LOCUS       NM_001345887            5765 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cyclin and CBS domain divalent metal cation transport
            mediator 1 (CNNM1), transcript variant 2, mRNA.
ACCESSION   NM_001345887 XM_011539629
VERSION     NM_001345887.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5765)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5765)
  AUTHORS   Xie,Y., Wang,Y., Gong,R., Lin,J., Li,X., Ma,J. and Huo,L.
  TITLE     SNHG7 Facilitates Hepatocellular Carcinoma Occurrence by
            Sequestering miR-9-5p to Upregulate CNNM1 Expression
  JOURNAL   Cancer Biother Radiopharm 35 (10), 731-740 (2020)
   PUBMED   32397799
  REMARK    GeneRIF: SNHG7 Facilitates Hepatocellular Carcinoma Occurrence by
            Sequestering miR-9-5p to Upregulate CNNM1 Expression.
REFERENCE   3  (bases 1 to 5765)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5765)
  AUTHORS   Yadav,L., Tamene,F., Goos,H., van Drogen,A., Katainen,R.,
            Aebersold,R., Gstaiger,M. and Varjosalo,M.
  TITLE     Systematic Analysis of Human Protein Phosphatase Interactions and
            Dynamics
  JOURNAL   Cell Syst 4 (4), 430-444 (2017)
   PUBMED   28330616
REFERENCE   5  (bases 1 to 5765)
  AUTHORS   St-Denis,N., Gupta,G.D., Lin,Z.Y., Gonzalez-Badillo,B., Veri,A.O.,
            Knight,J.D.R., Rajendran,D., Couzens,A.L., Currie,K.W., Tkach,J.M.,
            Cheung,S.W.T., Pelletier,L. and Gingras,A.C.
  TITLE     Phenotypic and Interaction Profiling of the Human Phosphatases
            Identifies Diverse Mitotic Regulators
  JOURNAL   Cell Rep 17 (9), 2488-2501 (2016)
   PUBMED   27880917
REFERENCE   6  (bases 1 to 5765)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet 8 (3), e1002559 (2012)
   PUBMED   22412388
REFERENCE   7  (bases 1 to 5765)
  AUTHORS   Gomez Garcia,I., Oyenarte,I. and Martinez-Cruz,L.A.
  TITLE     Purification, crystallization and preliminary crystallographic
            analysis of the CBS pair of the human metal transporter CNNM4
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 67 (Pt 3), 349-353
            (2011)
   PUBMED   21393841
REFERENCE   8  (bases 1 to 5765)
  AUTHORS   Wang,C.Y., Yang,P., Shi,J.D., Purohit,S., Guo,D., An,H., Gu,J.G.,
            Ling,J., Dong,Z. and She,J.X.
  TITLE     Molecular cloning and characterization of the mouse Acdp gene
            family
  JOURNAL   BMC Genomics 5 (1), 7 (2004)
   PUBMED   14723793
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5765)
  AUTHORS   Wang,C.Y., Shi,J.D., Yang,P., Kumar,P.G., Li,Q.Z., Run,Q.G.,
            Su,Y.C., Scott,H.S., Kao,K.J. and She,J.X.
  TITLE     Molecular cloning and characterization of a novel gene family of
            four ancient conserved domain proteins (ACDP)
  JOURNAL   Gene 306, 37-44 (2003)
   PUBMED   12657465
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB067736.1, AK308618.1,
            AK296545.1 and AL391684.6.
            
            On Aug 13, 2020 this sequence version replaced NM_001345887.1.
