LOCUS       NP_065081                951 aa            linear   PRI 28-APR-2025
DEFINITION  metal transporter CNNM1 isoform 1 [Homo sapiens].
ACCESSION   NP_065081
VERSION     NP_065081.2
DBSOURCE    REFSEQ: accession NM_020348.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 951)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 951)
  AUTHORS   Xie,Y., Wang,Y., Gong,R., Lin,J., Li,X., Ma,J. and Huo,L.
  TITLE     SNHG7 Facilitates Hepatocellular Carcinoma Occurrence by
            Sequestering miR-9-5p to Upregulate CNNM1 Expression
  JOURNAL   Cancer Biother Radiopharm 35 (10), 731-740 (2020)
   PUBMED   32397799
  REMARK    GeneRIF: SNHG7 Facilitates Hepatocellular Carcinoma Occurrence by
            Sequestering miR-9-5p to Upregulate CNNM1 Expression.
REFERENCE   3  (residues 1 to 951)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 951)
  AUTHORS   Yadav,L., Tamene,F., Goos,H., van Drogen,A., Katainen,R.,
            Aebersold,R., Gstaiger,M. and Varjosalo,M.
  TITLE     Systematic Analysis of Human Protein Phosphatase Interactions and
            Dynamics
  JOURNAL   Cell Syst 4 (4), 430-444 (2017)
   PUBMED   28330616
REFERENCE   5  (residues 1 to 951)
  AUTHORS   St-Denis,N., Gupta,G.D., Lin,Z.Y., Gonzalez-Badillo,B., Veri,A.O.,
            Knight,J.D.R., Rajendran,D., Couzens,A.L., Currie,K.W., Tkach,J.M.,
            Cheung,S.W.T., Pelletier,L. and Gingras,A.C.
  TITLE     Phenotypic and Interaction Profiling of the Human Phosphatases
            Identifies Diverse Mitotic Regulators
  JOURNAL   Cell Rep 17 (9), 2488-2501 (2016)
   PUBMED   27880917
REFERENCE   6  (residues 1 to 951)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet 8 (3), e1002559 (2012)
   PUBMED   22412388
REFERENCE   7  (residues 1 to 951)
  AUTHORS   Gomez Garcia,I., Oyenarte,I. and Martinez-Cruz,L.A.
  TITLE     Purification, crystallization and preliminary crystallographic
            analysis of the CBS pair of the human metal transporter CNNM4
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 67 (Pt 3), 349-353
            (2011)
   PUBMED   21393841
REFERENCE   8  (residues 1 to 951)
  AUTHORS   Wang,C.Y., Yang,P., Shi,J.D., Purohit,S., Guo,D., An,H., Gu,J.G.,
            Ling,J., Dong,Z. and She,J.X.
  TITLE     Molecular cloning and characterization of the mouse Acdp gene
            family
  JOURNAL   BMC Genomics 5 (1), 7 (2004)
   PUBMED   14723793
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 951)
  AUTHORS   Wang,C.Y., Shi,J.D., Yang,P., Kumar,P.G., Li,Q.Z., Run,Q.G.,
            Su,Y.C., Scott,H.S., Kao,K.J. and She,J.X.
  TITLE     Molecular cloning and characterization of a novel gene family of
            four ancient conserved domain proteins (ACDP)
  JOURNAL   Gene 306, 37-44 (2003)
   PUBMED   12657465
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB067736.1, DA326933.1,
            DA758649.1, BC098103.1, AL391684.6, AF169226.1 and BI868774.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 21, 2007 this sequence version replaced NP_065081.1.
