LOCUS       NM_199078               4756 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cyclin and CBS domain divalent metal cation transport
            mediator 3 (CNNM3), transcript variant 2, mRNA.
ACCESSION   NM_199078 XM_001127059
VERSION     NM_199078.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4756)
  AUTHORS   Bai,Z., Feng,J., Franken,G.A.C., Al'Saadi,N., Cai,N., Yu,A.S.,
            Lou,L., Komiya,Y., Hoenderop,J.G.J., de Baaij,J.H.F., Yue,L. and
            Runnels,L.W.
  TITLE     CNNM proteins selectively bind to the TRPM7 channel to stimulate
            divalent cation entry into cells
  JOURNAL   PLoS Biol 19 (12), e3001496 (2021)
   PUBMED   34928937
  REMARK    GeneRIF: CNNM proteins selectively bind to the TRPM7 channel to
            stimulate divalent cation entry into cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4756)
  AUTHORS   Xu,H., Chai,S.S., Lv,P. and Wang,J.J.
  TITLE     CNN3 in glioma: The prognostic factor and a potential
            immunotherapeutic target
  JOURNAL   Medicine (Baltimore) 100 (46), e27931 (2021)
   PUBMED   34797350
  REMARK    GeneRIF: CNN3 in glioma: The prognostic factor and a potential
            immunotherapeutic target.
REFERENCE   3  (bases 1 to 4756)
  AUTHORS   Cai,F., Huang,Y., Wang,M., Sun,M., Zhao,Y. and Hattori,M.
  TITLE     A FRET-based screening method to detect potential inhibitors of the
            binding of CNNM3 to PRL2
  JOURNAL   Sci Rep 10 (1), 12879 (2020)
   PUBMED   32733084
  REMARK    GeneRIF: A FRET-based screening method to detect potential
            inhibitors of the binding of CNNM3 to PRL2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4756)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4756)
  AUTHORS   Chen,Y.S., Kozlov,G., Fakih,R., Funato,Y., Miki,H. and Gehring,K.
  TITLE     The cyclic nucleotide-binding homology domain of the integral
            membrane protein CNNM mediates dimerization and is required for
            Mg2+ efflux activity
  JOURNAL   J Biol Chem 293 (52), 19998-20007 (2018)
   PUBMED   30341174
  REMARK    GeneRIF: This study determined the first crystal structures of the
            cyclic nucleotide-binding homology (CNBH) domain domains of CNNM2
            and CNNM3 at 2.6 and 1.9 A resolutions.
REFERENCE   6  (bases 1 to 4756)
  AUTHORS   Gomez Garcia,I., Oyenarte,I. and Martinez-Cruz,L.A.
  TITLE     Purification, crystallization and preliminary crystallographic
            analysis of the CBS pair of the human metal transporter CNNM4
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 67 (Pt 3), 349-353
            (2011)
   PUBMED   21393841
REFERENCE   7  (bases 1 to 4756)
  AUTHORS   Kerns,S.L., Ostrer,H., Stock,R., Li,W., Moore,J., Pearlman,A.,
            Campbell,C., Shao,Y., Stone,N., Kusnetz,L. and Rosenstein,B.S.
  TITLE     Genome-wide association study to identify single nucleotide
            polymorphisms (SNPs) associated with the development of erectile
            dysfunction in African-American men after radiotherapy for prostate
            cancer
  JOURNAL   Int J Radiat Oncol Biol Phys 78 (5), 1292-1300 (2010)
   PUBMED   20932654
REFERENCE   8  (bases 1 to 4756)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 4756)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   10 (bases 1 to 4756)
  AUTHORS   Wang,C.Y., Shi,J.D., Yang,P., Kumar,P.G., Li,Q.Z., Run,Q.G.,
            Su,Y.C., Scott,H.S., Kao,K.J. and She,J.X.
  TITLE     Molecular cloning and characterization of a novel gene family of
            four ancient conserved domain proteins (ACDP)
  JOURNAL   Gene 306, 37-44 (2003)
   PUBMED   12657465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK126847.1, BC007199.1 and AC092636.3.
            
            On May 31, 2019 this sequence version replaced NM_199078.2.