            
            Summary: This gene encodes a member of the ancient conserved domain
            protein family. The encoded protein may bind copper. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK296545.1, SRR1803615.261684.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DB067736.1         258-259
            3-575               AK308618.1         1-573
            576-914             AK296545.1         1-339
            915-915             AL391684.6         17303-17303
            916-999             AK296545.1         341-424
            1000-1000           AL391684.6         17388-17388
            1001-1315           AK296545.1         426-740
            1316-1316           AL391684.6         17704-17704
            1317-1385           AK296545.1         742-810
            1386-1386           AL391684.6         17774-17774
            1387-2974           AK296545.1         812-2399
            2975-5765           AL391684.6         78573-81363
FEATURES             Location/Qualifiers
     source          1..5765
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     gene            1..5765
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /note="cyclin and CBS domain divalent metal cation
                     transport mediator 1"
                     /db_xref="GeneID:26507"
                     /db_xref="HGNC:HGNC:102"
                     /db_xref="MIM:607802"
     exon            1..1605
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2951
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /note="isoform 2 is encoded by transcript variant 2; metal
                     transporter CNNM1; cyclin-M1; ancient conserved
                     domain-containing protein 1"
                     /codon_start=1
                     /product="metal transporter CNNM1 isoform 2"
                     /protein_id="NP_001332816.1"
                     /db_xref="CCDS:CCDS91317.1"
                     /db_xref="GeneID:26507"
                     /db_xref="HGNC:HGNC:102"
                     /db_xref="MIM:607802"
                     /translation="MAAAAAAAAAVGVRLRDCCSRGAVLLLFFSLSPRPPAAAAWLLG
                     LRPEDTAGGRVSLEGGTLRAAEGTSFLLRVYFQPGPPATAAPVPSPTLNSGENGTGDW
                     APRLVFIEEPPGGGGVAPSAVPTRPPGPQRCREQSDWASDVEVLGPLRPGGVAGSALV
                     QVRVRELRKGEAERGGAGGGGKLFSLCAWDGRAWHHHGAAGGFLLRVRPRLYGPGGDL
                     LPPAWLRALGALLLLALSALFSGLRLSLLSLDPVELRVLRNSGSAAEQEQARRVQAVR
                     GRGTHLLCTLLLGQAGANAALAGWLYTSLPPGFGGTGEDYSEEGIHFPWLPALVCTGA
                     VFLGAEICPYSVCSRHGLAIASHSVCLTRLLMAAAFPVCYPLGRLLDWALRQEISTFY
                     TREKLLETLRAADPYSDLVKEELNIIQGALELRTKVVEEVLTPLGDCFMLRSDAVLDF
                     ATVSEILRSGYTRIPVYEGDQRHNIVDILFVKDLAFVDPDDCTPLLTVTRFYNRPLHC
                     VFNDTRLDTVLEEFKKGKSHLAIVQRVNNEGEGDPFYEVMGIVTLEDIIEEIIKSEIL
                     DETDLYTDNRKKQRVPQRERKRHDFSLFKLSDTEMRVKISPQLLLATHRFMATEVEPF
                     KSLYLSEKILLRLLKHPNVIQELKFDEKNKKAPEHYLYQRNRPVDYFVLLLQGKVEVE
                     VGKEGLRFENGAFTYYGVPAIMTTACSDNDVRKVGSLAGSSVFLPVSVSRTFAVSRGD
                     SLAGSPVNRSPSRCSGLNRSESPNRERSDFGGSNTQLYSSSNNLYMPDYSVHILSDVQ
                     FVKITRQQYQNALTACHMDSSPQSPDMEAFTDGDSTKAPTTRGTPQTPKDDPAITLLN
                     NRNSLPCSRSDGLRSPSEVVYLRMEELAFTQEEMTDFEEHSTQQLTLSPAAVPTRAAS
                     DSECCNINLDTETSPCSSDFEENVGKKLLRTLSGQKRKRSPEGERTSEDNSNLTPLIT
                     "
     exon            1606..1749
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1890
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2060
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2160
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2208
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2271
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2435
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2619
