LOCUS       NM_173515              21078 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens CNKSR family member 3 (CNKSR3), transcript variant 2,
            mRNA.
ACCESSION   NM_173515
VERSION     NM_173515.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 21078)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 21078)
  AUTHORS   Ergun,S., Guney,S., Temiz,E., Petrovic,N. and Gunes,S.
  TITLE     Significance of miR-15a-5p and CNKSR3 as Novel Prognostic
            Biomarkers in Non-Small Cell Lung Cancer
  JOURNAL   Anticancer Agents Med Chem 18 (12), 1695-1701 (2018)
   PUBMED   30019650
  REMARK    GeneRIF: Significance of miR-15a-5p and CNKSR3 as Novel Prognostic
            Biomarkers in Non-Small Cell Lung Cancer
REFERENCE   3  (bases 1 to 21078)
  AUTHORS   Jin,L., Wang,T., Jiang,S., Chen,M., Zhang,R., Hu,C., Jia,W. and
            Liu,Z.
  TITLE     The Association of a Genetic Variant in SCAF8-CNKSR3 with Diabetic
            Kidney Disease and Diabetic Retinopathy in a Chinese Population
  JOURNAL   J Diabetes Res 2017, 6542689 (2017)
   PUBMED   28401168
  REMARK    GeneRIF: SCAF8-CNKSR3 variant rs955333 was not associated with
            diabetic kidney disease but showed association with diabetic
            retinopathy in Chinese type 2 diabetes patients
REFERENCE   4  (bases 1 to 21078)
  AUTHORS   Lake,S.L., Damato,B.E., Kalirai,H., Dodson,A.R., Taktak,A.F.,
            Lloyd,B.H. and Coupland,S.E.
  TITLE     Single nucleotide polymorphism array analysis of uveal melanomas
            reveals that amplification of CNKSR3 is correlated with improved
            patient survival
  JOURNAL   Am J Pathol 182 (3), 678-687 (2013)
   PUBMED   23357503
  REMARK    GeneRIF: Cox regression and Kaplan-Meier survival analysis
            identified that amplification of the CNKSR3 gene (log-rank, P =
            0.022) with an associated increase in its protein expression
            (log-rank, P = 0.011) correlated with longer patient survival.
REFERENCE   5  (bases 1 to 21078)
  AUTHORS   Soundararajan,R., Ziera,T., Koo,E., Ling,K., Wang,J., Borden,S.A.
            and Pearce,D.
  TITLE     Scaffold protein connector enhancer of kinase suppressor of Ras
            isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial
            sodium channel (ENaC)-regulatory complex
  JOURNAL   J Biol Chem 287 (39), 33014-33025 (2012)
   PUBMED   22851176
  REMARK    GeneRIF: CNK3 is a molecular scaffold, which coordinates the
            assembly of a multiprotein ENaC-regulatory complex and hence plays
            a central role in Na(+) homeostasis.
REFERENCE   6  (bases 1 to 21078)
  AUTHORS   Okada,Y., Sim,X., Go,M.J., Wu,J.Y., Gu,D., Takeuchi,F.,
            Takahashi,A., Maeda,S., Tsunoda,T., Chen,P., Lim,S.C., Wong,T.Y.,
            Liu,J., Young,T.L., Aung,T., Seielstad,M., Teo,Y.Y., Kim,Y.J.,
            Lee,J.Y., Han,B.G., Kang,D., Chen,C.H., Tsai,F.J., Chang,L.C.,
            Fann,S.J., Mei,H., Rao,D.C., Hixson,J.E., Chen,S., Katsuya,T.,
            Isono,M., Ogihara,T., Chambers,J.C., Zhang,W., Kooner,J.S.,
            Albrecht,E., Yamamoto,K., Kubo,M., Nakamura,Y., Kamatani,N.,
            Kato,N., He,J., Chen,Y.T., Cho,Y.S., Tai,E.S. and Tanaka,T.
  CONSRTM   KidneyGen Consortium; CKDGen Consortium; GUGC consortium
  TITLE     Meta-analysis identifies multiple loci associated with kidney
            function-related traits in east Asian populations
  JOURNAL   Nat Genet 44 (8), 904-909 (2012)
   PUBMED   22797727
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 21078)
  AUTHORS   Shin,S., Park,J.S., Kim,Y.J., Oh,T., An,S. and Park,C.S.