            
            Summary: This gene encodes a member of the ancient conserved domain
            protein family. The encoded protein may bind copper. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF169226.1, SRR1660809.236112.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356713.5/ ENSP00000349147.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..951
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     Protein         1..951
                     /product="metal transporter CNNM1 isoform 1"
                     /note="metal transporter CNNM1; cyclin-M1; ancient
                     conserved domain-containing protein 1"
                     /calculated_mol_wt=104220
     Site            23..43
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NRU3.3)"
     Region          46..>148
                     /region_name="KLF9_13_N-like"
                     /note="Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16,
                     and similar proteins; cl41730"
                     /db_xref="CDD:425361"
     Region          116..135
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NRU3.3)"
     Site            222..242
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NRU3.3)"
     Region          250..>554
                     /region_name="TlyC"
                     /note="Hemolysin-related protein, contains CBS domains,
                     UPF0053 family [General function prediction only];
                     COG1253"
                     /db_xref="CDD:440865"
     Site            282..302
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NRU3.3)"
     Site            321..341
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NRU3.3)"
     Region          428..553
                     /region_name="CBS_pair_CorC_HlyC_assoc"
                     /note="Two tandem repeats of the cystathionine
                     beta-synthase (CBS pair) domains the majority of which are
                     associated with the CorC_HlyC domain; cd04590"
                     /db_xref="CDD:341366"
     Region          436..503
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341366"
     Site            order(463,478,482..483,486,507,529..531)
                     /site_type="other"
                     /note="putative ligand binding site I [chemical binding]"
                     /db_xref="CDD:341366"
     Region          507..552
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341366"
     Region          731..753
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NRU3.3)"
     Region          795..830
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NRU3.3)"
     Site            821
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q0GA42; propagated from
                     UniProtKB/Swiss-Prot (Q9NRU3.3)"
     Site            824
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q0GA42; propagated from
                     UniProtKB/Swiss-Prot (Q9NRU3.3)"
     Site            850
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q0GA42; propagated from
                     UniProtKB/Swiss-Prot (Q9NRU3.3)"
     Region          920..951
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NRU3.3)"
     CDS             1..951
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /coded_by="NM_020348.3:33..2888"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS7478.2"
                     /db_xref="GeneID:26507"
                     /db_xref="HGNC:HGNC:102"
                     /db_xref="MIM:607802"
ORIGIN      
        1 maaaaaaaaa vgvrlrdccs rgavlllffs lsprppaaaa wllglrpedt aggrvslegg
       61 tlraaegtsf llrvyfqpgp pataapvpsp tlnsgengtg dwaprlvfie eppggggvap
      121 savptrppgp qrcreqsdwa sdvevlgplr pggvagsalv qvrvrelrkg eaerggaggg
      181 gklfslcawd grawhhhgaa ggfllrvrpr lygpggdllp pawlralgal lllalsalfs
      241 glrlsllsld pvelrvlrns gsaaeqeqar rvqavrgrgt hllctlllgq aganaalagw
      301 lytslppgfg gtgedyseeg ihfpwlpalv ctgavflgae icpysvcsrh glaiashsvc
      361 ltrllmaaaf pvcyplgrll dwalrqeist fytrekllet lraadpysdl vkeelniiqg
      421 alelrtkvve evltplgdcf mlrsdavldf atvseilrsg ytripvyegd qrhnivdilf
      481 vkdlafvdpd dctplltvtr fynrplhcvf ndtrldtvle efkkgkshla ivqrvnnege
      541 gdpfyevmgi vtlediieei ikseildetd lytdnrkkqr vpqrerkrhd fslfklsdte
      601 mrvkispqll lathrfmate vepfkslyls ekillrllkh pnviqelkfd eknkkapehy
      661 lyqrnrpvdy fvlllqgkve vevgkeglrf engaftyygv paimttacsd ndvrkvgsla
      721 gssvflnrsp srcsglnrse spnrersdfg gsntqlysss nnlympdysv hilsdvqfvk
      781 itrqqyqnal tachmdsspq spdmeaftdg dstkapttrg tpqtpkddpa itllnnrnsl
      841 pcsrsdglrs psevvylrme elaftqeemt dfeehstqql tlspaavptr aasdseccni
      901 nldtetspcs sdfeenvgkk llrtlsgqkr krspegerts ednsnltpli t
//