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2769
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2871
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..5765
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5744..5749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /note="hexamer: AATGAA"
     polyA_site      5765
                     /gene="CNNM1"
                     /gene_synonym="ACDP1; CLP-1; SLC70A1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtatcac gtgcagctgc gctgggtgca ggatggcggc ggccgcggcg gcggcagcag
       61 cggtgggtgt caggctccgg gactgctgca gccgaggcgc tgtgctcctg ctcttctttt
      121 ccctgtctcc tcggcccccg gccgccgccg cctggctgct gggcctgcgg cccgaggaca
      181 ctgctggagg ccgcgtgtcc ctggaggggg gcaccctgcg cgccgccgaa ggcaccagct
      241 tcctcctgcg tgtctatttc cagccaggac cgccggccac cgccgcaccg gtgccctcac
      301 cgaccctcaa ctcgggggag aatggcaccg gcgactgggc tccgcggctc gtgttcatcg
      361 aggagccccc gggcggtggc ggcgtggccc ccagcgcggt ccccactcgc cccccgggac
      421 cgcagcgctg cagggagcag agcgactggg catcggacgt ggaagtcctg gggcccttgc
      481 gtcccggggg cgtggcaggc tcggccctgg tccaggtgcg agtgcgggag ctgcgcaagg
      541 gcgaagcgga gcggggcggc gcgggcggtg gcgggaagct cttttcactc tgcgcctggg
      601 atgggcgcgc gtggcaccac cacggcgccg ccggcggctt cctgctgcgc gttcgcccgc
      661 ggttgtacgg cccaggcggg gacctgctgc cccctgcgtg gctgcgggcg ctcggggcgc
      721 tcctgctgct agccttgtcg gccctgttca gcggcctgcg cctgagcctg ctgtcgctgg
      781 acccggtgga gttacgggtg ctgcggaaca gcggctcggc cgccgagcag gagcaggcgc
      841 gccgcgtgca ggccgttcgc ggcaggggga cccatctgct ctgcacccta ctcctgggcc
      901 aagccggagc caacgcggcc ctggctggct ggctgtacac ctcgctgccg ccgggcttcg
      961 ggggcaccgg ggaagactac agcgaagagg ggatccactt cccgtggctg ccggcgctcg
     1021 tgtgcaccgg cgcggtattc ctgggcgccg aaatctgccc ctactcagtg tgttcgcggc
     1081 acgggctggc catcgcctcg cacagcgtgt gcctgacccg gcttctgatg gcagccgcct
     1141 tccccgtgtg ctacccgctg ggccgcctgc tggactgggc gctgcgccag gagataagca
     1201 ccttctacac gcgggagaag ttgctggaga cgttgcgggc cgcagacccc tacagtgacc
     1261 tggtgaagga ggagctcaac atcatacagg gtgccctgga gctgcgcacc aaagttgtgg
     1321 aggaggtgct gacccccctg ggagactgct tcatgctgcg ctcagacgcg gtgctcgact
     1381 tcgccactgt ctccgagatc ctgcgcagcg gctacactcg catcccagtg tacgagggtg
     1441 accagcggca caacattgtg gacattttat ttgtcaagga cttggccttc gtggaccccg
     1501 acgactgcac cccgctcctc actgtcaccc gcttctacaa ccggcccctg cattgtgttt
     1561 tcaatgacac ccgactggac acggttctgg aggagtttaa gaagggaaaa tctcacctgg
     1621 ccattgtcca gcgggtgaat aatgagggag aaggggaccc tttctatgag gtgatgggca
     1681 ttgtcacgct ggaggatatc atagaggaga ttatcaagtc ggagatcctg gatgaaactg
     1741 atctctacac tgacaatcgg aaaaagcaga gggtcccgca acgggagcgg aagcggcatg
     1801 acttctcctt gtttaagctt tcggacacgg agatgcgggt gaagatctca ccacagcttc
     1861 tgctagccac acaccgcttc atggccacag aagtggagcc ctttaagtct ctgtaccttt
     1921 cggagaagat cctgctccgg ctcctgaaac atcccaacgt gatccaggag ctgaagtttg
     1981 atgagaagaa caagaaggcc ccggaacact acctctacca gcgcaaccgc cctgtggact
     2041 actttgtgct gcttctacag ggtaaagtgg aggtggaggt tggtaaggaa ggccttcgct
     2101 ttgaaaatgg agcctttact tactatggcg tcccagccat catgaccact gcttgctcag
     2161 ataatgacgt gcggaaggtt ggaagtctgg ctggatcttc tgtctttctg cctgtctctg
     2221 tgtctcgtac cttcgctgtc agcagagggg actctctggc aggctcccca gtaaaccggt
     2281 ccccttctcg ctgcagtggg ttgaatcgct ctgagtctcc aaaccgagag cgcagtgact
     2341 ttgggggcag caacacccag ctgtacagca gcagcaacaa cctctacatg cctgactact
     2401 cagtccacat cctcagcgat gtgcagtttg tgaagatcac acggcagcaa tatcagaacg
     2461 cactcactgc ctgccacatg gacagctcac ctcagtcccc tgacatggag gccttcacag
     2521 acggggactc cactaaggcc cccacaaccc ggggcacacc ccagacccct aaggatgacc
     2581 ccgccatcac gctcctcaac aacaggaaca gcctgccgtg cagccgctca gacgggctga
     2641 gaagccccag cgaggtagtg tacctgagga tggaggagct ggccttcacc caggaagaaa