  TITLE     Differential gene expression profile in PBMCs from subjects with
            AERD and ATA: a gene marker for AERD
  JOURNAL   Mol Genet Genomics 287 (5), 361-371 (2012)
   PUBMED   22457146
  REMARK    GeneRIF: two gene markers (CNKSR3 and SPTBN2) differentiate between
            aspirin-exacerbated respiratory disease and aspirin-tolerant asthma
            with a perfect discriminative power
REFERENCE   8  (bases 1 to 21078)
  AUTHORS   Pankratz,N., Beecham,G.W., DeStefano,A.L., Dawson,T.M.,
            Doheny,K.F., Factor,S.A., Hamza,T.H., Hung,A.Y., Hyman,B.T.,
            Ivinson,A.J., Krainc,D., Latourelle,J.C., Clark,L.N., Marder,K.,
            Martin,E.R., Mayeux,R., Ross,O.A., Scherzer,C.R., Simon,D.K.,
            Tanner,C., Vance,J.M., Wszolek,Z.K., Zabetian,C.P., Myers,R.H.,
            Payami,H., Scott,W.K. and Foroud,T.
  CONSRTM   PD GWAS Consortium
  TITLE     Meta-analysis of Parkinson's disease: identification of a novel
            locus, RIT2
  JOURNAL   Ann Neurol 71 (3), 370-384 (2012)
   PUBMED   22451204
REFERENCE   9  (bases 1 to 21078)
  AUTHORS   Attar,M.A., Salem,J.C., Pursel,H.S. and Santy,L.C.
  TITLE     CNK3 and IPCEF1 produce a single protein that is required for HGF
            dependent Arf6 activation and migration
  JOURNAL   Exp Cell Res 318 (3), 228-237 (2012)
   PUBMED   22085542
  REMARK    GeneRIF: CNK3 and IPCEF1 produce a single protein that is required
            for HGF dependent Arf6 activation and migration.
REFERENCE   10 (bases 1 to 21078)
  AUTHORS   Ziera,T., Irlbacher,H., Fromm,A., Latouche,C., Krug,S.M., Fromm,M.,
            Jaisser,F. and Borden,S.A.
  TITLE     Cnksr3 is a direct mineralocorticoid receptor target gene and plays
            a key role in the regulation of the epithelial sodium channel
  JOURNAL   FASEB J 23 (11), 3936-3946 (2009)
   PUBMED   19567370
  REMARK    GeneRIF: CNKSR3, a homologue of scaffold proteins involved in MAPK
            pathway regulation, is a direct target of MR and is required for
            the maintenance of transepithelial sodium transport in the kidney.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL357075.17, AK055911.1, AY328893.1, AY328892.1, BC060761.1,
            AL590401.6 and AL033376.17.
            
            On Nov 22, 2018 this sequence version replaced NM_173515.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY328891.1, SRR1803611.222170.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000607772.6/ ENSP00000475915.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AL357075.17        116022-116047       c
            27-66               AK055911.1         1-40
            67-1571             AY328893.1         1-1505
            1572-2703           AK055911.1         1546-2677
            2704-3129           AY328892.1         2638-3063
            3130-3294           BC060761.1         2981-3145
            3295-13854          AL357075.17        101-10660           c
            13855-17826         AL590401.6         101-4072            c
            17827-21078         AL033376.17        75282-78533         c
FEATURES             Location/Qualifiers
     source          1..21078
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.2"
     gene            1..21078
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /note="CNKSR family member 3"
                     /db_xref="GeneID:154043"
                     /db_xref="HGNC:HGNC:23034"
                     /db_xref="MIM:617476"
     exon            1..623
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             572..2239
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     connector enhancer of kinase suppressor of ras 3; membrane
                     associated guanylate kinase, WW and PDZ domain containing
