LOCUS       NM_001299               1499 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens calponin 1 (CNN1), transcript variant 1, mRNA.
ACCESSION   NM_001299
VERSION     NM_001299.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1499)
  AUTHORS   Yi,D., Wang,Z., Yang,H., Wang,R., Shi,X., Liu,Z., Xu,F., Lu,Q.,
            Chu,X. and Sang,J.
  TITLE     Long non-coding RNA MEG3 acts as a suppressor in breast cancer by
            regulating miR-330/CNN1
  JOURNAL   Aging (Albany NY) 16 (2), 1318-1335 (2024)
   PUBMED   38240701
  REMARK    GeneRIF: Long non-coding RNA MEG3 acts as a suppressor in breast
            cancer by regulating miR-330/CNN1.
REFERENCE   2  (bases 1 to 1499)
  AUTHORS   Wong,N.A.C.S., Beavers,S., Gill,P., Heryet,A. and Linares,J.
  TITLE     Calponin and MUC6 complement inhibin as diagnostic immunomarkers of
            serous cystadenoma in endoscopic ultrasound-guided
            aspiration/biopsy specimens
  JOURNAL   Histopathology 79 (2), 252-259 (2021)
   PUBMED   33657658
  REMARK    GeneRIF: Calponin and MUC6 complement inhibin as diagnostic
            immunomarkers of serous cystadenoma in endoscopic ultrasound-guided
            aspiration/biopsy specimens.
REFERENCE   3  (bases 1 to 1499)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1499)
  AUTHORS   Cetin,O., Karaman,E., Boza,B., Cim,N. and Sahin,H.G.
  TITLE     Maternal serum calponin 1 level as a biomarker for the short-term
            prediction of preterm birth in women with threatened preterm labor
  JOURNAL   J Matern Fetal Neonatal Med 31 (2), 216-222 (2018)
   PUBMED   28068849
  REMARK    GeneRIF: Studied maternal serum calponin 1 levels in the prediction
            of delivery within 7 days among pregnancies complicated with
            threatened preterm labor. Of 73 women included in the study, found
            the maternal serum calponin 1 level was significantly high in women
            who delivered within 7 days vs. those who delivered after 7 days.
REFERENCE   5  (bases 1 to 1499)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 1499)
  AUTHORS   Takahashi,K., Tazunoki,T., Okada,T., Ohgami,K., Miwa,T., Miki,A.
            and Shibata,N.
  TITLE     The 5'-flanking region of the human smooth muscle cell calponin
            gene contains a cis-acting domain for interaction with a methylated
            DNA-binding transcription repressor
  JOURNAL   J Biochem 120 (1), 18-21 (1996)
   PUBMED   8864837
REFERENCE   7  (bases 1 to 1499)
  AUTHORS   Shah,N.M., Groves,A.K. and Anderson,D.J.
  TITLE     Alternative neural crest cell fates are instructively promoted by
            TGFbeta superfamily members
  JOURNAL   Cell 85 (3), 331-343 (1996)
   PUBMED   8616889
REFERENCE   8  (bases 1 to 1499)
  AUTHORS   Maguchi,M., Nishida,W., Kohara,K., Kuwano,A., Kondo,I. and
            Hiwada,K.
  TITLE     Molecular cloning and gene mapping of human basic and acidic
            calponins
  JOURNAL   Biochem Biophys Res Commun 217 (1), 238-244 (1995)
   PUBMED   8526917
REFERENCE   9  (bases 1 to 1499)
  AUTHORS   Winder,S.J. and Walsh,M.P.
  TITLE     Smooth muscle calponin. Inhibition of actomyosin MgATPase and
            regulation by phosphorylation
  JOURNAL   J Biol Chem 265 (17), 10148-10155 (1990)
   PUBMED   2161834
REFERENCE   10 (bases 1 to 1499)
  AUTHORS   Takahashi,K., Hiwada,K. and Kokubu,T.
  TITLE     Vascular smooth muscle calponin. A novel troponin T-like protein
  JOURNAL   Hypertension 11 (6 Pt 2), 620-626 (1988)
   PUBMED   2455687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC022015.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001299.5.