     2701 tgactgactt cgaggagcac agcacacagc agctcacgct gtctcctgca gccgttccca
     2761 cgagagcagc atcagatagt gaatgttgta acatcaacct ggatacagag accagcccct
     2821 gcagtagcga ttttgaggaa aacgtgggca agaagctgct gagaaccttg agtggccaaa
     2881 aaaggaagag gtcaccagaa ggagagagaa cctctgagga caactccaat ttaacacctc
     2941 tgatcacatg acagggcaaa gccagcattc actgggtgtg tgaaattcca gagctttggg
     3001 ggagaatcca ccctcccatc atctgcttcc cccaaggcct cccacaggtg acagaatgtt
     3061 ctgccttccc ttccatctct tcacccctag ctgtcagttt ggcagatttt ccctcgttac
     3121 ctccagttcg actcagaacc ttgacatggc cataacagaa ggaggtgcct ctgatagaac
     3181 atgctagaaa tggtcttttc cacagcatag tctgggactg gaaaagagat gtctgactgc
     3241 aagctgacaa tgccactctg ggacccctga tgctcttctt tgttctttgg gtcccctgat
     3301 gccataggag acctatcgtc ttggaacttg ccattctttc ctccagaaca aaatgttaac
     3361 tttctaacac atttcatgca tagcttggct cagaaggtgc cattggcaga caggcacatg
     3421 ggaggctgga gtaggaggtc tgaagattag ttcaggggat ggaccaagaa tttcccccag
     3481 agctttaaag aagtgggact cagccatgtt ggcgcgtgat tgacattaca gcacagaaaa
     3541 ctgttagtga ctggtttcct gttagataag ggttccagca gcctggggca gtatgtctca
     3601 gctggaatgg aaagaatgtg agatggaacc tcaagtcact gtttttacca gggacacatc
     3661 tgttttggct cccaatcagc agtcttcaat cgatcaataa ttctgctctg gaagagaagg
     3721 aacagggagc agagagaccc aactgggagc cagagatgga acttcaggtc ttaagtgcaa
     3781 atcaaagcaa aaaacaaaca aaacttacat ggaaaaactg taagtgctga aagcaagttt
     3841 agccatgaca aaccaaagag tgcccaggtc agccaagaaa gatacataat ctcatgggac
     3901 ttcagtggga gttacacagg aatgttgaag aatcattctt ctttttcatg catttgtcct
     3961 tctcccaccc ccttactaca ccctagcaga tcagctgagt gtactttatt ccaagaactt
     4021 actggatctc tggtttttct cctgaagttg gggcaggtgc aattccaagc ataaccacca
     4081 gatggcagag tgaccgcgca tacctgcttc caagaataaa acagttctga aaagcaaccg
     4141 caaagccggg cgcggtggct cacacctgta atcccaacag tttggaagac cgaggcgggt
     4201 ggatcacttg aagtcaggag tttgagacca gcctggccaa catggtgaaa ccccatctct
     4261 cctgggcatg tagtcccagc tactcgggag gctgaggcag gagaatcgct tgaacctggg
     4321 aggcagaggt tgcagtgagc tgagatcaca ccactgcact tcatcctagg caacagagcg
     4381 agactctgtc tccccccgca aaaaaaaaaa agaaagaaag aaagagaaaa gaaaagaaaa
     4441 gcaaccacag ccagccttag ggaaaacttg gaagtaagtg aaatttgtct tcagaataac
     4501 tatctccctt tctgatctgt ctcctactct ttagatgttc tcagtcaagt actcactgaa
     4561 ctcattgatc gagtgctgtc tgctaaatct ccaaaccatt cccaaacctt tccccgtagt
     4621 ataccatcca gcttccctcc ccttcctcca aaaccctccc tcccacctcc ccacacccat
     4681 tgagtcattc acaggcagga gggagactga tcattcctct gggttatctg catctcaaaa
     4741 gaaaatgctt acccacagga actgttaact caggggttct taacttgggg tccatcaccc
     4801 cagggggtcc atagttggac ttcagagggt ctatgaaacc cctaaaactg tcagtattta
     4861 atgtatttat tcttgtatgt tttttccaga gcattaaagc tttcataagg ttctcaaagg
     4921 tctcagacct acaaagagtt aaaacaaaca gacaaacaaa aaaaaacact actattttaa
     4981 atagtggaac tttcagccca gcgtttctgc aatgcagagt gaagtggata ctgggcagtt
     5041 cgagacaggt ttttaatcat aagtggtctt ttcaaatgtc catcaattga tggggaaggc
     5101 tggcacccac caagaagtgg aagtcctcag aaattctcgg cacaccctag agtattgtac
     5161 aaccaacacc cccacataac tttgtcccct cttccccaac aacccagagc aggtgttgca
     5221 gacaggaggg ccacagcgtg tggaagtaaa gactttggag ctagagaagc cttttccagc
     5281 aatgattatt gacttcacca caccccttgc ctggcctggc ctgaggctca gcagtgcatg
     5341 acttctcgta gataacttca cagtcatcca gtcccaacac ctgctcttgc ctggtaggaa
     5401 caggcgaagt gtcagccctc aatgttgggt acttagaccc aaaccaataa atggtgagtt
     5461 ttgaacaaga actaccatca tgcaggcttc ttgcccagct gaccactggc cccggggtgc
     5521 ctgcctggct ggtcttcatc acctgaggcc accaggctca agccactgct gttgcattac
     5581 acccatccct ttgcaaaatc cctatggagc ctgtcaccac tcccctccct atataccccc
     5641 accccacaaa gattttcttc aggttaaaaa aaaagtttaa aaaaaagatt ttaaaataaa
     5701 gcatttatga aggcttaata aattgtaaat aatttttaaa taaaatgaaa atgcctttcc
     5761 tggaa
//
