LOCUS       NM_017649              15857 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cyclin and CBS domain divalent metal cation transport
            mediator 2 (CNNM2), transcript variant 1, mRNA.
ACCESSION   NM_017649
VERSION     NM_017649.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15857)
  AUTHORS   Bosman,W., Franken,G.A.C., de Las Heras,J., Madariaga,L.,
            Barakat,T.S., Oostenbrink,R., van Slegtenhorst,M.,
            Perdomo-Ramirez,A., Claverie-Martin,F., van Eerde,A.M.,
            Vargas-Poussou,R., Dubourg,L.D., Gonzalez-Recio,I.,
            Martinez-Cruz,L.A., de Baaij,J.H.F. and Hoenderop,J.G.J.
  TITLE     Hypomagnesaemia with varying degrees of extrarenal symptoms as a
            consequence of heterozygous CNNM2 variants
  JOURNAL   Sci Rep 14 (1), 6917 (2024)
   PUBMED   38519529
  REMARK    GeneRIF: Hypomagnesaemia with varying degrees of extrarenal
            symptoms as a consequence of heterozygous CNNM2 variants.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15857)
  AUTHORS   Zhou,D.Y., Su,X., Wu,Y., Yang,Y., Zhang,L., Cheng,S., Shao,M.,
            Li,W., Zhang,Z., Wang,L., Lv,L., Li,M. and Song,M.
  TITLE     Decreased CNNM2 expression in prefrontal cortex affects
            sensorimotor gating function, cognition, dendritic spine
            morphogenesis and risk of schizophrenia
  JOURNAL   Neuropsychopharmacology 49 (2), 433-442 (2024)
   PUBMED   37715107
  REMARK    GeneRIF: Decreased CNNM2 expression in prefrontal cortex affects
            sensorimotor gating function, cognition, dendritic spine
            morphogenesis and risk of schizophrenia.
REFERENCE   3  (bases 1 to 15857)
  AUTHORS   Franken,G.A.C., Muller,D., Mignot,C., Keren,B., Levy,J.,
            Tabet,A.C., Germanaud,D., Tejada,M.I., Kroes,H.Y.,
            Nievelstein,R.A.J., Brimble,E., Ruzhnikov,M., Claverie-Martin,F.,
            Szczepanska,M., Cuk,M., Latta,F., Konrad,M., Martinez-Cruz,L.A.,
            Bindels,R.J.M., Hoenderop,J.G.J., Schlingmann,K.P. and de
            Baaij,J.H.F.
  TITLE     The phenotypic and genetic spectrum of patients with heterozygous
            mutations in cyclin M2 (CNNM2)
  JOURNAL   Hum Mutat 42 (4), 473-486 (2021)
   PUBMED   33600043
  REMARK    GeneRIF: The phenotypic and genetic spectrum of patients with
            heterozygous mutations in cyclin M2 (CNNM2).
REFERENCE   4  (bases 1 to 15857)
  AUTHORS   Garcia-Castano,A., Madariaga,L., Anton-Gamero,M., Mejia,N.,
            Ponce,J., Gomez-Conde,S., Perez de Nanclares,G., De la Hoz,A.B.,
            Martinez,R., Saso,L., Martinez de LaPiscina,I., Urrutia,I.,
            Velasco,O., Aguayo,A., Castano,L. and Gaztambide,S.
  TITLE     Novel variant in the CNNM2 gene associated with dominant
            hypomagnesemia
  JOURNAL   PLoS One 15 (9), e0239965 (2020)
   PUBMED   32997713
  REMARK    GeneRIF: Novel variant in the CNNM2 gene associated with dominant
            hypomagnesemia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 15857)
  AUTHORS   Stuiver,M., Lainez,S., Will,C., Terryn,S., Gunzel,D., Debaix,H.,
            Sommer,K., Kopplin,K., Thumfart,J., Kampik,N.B., Querfeld,U.,
            Willnow,T.E., Nemec,V., Wagner,C.A., Hoenderop,J.G., Devuyst,O.,
            Knoers,N.V., Bindels,R.J., Meij,I.C. and Muller,D.
  TITLE     CNNM2, encoding a basolateral protein required for renal Mg2+
            handling, is mutated in dominant hypomagnesemia
  JOURNAL   Am J Hum Genet 88 (3), 333-343 (2011)
   PUBMED   21397062
  REMARK    GeneRIF: The CNNM2 locus is associated with serum Mg(2+)
            concentrations.
REFERENCE   6  (bases 1 to 15857)
  CONSRTM   Coronary Artery Disease (C4D) Genetics Consortium
  TITLE     A genome-wide association study in Europeans and South Asians
            identifies five new loci for coronary artery disease
  JOURNAL   Nat Genet 43 (4), 339-344 (2011)
   PUBMED   21378988
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 15857)
  AUTHORS   Gomez Garcia,I., Oyenarte,I. and Martinez-Cruz,L.A.
  TITLE     Purification, crystallization and preliminary crystallographic
            analysis of the CBS pair of the human metal transporter CNNM4
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 67 (Pt 3), 349-353
            (2011)
   PUBMED   21393841
REFERENCE   8  (bases 1 to 15857)
  AUTHORS   Sponder,G., Svidova,S., Schweigel,M., Vormann,J. and Kolisek,M.
  TITLE     Splice-variant 1 of the ancient domain protein 2 (ACDP2)
            complements the magnesium-deficient growth phenotype of Salmonella
            enterica sv. typhimurium strain MM281
  JOURNAL   Magnes Res 23 (2), 105-114 (2010)
   PUBMED   20519162
  REMARK    GeneRIF: ACDP2 splice-variant 1 is a functional Mg2+-transporting
            entity per se.
