LOCUS       NM_020348               5702 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cyclin and CBS domain divalent metal cation transport
            mediator 1 (CNNM1), transcript variant 1, mRNA.
ACCESSION   NM_020348
VERSION     NM_020348.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5702)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5702)
  AUTHORS   Xie,Y., Wang,Y., Gong,R., Lin,J., Li,X., Ma,J. and Huo,L.
  TITLE     SNHG7 Facilitates Hepatocellular Carcinoma Occurrence by
            Sequestering miR-9-5p to Upregulate CNNM1 Expression
  JOURNAL   Cancer Biother Radiopharm 35 (10), 731-740 (2020)
   PUBMED   32397799
  REMARK    GeneRIF: SNHG7 Facilitates Hepatocellular Carcinoma Occurrence by
            Sequestering miR-9-5p to Upregulate CNNM1 Expression.
REFERENCE   3  (bases 1 to 5702)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5702)
  AUTHORS   Yadav,L., Tamene,F., Goos,H., van Drogen,A., Katainen,R.,
            Aebersold,R., Gstaiger,M. and Varjosalo,M.
  TITLE     Systematic Analysis of Human Protein Phosphatase Interactions and
            Dynamics
  JOURNAL   Cell Syst 4 (4), 430-444 (2017)
   PUBMED   28330616
REFERENCE   5  (bases 1 to 5702)
  AUTHORS   St-Denis,N., Gupta,G.D., Lin,Z.Y., Gonzalez-Badillo,B., Veri,A.O.,
            Knight,J.D.R., Rajendran,D., Couzens,A.L., Currie,K.W., Tkach,J.M.,
            Cheung,S.W.T., Pelletier,L. and Gingras,A.C.
  TITLE     Phenotypic and Interaction Profiling of the Human Phosphatases
            Identifies Diverse Mitotic Regulators
  JOURNAL   Cell Rep 17 (9), 2488-2501 (2016)
   PUBMED   27880917
REFERENCE   6  (bases 1 to 5702)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet 8 (3), e1002559 (2012)
   PUBMED   22412388
REFERENCE   7  (bases 1 to 5702)
  AUTHORS   Gomez Garcia,I., Oyenarte,I. and Martinez-Cruz,L.A.
  TITLE     Purification, crystallization and preliminary crystallographic
            analysis of the CBS pair of the human metal transporter CNNM4
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 67 (Pt 3), 349-353
            (2011)
   PUBMED   21393841
REFERENCE   8  (bases 1 to 5702)
  AUTHORS   Wang,C.Y., Yang,P., Shi,J.D., Purohit,S., Guo,D., An,H., Gu,J.G.,
            Ling,J., Dong,Z. and She,J.X.
  TITLE     Molecular cloning and characterization of the mouse Acdp gene
            family
  JOURNAL   BMC Genomics 5 (1), 7 (2004)
   PUBMED   14723793
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5702)
  AUTHORS   Wang,C.Y., Shi,J.D., Yang,P., Kumar,P.G., Li,Q.Z., Run,Q.G.,
            Su,Y.C., Scott,H.S., Kao,K.J. and She,J.X.
  TITLE     Molecular cloning and characterization of a novel gene family of
            four ancient conserved domain proteins (ACDP)
  JOURNAL   Gene 306, 37-44 (2003)
   PUBMED   12657465
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB067736.1, DA326933.1,
            DA758649.1, BC098103.1, AL391684.6, AF169226.1 and BI868774.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_020348.2.
