LOCUS       NM_001839               1991 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens calponin 3 (CNN3), transcript variant 1, mRNA.
ACCESSION   NM_001839
VERSION     NM_001839.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1991)
  AUTHORS   Xie,Y., Ding,W., Xiang,Y., Wang,X. and Yang,J.
  TITLE     Calponin 3 Acts as a Potential Diagnostic and Prognostic Marker and
            Promotes Glioma Cell Proliferation, Migration, and Invasion
  JOURNAL   World Neurosurg 165, e721-e731 (2022)
   PUBMED   35792226
  REMARK    GeneRIF: Calponin 3 Acts as a Potential Diagnostic and Prognostic
            Marker and Promotes Glioma Cell Proliferation, Migration, and
            Invasion.
REFERENCE   2  (bases 1 to 1991)
  AUTHORS   Dai,F., Luo,F., Zhou,R., Zhou,Q., Xu,J., Zhang,Z., Xiao,J. and
            Song,L.
  TITLE     Calponin 3 is associated with poor prognosis and regulates
            proliferation and metastasis in osteosarcoma
  JOURNAL   Aging (Albany NY) 12 (14), 14037-14049 (2020)
   PUBMED   32667904
  REMARK    GeneRIF: Calponin 3 is associated with poor prognosis and regulates
            proliferation and metastasis in osteosarcoma.
REFERENCE   3  (bases 1 to 1991)
  AUTHORS   Xia,L., Yue,Y., Li,M., Zhang,Y.N., Zhao,L., Lu,W., Wang,X. and
            Xie,X.
  TITLE     CNN3 acts as a potential oncogene in cervical cancer by affecting
            RPLP1 mRNA expression
  JOURNAL   Sci Rep 10 (1), 2427 (2020)
   PUBMED   32051425
  REMARK    GeneRIF: CNN3 acts as a potential oncogene in cervical cancer by
            affecting RPLP1 mRNA expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1991)
  AUTHORS   Ciuba,K., Hawkes,W., Tojkander,S., Kogan,K., Engel,U., Iskratsch,T.
            and Lappalainen,P.
  TITLE     Calponin-3 is critical for coordinated contractility of actin
            stress fibers
  JOURNAL   Sci Rep 8 (1), 17670 (2018)
   PUBMED   30518778
  REMARK    GeneRIF: Cnn3 depletion resulted in increased and uncoordinated
            contractility of stress fibers that often led to breakage of
            individual actomyosin bundles within the stress fiber network.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1991)
  AUTHORS   Hirata,H., Ku,W.C., Yip,A.K., Ursekar,C.P., Kawauchi,K., Roy,A.,
            Guo,A.K., Vedula,S.R., Harada,I., Chiam,K.H., Ishihama,Y.,
            Lim,C.T., Sawada,Y. and Sokabe,M.
  TITLE     MEKK1-dependent phosphorylation of calponin-3 tunes cell
            contractility
  JOURNAL   J Cell Sci 129 (19), 3574-3582 (2016)
   PUBMED   27528401
  REMARK    GeneRIF: These results reveal the importance of the
            MEKK1-calponin-3 signaling pathway to cell contractility.
REFERENCE   6  (bases 1 to 1991)
  AUTHORS   Abouzaglou,J., Benistant,C., Gimona,M., Roustan,C., Kassab,R. and
            Fattoum,A.
  TITLE     Tyrosine phosphorylation of calponins. Inhibition of the
            interaction with F-actin
  JOURNAL   Eur J Biochem 271 (13), 2615-2623 (2004)
   PUBMED   15206927
REFERENCE   7  (bases 1 to 1991)
  AUTHORS   Fujii,T., Yabe,S., Nakamura,K. and Koizumi,Y.
  TITLE     Functional analysis of rat acidic calponin
  JOURNAL   Biol Pharm Bull 25 (5), 573-579 (2002)
   PUBMED   12033495
REFERENCE   8  (bases 1 to 1991)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   9  (bases 1 to 1991)
  AUTHORS   Plantier,M., Fattoum,A., Menn,B., Ben-Ari,Y., Der Terrossian,E. and
            Represa,A.
  TITLE     Acidic calponin immunoreactivity in postnatal rat brain and
            cultures: subcellular localization in growth cones, under the
            plasma membrane and along actin and glial filaments
  JOURNAL   Eur J Neurosci 11 (8), 2801-2812 (1999)
   PUBMED   10457177
REFERENCE   10 (bases 1 to 1991)
  AUTHORS   Maguchi,M., Nishida,W., Kohara,K., Kuwano,A., Kondo,I. and
            Hiwada,K.
  TITLE     Molecular cloning and gene mapping of human basic and acidic
            calponins
  JOURNAL   Biochem Biophys Res Commun 217 (1), 238-244 (1995)
   PUBMED   8526917
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105942.2, AK312370.1 and AC093429.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001839.4.