REFERENCE   9  (bases 1 to 15857)
  AUTHORS   Yasuno,K., Bilguvar,K., Bijlenga,P., Low,S.K., Krischek,B.,
            Auburger,G., Simon,M., Krex,D., Arlier,Z., Nayak,N., Ruigrok,Y.M.,
            Niemela,M., Tajima,A., von und zu Fraunberg,M., Doczi,T.,
            Wirjatijasa,F., Hata,A., Blasco,J., Oszvald,A., Kasuya,H.,
            Zilani,G., Schoch,B., Singh,P., Stuer,C., Risselada,R., Beck,J.,
            Sola,T., Ricciardi,F., Aromaa,A., Illig,T., Schreiber,S., van
            Duijn,C.M., van den Berg,L.H., Perret,C., Proust,C., Roder,C.,
            Ozturk,A.K., Gaal,E., Berg,D., Geisen,C., Friedrich,C.M.,
            Summers,P., Frangi,A.F., State,M.W., Wichmann,H.E., Breteler,M.M.,
            Wijmenga,C., Mane,S., Peltonen,L., Elio,V., Sturkenboom,M.C.,
            Lawford,P., Byrne,J., Macho,J., Sandalcioglu,E.I., Meyer,B.,
            Raabe,A., Steinmetz,H., Rufenacht,D., Jaaskelainen,J.E.,
            Hernesniemi,J., Rinkel,G.J., Zembutsu,H., Inoue,I., Palotie,A.,
            Cambien,F., Nakamura,Y., Lifton,R.P. and Gunel,M.
  TITLE     Genome-wide association study of intracranial aneurysm identifies
            three new risk loci
  JOURNAL   Nat Genet 42 (5), 420-425 (2010)
   PUBMED   20364137
REFERENCE   10 (bases 1 to 15857)
  AUTHORS   Wang,C.Y., Shi,J.D., Yang,P., Kumar,P.G., Li,Q.Z., Run,Q.G.,
            Su,Y.C., Scott,H.S., Kao,K.J. and She,J.X.
  TITLE     Molecular cloning and characterization of a novel gene family of
            four ancient conserved domain proteins (ACDP)
  JOURNAL   Gene 306, 37-44 (2003)
   PUBMED   12657465
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356608.23, BC021222.2,
            AK023066.1, BX113753.1, BU621540.1 and AL139817.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_017649.4.
            
            Summary: This gene encodes a member of the ancient conserved domain
            containing protein family. Members of this protein family contain a
            cyclin box motif and have structural similarity to the cyclins. The
            encoded protein may play an important role in magnesium homeostasis
            by mediating the epithelial transport and renal reabsorption of
            Mg2+. Mutations in this gene are associated with renal
            hypomagnesemia. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.236305.1,
                                           SRR1803617.232180.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369878.9/ ENSP00000358894.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AL356608.23        15591-15614
            25-1611             BC021222.2         1-1587
            1612-3575           AK023066.1         702-2665
            3576-4119           BX113753.1         115-658
            4120-4222           BU621540.1         17-119              c
            4223-15857          AL139817.9         16832-28466
FEATURES             Location/Qualifiers
     source          1..15857
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..15857
                     /gene="CNNM2"
                     /gene_synonym="ACDP2; HOMG6; HOMGSMR; SLC70A2"
                     /note="cyclin and CBS domain divalent metal cation
                     transport mediator 2"
                     /db_xref="GeneID:54805"
                     /db_xref="HGNC:HGNC:103"
                     /db_xref="MIM:607803"
     exon            1..1808
                     /gene="CNNM2"
                     /gene_synonym="ACDP2; HOMG6; HOMGSMR; SLC70A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2815
                     /gene="CNNM2"
                     /gene_synonym="ACDP2; HOMG6; HOMGSMR; SLC70A2"
                     /note="isoform 1 is encoded by transcript variant 1; metal
                     transporter CNNM2; cyclin M2; ancient conserved
                     domain-containing protein 2"
                     /codon_start=1
                     /product="metal transporter CNNM2 isoform 1"
