LOCUS       NM_017623               4900 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cyclin and CBS domain divalent metal cation transport
            mediator 3 (CNNM3), transcript variant 1, mRNA.
ACCESSION   NM_017623
VERSION     NM_017623.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4900)
  AUTHORS   Bai,Z., Feng,J., Franken,G.A.C., Al'Saadi,N., Cai,N., Yu,A.S.,
            Lou,L., Komiya,Y., Hoenderop,J.G.J., de Baaij,J.H.F., Yue,L. and
            Runnels,L.W.
  TITLE     CNNM proteins selectively bind to the TRPM7 channel to stimulate
            divalent cation entry into cells
  JOURNAL   PLoS Biol 19 (12), e3001496 (2021)
   PUBMED   34928937
  REMARK    GeneRIF: CNNM proteins selectively bind to the TRPM7 channel to
            stimulate divalent cation entry into cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4900)
  AUTHORS   Xu,H., Chai,S.S., Lv,P. and Wang,J.J.
  TITLE     CNN3 in glioma: The prognostic factor and a potential
            immunotherapeutic target
  JOURNAL   Medicine (Baltimore) 100 (46), e27931 (2021)
   PUBMED   34797350
  REMARK    GeneRIF: CNN3 in glioma: The prognostic factor and a potential
            immunotherapeutic target.
REFERENCE   3  (bases 1 to 4900)
  AUTHORS   Cai,F., Huang,Y., Wang,M., Sun,M., Zhao,Y. and Hattori,M.
  TITLE     A FRET-based screening method to detect potential inhibitors of the
            binding of CNNM3 to PRL2
  JOURNAL   Sci Rep 10 (1), 12879 (2020)
   PUBMED   32733084
  REMARK    GeneRIF: A FRET-based screening method to detect potential
            inhibitors of the binding of CNNM3 to PRL2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4900)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4900)
  AUTHORS   Chen,Y.S., Kozlov,G., Fakih,R., Funato,Y., Miki,H. and Gehring,K.
  TITLE     The cyclic nucleotide-binding homology domain of the integral
            membrane protein CNNM mediates dimerization and is required for
            Mg2+ efflux activity
  JOURNAL   J Biol Chem 293 (52), 19998-20007 (2018)
   PUBMED   30341174
  REMARK    GeneRIF: This study determined the first crystal structures of the
            cyclic nucleotide-binding homology (CNBH) domain domains of CNNM2
            and CNNM3 at 2.6 and 1.9 A resolutions.
REFERENCE   6  (bases 1 to 4900)
  AUTHORS   Gomez Garcia,I., Oyenarte,I. and Martinez-Cruz,L.A.
  TITLE     Purification, crystallization and preliminary crystallographic
            analysis of the CBS pair of the human metal transporter CNNM4
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 67 (Pt 3), 349-353
            (2011)
   PUBMED   21393841
REFERENCE   7  (bases 1 to 4900)
  AUTHORS   Kerns,S.L., Ostrer,H., Stock,R., Li,W., Moore,J., Pearlman,A.,
            Campbell,C., Shao,Y., Stone,N., Kusnetz,L. and Rosenstein,B.S.
  TITLE     Genome-wide association study to identify single nucleotide
            polymorphisms (SNPs) associated with the development of erectile
            dysfunction in African-American men after radiotherapy for prostate
            cancer
  JOURNAL   Int J Radiat Oncol Biol Phys 78 (5), 1292-1300 (2010)
   PUBMED   20932654
REFERENCE   8  (bases 1 to 4900)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 4900)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   10 (bases 1 to 4900)
  AUTHORS   Wang,C.Y., Shi,J.D., Yang,P., Kumar,P.G., Li,Q.Z., Run,Q.G.,
            Su,Y.C., Scott,H.S., Kao,K.J. and She,J.X.
  TITLE     Molecular cloning and characterization of a novel gene family of
            four ancient conserved domain proteins (ACDP)
  JOURNAL   Gene 306, 37-44 (2003)
   PUBMED   12657465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK126847.1 and AC092636.3.
