LOCUS       NM_001345889            5615 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cyclin and CBS domain divalent metal cation transport
            mediator 1 (CNNM1), transcript variant 4, mRNA.
ACCESSION   NM_001345889 XM_011539630
VERSION     NM_001345889.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5615)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5615)
  AUTHORS   Xie,Y., Wang,Y., Gong,R., Lin,J., Li,X., Ma,J. and Huo,L.
  TITLE     SNHG7 Facilitates Hepatocellular Carcinoma Occurrence by
            Sequestering miR-9-5p to Upregulate CNNM1 Expression
  JOURNAL   Cancer Biother Radiopharm 35 (10), 731-740 (2020)
   PUBMED   32397799
  REMARK    GeneRIF: SNHG7 Facilitates Hepatocellular Carcinoma Occurrence by
            Sequestering miR-9-5p to Upregulate CNNM1 Expression.
REFERENCE   3  (bases 1 to 5615)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5615)
  AUTHORS   Yadav,L., Tamene,F., Goos,H., van Drogen,A., Katainen,R.,
            Aebersold,R., Gstaiger,M. and Varjosalo,M.
  TITLE     Systematic Analysis of Human Protein Phosphatase Interactions and
            Dynamics
  JOURNAL   Cell Syst 4 (4), 430-444 (2017)
   PUBMED   28330616
REFERENCE   5  (bases 1 to 5615)
  AUTHORS   St-Denis,N., Gupta,G.D., Lin,Z.Y., Gonzalez-Badillo,B., Veri,A.O.,
            Knight,J.D.R., Rajendran,D., Couzens,A.L., Currie,K.W., Tkach,J.M.,
            Cheung,S.W.T., Pelletier,L. and Gingras,A.C.
  TITLE     Phenotypic and Interaction Profiling of the Human Phosphatases
            Identifies Diverse Mitotic Regulators
  JOURNAL   Cell Rep 17 (9), 2488-2501 (2016)
   PUBMED   27880917
REFERENCE   6  (bases 1 to 5615)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet 8 (3), e1002559 (2012)
   PUBMED   22412388
REFERENCE   7  (bases 1 to 5615)
  AUTHORS   Gomez Garcia,I., Oyenarte,I. and Martinez-Cruz,L.A.
  TITLE     Purification, crystallization and preliminary crystallographic
            analysis of the CBS pair of the human metal transporter CNNM4
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 67 (Pt 3), 349-353
            (2011)
   PUBMED   21393841
REFERENCE   8  (bases 1 to 5615)
  AUTHORS   Wang,C.Y., Yang,P., Shi,J.D., Purohit,S., Guo,D., An,H., Gu,J.G.,
            Ling,J., Dong,Z. and She,J.X.
  TITLE     Molecular cloning and characterization of the mouse Acdp gene
            family
  JOURNAL   BMC Genomics 5 (1), 7 (2004)
   PUBMED   14723793
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5615)
  AUTHORS   Wang,C.Y., Shi,J.D., Yang,P., Kumar,P.G., Li,Q.Z., Run,Q.G.,
            Su,Y.C., Scott,H.S., Kao,K.J. and She,J.X.
  TITLE     Molecular cloning and characterization of a novel gene family of
            four ancient conserved domain proteins (ACDP)
  JOURNAL   Gene 306, 37-44 (2003)
   PUBMED   12657465
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391684.6.
            
            On Aug 13, 2020 this sequence version replaced NM_001345889.1.