                     /protein_id="NP_060119.3"
                     /db_xref="CCDS:CCDS44474.1"
                     /db_xref="GeneID:54805"
                     /db_xref="HGNC:HGNC:103"
                     /db_xref="MIM:607803"
                     /translation="MIGCGACEPKVKMAGGQAAAALPTWKMAARRSLSARGRGILQAA
                     AGRLLPLLLLSCCCGAGGCAAVGENEETVIIGLRLEDTNDVSFMEGGALRVSERTRVK
                     LRVYGQNINNETWSRIAFTEHERRRHSPGERGLGGPAPPEPDSGPQRCGIRTSDIIIL
                     PHIILNRRTSGIIEIEIKPLRKMEKSKSYYLCTSLSTPALGAGGSGSTGGAVGGKGGS
                     GVAGLPPPPWAETTWIYHDGEDTKMIVGEEKKFLLPFWLQVIFISLLLCLSGMFSGLN
                     LGLMALDPMELRIVQNCGTEKEKNYAKRIEPVRRQGNYLLCSLLLGNVLVNTTLTILL
                     DDIAGSGLVAVVVSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMMMTFPASYP
                     VSKLLDCVLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVM
                     TPLRDCFMITGEAILDFNTMSEIMESGYTRIPVFEGERSNIVDLLFVKDLAFVDPDDC
                     TPLKTITKFYNHPLHFVFNDTKLDAMLEEFKKGKSHLAIVQRVNNEGEGDPFYEVLGI
                     VTLEDVIEEIIKSEILDETDLYTDNRTKKKVAHRERKQDFSAFKQTDSEMKVKISPQL
                     LLAMHRFLATEVEAFSPSQMSEKILLRLLKHPNVIQELKYDEKNKKAPEYYLYQRNKP
                     VDYFVLILQGKVEVEAGKEGMKFEASAFSYYGVMALTASPVPLSLSRTFVVSRTELLA
                     AGSPGENKSPPRPCGLNHSDSLSRSDRIDAVTPTLGSSNNQLNSSLLQVYIPDYSVRA
                     LSDLQFVKISRQQYQNALMASRMDKTPQSSDSENTKIELTLTELHDGLPDETANLLNE
                     QNCVTHSKANHSLHNEGAI"
     exon            1809..1952
                     /gene="CNNM2"
                     /gene_synonym="ACDP2; HOMG6; HOMGSMR; SLC70A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2090
                     /gene="CNNM2"
                     /gene_synonym="ACDP2; HOMG6; HOMGSMR; SLC70A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2260
                     /gene="CNNM2"
                     /gene_synonym="ACDP2; HOMG6; HOMGSMR; SLC70A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2354
                     /gene="CNNM2"
                     /gene_synonym="ACDP2; HOMG6; HOMGSMR; SLC70A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2420
                     /gene="CNNM2"
                     /gene_synonym="ACDP2; HOMG6; HOMGSMR; SLC70A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2605
                     /gene="CNNM2"
                     /gene_synonym="ACDP2; HOMG6; HOMGSMR; SLC70A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..15857
                     /gene="CNNM2"
                     /gene_synonym="ACDP2; HOMG6; HOMGSMR; SLC70A2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4119
                     /gene="CNNM2"
                     /gene_synonym="ACDP2; HOMG6; HOMGSMR; SLC70A2"
                     /note="major polyA site"
     regulatory      9001..9006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNNM2"
                     /gene_synonym="ACDP2; HOMG6; HOMGSMR; SLC70A2"
                     /note="hexamer: GATAAA"
     polyA_site      9020
                     /gene="CNNM2"
                     /gene_synonym="ACDP2; HOMG6; HOMGSMR; SLC70A2"
     regulatory      15837..15842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNNM2"
                     /gene_synonym="ACDP2; HOMG6; HOMGSMR; SLC70A2"
                     /note="hexamer: AATAAA"
     polyA_site      15857
                     /gene="CNNM2"
                     /gene_synonym="ACDP2; HOMG6; HOMGSMR; SLC70A2"
ORIGIN      
        1 ccctccctct ttccctcccg cgagcctcgg ggttcctcag ctggctgagg tggagtcagt
       61 gtcagtcagg gaggcgaact gctgagcact ggccgcggac gctccgttgc agtctcgccc
      121 aggggccggt acctgcgctc gcgccgccgg gttgaaagga tgaagccgca gctggagcag
      181 ccaccctatg attggctgtg gcgcttgtga acccaaagta aagatggcgg gcgggcaggc
      241 agccgccgca ctgcccactt ggaagatggc ggcgcgccgc agcctcagcg ctcgcggccg
      301 ggggatcctg caggcggctg cggggcggct gctgccgctg ctcctgctga gctgctgctg