            
            Summary: This gene encodes a member of the ancient conserved domain
            protein family. The encoded protein may bind copper. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF169226.1, SRR1660809.236112.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356713.5/ ENSP00000349147.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               DB067736.1         258-404
            148-640             DA326933.1         140-632
            641-980             DA758649.1         55-394
            981-1315            BC098103.1         12-346
            1316-1316           AL391684.6         17704-17704
            1317-2967           BC098103.1         348-1998
            2968-4191           AF169226.1         2048-3271
            4192-4347           BI868774.1         351-506
            4348-5204           AF169226.1         3429-4285
            5205-5205           AL391684.6         80866-80866
            5206-5702           AF169226.1         4287-4783
FEATURES             Location/Qualifiers
     source          1..5702
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     gene            1..5702
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /note="cyclin and CBS domain divalent metal cation
                     transport mediator 1"
                     /db_xref="GeneID:26507"
                     /db_xref="HGNC:HGNC:102"
                     /db_xref="MIM:607802"
     exon            1..1605
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2888
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /note="isoform 1 is encoded by transcript variant 1; metal
                     transporter CNNM1; cyclin-M1; ancient conserved
                     domain-containing protein 1"
                     /codon_start=1
                     /product="metal transporter CNNM1 isoform 1"
                     /protein_id="NP_065081.2"
                     /db_xref="CCDS:CCDS7478.2"
                     /db_xref="GeneID:26507"
                     /db_xref="HGNC:HGNC:102"
                     /db_xref="MIM:607802"
                     /translation="MAAAAAAAAAVGVRLRDCCSRGAVLLLFFSLSPRPPAAAAWLLG
                     LRPEDTAGGRVSLEGGTLRAAEGTSFLLRVYFQPGPPATAAPVPSPTLNSGENGTGDW
                     APRLVFIEEPPGGGGVAPSAVPTRPPGPQRCREQSDWASDVEVLGPLRPGGVAGSALV
                     QVRVRELRKGEAERGGAGGGGKLFSLCAWDGRAWHHHGAAGGFLLRVRPRLYGPGGDL
                     LPPAWLRALGALLLLALSALFSGLRLSLLSLDPVELRVLRNSGSAAEQEQARRVQAVR
                     GRGTHLLCTLLLGQAGANAALAGWLYTSLPPGFGGTGEDYSEEGIHFPWLPALVCTGA
                     VFLGAEICPYSVCSRHGLAIASHSVCLTRLLMAAAFPVCYPLGRLLDWALRQEISTFY
                     TREKLLETLRAADPYSDLVKEELNIIQGALELRTKVVEEVLTPLGDCFMLRSDAVLDF
                     ATVSEILRSGYTRIPVYEGDQRHNIVDILFVKDLAFVDPDDCTPLLTVTRFYNRPLHC
                     VFNDTRLDTVLEEFKKGKSHLAIVQRVNNEGEGDPFYEVMGIVTLEDIIEEIIKSEIL
                     DETDLYTDNRKKQRVPQRERKRHDFSLFKLSDTEMRVKISPQLLLATHRFMATEVEPF
                     KSLYLSEKILLRLLKHPNVIQELKFDEKNKKAPEHYLYQRNRPVDYFVLLLQGKVEVE
                     VGKEGLRFENGAFTYYGVPAIMTTACSDNDVRKVGSLAGSSVFLNRSPSRCSGLNRSE
                     SPNRERSDFGGSNTQLYSSSNNLYMPDYSVHILSDVQFVKITRQQYQNALTACHMDSS
                     PQSPDMEAFTDGDSTKAPTTRGTPQTPKDDPAITLLNNRNSLPCSRSDGLRSPSEVVY
                     LRMEELAFTQEEMTDFEEHSTQQLTLSPAAVPTRAASDSECCNINLDTETSPCSSDFE
                     ENVGKKLLRTLSGQKRKRSPEGERTSEDNSNLTPLIT"
     exon            1606..1749
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1890
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2060
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2160
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2208
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2372
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2556