            
            On Nov 23, 2018 this sequence version replaced NM_017623.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037272.1, AK126847.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305510.4/ ENSP00000305449.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3062              AK126847.1         15-3076
            3063-4900           AC092636.3         86791-88628
FEATURES             Location/Qualifiers
     source          1..4900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..4900
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /note="cyclin and CBS domain divalent metal cation
                     transport mediator 3"
                     /db_xref="GeneID:26505"
                     /db_xref="HGNC:HGNC:104"
                     /db_xref="MIM:607804"
     exon            1..1235
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..2134
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ancient conserved domain protein 3; metal
                     transporter CNNM3; cyclin-M3; ancient conserved
                     domain-containing protein 3"
                     /codon_start=1
                     /product="metal transporter CNNM3 isoform 1 precursor"
                     /protein_id="NP_060093.3"
                     /db_xref="CCDS:CCDS2025.1"
                     /db_xref="GeneID:26505"
                     /db_xref="HGNC:HGNC:104"
                     /db_xref="MIM:607804"
                     /translation="MAAAVAAAGRLGWLFAALCLGNAAGEAAPGPRVLGFCLEEDGAA
                     GAGWVRGGAARDTPDATFLLRLFGPGFANSSWSWVAPEGAGCREEAASPAGEWRALLR
                     LRLRAEAVRPHSALLAVRVEPGGGAAEEAAPPWALGLGAAGLLALAALARGLQLSALA
                     LAPAEVQVLRESGSEAERAAARRLEPARRWAGCALGALLLLASLAQAALAVLLYRAAG
                     QRAVPAVLGSAGLVFLVGEVVPAAVSGRWTLALAPRALGLSRLAVLLTLPVALPVGQL
                     LELAARPGRLRERVLELARGGGDPYSDLSKGVLRCRTVEDVLTPLEDCFMLDASTVLD
                     FGVLASIMQSGHTRIPVYEEERSNIVDMLYLKDLAFVDPEDCTPLSTITRFYNHPLHF
                     VFNDTKLDAVLEEFKRGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIRSEIL
                     DESEDYRDTVVKRKPASLMAPLKRKEEFSLFKVSDDEYKVTISPQLLLATQRFLSREV
                     DVFSPLRISEKVLLHLLKHPSVNQEVRFDESNRLATHHYLYQRSQPVDYFILILQGRV
                     EVEIGKEGLKFENGAFTYYGVSALTVPSSVHQSPVSSLQPIRHDLQPDPGDGTHSSAY
                     CPDYTVRALSDLQLIKVTRLQYLNALLATRAQNLPQSPENTDLQVIPGSQTRLLGEKT
                     TTAAGSSHSRPGVPVEGSPGRNPGV"
     exon            1236..1379
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1529
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1699
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1796
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1930
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2069
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..4900
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3092
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /note="major polyA site"
     regulatory      3370..3375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /note="hexamer: AATAAA"
     polyA_site      3387
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /note="major polyA site"
     regulatory      4687..4692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /note="hexamer: TATAAA"
