LOCUS       NM_007015               1455 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chondromodulin (CNMD), transcript variant 1, mRNA.
ACCESSION   NM_007015
VERSION     NM_007015.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1455)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1455)
  AUTHORS   Kumagai,Y., Tachikawa,T., Higashi,M., Sobajima,J., Takahashi,A.,
            Amano,K., Ishibashi,K.I., Mochiki,E., Yakabi,K., Tamaru,J.I. and
            Ishida,H.
  TITLE     Chondromodulin-1 and vascular endothelial growth factor-A
            expression in esophageal squamous cell carcinoma: accelerator and
            brake theory for angiogenesis at the early stage of cancer
            progression
  JOURNAL   Esophagus 17 (2), 159-167 (2020)
   PUBMED   31595395
  REMARK    GeneRIF: Chondromodulin-1 and vascular endothelial growth factor-A
            expression in esophageal squamous cell carcinoma: accelerator and
            brake theory for angiogenesis at the early stage of cancer
            progression.
REFERENCE   3  (bases 1 to 1455)
  AUTHORS   Lin,X., Wang,L. and Wang,F.
  TITLE     Chondromodulin-I suppresses tumorigenesis of human osteosarcoma
            cells
  JOURNAL   Mol Med Rep 16 (6), 8542-8548 (2017)
   PUBMED   28983591
  REMARK    GeneRIF: ChMI directly suppressed the proliferation and growth of
            osteosarcoma cells.
REFERENCE   4  (bases 1 to 1455)
  AUTHORS   von Heyking,K., Calzada-Wack,J., Gollner,S., Neff,F., Schmidt,O.,
            Hensel,T., Schirmer,D., Fasan,A., Esposito,I., Muller-Tidow,C.,
            Sorensen,P.H., Burdach,S. and Richter,G.H.S.
  TITLE     The endochondral bone protein CHM1 sustains an undifferentiated,
            invasive phenotype, promoting lung metastasis in Ewing sarcoma
  JOURNAL   Mol Oncol 11 (9), 1288-1301 (2017)
   PUBMED   28319320
  REMARK    GeneRIF: CHM1 seems to have pleiotropic functions in Ewing sarcoma.
REFERENCE   5  (bases 1 to 1455)
  AUTHORS   Shao,J., Gan,L. and Wang,J.
  TITLE     Transfection of chondromodulin I into human breast cancer cells and
            its effect on the inhibition of cancer cell growth
  JOURNAL   Mol Med Rep 13 (5), 4303-4308 (2016)
   PUBMED   27035228
  REMARK    GeneRIF: The results of the present study indicated that ChMI was
            able to inhibit the growth of breast cancer cells; thus suggesting
            that ChM-I may have potential clinical applications in the
            treatment of breast cancer.
REFERENCE   6  (bases 1 to 1455)
  AUTHORS   Azizan,A., Holaday,N. and Neame,P.J.
  TITLE     Post-translational processing of bovine chondromodulin-I
  JOURNAL   J Biol Chem 276 (26), 23632-23638 (2001)
   PUBMED   11323410
REFERENCE   7  (bases 1 to 1455)
  AUTHORS   Hiraki,Y. and Shukunami,C.
  TITLE     Chondromodulin-I as a novel cartilage-specific growth-modulating
            factor
  JOURNAL   Pediatr Nephrol 14 (7), 602-605 (2000)
   PUBMED   10912526
  REMARK    Review article
REFERENCE   8  (bases 1 to 1455)
  AUTHORS   Yanagihara,I., Yamagata,M., Sakai,N., Shukunami,C., Kurahashi,H.,
            Yamazaki,M., Michigami,T., Hiraki,Y. and Ozono,K.
  TITLE     Genomic organization of the human chondromodulin-1 gene containing
            a promoter region that confers the expression of reporter gene in
            chondrogenic ATDC5 cells
  JOURNAL   J Bone Miner Res 15 (3), 421-429 (2000)
   PUBMED   10750556
REFERENCE   9  (bases 1 to 1455)
  AUTHORS   Hayami,T., Shukunami,C., Mitsui,K., Endo,N., Tokunaga,K., Kondo,J.,
            Takahashi,H.E. and Hiraki,Y.