      361 cggtgcgggc ggctgcgcag cggtgggcga gaatgaggag acggtgatca tcgggctgcg
      421 actggaggac acgaacgacg tgtcgttcat ggaagggggg gcgctgcggg tgagcgaacg
      481 gacccgggtc aagctgcggg tgtacgggca gaacatcaat aacgagacgt ggtcccgcat
      541 cgccttcacc gagcacgagc ggcggcgcca cagcccgggg gagcgcgggc tggggggccc
      601 cgcgccgcca gagccggaca gcggccccca gcgatgcggc atccgcacct cagacatcat
      661 catcttgccc cacatcattc tcaaccgccg cacctcgggc atcatcgaga tcgagatcaa
      721 accgctacgc aagatggaga agagcaagtc ctattacctg tgcacgtcgc tctccacgcc
      781 cgccctgggc gccggcggct cggggtccac gggtggcgcc gtcgggggca agggtggctc
      841 gggggtggcc gggctcccgc cgcccccgtg ggccgagacc acctggattt accacgacgg
      901 cgaggacacc aagatgatcg taggcgaaga gaagaagttc ctgctgccct tctggctgca
      961 ggtgatcttc atttcgctgc tgctgtgcct gtcgggcatg ttcagcggcc tcaacctggg
     1021 gctcatggcc ctggacccga tggagctgcg catcgtgcag aactgcggca cggagaagga
     1081 gaagaattac gccaagcgca tcgagccggt gcgcaggcag ggcaactacc tgctgtgctc
     1141 actgctgctg ggcaacgtgc tggtcaacac cacgctcacc atcctgctcg acgacatcgc
     1201 cggctcgggc ctcgtggccg tggtagtctc caccatcggt atcgtcatct tcggagagat
     1261 cgtgccccag gccatctgct cccggcatgg cctggctgtg ggggccaaca ccatcttcct
     1321 caccaagttt ttcatgatga tgaccttccc cgcttcctac ccggtcagca agctgctgga
     1381 ctgcgtcctg ggccaggaga taggcaccgt ctataaccgg gaaaaactgc tggagatgct
     1441 ccgggtcacc gatccctaca acgacctcgt taaggaggag ctgaacatca tccaaggggc
     1501 gctggagctc cgcaccaaga cggtggagga cgtgatgacc ccactccggg actgcttcat
     1561 gatcaccggc gaagccatcc tggacttcaa caccatgtct gagatcatgg agagcggcta
     1621 cacccgcatt ccagtgtttg aaggggagcg ctccaatatc gtggacctgc tgtttgtcaa
     1681 agacttggcc ttcgtggatc ccgatgactg tacccccctg aaaaccatca ccaaatttta
     1741 taaccacccc ttgcactttg ttttcaatga caccaagttg gacgctatgc tggaagaatt
     1801 taagaaaggt aaatctcacc tggctatcgt gcagcgggta aacaatgagg gagaagggga
     1861 tccattttat gaagttctgg gaatcgtcac cttagaagat gtgattgaag aaatcatcaa
     1921 atctgagatt cttgatgaaa cagatttata cactgacaac agaacgaaaa agaaagtggc
     1981 tcaccgggaa cgaaagcaag atttttctgc ctttaagcag acagacagtg agatgaaggt
     2041 taaaatatca ccacagctcc tcctggccat gcaccgtttc ctagcaacag aagtagaagc
     2101 atttagccca tcccagatgt cagagaagat ccttctaagg ctgctaaagc accccaatgt
     2161 catccaggaa ctgaaatatg atgagaagaa caagaaagcc cccgaatact acctctacca
     2221 gcgcaacaag ccagtagact acttcgttct cattctgcag gggaaagtgg aagttgaagc
     2281 tgggaaagaa ggtatgaagt ttgaagcgag cgccttctca tactatggcg tgatggccct
     2341 gacagcctct ccagttcctt tgtccctgtc tcgtaccttt gttgtcagca gaacagagtt
     2401 gttagcagca ggttctccag gtgaaaataa gtcccctcct cgcccatgtg gcttgaatca
     2461 ctcagactct ctcagtcgaa gcgaccggat tgacgccgtc acaccaacac tggggagcag
     2521 caataaccag ctcaattctt cgctcctcca agtctacatc cccgattact cggtgcgagc
     2581 cctttcggat ctgcagtttg ttaagatctc aagacagcaa taccaaaatg ccttgatggc
     2641 atcccggatg gacaaaaccc cccagtcttc agacagtgaa aacactaaaa tcgaattgac
     2701 tcttacggag ctgcatgacg ggttgccaga cgagacagcc aacctgctca acgaacagaa
     2761 ctgtgtgacg cacagtaagg ccaaccacag cctgcacaac gaaggcgcca tctaggccgc
     2821 gctggctgca cccgcccagg cccgcacccg cccagtcccg agggcccggc cctgtctgcc
     2881 catgacttca ctggtgtgag cttgtccgcc atgctgtacc ctgcaacatc ctgagaccaa
     2941 agaccttgtg cccttcccag gagccgcgga ggaggacagt gagggaggaa tggaaacgag
     3001 agatgtgaag ttggcagccg gggcatggcg ttcaagattt tggagatgaa ctgattccgc
     3061 ccaaatagaa tcatgtttat tttttcagct ctccctttta tcattattca cactcctctg
     3121 ccctcgattt gcatgaagtt gaaaattgtt gcgatttatt ttttcaagag atcatgtttt
     3181 taaagtgtct tttgcagagt tttaagttgt tctgtctgaa ctctgctgtg atcccatgat
     3241 gtgaccctga tgggctggac ttgcccctcc ggtagccttc cttggccctc ccagcgaggg
     3301 gcacccttcc tctgtgcccc agtgggcatc accgtcgatc tcgctggctg aatgaagaag
     3361 accgtgttac tgcagaacct gccaagtctg tcatcactgt ggggtgtagc ctgcctcaga