                     1; maguin-like protein; CNK homolog protein 3; connector
                     enhancer of KSR 3; membrane-associated guanylate
                     kinase-interacting protein-like 1"
                     /codon_start=1
                     /product="connector enhancer of kinase suppressor of ras 3
                     isoform 2"
                     /protein_id="NP_775786.2"
                     /db_xref="CCDS:CCDS5246.1"
                     /db_xref="GeneID:154043"
                     /db_xref="HGNC:HGNC:23034"
                     /db_xref="MIM:617476"
                     /translation="MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQIS
                     HQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSR
                     RKSPAYDGNTSRKAPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLC
                     LDLTTTVQKDCFVAEMEDKVLTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIK
                     PGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVK
                     KLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSL
                     KKEKSAILDLYIPPPPAVPYSPRDENGSFVYGGSSKCKQPLPGPKGSESPNSFLDQES
                     RRRRFTIADSDQLPGYSVETNILPTKMREKTPSYGKPRPLSMPADGNWMGIVDPFARP
                     RGHGRKGEDALCRYFSNERIPPIIEESSSPPYRFSRPTTERHLVRGADYIRGSRCYIN
                     SDLHSSATIPFQEEGTKKKSGSSATKSSSTEPSLLVSWFTRLKLLTH"
     exon            624..787
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..990
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1078
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1120
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1240
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1300
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1369
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1516
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1641
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1850
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1940
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..21078
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3266..3271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /note="hexamer: AATATA"
     polyA_site      3294
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /note="major polyA site"
     regulatory      12978..12983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /note="hexamer: AATAAA"
     polyA_site      13000
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
     regulatory      21000..21005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /note="hexamer: GATAAA"
     polyA_site      21023
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
     regulatory      21059..21064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
                     /note="hexamer: AATAAA"
     polyA_site      21078
                     /gene="CNKSR3"
                     /gene_synonym="CNK3; CNK3/IPCEF1; MAGI1"
ORIGIN      
        1 attcggtttg cagcaaccgg agctgaaact ttgcaacccg agcgcgcacg ctctgcgctc
       61 ggccctgcca gggcggcacg ggagggcggc gcaggaggtg ggacctgcgc cgggaaggct
      121 ccgggacgcc agcgcacgcg gagcggggac cccggagagc cagcaggcga gaagaccggc
      181 cgagggagag ccgatcgcgc ctcgagagat ccgaggaagt ggtcgcgggc cgggaggctc
      241 ccgtgccgag ccgaggccag gggtctgggg tcgcagcccg gcgtgcctgc agctgccgtc
      301 gctcgggagc agcagctgtg cccgggatcc cggcggcggc gggggaagga ggagctgcag
      361 ctggactgtg gcagctggag ggagagggcc gggctcccct ggcggagccg cgctgggacg
      421 actggctgac cgcggccatg cagtcttgac ggagtcgctc gggcgcaggg gagcagccgc
      481 gggcgcgccc tcccgggaag gggcaccgga gcgcaggcag cagcacttta tctgcgactc
      541 tccagcccag cgagaggcga agcggtttac catggaaccc gtgaccaagt ggagccccaa