            
            Transcript Variant: This variant (2) lacks an in-frame coding exon,
            compared to variant 1. The resulting isoform (2) is shorter than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000025.1, SRR14038192.2737132.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1235              AK126847.1         15-1249
            1236-1925           BC007199.1         406-1095
            1926-4756           AC092636.3         85798-88628
FEATURES             Location/Qualifiers
     source          1..4756
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..4756
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /note="cyclin and CBS domain divalent metal cation
                     transport mediator 3"
                     /db_xref="GeneID:26505"
                     /db_xref="HGNC:HGNC:104"
                     /db_xref="MIM:607804"
     exon            1..1235
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1990
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; ancient conserved domain protein 3; metal
                     transporter CNNM3; cyclin-M3; ancient conserved
                     domain-containing protein 3"
                     /codon_start=1
                     /product="metal transporter CNNM3 isoform 2 precursor"
                     /protein_id="NP_951060.1"
                     /db_xref="CCDS:CCDS2026.1"
                     /db_xref="GeneID:26505"
                     /db_xref="HGNC:HGNC:104"
                     /db_xref="MIM:607804"
                     /translation="MAAAVAAAGRLGWLFAALCLGNAAGEAAPGPRVLGFCLEEDGAA
                     GAGWVRGGAARDTPDATFLLRLFGPGFANSSWSWVAPEGAGCREEAASPAGEWRALLR
                     LRLRAEAVRPHSALLAVRVEPGGGAAEEAAPPWALGLGAAGLLALAALARGLQLSALA
                     LAPAEVQVLRESGSEAERAAARRLEPARRWAGCALGALLLLASLAQAALAVLLYRAAG
                     QRAVPAVLGSAGLVFLVGEVVPAAVSGRWTLALAPRALGLSRLAVLLTLPVALPVGQL
                     LELAARPGRLRERVLELARGGGDPYSDLSKGVLRCRTVEDVLTPLEDCFMLDASTVLD
                     FGVLASIMQSGHTRIPVYEEERSNIVDMLYLKDLAFVDPEDCTPLSTITRFYNHPLHF
                     VFNDTKLDAVLEEFKRGDTVVKRKPASLMAPLKRKEEFSLFKVSDDEYKVTISPQLLL
                     ATQRFLSREVDVFSPLRISEKVLLHLLKHPSVNQEVRFDESNRLATHHYLYQRSQPVD
                     YFILILQGRVEVEIGKEGLKFENGAFTYYGVSALTVPSSVHQSPVSSLQPIRHDLQPD
                     PGDGTHSSAYCPDYTVRALSDLQLIKVTRLQYLNALLATRAQNLPQSPENTDLQVIPG
                     SQTRLLGEKTTTAAGSSHSRPGVPVEGSPGRNPGV"
     exon            1236..1385
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1555
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1652
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1786
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1925
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..4756
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2948
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /note="major polyA site"
     regulatory      3226..3231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /note="hexamer: AATAAA"
     polyA_site      3243
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /note="major polyA site"
     regulatory      4543..4548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /note="hexamer: TATAAA"