            
            Transcript Variant: This variant (1) represents the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223234.1, BC022015.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252456.7/ ENSP00000252456.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1330              BC022015.2         88-1417
            1331-1499           BC022015.2         1419-1587
FEATURES             Location/Qualifiers
     source          1..1499
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1499
                     /gene="CNN1"
                     /gene_synonym="HEL-S-14; Sm-Calp; SMCC"
                     /note="calponin 1"
                     /db_xref="GeneID:1264"
                     /db_xref="HGNC:HGNC:2155"
                     /db_xref="MIM:600806"
     exon            1..140
                     /gene="CNN1"
                     /gene_synonym="HEL-S-14; Sm-Calp; SMCC"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..971
                     /gene="CNN1"
                     /gene_synonym="HEL-S-14; Sm-Calp; SMCC"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calponins, basic; basic calponin; calponin H1, smooth
                     muscle; epididymis secretory protein Li 14; calponin 1,
                     basic, smooth muscle"
                     /codon_start=1
                     /product="calponin-1 isoform 1"
                     /protein_id="NP_001290.2"
                     /db_xref="CCDS:CCDS12263.1"
                     /db_xref="GeneID:1264"
                     /db_xref="HGNC:HGNC:2155"
                     /db_xref="MIM:600806"
                     /translation="MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGR
                     RIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKP
                     HDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREG
                     RNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAG
                     MTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTP
                     EYPELGEPAHNHHAHNYYNSA"
     exon            141..262
                     /gene="CNN1"
                     /gene_synonym="HEL-S-14; Sm-Calp; SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            263..329
                     /gene="CNN1"
                     /gene_synonym="HEL-S-14; Sm-Calp; SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            330..467
                     /gene="CNN1"
                     /gene_synonym="HEL-S-14; Sm-Calp; SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            468..578
                     /gene="CNN1"
                     /gene_synonym="HEL-S-14; Sm-Calp; SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            579..725
                     /gene="CNN1"
                     /gene_synonym="HEL-S-14; Sm-Calp; SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            726..1499
                     /gene="CNN1"
                     /gene_synonym="HEL-S-14; Sm-Calp; SMCC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1479..1484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNN1"
                     /gene_synonym="HEL-S-14; Sm-Calp; SMCC"
                     /note="hexamer: AATAAA"
     polyA_site      1499
                     /gene="CNN1"
                     /gene_synonym="HEL-S-14; Sm-Calp; SMCC"
                     /note="major polyA site"
ORIGIN      
        1 gcagacggaa cttcagccgc tgcctctgtt ctcagcgtca gtgccgccac tgcccccgcc
       61 agagcccacc ggccagcatg tcctctgctc acttcaaccg aggccctgcc tacgggctgt
      121 cagccgaggt taagaacaag ctggcccaga agtatgacca ccagcgggag caggagctga
      181 gagagtggat cgagggggtg acaggccgtc gcatcggcaa caacttcatg gacggcctca
      241 aagatggcat cattctttgc gaattcatca ataagctgca gccaggctcc gtgaagaaga
      301 tcaatgagtc aacccaaaat tggcaccagc tggagaacat cggcaacttc atcaaggcca
      361 tcaccaagta tggggtgaag ccccacgaca tttttgaggc caacgacctg tttgagaaca
      421 ccaaccatac acaggtgcag tccaccctcc tggctttggc cagcatggcg aagacgaaag
      481 gaaacaaggt gaacgtggga gtgaagtacg cagagaagca ggagcggaaa ttcgagccgg
      541 ggaagctaag agaagggcgg aacatcattg ggctgcagat gggcaccaac aagtttgcca
      601 gccagcaggg catgacggcc tatggcaccc ggcgccacct ctacgacccc aagctgggca
      661 cagaccagcc tctggaccag gcgaccatca gcctgcagat gggcaccaac aaaggagcca
      721 gccaggctgg catgactgcg ccagggacca agcggcagat cttcgagccg gggctgggca
      781 tggagcactg cgacacgctc aatgtcagcc tgcagatggg cagcaacaag ggcgcctcgc
      841 agcggggcat gacggtgtat gggctgccac gccaggtcta cgaccccaag tactgtctga
      901 ctcccgagta cccagagctg ggtgagcccg cccacaacca ccacgcacac aactactaca
      961 attccgccta gggccacaag gccttccctg ttttcccccc aagggaggct gctgctgctc
     1021 ttggctggac ccagccaggc ccagccgacc ccctctccct gcatggcatc ctccagcccc
     1081 tgtagaactc aacctctaca gggttagagt ttggagagag cagactggcg gggggcccat
     1141 tggggggaag gggaccctcc gctctgtagt gctacagggt ccaacataga gccgggtgtc
     1201 cccaacagcg cccaaaggac gcactgagca acgctattcc agctgtcccc ccactccctc
     1261 acaagtgggt acccccagga ccagaagctc ccccagcaaa gcccccagag cccaggctcg
     1321 gcctgccccc accccattcc cgcagtggga gcaaactgca tgcccagaga cccagcggac
     1381 acacgcggtt tggtttgcag cgactggcat actatgtgga tgtgacagtg gcgtttgtaa
     1441 tgagagcact ttcttttttt tctatttcac tggagcacaa taaatggctg taaaatctc
//