     3421 gggacctgca atcacctctc tgagctcagt ggtattttga gaatttaatg tttaactgta
     3481 cccctttccc tcaggaagat ttaacatttg cttgggaatg tgattttgct cccaccctaa
     3541 ggaattttta tcaccaaaat gaatgttaat gaatttaaaa cccatggttt atcattggca
     3601 agaggcaagt tgacttcatc ctgtcattcc agcctggggt ctgccagcca gccctcctcc
     3661 ccgacccagc gcctaagctc acagagtgtc gtcgcccacc tccctggtcc ttgctcttgt
     3721 taacccaaga tgctgctaca cagatgccaa atggaaatct tccacagggc tttttcagta
     3781 aacacgtgat gtggagtgca agctcctccc cttcccacta gaacatactt taacagaaaa
     3841 cgagtcggac cttctagctg cactctgtac tgtgtgccga gaaggcattt ctagacccgt
     3901 gtttttaaag gagggaactt tggggattgc cagcccctgc tcctcctccc agggagccaa
     3961 ctgtccctcc tcccctgtcc ctgggcccat ggggcccggc agtggctgtg tcccctgcct
     4021 gagggctctg tgcctcctgc ctcagatgcg gcctgtgcca gagaggctgc ctgtacagcc
     4081 agggtcagtt tggccccaaa cagggattca gaaaccaaat gtgtgttgtg gccattttat
     4141 gtgtgtctcc gtcttatttt aataccaaat tcatcatgta gtgaaattat gtcaggaggt
     4201 atatgagtga ctgaattctt aactatagct tatctgtgtt ttgttagccc gagggatatg
     4261 tgcaggttgt tggcgctatt catgcactga aatgaaatca tactgaccag tgtacacaca
     4321 agattatcag tgcccgccgc atccatcact aggaaaggag agagcgtttt ctgtttaggc
     4381 tcactgcgca aagggaggcc ttggctaagt ggcagttttc ttctccctac tccaggtagg
     4441 aagtctgttc agccacggct gggctgtgtg cggggcaggg agcgtggctg aggagcagac
     4501 agcagcgggc cgggctggct gcctggtgag cagtttggtg cctcgggtgt tgtgcatgcc
     4561 cggctcagta tttcctctgg gatgccagtc ctggagtgtc ttcctcagaa ggtgccgtgt
     4621 cccttagtgg ggggaagtac tgatctcact tggtgtagag ggtcacaggg accccccgag
     4681 ggtgctgagt ggcctgctac tggcacgcaa cctgcccccg tgggatgaag ccccaccgcg
     4741 tagcttgacc ttagagggga ccccactcta agcatccttt tttttaaaca gagccatcta
     4801 gatacaaaag tcagtttctt aagatgcctc tcactgagca caacaccagt gtgatgagtg
     4861 tataaagatg aggggtcctt gcaacaaagc aaagcgtagc ccatgctgga agagggcatc
     4921 tatccccctc ttcgggtctg cgcagtgctg gccttccctg agctgtgggg agccaagcct
     4981 gcctagccca gcttctctgg cctcaggaac tctgccctgt caacctatct gggctcacgt
     5041 ctgcttctcc acacacagtc tctcggggat gccttgctac tgggagagcc tctggaatca
     5101 gagctagtgt gttggtgccc ttttcagagc tctgctgttc ctttataaat cctaaagaac
     5161 tgagtctggg gagaggagag gggatgccag ctgctgcctc tgacttcagg gagaagcaga
     5221 cttcttaata ctgtcttacg tgctcggtgt gatggcttct tgcaaattat tctcttataa
     5281 aagagctcgg caggagtggc atcagtgagg ctcccaaagg atgaaatttt agccgccaag
     5341 ttcgtattca ttttctgtta ttctttacct tctgttagtc acactatttt ataacattag
     5401 ggaatctaaa ataattcctg tcaggtccct gaaggaatga aggctaacat ctcctttggg
     5461 gagagcttag gacccttcaa acaacactca tgtctgagcg gccagattcc tcctccaggc
     5521 cccattttcc ctcaggaaac caacctctca gatggttgga ggagaaacac tgggctgttg
     5581 cttctttggg gcagcaggag aatgactttg gcttggaagg cctctgccat tcatctctac
     5641 aaagccagtg gggtccggca gagaaagacc gtggaatagc tgcggtctcg atgtggctgc
     5701 tctttggcac ctccgctgga ctgccctccc gcggcggtga ccttttcaag tgtggaaggg
     5761 agtgggtcga gtggaccaga tgcagacccc tgagttctgg atactgatgg gaggcctcac
     5821 cctcctttac ggggcctctc tgggtgggac agagcctcac ctgctcctga gcagccactg
     5881 gtgccccacg gttcctctga aactaaatcc ctagcatcca gatagtcctg ggacactctg
     5941 cctgctctgt aaatgaggag ggcttttctc ctgctgtttg gaggttccgt cccttcactg
     6001 cttgtcccat atgcgtcagg caaattcaaa atcatacatt taaactctta ggaaaacaaa
     6061 atcttaagac ttacacagat atcggggtgc taatcaactg gcttaaatct tgattcttac
     6121 ataatttgaa cttgaaaggt tacattgaac tctgttcttt cctccctcct cacctcactc
     6181 cctgcaggga gttcaatgcc atgttgaagt ggttggcatc cccaagtggg agggagtggg
     6241 gcatcttacc atcttctaat gtgacttcaa ggaacagtgc aaatgttgaa tgcagagctt
     6301 cacactaata cggaacagta actgtgagta tatttacctg tgctgtcgtc agcactgtac
     6361 actaaaggac cagcttttcc aagcctagga aaataatggt agatacaaat agaaatacat
     6421 tttccctagg aaatagagca ataggaattt gagctaagca ggtaccatga acttctgccc
     6481 tcaaattctc tctttgggtt gaggagcaga cctgtatagg ccctggctga tcaagtctgt