     polyA_site      4569
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /note="major polyA site"
     regulatory      4730..4735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /note="hexamer: AATAAA"
     polyA_site      4756
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
ORIGIN      
        1 gcagcaggcg atggcggcgg cggtagctgc ggcgggtcgg ttaggctggt tgttcgccgc
       61 gctctgcctg ggcaacgccg cgggggaggc cgcgccgggc ccgcgagtgc tgggcttctg
      121 cctggaggag gatggagcgg cgggcgcggg ttgggtacgc ggaggggcgg cgcgggacac
      181 gccggacgcc accttcctcc tgcgcctctt cggcccgggc ttcgccaaca gctcttggtc
      241 ctgggtggcc ccggaggggg cgggctgccg ggaggaggcg gcctcccccg cgggcgagtg
      301 gcgcgcgctg ctgcgcttgc gcctgcgggc cgaggccgtg cgcccgcact cggcgctgct
      361 ggcggtgcgc gtggagccgg gtggcggggc ggctgaggag gcggcgccgc cctgggctct
      421 gggcctgggg gcggccgggc tgctggcgct ggcagcgctg gcgcgaggcc tgcagctgag
      481 cgcgctggcg ctggcgcctg ccgaggtgca ggtgctgcgc gagagcggct cggaggcgga
      541 gcgtgcggcg gcgcggcgtt tggagcccgc gcggcgctgg gccggctgcg ccttgggcgc
      601 gctgctgctg ctggccagcc tggcgcaggc ggcgctggcg gtgctgctgt accgcgcggc
      661 cggccagcgt gcggtgcccg ccgtgttggg cagcgcgggg ctcgtgttcc tggtgggaga
      721 ggtggtgccg gccgccgtga gcgggcgctg gacgctggcg ctggcgccgc gagcgctcgg
      781 cctcagccgc ctggccgtcc tgctcactct gcccgtcgcg ctgcccgtgg ggcagctgct
      841 ggagctggcg gcgcggcccg ggcggctgcg ggagcgggtg ctggagctgg cgcgcggcgg
      901 cggcgacccc tacagcgatc tcagcaaggg cgtgctgcgc tgccggaccg tggaggacgt
      961 gctcacgccc ctcgaagact gcttcatgct ggacgccagc accgtgctgg acttcggcgt
     1021 cctggccagc atcatgcaga gcggccacac gcgcatcccg gtgtacgagg aggagcgctc
     1081 caacatcgtg gacatgctct acctcaagga cttggccttc gtggatcccg aagactgcac
     1141 gccgctcagc accatcactc gtttctacaa ccatccgctc cacttcgtct tcaacgacac
     1201 caagctggac gctgtcctgg aggaattcaa gcgaggagac accgtggtga agaggaagcc
     1261 tgcttctctg atggcccctc tgaagcggaa ggaggagttc tccttgttca aggtgtctga
     1321 tgatgaatat aaagtaacaa tctcgcctca gctgctcttg gccacccagc gcttcctgtc
     1381 ccgagaagtg gatgtattca gcccgctgcg catctctgag aaggtcctgc tgcacctgtt
     1441 gaagcatccc agtgtcaacc aggaagtgag gtttgacgag agcaaccggc tggccacaca
     1501 ccactacctg taccagcgca gccagccggt ggattacttc attctcatcc tgcagggcag
     1561 ggttgaagtg gagatcggga aagagggtct gaagtttgag aatggggcct tcacgtacta
     1621 tggagtgtcg gccctaactg tgccatcctc ggttcaccag tccccggtgt cctcgctcca
     1681 gcccatccgc catgacctgc agcccgaccc aggtgacggc acgcattcat ctgcgtattg
     1741 tcccgactac accgtgaggg cgctctctga tctgcagctc atcaaggtta cgcgactgca
     1801 gtacctcaat gcactcctgg ctacccgagc ccagaacctg ccacagtccc ctgagaacac
     1861 cgacctgcag gttattccag gcagccagac caggctcctt ggtgagaaga ccaccacagc
     1921 ggcagggtcc agccacagca ggcccggcgt cccggtggaa ggcagccctg ggcggaaccc
     1981 aggcgtttaa cggctcacta ggcagcccca gatctgggga acagatgagc acgtggggag
     2041 ctggagtgag ctgagcagaa gttttgtgcc cgcctgcccc catcccctcc aggccacgtt
     2101 ttagatggcc cttgtagttg cgggtcctgg gtgtcctcag aactagacat caatgcctgg
     2161 atccttcagc cggccctgcc ctcctttagg agacaggagt caccagggca cagccctcca