            
            Summary: This gene encodes a member of the ancient conserved domain
            protein family. The encoded protein may bind copper. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.54830.1,
                                           SRR1803611.117007.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1605              AL391684.6         16389-17993
            1606-1749           AL391684.6         44545-44688
            1750-1890           AL391684.6         47868-48008
            1891-2060           AL391684.6         49260-49429
            2061-2160           AL391684.6         51450-51549
            2161-2208           AL391684.6         51988-52035
            2209-2271           AL391684.6         55651-55713
            2272-2435           AL391684.6         64088-64251
            2436-2619           AL391684.6         74853-75036
            2620-2721           AL391684.6         77339-77440
            2722-5615           AL391684.6         78470-81363
FEATURES             Location/Qualifiers
     source          1..5615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     gene            1..5615
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /note="cyclin and CBS domain divalent metal cation
                     transport mediator 1"
                     /db_xref="GeneID:26507"
                     /db_xref="HGNC:HGNC:102"
                     /db_xref="MIM:607802"
     exon            1..1605
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2801
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /note="isoform 4 is encoded by transcript variant 4; metal
                     transporter CNNM1; cyclin-M1; ancient conserved
                     domain-containing protein 1"
                     /codon_start=1
                     /product="metal transporter CNNM1 isoform 4"
                     /protein_id="NP_001332818.1"
                     /db_xref="GeneID:26507"
                     /db_xref="HGNC:HGNC:102"
                     /db_xref="MIM:607802"
                     /translation="MAAAAAAAAAVGVRLRDCCSRGAVLLLFFSLSPRPPAAAAWLLG
                     LRPEDTAGGRVSLEGGTLRAAEGTSFLLRVYFQPGPPATAAPVPSPTLNSGENGTGDW
                     APRLVFIEEPPGGGGVAPSAVPTRPPGPQRCREQSDWASDVEVLGPLRPGGVAGSALV
                     QVRVRELRKGEAERGGAGGGGKLFSLCAWDGRAWHHHGAAGGFLLRVRPRLYGPGGDL
                     LPPAWLRALGALLLLALSALFSGLRLSLLSLDPVELRVLRNSGSAAEQEQARRVQAVR
                     GRGTHLLCTLLLGQAGANAALAGWLYTSLPPGFGGTGEDYSEEGIHFPWLPALVCTGA
                     VFLGAEICPYSVCSRHGLAIASHSVCLTRLLMAAAFPVCYPLGRLLDWALRQEISTFY
                     TREKLLETLRAADPYSDLVKEELNIIQGALELRTKVVEEVLTPLGDCFMLRSDAVLDF
                     ATVSEILRSGYTRIPVYEGDQRHNIVDILFVKDLAFVDPDDCTPLLTVTRFYNRPLHC
                     VFNDTRLDTVLEEFKKGKSHLAIVQRVNNEGEGDPFYEVMGIVTLEDIIEEIIKSEIL
                     DETDLYTDNRKKQRVPQRERKRHDFSLFKLSDTEMRVKISPQLLLATHRFMATEVEPF
                     KSLYLSEKILLRLLKHPNVIQELKFDEKNKKAPEHYLYQRNRPVDYFVLLLQGKVEVE
                     VGKEGLRFENGAFTYYGVPAIMTTACSDNDVRKVGSLAGSSVFLPVSVSRTFAVSRGD
                     SLAGSPVNRSPSRCSGLNRSESPNRERSDFGGSNTQLYSSSNNLYMPDYSVHILSDVQ
                     FVKITRQQYQNALTACHMDSSPQSPDMEAFTDGDSTKAPTTRGTPQTPKDDPAITLLN
                     NRNSLPSSDSECCNINLDTETSPCSSDFEENVGKKLLRTLSGQKRKRSPEGERTSEDN
                     SNLTPLIT"
     exon            1606..1749
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1890
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2060
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2160
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2208
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2271
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2435