     polyA_site      4713
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /note="major polyA site"
     regulatory      4874..4879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
                     /note="hexamer: AATAAA"
     polyA_site      4900
                     /gene="CNNM3"
                     /gene_synonym="ACDP3; SLC70A3"
ORIGIN      
        1 gcagcaggcg atggcggcgg cggtagctgc ggcgggtcgg ttaggctggt tgttcgccgc
       61 gctctgcctg ggcaacgccg cgggggaggc cgcgccgggc ccgcgagtgc tgggcttctg
      121 cctggaggag gatggagcgg cgggcgcggg ttgggtacgc ggaggggcgg cgcgggacac
      181 gccggacgcc accttcctcc tgcgcctctt cggcccgggc ttcgccaaca gctcttggtc
      241 ctgggtggcc ccggaggggg cgggctgccg ggaggaggcg gcctcccccg cgggcgagtg
      301 gcgcgcgctg ctgcgcttgc gcctgcgggc cgaggccgtg cgcccgcact cggcgctgct
      361 ggcggtgcgc gtggagccgg gtggcggggc ggctgaggag gcggcgccgc cctgggctct
      421 gggcctgggg gcggccgggc tgctggcgct ggcagcgctg gcgcgaggcc tgcagctgag
      481 cgcgctggcg ctggcgcctg ccgaggtgca ggtgctgcgc gagagcggct cggaggcgga
      541 gcgtgcggcg gcgcggcgtt tggagcccgc gcggcgctgg gccggctgcg ccttgggcgc
      601 gctgctgctg ctggccagcc tggcgcaggc ggcgctggcg gtgctgctgt accgcgcggc
      661 cggccagcgt gcggtgcccg ccgtgttggg cagcgcgggg ctcgtgttcc tggtgggaga
      721 ggtggtgccg gccgccgtga gcgggcgctg gacgctggcg ctggcgccgc gagcgctcgg
      781 cctcagccgc ctggccgtcc tgctcactct gcccgtcgcg ctgcccgtgg ggcagctgct
      841 ggagctggcg gcgcggcccg ggcggctgcg ggagcgggtg ctggagctgg cgcgcggcgg
      901 cggcgacccc tacagcgatc tcagcaaggg cgtgctgcgc tgccggaccg tggaggacgt
      961 gctcacgccc ctcgaagact gcttcatgct ggacgccagc accgtgctgg acttcggcgt
     1021 cctggccagc atcatgcaga gcggccacac gcgcatcccg gtgtacgagg aggagcgctc
     1081 caacatcgtg gacatgctct acctcaagga cttggccttc gtggatcccg aagactgcac
     1141 gccgctcagc accatcactc gtttctacaa ccatccgctc cacttcgtct tcaacgacac
     1201 caagctggac gctgtcctgg aggaattcaa gcgagggaag tcccacctgg ccatcgtgca
     1261 gaaggtgaac aacgagggtg aaggcgaccc cttctacgag gtcctgggcc tggtcaccct
     1321 ggaggacgtg atcgaggaga tcatcaggtc cgagatcctg gacgagtctg aagactaccg
     1381 agacaccgtg gtgaagagga agcctgcttc tctgatggcc cctctgaagc ggaaggagga
     1441 gttctccttg ttcaaggtgt ctgatgatga atataaagta acaatctcgc ctcagctgct
     1501 cttggccacc cagcgcttcc tgtcccgaga agtggatgta ttcagcccgc tgcgcatctc
     1561 tgagaaggtc ctgctgcacc tgttgaagca tcccagtgtc aaccaggaag tgaggtttga
     1621 cgagagcaac cggctggcca cacaccacta cctgtaccag cgcagccagc cggtggatta
     1681 cttcattctc atcctgcagg gcagggttga agtggagatc gggaaagagg gtctgaagtt
     1741 tgagaatggg gccttcacgt actatggagt gtcggcccta actgtgccat cctcggttca
     1801 ccagtccccg gtgtcctcgc tccagcccat ccgccatgac ctgcagcccg acccaggtga
     1861 cggcacgcat tcatctgcgt attgtcccga ctacaccgtg agggcgctct ctgatctgca
     1921 gctcatcaag gttacgcgac tgcagtacct caatgcactc ctggctaccc gagcccagaa
     1981 cctgccacag tcccctgaga acaccgacct gcaggttatt ccaggcagcc agaccaggct
     2041 ccttggtgag aagaccacca cagcggcagg gtccagccac agcaggcccg gcgtcccggt
     2101 ggaaggcagc cctgggcgga acccaggcgt ttaacggctc actaggcagc cccagatctg
     2161 gggaacagat gagcacgtgg ggagctggag tgagctgagc agaagttttg tgcccgcctg
     2221 cccccatccc ctccaggcca cgttttagat ggcccttgta gttgcgggtc ctgggtgtcc
