721 tcaaacttcc ttgacacgct gaagaatcct gaatttaaca agatggttct gaatgagacc
     3781 tacagaaaca ttaaagtgct cctgacctct gataaagctg cagccaattt ctcagatcgt
     3841 tctttgctga agaacttggg acattggcta ggaatgatca cattagctaa aaacaaaccc
     3901 atcttacaca ctgacttgga tgtgaaatca ttgctgctag aggcttatgt taaaggacaa
     3961 caagaattgc tctatgtagt gccctttgtt gccaaagtct tagaatctag cattcgtagt
     4021 gtggttttta ggccaccaaa cccttggaca atggcaatta tgaatgtatt agctgagcta
     4081 catcaggagc atgacttaaa gttaaacttg aagtttgaaa tcgaggttct ctgcaagaac
     4141 cttgcattag acatcaatga gctaaaacct ggaaacctcc taaaggataa agatcgcctg
     4201 aagaatttag atgagcaact ctctgctcca aagaaagatg tcaagcagcc agaagaactc
     4261 cctcccatca caaccacaac aacttctact acaccagcta ccaacaccac ttgtacagcc
     4321 acggttccac cacagccaca gtacagctac cacgacatca atgtctattc ccttgcgggc
     4381 ttggcaccac acattactct gaatccaaca attcccttgt ttcaggccca tccacagttg
     4441 aagcagtgtg tgcgtcaggc aattgaacgg gctgtccagg agctggtcca tcctgtggtg
     4501 gatcgatcaa ttaagattgc catgactact tgtgagcaaa tagtcaggaa ggattttgcc
     4561 ctggattcgg aggaatctcg aatgcgaata gcagctcatc acatgatgcg taacttgaca
     4621 gctggaatgg ctatgattac atgcagggaa cctttgctca tgagcatatc taccaactta
     4681 aaaaacagtt ttgcctcagc ccttcgtact gcttccccac aacaaagaga aatgatggat
     4741 caggcagctg ctcaattagc tcaggacaat tgtgagttgg cttgctgttt tattcagaag
     4801 actgcagtag aaaaagcagg ccctgagatg gacaagagat tagcaactga atttgagctg
     4861 agaaaacatg ctaggcaaga aggacgcaga tactgtgatc ctgttgtttt aacatatcaa
     4921 gctgaacgga tgccagagca aatcaggctg aaagttggtg gtgtggaccc aaagcagttg
     4981 gctgtttacg aagagtttgc acgcaatgtt cctggcttct tacctacaaa tgacttaagt
     5041 cagcccacgg gatttttagc ccagcccatg aagcaagctt gggcaacaga tgatgtagct
     5101 cagatttatg ataagtgtat tacagaactg gagcaacatc tacatgccat cccaccaact
     5161 ttggccatga accctcaagc tcaggctctt cgaagtctct tggaggttgt agttttatct
     5221 cgaaactctc gggatgccat agctgctctt ggattgctcc aaaaggctgt agagggctta
     5281 ctagatgcca caagtggtgc tgatgctgac cttctgctgc gctacaggga atgccacctc
     5341 ttggtcctaa aagctctgca ggatggccgg gcatatgggt ctccatggtg caacaaacag
     5401 atcacaaggt gcctaattga atgtcgagat gaatataaat ataatgtgga ggctgtggag
     5461 ctgctaattc gcaatcattt ggttaatatg cagcagtatg atcttcacct agcgcagtca
     5521 atggagaatg gcttaaacta catggctgtg gcatttgcta tgcagttagt aaaaatcctg
     5581 ctggtggatg aaaggagtgt tgctcatgtt actgaggcag atctgttcca caccattgaa
     5641 accctcatga ggattaatgc tcattccaga ggcaatgctc cagaaggatt gccccagctg
     5701 atggaagtag tgcgatccaa ctatgaagca atgattgatc gtgctcatgg aggcccaaac
     5761 tttatgatgc attctgggat ctctcaagcc tcagagtatg atgaccctcc aggcctgagg
     5821 gagaaggcag agtatcttct gagggaatgg gtgaatctct accattcagc agcagctggc
     5881 cgcgacagta ccaaagcttt ctctgcattt gttggacaga tgcaccagca aggaatactg
     5941 aagaccgatg atctcataac aaggttcttt cgtctgtgta ctgaaatgtg tgttgaaatc
     6001 agttaccgtg ctcaggctga gcagcagcac aatcctgctg ccaatcccac catgatccga