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2706
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2808
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..5702
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5681..5686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /note="hexamer: AATGAA"
     polyA_site      5702
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtatcac gtgcagctgc gctgggtgca ggatggcggc ggccgcggcg gcggcagcag
       61 cggtgggtgt caggctccgg gactgctgca gccgaggcgc tgtgctcctg ctcttctttt
      121 ccctgtctcc tcggcccccg gccgccgccg cctggctgct gggcctgcgg cccgaggaca
      181 ctgctggagg ccgcgtgtcc ctggaggggg gcaccctgcg cgccgccgaa ggcaccagct
      241 tcctcctgcg tgtctatttc cagccaggac cgccggccac cgccgcaccg gtgccctcac
      301 cgaccctcaa ctcgggggag aatggcaccg gcgactgggc tccgcggctc gtgttcatcg
      361 aggagccccc gggcggtggc ggcgtggccc ccagcgcggt ccccactcgc cccccgggac
      421 cgcagcgctg cagggagcag agcgactggg catcggacgt ggaagtcctg gggcccttgc
      481 gtcccggggg cgtggcaggc tcggccctgg tccaggtgcg agtgcgggag ctgcgcaagg
      541 gcgaagcgga gcggggcggc gcgggcggtg gcgggaagct cttttcactc tgcgcctggg
      601 atgggcgcgc gtggcaccac cacggcgccg ccggcggctt cctgctgcgc gttcgcccgc
      661 ggttgtacgg cccaggcggg gacctgctgc cccctgcgtg gctgcgggcg ctcggggcgc
      721 tcctgctgct agccttgtcg gccctgttca gcggcctgcg cctgagcctg ctgtcgctgg
      781 acccggtgga gttacgggtg ctgcggaaca gcggctcggc cgccgagcag gagcaggcgc
      841 gccgcgtgca ggccgttcgc ggcaggggga cccatctgct ctgcacccta ctcctgggcc
      901 aagccggagc caacgcggcc ctggctggct ggctgtacac ctcgctgccg ccgggcttcg
      961 ggggcaccgg ggaagactac agcgaagagg ggatccactt cccgtggctg ccggcgctcg
     1021 tgtgcaccgg cgcggtattc ctgggcgccg aaatctgccc ctactcagtg tgttcgcggc
     1081 acgggctggc catcgcctcg cacagcgtgt gcctgacccg gcttctgatg gcagccgcct
     1141 tccccgtgtg ctacccgctg ggccgcctgc tggactgggc gctgcgccag gagataagca
     1201 ccttctacac gcgggagaag ttgctggaga cgttgcgggc cgcagacccc tacagtgacc
     1261 tggtgaagga ggagctcaac atcatacagg gtgccctgga gctgcgcacc aaagttgtgg
     1321 aggaggtgct gacccccctg ggagactgct tcatgctgcg ctcagacgcg gtgctcgact
     1381 tcgccactgt ctccgagatc ctgcgcagcg gctacactcg catcccagtg tacgagggtg
     1441 accagcggca caacattgtg gacattttat ttgtcaagga cttggccttc gtggaccccg
     1501 acgactgcac cccgctcctc actgtcaccc gcttctacaa ccggcccctg cattgtgttt
     1561 tcaatgacac ccgactggac acggttctgg aggagtttaa gaagggaaaa tctcacctgg
     1621 ccattgtcca gcgggtgaat aatgagggag aaggggaccc tttctatgag gtgatgggca
     1681 ttgtcacgct ggaggatatc atagaggaga ttatcaagtc ggagatcctg gatgaaactg
     1741 atctctacac tgacaatcgg aaaaagcaga gggtcccgca acgggagcgg aagcggcatg
     1801 acttctcctt gtttaagctt tcggacacgg agatgcgggt gaagatctca ccacagcttc
     1861 tgctagccac acaccgcttc atggccacag aagtggagcc ctttaagtct ctgtaccttt
     1921 cggagaagat cctgctccgg ctcctgaaac atcccaacgt gatccaggag ctgaagtttg
     1981 atgagaagaa caagaaggcc ccggaacact acctctacca gcgcaaccgc cctgtggact
     2041 actttgtgct gcttctacag ggtaaagtgg aggtggaggt tggtaaggaa ggccttcgct
     2101 ttgaaaatgg agcctttact tactatggcg tcccagccat catgaccact gcttgctcag
     2161 ataatgacgt gcggaaggtt ggaagtctgg ctggatcttc tgtctttcta aaccggtccc
     2221 cttctcgctg cagtgggttg aatcgctctg agtctccaaa ccgagagcgc agtgactttg
     2281 ggggcagcaa cacccagctg tacagcagca gcaacaacct ctacatgcct gactactcag
     2341 tccacatcct cagcgatgtg cagtttgtga agatcacacg gcagcaatat cagaacgcac
     2401 tcactgcctg ccacatggac agctcacctc agtcccctga catggaggcc ttcacagacg
     2461 gggactccac taaggccccc acaacccggg gcacacccca gacccctaag gatgaccccg
     2521 ccatcacgct cctcaacaac aggaacagcc tgccgtgcag ccgctcagac gggctgagaa
     2581 gccccagcga ggtagtgtac ctgaggatgg aggagctggc cttcacccag gaagaaatga
     2641 ctgacttcga ggagcacagc acacagcagc tcacgctgtc tcctgcagcc gttcccacga