     2281 tcagaactag acatcaatgc ctggatcctt cagccggccc tgccctcctt taggagacag
     2341 gagtcaccag ggcacagccc tccaggcccg cctcaggaag gaatgaaagg aatgccatca
     2401 tctctagttc ccagggccca gccttcccct tctcccccgg ggcagggaca gtgcggcata
     2461 ttcagattca gacctctttg ggctgagcca ccttgtgagt gcagttactg cctttgtgtg
     2521 gccgtgacct ctatttgttt gcttttaatt tgccaaccta tcgctgctgg cagcactttt
     2581 tgagcaagcc gagagcaccc attttggctg ggggttcaga tcgatggcct tgtccatgtt
     2641 gtcctttctg gcttccctga tggtgtcatg tttcagcgca tgcgccccag cctttcccat
     2701 gtgccaaacc agaagctcca ctgcccgtag gctgtccctg tagccctgct ccctccctgg
     2761 aggctgctct tctgattctg agagctggcc tagtggtgct gagggcccct ttctgcttct
     2821 ctgcccacct gctgagttgc cactcgcagt gttgtcagtt cccgtgttct gagaagaggt
     2881 catgcctggg aggaagggat cgtcatgctg catcgaatcc tctctccgcc gtgtggcccc
     2941 caggagagta gctgcctgtt gcacctgctc cacacctccc cacagcctcc ctgcaggtgc
     3001 tgtgtggccg tgatgtgcag agagcagtga gggagggttc atgaaccagg tggatcctct
     3061 ttaaaaaaaa aaaagttttt gttatatctc tagaacattt caagtctttt cctttttttc
     3121 tgttcctagc tatggggttt tagagaagtg ggaacaggaa ggcatttgtc tttttcttct
     3181 agtttactac attttccttc cgtagttctt cagctgtgtg gaaacgggca tcacaaggac
     3241 ataggatcat agattgggta gggagggagg aggatttctg gaacttttct caaaggaatt
     3301 tggaccctta taaatgggac tgaaggtcaa aacaacagtg atatccttgc ttagaaattg
     3361 tcctcaagga ataaactctg agagcaagcc cgggttggaa acagatgctt taaaatcctc
     3421 tctccagaac agtggttttt tgtttgttta tttgagatgg agtctcactc tgtcacccag
     3481 gctggagtgc agtggtgaga tcttggctca ctgcaacctc cacctcccag gttcaagcca
     3541 ttctcctgtc tcagccccct gagtagctgg gattacaggt gcccaccacc acacccggct
     3601 aatttttgta tttttagtag agatggggtt tcaccatgtt ggccaggctg atcttgaact
     3661 cctgacctca ggtgatctgc ctgccttggc ctcccaaagt gctgggatta taggtgtgag
     3721 ctaagatcag ggattcttaa ccttggctgc acaccagaat cacctggcaa attaaaaata
     3781 cgtggacctg ccaccagagc ttgtgattta atcagagtcg gcatcagagt tttcaatttt
     3841 ttatttattt attattatta ttattattat tattattatt gagacaagat cttgctctgt
     3901 cgcccagact ggagtgcagt ggtgtgatca cggcttgctg cagcctcgac ctccctggtt
     3961 caggccatcc tgccacctca gcctcctgag tagtagggac tacaggtagg caccaccaca
     4021 cccagctaat acttttaatt tttttttgta gagatagggt ctcattatgt tgcctggggt
     4081 agtctcgaac tcctaggctc aagcgatcct cctgcctcgg cctcccaaag tgttgagatt
     4141 ataggcgtga gccaccgtgc ccagattcac agaagtttca tacacctttc acccaggttc
     4201 ccctaatgtt aacagcttac atataacctt ggtacattta tcaaaactaa aggtgcaatc
     4261 atactaatag ctagagttta tttggatttt accatttttc ccaatgtccc ttttctgctg
     4321 cagcagccaa tccaggatgc catactgcac ttagagctgt tgctttcttt tttcctaact
     4381 ttatattttg aaataatttc agatgatagg aagttgtaaa ggtaagggcc ccacgcaccc
     4441 ttcatctagt ttccctccat ggttacatct tatatggttg taatgcagta ttccaacaaa
     4501 gactctgaca ctggtgcgat gtgggtggac agtccaaatc atttgtcaca tgtacatctg
     4561 tgtaactacc actgcaatca ggataaagaa gtcccatccc cacaaggatc tccctcccca
     4621 ccttccctaa ctcctggtaa ccactaatcg ttcatctctt cttattttgt catttcaaga
     4681 atgttgtata aatgggagca tagtgtgtaa gcattcggga ttgtcttttt tcactcggcg
     4741 tcattctcgg gagatcatcc aggcattgca tgtgtcaaca gtttgctcct ttttattgct
     4801 gagtggtatt ccgtggtgta tgcattggcc ccctgaagga cacctgggat gtttccagtt
     4861 tggggctatt ccaaataaag ctgctacgac tattcatgta
//