     6061 gccaagtgct atcacaacct ggatgccttt gttcgactca ttgcactgct cgtgaaacac
     6121 tcaggggagg ccaccaacac tgtcacaaag attaatctgc tgaacaaggt ccttggtata
     6181 gtagtgggag ttctccttca ggatcatgat gttcgtcaga gtgaatttca gcaacttccc
     6241 taccatcgaa tttttatcat gcttctcttg gaactcaatg cacctgagca tgtgttggaa
     6301 accattaatt tccagacact tacagctttc tgcaatacat tccacatctt gaggcctacc
     6361 aaagctcctg gctttgtata tgcctggctt gaactgattt cccatcggat atttattgca
     6421 agaatgctgg cacatacgcc acagcagaag gggtggccta tgtatgcaca gctactgatt
     6481 gatttattca aatatttagc gcctttcctt agaaatgtgg aactcaccaa acctatgcaa
     6541 atcctctaca agggcacttt aagagtgctg ctggttcttt tgcatgattt cccagagttc
     6601 ctttgtgatt accattatgg gttctgtgat gtgatcccac ctaattgtat ccagttaaga
     6661 aatttgatcc tgagtgcctt tccaagaaac atgaggctcc ccgacccatt cactcctaat
     6721 ctaaaggtgg acatgttgag tgaaattaac attgctcccc ggattctcac caatttcact
     6781 ggagtaatgc cacctcagtt caaaaaggat ttggattcct atcttaaaac tcgatcacca
     6841 gtcactttcc tgtctgatct gcgcagcaac ctacaggtat ccaatgaacc tgggaatcgc
     6901 tacaacctcc agctcatcaa tgcactggtg ctctatgtcg ggactcaggc cattgcgcac
     6961 atccacaaca agggcagcac accttcaatg agcaccatca ctcactcagc acacatggat
     7021 atcttccaga atttggctgt ggacttggac actgagggtc gctatctctt tttgaatgca
     7081 attgcaaatc agctccggta cccaaatagc cacactcact acttcagttg caccatgctg
     7141 tacctttttg cagaggccaa tacggaagcc atccaagaac agatcacaag agttctcttg
     7201 gaacggttga ttgtaaatag gccacatcct tggggtcttc ttattacctt cattgagctg
     7261 attaaaaacc cagcgtttaa gttctggaac catgaatttg tacactgtgc cccagaaatc
     7321 gaaaagttat tccagtcggt cgcacagtgc tgcatgggac agaagcaggc ccagcaagta
     7381 atggaaggga caggtgccag ttagacgaaa ctgcatctct gttgtacgtg tcagtctaga
     7441 ggtctcactg caccgagttc ataaactgac tgaagaatcc tttcagctct tcctgacttt
     7501 cccagccctt tggtttgtgg gtatctgccc caactactgt tgggatcagc ctcctgtctt
     7561 atgtgggcac gttccaaagt ttaaatgcat ttttttgact cttggccaaa atttagaaga
     7621 tgctgtgaat atcattttga acttgtgtaa atacatgaaa gagaaaacct ttgtctggaa
     7681 cttcttggct ttgtgcaagc tgtgtccaag gcaagtacat aaactggtac cttgtaatga
     7741 agaggcagct gatgccatgc acttgtctga gggcatagct ccatgtcttc tgacattcct
     7801 ggtgtcccaa agaatagcaa aaagccagtt tgaatattat gtaacttatt tttttaatgt
     7861 ggacagggga ccttgaaaat cactaagtta ttaaaaatgt ggatgtgcta gaattggata
     7921 tgtccaggaa catgggaagg gctcactatt ggaatcccat gagtttccat tttgtctcta
     7981 cccaaacgta ttccaaagct gactgcattt gtaccatctt atttcttttg gggattatac
     8041 acctcagccg cctgagatgg gggtcagctc tttatataaa gggaaaccag accaggccta
     8101 aagcccaccc ctaccctcac ccccccaatc ctctcctgaa acttaaaaac agtgggaata
     8161 taggaaaggg aaccaaatct cattaattaa ttgttctccc ccattacccc actgaatgaa
     8221 tggccataca ggctaagctg aataatgaca aagttgaaag gaccaataca gcccctttta
     8281 taaggatttt gaatgttttg caaatgtatt ggtccctgtg ttgtattttg tagccttttc
     8341 ctgggcttca gctcccctac ttcttgtatg tgtatgcata ctgtagctaa ccattaaagt
     8401 catgacacac a
//