     6541 gtcctgccta gtaaaaacac acaaccacct ctgtcatctg aaggccagcc ggggatctgt
     6601 agccatcctc gccttgccta ggcccaggaa ggtgaggtct cctgggcaac cagagttgcc
     6661 cctgtggttc cccaggggtg atcctaggca gatgactcac ccgggctggc acaggaaggt
     6721 gctcaccttg ttctctgggg ctccaagcaa gagcaggcca gggagggctg gctttgcacg
     6781 ctatgtagca tgacccaagc tccctggtgg catgggaaaa actcccctct gcttttgagc
     6841 ccagatatgg gcttttcttt gcaaagggtt gaggagaaat acaagactga gctggtaggt
     6901 tagggtccag aaggcctctg aggtgccatt gcttacttcc ttactgagga aactggctct
     6961 tgtcctgggc catgtagttc cattctgggc tctaggctag tggtgcttct gtccatcaag
     7021 ggtatctggg tgagttgtag gttaacccag aatttagtag ggatataggg gtttgaatag
     7081 gaaagtgatc tggggattca gaaatttttc tgatgtatca atgagcaact tctcagtgga
     7141 tttttatacc tcagggtcat ttgcaaatct ttatcttttc ctatttctta ggtgttcaag
     7201 ttggttaata ggagagagac gttcagagac ttctaagttg aggttcattt gcctccgttt
     7261 gaggggtgag tggtgcacca atagcttgct gctgttactt agcaaggctg tgacaagtag
     7321 gccttcctcc tctagcactt gcaagctttc tgtctgcgat cacggtttac ttgcccattt
     7381 cccttttgct accttctttc ctatctggag attcatattc tagagtccct ggtcaaccct
     7441 acggatgcga agaagagatg gcagttcaca gcaactgcat agagtaggga gcagctttcc
     7501 tcccaccatc ctaggctggg gaccttcttt gcttctcaca ccactgtggt tggctcagct
     7561 caagtaagca cgttctctct gtatgctaga gctactgaca tcatctctac tagaattgtt
     7621 ttaaatatct tttgatggga aataccaggt tgaacttcaa gcatcatgga aacaaaggtt
     7681 ctagctgcaa gagagtaaag ttctaggtgt ttgtatgcca aggtttatat gtacacagat
     7741 ccaacacata ctgtaagaaa gacttgagta cacaaggttt tcaggtttta atgcccattg
     7801 ggaccgtgaa caaatgagaa gaatgggagc attgtcttgc ctcgcttgga aggacgcctt
     7861 ccggcatctg atccacatgg attcactttt aggatgcagt tctttggggg ccagatttgg
     7921 ctgcagattc accctgaaga gaactatcca atgggcctgg tggggcttgg gtgcctgcct
     7981 tttttgttgg aggctcagac ttctagagca gagcaaagtt gggaagaatg aggtcttagg
     8041 attctcattc cccagagagc cccagcctcg cttctgatca ttactcccca agtctgaatc
     8101 tactgtgaag gtgaagttat caattttttc ttgtttgagt cctttaaacc cacaaatgta
     8161 tatgctttat tttatattat ttattatgta catatgcctg ttagtacttc gtctgtgact
     8221 aggacaaggt ctgtcttgaa gcttcctcat ccatggatcc tagggttctg ctgtccttta
     8281 aggcgggtga gagggtagtg ttgtttttta taaacaggtt gctgctttta tgttggccct
     8341 agcatcccca gcccctttag ttgggcccac ctgtattcct tatgaccagt gttttggatg
     8401 aggatggagg caggtctcct accttgtggg cagggcctct caagtacctc catgaaatat
     8461 ttccaaggtg gtttcttggt gacaggctct cttcccctat gtagggtaca gtacagctgt
     8521 gagtccacgg cctccctcct cccaaggcag gtcacttgcc tggccccaca gtgataatgg
     8581 tttcttccac ttaccttaga ttgcataatc catctttctg gataatggaa gctgcctgcc
     8641 tatctgggct cttaatatgc cttttcttgg ttttgaggcc cagtgccaac attgccttgg
     8701 ccctcaagta agaccctgct ttgtgtctga ctttgatcct cctcagcctt tattcactgt
     8761 atcatagtgt acaggtcatg catttgagca gtgaagtttt ctgaacacag tattcagagc
     8821 tgtgtacata aacctaaata agcacaaatg acatgtatag gattgagctg attgtcttaa
     8881 tgaatgcatt ttataattca aatgatgtag atgtacagtc tctcctattt attttgtacc
     8941 aatttatttg taaattttgt gattgtttta caaggttttt gtttatttct attctattta
     9001 gataaatgat gttctgttca ccctgctagc agatgtgtgt tccctcttcc ctttcatctg
     9061 tgcaacacca accatgccat tgtattcagc ttggctgaac caactgccct acccacttgc
     9121 ctggctttgc tggtgggaaa gctgggactg gatctcagca tgacaacata gaagagcatc
     9181 ttctttggac agtgtaaagt cttaagagaa gtgggtacta gttctgtgcc tccaagtcac
     9241 agcctggtac agccaatcct agggggaagg tgtccttctt tgcaaggatt ataatctgtt
     9301 ctccatcagt tactctctac ataagaacat tcggagtatc cagtcaaatt gccccagaca
     9361 ttggctgctc agtcactaat aacaacacac agtgccgctg ggctaagccg gcatttccta
     9421 ggtaagacca aaggtctcat tcaggcctct caattggctc ttgaaaacaa ggatggcttt
     9481 ataggtcctc ctctgctatg ctaagcctgg gaggaaggtc ggagcaggca tggatagtca
     9541 ctttcaagtg gaaaacatcc ggcctgagtg tggcgaggcg tgtgcaggtg ggtcttcagg
     9601 attcagtgga tatcctgcat tccccagtaa tcggtgtgta tgatacacgt tcttttccat