  TITLE     Specific loss of chondromodulin-I gene expression in chondrosarcoma
            and the suppression of tumor angiogenesis and growth by its
            recombinant protein in vivo
  JOURNAL   FEBS Lett 458 (3), 436-440 (1999)
   PUBMED   10570955
REFERENCE   10 (bases 1 to 1455)
  AUTHORS   Hiraki,Y., Mitsui,K., Endo,N., Takahashi,K., Hayami,T., Inoue,H.,
            Shukunami,C., Tokunaga,K., Kono,T., Yamada,M., Takahashi,H.E. and
            Kondo,J.
  TITLE     Molecular cloning of human chondromodulin-I, a cartilage-derived
            growth modulating factor, and its expression in Chinese hamster
            ovary cells
  JOURNAL   Eur J Biochem 260 (3), 869-878 (1999)
   PUBMED   10103018
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139085.13 and AL139089.13.
            
            On Nov 23, 2018 this sequence version replaced NM_007015.2.
            
            Summary: This gene encodes a glycosylated transmembrane protein
            that is cleaved to form a mature, secreted protein. The N-terminus
            of the precursor protein shares characteristics with other
            surfactant proteins and is sometimes called chondrosurfactant
            protein although no biological activity has yet been defined for
            it. The C-terminus of the precursor protein contains a 25 kDa
            mature protein called leukocyte cell-derived chemotaxin-1 or
            chondromodulin-1. The mature protein promotes chondrocyte growth
            and inhibits angiogenesis. This gene is expressed in the avascular
            zone of prehypertrophic cartilage and its expression decreases
            during chondrocyte hypertrophy and vascular invasion. The mature
            protein likely plays a role in endochondral bone development by
            permitting cartilaginous anlagen to be vascularized and replaced by
            bone. It may be involved also in the broad control of tissue
            vascularization during development. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.542565.1, AB006000.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            MANE Ensembl match               :: ENST00000377962.8/
                                                ENSP00000367198.3
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AL139085.13        28148-28338         c
            192-332             AL139085.13        27549-27689         c
            333-473             AL139085.13        21737-21877         c
            474-587             AL139085.13        12515-12628         c
            588-741             AL139085.13        1234-1387           c
            742-908             AL139089.13        64119-64285         c
            909-1455            AL139089.13        58847-59393         c
FEATURES             Location/Qualifiers
     source          1..1455
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.3"
     gene            1..1455
                     /gene="CNMD"
                     /gene_synonym="BRICD3; CHM-I; CHM1; LECT1; MYETS1"
                     /note="chondromodulin"
                     /db_xref="GeneID:11061"
                     /db_xref="HGNC:HGNC:17005"
                     /db_xref="MIM:605147"
     exon            1..191
                     /gene="CNMD"
                     /gene_synonym="BRICD3; CHM-I; CHM1; LECT1; MYETS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1124
                     /gene="CNMD"
                     /gene_synonym="BRICD3; CHM-I; CHM1; LECT1; MYETS1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; BRICHOS domain containing 3; multiple myeloma
                     tumor suppressor 1; chondromodulin-1; chondromodulin-I;
                     leukocyte cell derived chemotaxin 1"
                     /codon_start=1
                     /product="leukocyte cell-derived chemotaxin 1 isoform 1
                     precursor"
                     /protein_id="NP_008946.1"