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2619
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2721
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..5615
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5594..5599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /note="hexamer: AATGAA"
     polyA_site      5615
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtatcac gtgcagctgc gctgggtgca ggatggcggc ggccgcggcg gcggcagcag
       61 cggtgggtgt caggctccgg gactgctgca gccgaggcgc tgtgctcctg ctcttctttt
      121 ccctgtctcc tcggcccccg gccgccgccg cctggctgct gggcctgcgg cccgaggaca
      181 ctgctggagg ccgcgtgtcc ctggaggggg gcaccctgcg cgccgccgaa ggcaccagct
      241 tcctcctgcg tgtctatttc cagccaggac cgccggccac cgccgcaccg gtgccctcac
      301 cgaccctcaa ctcgggggag aatggcaccg gcgactgggc tccgcggctc gtgttcatcg
      361 aggagccccc gggcggtggc ggcgtggccc ccagcgcggt ccccactcgc cccccgggac
      421 cgcagcgctg cagggagcag agcgactggg catcggacgt ggaagtcctg gggcccttgc
      481 gtcccggggg cgtggcaggc tcggccctgg tccaggtgcg agtgcgggag ctgcgcaagg
      541 gcgaagcgga gcggggcggc gcgggcggtg gcgggaagct cttttcactc tgcgcctggg
      601 atgggcgcgc gtggcaccac cacggcgccg ccggcggctt cctgctgcgc gttcgcccgc
      661 ggttgtacgg cccaggcggg gacctgctgc cccctgcgtg gctgcgggcg ctcggggcgc
      721 tcctgctgct agccttgtcg gccctgttca gcggcctgcg cctgagcctg ctgtcgctgg
      781 acccggtgga gttacgggtg ctgcggaaca gcggctcggc cgccgagcag gagcaggcgc
      841 gccgcgtgca ggccgttcgc ggcaggggga cccatctgct ctgcacccta ctcctgggcc
      901 aagccggagc caacgcggcc ctggctggct ggctgtacac ctcgctgccg ccgggcttcg
      961 ggggcaccgg ggaagactac agcgaagagg ggatccactt cccgtggctg ccggcgctcg
     1021 tgtgcaccgg cgcggtattc ctgggcgccg aaatctgccc ctactcagtg tgttcgcggc
     1081 acgggctggc catcgcctcg cacagcgtgt gcctgacccg gcttctgatg gcagccgcct
     1141 tccccgtgtg ctacccgctg ggccgcctgc tggactgggc gctgcgccag gagataagca
     1201 ccttctacac gcgggagaag ttgctggaga cgttgcgggc cgcagacccc tacagtgacc
     1261 tggtgaagga ggagctcaac atcatacagg gtgccctgga gctgcgcacc aaagttgtgg
     1321 aggaggtgct gacccccctg ggagactgct tcatgctgcg ctcagacgcg gtgctcgact
     1381 tcgccactgt ctccgagatc ctgcgcagcg gctacactcg catcccagtg tacgagggtg
     1441 accagcggca caacattgtg gacattttat ttgtcaagga cttggccttc gtggaccccg
     1501 acgactgcac cccgctcctc actgtcaccc gcttctacaa ccggcccctg cattgtgttt
     1561 tcaatgacac ccgactggac acggttctgg aggagtttaa gaagggaaaa tctcacctgg
     1621 ccattgtcca gcgggtgaat aatgagggag aaggggaccc tttctatgag gtgatgggca
     1681 ttgtcacgct ggaggatatc atagaggaga ttatcaagtc ggagatcctg gatgaaactg
     1741 atctctacac tgacaatcgg aaaaagcaga gggtcccgca acgggagcgg aagcggcatg
     1801 acttctcctt gtttaagctt tcggacacgg agatgcgggt gaagatctca ccacagcttc
     1861 tgctagccac acaccgcttc atggccacag aagtggagcc ctttaagtct ctgtaccttt
     1921 cggagaagat cctgctccgg ctcctgaaac atcccaacgt gatccaggag ctgaagtttg
     1981 atgagaagaa caagaaggcc ccggaacact acctctacca gcgcaaccgc cctgtggact
     2041 actttgtgct gcttctacag ggtaaagtgg aggtggaggt tggtaaggaa ggccttcgct
     2101 ttgaaaatgg agcctttact tactatggcg tcccagccat catgaccact gcttgctcag
     2161 ataatgacgt gcggaaggtt ggaagtctgg ctggatcttc tgtctttctg cctgtctctg
     2221 tgtctcgtac cttcgctgtc agcagagggg actctctggc aggctcccca gtaaaccggt
     2281 ccccttctcg ctgcagtggg ttgaatcgct ctgagtctcc aaaccgagag cgcagtgact
     2341 ttgggggcag caacacccag ctgtacagca gcagcaacaa cctctacatg cctgactact
     2401 cagtccacat cctcagcgat gtgcagtttg tgaagatcac acggcagcaa tatcagaacg
     2461 cactcactgc ctgccacatg gacagctcac ctcagtcccc tgacatggag gccttcacag
     2521 acggggactc cactaaggcc cccacaaccc ggggcacacc ccagacccct aaggatgacc
     2581 ccgccatcac gctcctcaac aacaggaaca gcctgccgtc atcagatagt gaatgttgta