     2221 ggcccgcctc aggaaggaat gaaaggaatg ccatcatctc tagttcccag ggcccagcct
     2281 tccccttctc ccccggggca gggacagtgc ggcatattca gattcagacc tctttgggct
     2341 gagccacctt gtgagtgcag ttactgcctt tgtgtggccg tgacctctat ttgtttgctt
     2401 ttaatttgcc aacctatcgc tgctggcagc actttttgag caagccgaga gcacccattt
     2461 tggctggggg ttcagatcga tggccttgtc catgttgtcc tttctggctt ccctgatggt
     2521 gtcatgtttc agcgcatgcg ccccagcctt tcccatgtgc caaaccagaa gctccactgc
     2581 ccgtaggctg tccctgtagc cctgctccct ccctggaggc tgctcttctg attctgagag
     2641 ctggcctagt ggtgctgagg gcccctttct gcttctctgc ccacctgctg agttgccact
     2701 cgcagtgttg tcagttcccg tgttctgaga agaggtcatg cctgggagga agggatcgtc
     2761 atgctgcatc gaatcctctc tccgccgtgt ggcccccagg agagtagctg cctgttgcac
     2821 ctgctccaca cctccccaca gcctccctgc aggtgctgtg tggccgtgat gtgcagagag
     2881 cagtgaggga gggttcatga accaggtgga tcctctttaa aaaaaaaaaa gtttttgtta
     2941 tatctctaga acatttcaag tcttttcctt tttttctgtt cctagctatg gggttttaga
     3001 gaagtgggaa caggaaggca tttgtctttt tcttctagtt tactacattt tccttccgta
     3061 gttcttcagc tgtgtggaaa cgggcatcac aaggacatag gatcatagat tgggtaggga
     3121 gggaggagga tttctggaac ttttctcaaa ggaatttgga cccttataaa tgggactgaa
     3181 ggtcaaaaca acagtgatat ccttgcttag aaattgtcct caaggaataa actctgagag
     3241 caagcccggg ttggaaacag atgctttaaa atcctctctc cagaacagtg gttttttgtt
     3301 tgtttatttg agatggagtc tcactctgtc acccaggctg gagtgcagtg gtgagatctt
     3361 ggctcactgc aacctccacc tcccaggttc aagccattct cctgtctcag ccccctgagt
     3421 agctgggatt acaggtgccc accaccacac ccggctaatt tttgtatttt tagtagagat
     3481 ggggtttcac catgttggcc aggctgatct tgaactcctg acctcaggtg atctgcctgc
     3541 cttggcctcc caaagtgctg ggattatagg tgtgagctaa gatcagggat tcttaacctt
     3601 ggctgcacac cagaatcacc tggcaaatta aaaatacgtg gacctgccac cagagcttgt
     3661 gatttaatca gagtcggcat cagagttttc aattttttat ttatttatta ttattattat
     3721 tattattatt attattgaga caagatcttg ctctgtcgcc cagactggag tgcagtggtg
     3781 tgatcacggc ttgctgcagc ctcgacctcc ctggttcagg ccatcctgcc acctcagcct
     3841 cctgagtagt agggactaca ggtaggcacc accacaccca gctaatactt ttaatttttt
     3901 tttgtagaga tagggtctca ttatgttgcc tggggtagtc tcgaactcct aggctcaagc
     3961 gatcctcctg cctcggcctc ccaaagtgtt gagattatag gcgtgagcca ccgtgcccag
     4021 attcacagaa gtttcataca cctttcaccc aggttcccct aatgttaaca gcttacatat
     4081 aaccttggta catttatcaa aactaaaggt gcaatcatac taatagctag agtttatttg
     4141 gattttacca tttttcccaa tgtccctttt ctgctgcagc agccaatcca ggatgccata
     4201 ctgcacttag agctgttgct ttcttttttc ctaactttat attttgaaat aatttcagat
     4261 gataggaagt tgtaaaggta agggccccac gcacccttca tctagtttcc ctccatggtt
     4321 acatcttata tggttgtaat gcagtattcc aacaaagact ctgacactgg tgcgatgtgg
     4381 gtggacagtc caaatcattt gtcacatgta catctgtgta actaccactg caatcaggat
     4441 aaagaagtcc catccccaca aggatctccc tccccacctt ccctaactcc tggtaaccac
     4501 taatcgttca tctcttctta ttttgtcatt tcaagaatgt tgtataaatg ggagcatagt
     4561 gtgtaagcat tcgggattgt cttttttcac tcggcgtcat tctcgggaga tcatccaggc
     4621 attgcatgtg tcaacagttt gctccttttt attgctgagt ggtattccgt ggtgtatgca
     4681 ttggccccct gaaggacacc tgggatgttt ccagtttggg gctattccaa ataaagctgc
     4741 tacgactatt catgta
//