                     /db_xref="CCDS:CCDS9437.1"
                     /db_xref="GeneID:11061"
                     /db_xref="HGNC:HGNC:17005"
                     /db_xref="MIM:605147"
                     /translation="MTENSDKVPIALVGPDDVEFCSPPAYATLTVKPSSPARLLKVGA
                     VVLISGAVLLLFGAIGAFYFWKGSDSHIYNVHYTMSINGKLQDGSMEIDAGNNLETFK
                     MGSGAEEAIAVNDFQNGITGIRFAGGEKCYIKAQVKARIPEVGAVTKQSISSKLEGKI
                     MPVKYEENSLIWVAVDQPVKDNSFLSSKVLELCGDLPIFWLKPTYPKEIQRERREVVR
                     KIVPTTTKRPHSGPRSNPGAGRLNNETRPSVQEDSQAFNPDNPYHQQEGESMTFDPRL
                     DHEGICCIECRRSYTHCQKICEPLGGYYPWPYNYQGCRSACRVIMPCSWWVARILGMV
                     "
     exon            192..332
                     /gene="CNMD"
                     /gene_synonym="BRICD3; CHM-I; CHM1; LECT1; MYETS1"
                     /inference="alignment:Splign:2.1.0"
     exon            333..473
                     /gene="CNMD"
                     /gene_synonym="BRICD3; CHM-I; CHM1; LECT1; MYETS1"
                     /inference="alignment:Splign:2.1.0"
     exon            474..587
                     /gene="CNMD"
                     /gene_synonym="BRICD3; CHM-I; CHM1; LECT1; MYETS1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..741
                     /gene="CNMD"
                     /gene_synonym="BRICD3; CHM-I; CHM1; LECT1; MYETS1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..908
                     /gene="CNMD"
                     /gene_synonym="BRICD3; CHM-I; CHM1; LECT1; MYETS1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1455
                     /gene="CNMD"
                     /gene_synonym="BRICD3; CHM-I; CHM1; LECT1; MYETS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1424..1429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNMD"
                     /gene_synonym="BRICD3; CHM-I; CHM1; LECT1; MYETS1"
                     /note="hexamer: AATAAA"
     polyA_site      1455
                     /gene="CNMD"
                     /gene_synonym="BRICD3; CHM-I; CHM1; LECT1; MYETS1"
                     /note="major polyA site"
ORIGIN      
        1 aggcgggacc gtgcaccgtg tgtgcgcgcg gcgttgaaat gccctgcacg tcggggcagc
       61 gggacagatc ccagggtgcc cagggagtct ccaagtgcct cactcctccc gccgcaaaca
      121 tgacagagaa ctccgacaaa gttcccattg ccctggtggg acctgatgac gtggaattct
      181 gcagcccccc ggcgtacgct acgctgacgg tgaagccctc cagccccgcg cggctgctca
      241 aggtgggagc cgtggtcctc atttcgggag ctgtgctgct gctctttggg gccatcgggg
      301 ccttctactt ctggaagggg agcgacagtc acatttacaa tgtccattac accatgagta
      361 tcaatgggaa attacaagat gggtcaatgg aaatagacgc tgggaacaac ttggagacct
      421 ttaaaatggg aagtggagct gaagaagcaa ttgcagttaa tgatttccag aatggcatca
      481 caggaattcg ttttgctgga ggagagaagt gctacattaa agcgcaagtg aaggctcgta
      541 ttcctgaggt gggcgccgtg accaaacaga gcatctcctc caaactggaa ggcaagatca
      601 tgccagtcaa atatgaagaa aattctctta tctgggtggc tgtagatcag cctgtgaagg
      661 acaacagctt cttgagttct aaggtgttag aactctgcgg tgaccttcct attttctggc
      721 ttaaaccaac ctatccaaaa gaaatccaga gggaaagaag agaagtggta agaaaaattg
      781 ttccaactac cacaaaaaga ccacacagtg gaccacggag caacccaggc gctggaagac
      841 tgaataatga aaccagaccc agtgttcaag aggactcaca agccttcaat cctgataatc
      901 cttatcatca gcaggaaggg gaaagcatga cattcgaccc tagactggat cacgaaggaa
      961 tctgttgtat agaatgtagg cggagctaca cccactgcca gaagatctgt gaacccctgg
     1021 ggggctatta cccatggcct tataattatc aaggctgccg ttcggcctgc agagtcatca
     1081 tgccatgtag ctggtgggtg gcccgtatct tgggcatggt gtgaaatcac ttcatatatc
     1141 atgtgctgta aaataagaac tagctgaaga gacaaccaaa gaagcattaa ggcaggttga
     1201 tgctgatagg accacaaaat atttttacac tcaacctgag cggttattct tgacactctt
     1261 aacagaattt tttcaattgt tttccagaac tttagtatat gcaaatgtac tgaaagggta
     1321 gttcaagtct aaaatgccat aaccccttta ttatttgtta ttttttattt gcattgcttt
     1381 gccataagtc ttcccttgct tgtatcttcc aaagctattt tgaaataaac atgaaaattt
     1441 acagtttgcc aaaaa
//