     2641 acatcaacct ggatacagag accagcccct gcagtagcga ttttgaggaa aacgtgggca
     2701 agaagctgct gagaaccttg agtggccaaa aaaggaagag gtcaccagaa ggagagagaa
     2761 cctctgagga caactccaat ttaacacctc tgatcacatg acagggcaaa gccagcattc
     2821 actgggtgtg tgaaattcca gagctttggg ggagaatcca ccctcccatc atctgcttcc
     2881 cccaaggcct cccacaggtg acagaatgtt ctgccttccc ttccatctct tcacccctag
     2941 ctgtcagttt ggcagatttt ccctcgttac ctccagttcg actcagaacc ttgacatggc
     3001 cataacagaa ggaggtgcct ctgatagaac atgctagaaa tggtcttttc cacagcatag
     3061 tctgggactg gaaaagagat gtctgactgc aagctgacaa tgccactctg ggacccctga
     3121 tgctcttctt tgttctttgg gtcccctgat gccataggag acctatcgtc ttggaacttg
     3181 ccattctttc ctccagaaca aaatgttaac tttctaacac atttcatgca tagcttggct
     3241 cagaaggtgc cattggcaga caggcacatg ggaggctgga gtaggaggtc tgaagattag
     3301 ttcaggggat ggaccaagaa tttcccccag agctttaaag aagtgggact cagccatgtt
     3361 ggcgcgtgat tgacattaca gcacagaaaa ctgttagtga ctggtttcct gttagataag
     3421 ggttccagca gcctggggca gtatgtctca gctggaatgg aaagaatgtg agatggaacc
     3481 tcaagtcact gtttttacca gggacacatc tgttttggct cccaatcagc agtcttcaat
     3541 cgatcaataa ttctgctctg gaagagaagg aacagggagc agagagaccc aactgggagc
     3601 cagagatgga acttcaggtc ttaagtgcaa atcaaagcaa aaaacaaaca aaacttacat
     3661 ggaaaaactg taagtgctga aagcaagttt agccatgaca aaccaaagag tgcccaggtc
     3721 agccaagaaa gatacataat ctcatgggac ttcagtggga gttacacagg aatgttgaag
     3781 aatcattctt ctttttcatg catttgtcct tctcccaccc ccttactaca ccctagcaga
     3841 tcagctgagt gtactttatt ccaagaactt actggatctc tggtttttct cctgaagttg
     3901 gggcaggtgc aattccaagc ataaccacca gatggcagag tgaccgcgca tacctgcttc
     3961 caagaataaa acagttctga aaagcaaccg caaagccggg cgcggtggct cacacctgta
     4021 atcccaacag tttggaagac cgaggcgggt ggatcacttg aagtcaggag tttgagacca
     4081 gcctggccaa catggtgaaa ccccatctct cctgggcatg tagtcccagc tactcgggag
     4141 gctgaggcag gagaatcgct tgaacctggg aggcagaggt tgcagtgagc tgagatcaca
     4201 ccactgcact tcatcctagg caacagagcg agactctgtc tccccccgca aaaaaaaaaa
     4261 agaaagaaag aaagagaaaa gaaaagaaaa gcaaccacag ccagccttag ggaaaacttg
     4321 gaagtaagtg aaatttgtct tcagaataac tatctccctt tctgatctgt ctcctactct
     4381 ttagatgttc tcagtcaagt actcactgaa ctcattgatc gagtgctgtc tgctaaatct
     4441 ccaaaccatt cccaaacctt tccccgtagt ataccatcca gcttccctcc ccttcctcca
     4501 aaaccctccc tcccacctcc ccacacccat tgagtcattc acaggcagga gggagactga
     4561 tcattcctct gggttatctg catctcaaaa gaaaatgctt acccacagga actgttaact
     4621 caggggttct taacttgggg tccatcaccc cagggggtcc atagttggac ttcagagggt
     4681 ctatgaaacc cctaaaactg tcagtattta atgtatttat tcttgtatgt tttttccaga
     4741 gcattaaagc tttcataagg ttctcaaagg tctcagacct acaaagagtt aaaacaaaca
     4801 gacaaacaaa aaaaaacact actattttaa atagtggaac tttcagccca gcgtttctgc
     4861 aatgcagagt gaagtggata ctgggcagtt cgagacaggt ttttaatcat aagtggtctt
     4921 ttcaaatgtc catcaattga tggggaaggc tggcacccac caagaagtgg aagtcctcag
     4981 aaattctcgg cacaccctag agtattgtac aaccaacacc cccacataac tttgtcccct
     5041 cttccccaac aacccagagc aggtgttgca gacaggaggg ccacagcgtg tggaagtaaa
     5101 gactttggag ctagagaagc cttttccagc aatgattatt gacttcacca caccccttgc
     5161 ctggcctggc ctgaggctca gcagtgcatg acttctcgta gataacttca cagtcatcca
     5221 gtcccaacac ctgctcttgc ctggtaggaa caggcgaagt gtcagccctc aatgttgggt
     5281 acttagaccc aaaccaataa atggtgagtt ttgaacaaga actaccatca tgcaggcttc
     5341 ttgcccagct gaccactggc cccggggtgc ctgcctggct ggtcttcatc acctgaggcc
     5401 accaggctca agccactgct gttgcattac acccatccct ttgcaaaatc cctatggagc
     5461 ctgtcaccac tcccctccct atataccccc accccacaaa gattttcttc aggttaaaaa
     5521 aaaagtttaa aaaaaagatt ttaaaataaa gcatttatga aggcttaata aattgtaaat
     5581 aatttttaaa taaaatgaaa atgcctttcc tggaa
//