     9661 cactactttg tcttctgttc cttcttaccc tcatcactca catgagacca gtccctgaag
     9721 aacttacggt ggagcttcag ggaccctctg tgatccattc ctaaaccaca tctttttgga
     9781 atcccttttc tctccacttt tagtctctat tttacattcc aaagaggatc gtgctctgaa
     9841 aatttagcct cttgactggt ccatttatag tctccactga atttatttaa ccgtggcatt
     9901 tgcagtcttt tacttacact tgttctgtgg atggagacat ttcagggaag aactgctgac
     9961 agaattggct ttcagacact gcctgaccta actaccgctc ccatctcccc aggtatcgcc
    10021 caactacctg aaagtagaat gaggtgtatc ttagcccagt gaaatgctgt cttcgaaccc
    10081 tgcttgcttt cattagaagc agggcagaaa gtggcagcag agctagggaa agaaatcatg
    10141 gtagcacatt cactcccagc ctcctgcctt ggtttgtttt tcctgtttta ctcacttggt
    10201 ctagatgagc ccttagctca aatcaggaaa tgctccaagg aaaatggagg caatttttcc
    10261 tgctgtcaag atgagatttg cctaaaactc ccccctgcat cctcagagtg cgcacacatc
    10321 cgctcatttc taagctttat cgtgatgcac ccggggtttc tatttcacaa aaattgtgct
    10381 ccctagagcc gtttttcaac tcggcacttc tgaggaaaca aatattgatc agagggtctt
    10441 gtagagaaag tggttaaaaa ctgacctttt tatagcctgg agttgatttc tggaaactta
    10501 ttttatactt tttgaaggta atttaaaaga gatgattctt tattaaagcc aaaaagttga
    10561 attctattag gtggataata aactcttttg ctttctttgt atggtggttt tgtcattttc
    10621 cctccaaggg cctcatatct gtgctcttat tttcaagcag tcccaggaca aagggatggt
    10681 tctagggccc ttttctctga ctttctgctg gcatgccatc tcccctagtg gattactgag
    10741 gactgaggat gcacgtttct aagggagaat tagttgcccg acttctgaag tgcttttcct
    10801 gtcagggtat tagtgactgt gcagtgttca aacaggaggc caacacatga taggaaattt
    10861 tagatggggc cagttttcct actgcagttc tactaagtca ttgacttgag gtcagtgggt
    10921 ccaaaaagtg acttgtttaa agatacccac acactcaagt caaagataac tctggtgaga
    10981 acactctctc aaagactgga cactgagtaa acatttttca gtgtggggaa ggtttgcttg
    11041 gcaaatcttc tttccaagta tctcaagaac ttgtgagacg tggaaggact attgctgcct
    11101 ttcgtgggaa aaatgtgtgc tcagctgctt gggctccagt ttgtgtggga aggtttatct
    11161 caggccttgt ctactcccct cgccagacat ggctttggga agagctccat gggagaccag
    11221 aacatctggg gacatagttg tacctagtta ttttgtgtga agaaacaaag ggacgagatt
    11281 caaaattcat cattgtgttt taaatttaaa ttggaaaaca tagattcctc atccttaaac
    11341 agagtcagca agtttgagat gaaatgtttg tgttcaatgg ggagtacttt tttgtgttaa
    11401 agctctacag agaaacttct gtatatattt tatttttgag atcacatacc tttgttggaa
    11461 tgaatcagac tgttgtggcc ttgggatgaa gacattgtgt gtgaggacag ggaaaaatgg
    11521 ttgagaaatc caggttaaag aatagaaaag ctttttactc attctataaa tgaacatgct
    11581 gcctgtttaa aggacttgct ttctgctgtt tctagatacc tagcagcgcg agaactgtgt
    11641 gacgtgctgc gttcttgtta cgggaggtgc gtgacggggc agcgggggtt tctggaagtc
    11701 acctgtttct gctttctggt tgcctgtgcc tgtggtcatc cctgctcctt agcagtagtg
    11761 catgtttttc ttctatctgc agggttgctc tggtagctcc atggtagaga tttcactctc
    11821 agggcctccc aaaagttgtg tatcatttga aattgttcta tttgaggaaa aacttttaag
    11881 aaaagctgga ttccctgatc accactaaag atcatcatga gaaacataag tatttgagcc
    11941 ctaaactact aagcccagtg aggaattgga gcgttaactg tatggcaata gctagatcat
    12001 agttaccatt tttcccacca tcaaagacag attaaatagt ttccataaca tggaatgtgg
    12061 gtaaggttcc taccctaata cagacttaaa tatgtagttg tctcaggcta ttcgtggtga
    12121 ataagcagag tatttatttt aaaatgacca ggcagccttg gaaaaattgc tgggctttaa
    12181 agttgttgac aaagtatttc ttaaataaat acatctgatt tagaaatacc taaacatgga
    12241 caaaatactt ctaaatctga catgcaactg catgtggctt tttaaagtgg tttcttaaca
    12301 atgctaatgt gacttaagga tttgtagttc tattaaaaac gacttctaaa agtatcttag
    12361 ggtagcttga agggtttgcg ttattatttt aggtctcagc agaggtatgc ttatggcaag
    12421 agaaaaatct taggtctaaa tagaacccta aactttcttg gctgtgacca acttttctga
    12481 agtacaccat cagagttttc actgactatc tatctttgca gagatgaatg aatgtactgg
    12541 gcaattcctc tgcccaagga aacccagcag ggcctgggtc tgctgtacca ctgaccaact
    12601 gctggggagg ctaggggacc tgtcagtaca tgctgtaagg ttgggagttc agtctagcaa
    12661 ccaagaaggg gttgcctggt gttctacaat gcctatagtg ttttcaaaat gcctgggaaa
    12721 aaattctcaa aagaagtggc agaatggtct tctcacggta taaaactccg caggattttt