     2701 gagcagcatc agatagtgaa tgttgtaaca tcaacctgga tacagagacc agcccctgca
     2761 gtagcgattt tgaggaaaac gtgggcaaga agctgctgag aaccttgagt ggccaaaaaa
     2821 ggaagaggtc accagaagga gagagaacct ctgaggacaa ctccaattta acacctctga
     2881 tcacatgaca gggcaaagcc agcattcact gggtgtgtga aattccagag ctttggggga
     2941 gaatccaccc tcccatcatc tgcttccccc aaggcctccc acaggtgaca gaatgttctg
     3001 ccttcccttc catctcttca cccctagctg tcagtttggc agattttccc tcgttacctc
     3061 cagttcgact cagaaccttg acatggccat aacagaagga ggtgcctctg atagaacatg
     3121 ctagaaatgg tcttttccac agcatagtct gggactggaa aagagatgtc tgactgcaag
     3181 ctgacaatgc cactctggga cccctgatgc tcttctttgt tctttgggtc ccctgatgcc
     3241 ataggagacc tatcgtcttg gaacttgcca ttctttcctc cagaacaaaa tgttaacttt
     3301 ctaacacatt tcatgcatag cttggctcag aaggtgccat tggcagacag gcacatggga
     3361 ggctggagta ggaggtctga agattagttc aggggatgga ccaagaattt cccccagagc
     3421 tttaaagaag tgggactcag ccatgttggc gcgtgattga cattacagca cagaaaactg
     3481 ttagtgactg gtttcctgtt agataagggt tccagcagcc tggggcagta tgtctcagct
     3541 ggaatggaaa gaatgtgaga tggaacctca agtcactgtt tttaccaggg acacatctgt
     3601 tttggctccc aatcagcagt cttcaatcga tcaataattc tgctctggaa gagaaggaac
     3661 agggagcaga gagacccaac tgggagccag agatggaact tcaggtctta agtgcaaatc
     3721 aaagcaaaaa acaaacaaaa cttacatgga aaaactgtaa gtgctgaaag caagtttagc
     3781 catgacaaac caaagagtgc ccaggtcagc caagaaagat acataatctc atgggacttc
     3841 agtgggagtt acacaggaat gttgaagaat cattcttctt tttcatgcat ttgtccttct
     3901 cccaccccct tactacaccc tagcagatca gctgagtgta ctttattcca agaacttact
     3961 ggatctctgg tttttctcct gaagttgggg caggtgcaat tccaagcata accaccagat
     4021 ggcagagtga ccgcgcatac ctgcttccaa gaataaaaca gttctgaaaa gcaaccgcaa
     4081 agccgggcgc ggtggctcac acctgtaatc ccaacagttt ggaagaccga ggcgggtgga
     4141 tcacttgaag tcaggagttt gagaccagcc tggccaacat ggtgaaaccc catctctcct
     4201 gggcatgtag tcccagctac tcgggaggct gaggcaggag aatcgcttga acctgggagg
     4261 cagaggttgc agtgagctga gatcacacca ctgcacttca tcctaggcaa cagagcgaga
     4321 ctctgtctcc ccccgcaaaa aaaaaaaaga aagaaagaaa gagaaaagaa aagaaaagca
     4381 accacagcca gccttaggga aaacttggaa gtaagtgaaa tttgtcttca gaataactat
     4441 ctccctttct gatctgtctc ctactcttta gatgttctca gtcaagtact cactgaactc
     4501 attgatcgag tgctgtctgc taaatctcca aaccattccc aaacctttcc ccgtagtata
     4561 ccatccagct tccctcccct tcctccaaaa ccctccctcc cacctcccca cacccattga
     4621 gtcattcaca ggcaggaggg agactgatca ttcctctggg ttatctgcat ctcaaaagaa
     4681 aatgcttacc cacaggaact gttaactcag gggttcttaa cttggggtcc atcaccccag
     4741 ggggtccata gttggacttc agagggtcta tgaaacccct aaaactgtca gtatttaatg
     4801 tatttattct tgtatgtttt ttccagagca ttaaagcttt cataaggttc tcaaaggtct
     4861 cagacctaca aagagttaaa acaaacagac aaacaaaaaa aaacactact attttaaata
     4921 gtggaacttt cagcccagcg tttctgcaat gcagagtgaa gtggatactg ggcagttcga
     4981 gacaggtttt taatcataag tggtcttttc aaatgtccat caattgatgg ggaaggctgg
     5041 cacccaccaa gaagtggaag tcctcagaaa ttctcggcac accctagagt attgtacaac
     5101 caacaccccc acataacttt gtcccctctt ccccaacaac ccagagcagg tgttgcagac
     5161 aggagggcca cagcgtgtgg aagtaaagac tttggagcta gagaagcctt ttccagcaat
     5221 gattattgac ttcaccacac cccttgcctg gcctggcctg aggctcagca gtgcatgact
     5281 tctcgtagat aacttcacag tcatccagtc ccaacacctg ctcttgcctg gtaggaacag
     5341 gcgaagtgtc agccctcaat gttgggtact tagacccaaa ccaataaatg gtgagttttg
     5401 aacaagaact accatcatgc aggcttcttg cccagctgac cactggcccc ggggtgcctg
     5461 cctggctggt cttcatcacc tgaggccacc aggctcaagc cactgctgtt gcattacacc
     5521 catccctttg caaaatccct atggagcctg tcaccactcc cctccctata tacccccacc
     5581 ccacaaagat tttcttcagg ttaaaaaaaa agtttaaaaa aaagatttta aaataaagca
     5641 tttatgaagg cttaataaat tgtaaataat ttttaaataa aatgaaaatg cctttcctgg
     5701 aa
//