            
            Summary: This gene encodes a protein with a markedly acidic C
            terminus; the basic N-terminus is highly homologous to the
            N-terminus of a related gene, CNN1. Members of the CNN gene family
            all contain similar tandemly repeated motifs. This encoded protein
            is associated with the cytoskeleton but is not involved in
            contraction. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.111123.1,
                                           SRR3476690.359375.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370206.9/ ENSP00000359225.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC105942.2         104028-104106
            80-1206             AK312370.1         80-1206
            1207-1991           AC093429.2         25756-26540
FEATURES             Location/Qualifiers
     source          1..1991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.3"
     gene            1..1991
                     /gene="CNN3"
                     /note="calponin 3"
                     /db_xref="GeneID:1266"
                     /db_xref="HGNC:HGNC:2157"
                     /db_xref="MIM:602374"
     exon            1..273
                     /gene="CNN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1206
                     /gene="CNN3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dJ639P13.2.2 (acidic calponin 3); calponin 3, acidic"
                     /codon_start=1
                     /product="calponin-3 isoform 1"
                     /protein_id="NP_001830.1"
                     /db_xref="CCDS:CCDS30775.1"
                     /db_xref="GeneID:1266"
                     /db_xref="HGNC:HGNC:2157"
                     /db_xref="MIM:602374"
                     /translation="MTHFNKGPSYGLSAEVKNKIASKYDHQAEEDLRNWIEEVTGMSI
                     GPNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHD
                     IFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAG
                     QSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAG
                     MLAPGTRRDIYDQKLTLQPVDNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAP
                     TEPVIHNGSQGTGTNGSEISDSDYQAEYPDEYHGEYQDDYPRDYQYSDQGIDY"
     exon            274..395
                     /gene="CNN3"
                     /inference="alignment:Splign:2.1.0"
     exon            396..462
                     /gene="CNN3"
                     /inference="alignment:Splign:2.1.0"
     exon            463..600
                     /gene="CNN3"
                     /inference="alignment:Splign:2.1.0"
     exon            601..717
                     /gene="CNN3"
                     /inference="alignment:Splign:2.1.0"
     exon            718..864
                     /gene="CNN3"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1991
                     /gene="CNN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1718..1723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNN3"
                     /note="hexamer: AATAAA"
     polyA_site      1740
                     /gene="CNN3"
                     /note="major polyA site"
     regulatory      1967..1972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNN3"
                     /note="hexamer: AATAAA"
     polyA_site      1991
                     /gene="CNN3"
ORIGIN      
        1 agccgggtgc ttcgcagcgg agctcgaggc tctgtagcac ccagttggac ccagtcgccc
       61 aggcaccgcc cgcgccccgc ggccgtctcc tgcgcctccc agaggaggga gttcgagcat
      121 cccccgcggc ggccactcct cggggccagg agcggggaag cgaagtgcga gagaccccgg
      181 accccagcgc tgtctcttcc cgccgcccga accaccatga cccacttcaa caagggccct
      241 tcctatgggc tctcggccga agtcaagaac aagattgctt ccaagtatga tcatcaggca
      301 gaagaagatc ttcgcaattg gatagaagag gtgacaggca tgagcattgg ccccaacttc
      361 cagctgggct taaaggatgg catcatcctc tgcgaactta taaacaagct acagccaggc
      421 tcagtgaaga aggtcaacga gtcctcactg aactggcctc agttggagaa tattggcaac
      481 tttattaaag ctattcaggc ttatggtatg aagccacatg acatattcga agcaaatgat
      541 ctttttgaga atggaaacat gacccaggtt cagactactc tggtggctct agcaggtctg
      601 gctaaaacaa aaggattcca tacaaccatt gacattggag ttaagtatgc agaaaaacaa
      661 acaagacgtt ttgatgaagg aaaattaaaa gctggccaaa gtgtaattgg tctgcagatg
      721 ggaaccaaca aatgtgccag ccaggcaggt atgacagctt acgggactag gaggcatctt
      781 tatgatccca aaatgcaaac tgacaaacct tttgaccaga ccacaattag tctgcagatg
      841 ggcactaata aaggagccag ccaggcaggg atgttagcac caggtaccag aagagacatc
      901 tatgatcaga agctaacatt acagccggtg gacaactcga caatttccct acagatgggt
      961 accaacaaag ttgcttccca gaaaggaatg agtgtgtatg ggcttgggcg gcaagtatat
     1021 gatcccaaat actgtgctgc tcctacagaa cctgtcattc acaacggaag ccaaggaaca
     1081 ggaacaaatg gttcggaaat cagtgatagt gattatcagg cagaataccc tgatgagtat
     1141 catggcgagt accaggatga ctaccccaga gattaccaat atagcgacca aggcattgat
     1201 tattagatcc acacagaagg agctcagtat ttagtccttt gtttttattc agtgagaacc
     1261 aagctagcct tgagtaattt ttatcttgtc ttcctaaaac actattaagc ttattgtact
     1321 tttaagaaaa attgccttac gtacattcct ttttcctttt tctgcctctt ccctcaatag
     1381 ttgcctttta gtgctgtaat agttaaatcc tacagcataa tcaataactc gcatatgaag
     1441 taaaaaggaa tactgtgaaa ggggagtact cttgtacagc cagttctttt atgcaaaaat
     1501 ctatgcattt ttacaatctt atattaaact ggtattttca aacaatagga aacttttttt
     1561 tttttttttt ttttttacag tttagtgtat ctggtttcta catggaagac taaactcatg
     1621 cttattgcta aatgtggtct ttgccaacta aatttaagat gcagcatttt agaaatttac
     1681 atatcaatgt ttctacagta ttgtttgcta atttttaaat aaagtcatga tcagtgtgca
     1741 tttgtgatta tatgtgtact cattctctta cctagcgaac aagatctttt cagagtggtg
     1801 tttctaaaag agcatgtaca aaagtggcct gtggacattt aggcctgggt gatgcatttg
     1861 ctcttcctgt ttgtgccaat gtatcaatgt agagttgctc tgttttcttc aactgtattt
     1921 attgctgcat ttctcagcat aaacttatcc cattgtattt tttataaata aatatttttt
     1981 ttgaactttc a
//