    12781 tttttttttt tttttttttt tttttttaag gaaaaaagta taccttttaa gttcagcttc
    12841 cttaactact ggcaacagag agaaaactca taatttgttt taaaaagccc agttacagct
    12901 gccctgccta cccatggacc attgacttcc cagcacactc ttaagaataa tatacagaga
    12961 ggcaccattt tgctctgggt cttatggaat cctagagctc ttgaatacgt tttggtggtc
    13021 ctacggagag ctgtaactag cagtggagtt gttgcttatt ccagctgtgt gcttttcact
    13081 ttccgatctt tggacccaga gaatcatttg ccatggaatc atctggctag taagacactc
    13141 ttatatggat gcaatacaaa aagtggtaaa ttaaagcaaa gcaatcatgt ggtccttact
    13201 ctaaaagaga caatatgtaa atgtactatt ataataaggt agctctgcag atgtaataag
    13261 ctactcataa attatttggg tttaagaaaa cttaagacta tgttaaactg gacaacatct
    13321 ccatcttgag tgagagtaat tagtaactag gatgaccaca cattctccta acacgggcaa
    13381 cagtctagtc taattgttat tgcatttctg acctgattct tttaaagggg catatattcc
    13441 caatatatac catttagaat gtatgtatgt ttcttggatg acttaatctg aagccatata
    13501 agtccaaagt agtgagacag acagtatatc cttgactaag ttatcaggct gtgttctctg
    13561 cttataaaat aattttttaa aaagcctcac ttcacagtcc tgttccaaaa atctttctgt
    13621 gaaaaaattg aggcctatgt aacaccatga atataatcat gttagaacat aatcagttct
    13681 tgaatattta tttcctttaa gagaatatca aactgatgtc accaaatcta aacccacttg
    13741 aagaccaata gctattacag ttgtactaca gaataggtca aagtcaccgt tagaaatatt
    13801 acactttatt gaattctgga gcagctaatc taccctcccc tattgaccaa tgacaagaat
    13861 ggaagaaaat atacaatggt taaagaaaga gtctataacc actgtttgtt taaaatgttg
    13921 aaacaacttt cactgtactg gtgaaacagt tttaataccc taacatacac agtaatgatt
    13981 cattcttgtt taaaacaaga ggtgatttcg acttgggatt gggattttta ttttttgaga
    14041 tggagttttg ttcttgttgc ccaggctgga gtgcaatggc acaatcctgg ctcactgcaa
    14101 cctccgcctc ctgggttcaa gcaattctcc tgcctcagcc tcctgagtag atgatgggat
    14161 tacaggcatg caccaccacg cccaggtaat tttgtatttt tagtagagat ggggtttctc
    14221 catgttggta aggctggtct cgaactcccg acctcaggtg atccgcctgt ctcggcctcc
    14281 caaagtgctg ggattacagg cgtgagccgc cgtgcctggc cttgacttga gattctgaag
    14341 tgaatttatt cacactgatt gtgccctcta ctttagtaag gttctggctt acagagccct
    14401 cttcccatcc tctgatgttc aattttaata tacagcaatc aactcttaga ggacaaagaa
    14461 atctggaatt gggtagcatg agccacagct atatagccca cactaatgca tgttctgtag
    14521 tataagaagg cagttcttcc ctttcttttc tgggggcttg ttcctttgtc cacttgcagc
    14581 taaattcttt ctatagattt atcacagata agaaggaggt tgtttttgga taacaaataa
    14641 gcatttgtgc tattaaacaa acaaaaggta ataaggatac tgtcttttcc ctcaaaatag
    14701 aatcctgccc taaagcaacg caagtagagc atacttctgt gcaaagccag tgatagagaa
    14761 gcagccttgc cagagtcact gaggatgaat taaaggctta taaaagaaaa cttgacctta
    14821 acagagacta catttgatca tggaaataat acatttctcc actgatatac aataccatgt
    14881 aatgcactgg aaaagttgga ccttggagta atagcacaat ttgtaacatt acagatcacc
    14941 tcttcccact ctttgttcca ctctgagact ctttcctttt cctcgtgtat ccagatacac
    15001 tgacatacgg atgattttaa aagtgtcaca agccacagtg gagccatata catgcagttc
    15061 agcctgattt tacccttatt ttcttctaat acagactcca ttacaatttt ggaccatctg
    15121 cagagagtac agatacacaa aaccaaaaca agtatctatg ataataaaat cttcagaaac
    15181 ttttcagacg tacctttcat ggagccccct ccctcccccg agtagaaccc taacagggac
    15241 ctcgtttgtt cctgtgagtc ctgccaggac ttgtttaatg ggtgcttggg gttttggttt
    15301 tcctccttat tcttcctcct cctcctcctc ttcatcatca tcttcgtcat ggcagtgtgt
    15361 aatttcctgg ggggccagtg ggaagaggtt gggaggttta atctcactaa ttgaccgtgt
    15421 cagctggtgc cgcttgtagt cagtgtcttt gaaatccact gatgtgcggt tccgggtggc
    15481 aagaggagac tccatctcat tgatatctac gtgtgtgtgc tccaccgttg attcatgagg
    15541 catctagaca gaaaaaagct agaggctcag aaagcaggca gagcaaagta gctactcccc
    15601 aaatcctaac ccctctcctc tgttaggtgg ccatgcaatt acatctataa tggaccacag
    15661 gacaagtcaa tatagactta tcttcataga actacttata gttgcctgtc ttcctctctc
    15721 cctgcccctc aaaatggtgc ccatattgtc tactgcagct ggaaattgga aaagatggag
    15781 aggggagttt actttctatt ttacagcaaa aacaagatag tcctgaaaca gatcagaata
    15841 aaggaatgta aaaacca
//