      601 acaagtggtg gactggacta gagggttgga tgactgcctg caacaatatg tccacaagtt
      661 tgaacgagag aagatcaacg gcgagcagct gctgcagatt tcccatcagg acctggagga
      721 gctgggggtc acacggattg gacaccagga gcttgtgttg gaggctgtgg accttctctg
      781 tgcactgaat tatggcctcg aaactgataa catgaagaac ttggttctga aactgagagc
      841 atcttcccac aatttacaga attacataag tagccgacgg aaaagtcccg cttacgatgg
      901 caacacctcc cgcaaggccc ccaatgagtt cctgacctcg gtggtggagc tcatcggcgc
      961 cgccaaggcc ctgctggcgt ggctggaccg ggctccgttt acagggatca ctgatttctc
     1021 agtcacgaag aacaaaatta tccagctttg cttggacctg accactacag tccagaagga
     1081 ttgctttgta gcggaaatgg aggataaagt tttaactgtg gtcaaggttt taaatggcat
     1141 ctgtgacaaa acaatccgat ctaccacaga tcctgtgatg agccagtgtg catgtctgga
     1201 ggaagttcac ttaccaaaca ttaaacctgg ggaaggcctg ggcatgtaca tcaaatcaac
     1261 ctatgatggg ttacacgtga ttactggaac cacagaaaat tctcctgcag acagatctca
     1321 gaagattcat gctggtgacg aagtcattca agttaatcag caaactgtgg tgggatggca
     1381 gctgaaaaat ctggtgaaga aattgagaga gaatcccacc ggagttgtgt tactgcttaa
     1441 gaagcgcccc accgggtctt tcaactttac tcctgctccc ctgaaaaacc tacggtggaa
     1501 gccacctctt gtacagacct cacctccacc cgcgacaacc cagtcccctg aaagcactat
     1561 ggatacctca ctgaagaagg agaagtcagc catcctggat ctttatattc ctcctccgcc
     1621 tgctgttccc tactctcccc gggatgagaa tggcagtttt gtttatggag ggtccagtaa
     1681 gtgcaaacaa ccattgcctg gtcctaaggg ttcagagtcc ccgaattcct tcttggacca
     1741 ggaaagccgg agacgaagat tcaccattgc agactcggat cagttgcctg ggtactcggt
     1801 ggaaaccaac attctgccca caaaaatgag agagaaaaca ccatcttatg gcaagccacg
     1861 gcctttgtcc atgcctgctg atgggaactg gatggggatt gtggaccctt ttgccagacc
     1921 tcgaggtcat ggcaggaaag gggaggatgc cctttgccgg tatttcagta acgagcggat
     1981 tcctccgatc attgaagaga gctcctctcc cccataccgg ttctccagac ccacgaccga
     2041 gcggcatctg gtccggggtg cggactacat ccgaggaagc aggtgctaca tcaactcaga
     2101 tctccacagc agcgccacga ttccattcca ggaggaaggg accaaaaaga aatctggctc
     2161 ctcagctacg aagtcctcgt ccacagaacc gtccctcctg gtcagctggt ttacgcgcct
     2221 caaactgttg actcactgag agggaccctg ctcaggccac ctgcctggct cctgccccaa
     2281 gtgccttgct tttacagtgg acagcctctt ctcgtttcag cctcagtatt atgtagggac
     2341 cttatgcaat ttctttttct tttgaaaagt tatctactgc ccttcttgga agtttgcagg
     2401 attggatggg aacaaattca gaggatctta ggtgctggct tgtggagaca aaaggaggga
     2461 aatgggtaga gcctgtttgt cttgcttccc cagagataga atgtgaagac acgcgctaga
     2521 aatcgcagtc ctggccagag acgttatggt cattgtgagg gactggtggc attgttcctt
     2581 tttgaggggc tggggggact caaattggtg gctgttttca cacagatgtg ttggtttgtg
     2641 gtccaacttc tttatctgaa aaagccagtg agaaaacatt tttgatttga tttttctaaa
     2701 ctatctacca tattttaagt gtagcagctt tgactttgca ataacgtggc aagtatctga
     2761 tttctccttt gaggcagagg tttaagtgta ggcctgttac acttgtttga tacctttttc
     2821 atgacagtct cagtatagat cagttggtac agaaatacat gaacacattt tgatagggct
     2881 tatttcacac aaagaagttt atggttattt gtgtggggtg gtgttgttat atattattgt
     2941 ctttaaggga aaagaagcta taagattcgc tgacagccaa agtatcattt agaaaagtga
     3001 agcaacaaga tttaggttga tgaaagatac atgagtttgc attttgacct gttcagtgtc
     3061 tgtcttccag cacggtgtgt acacttcttc aaaattgtac acagtttgct aattagaaat
     3121 atcttggaaa gcctcatggt cactaatttt caactagcat caggtatttt gaaaacgtgt
     3181 gtctggatat taactcttgt ttaaactgaa tgtatgatat tttgttagaa tggaaaagta
     3241 ctatcttgtt aatttaagta ttttaaatat agttgtatat ttttcttact cttagtcacc
     3301 tgtaattgaa atatttctgt tttgcgtcat acacgaagct agtgaaaaag aaagtgcaag
     3361 gcattttcag atgagcaagt gactatcgtg gctgttgcca gcagggcagt attgttaaaa
     3421 aaaatcaaaa taaaccctcc caagcatttt gggattttat ggattagaaa tggaagaaca
     3481 ggagaagcat atgcaaagtg aaattgcacg aggggaattt tctgaggtat cttcctaggc
     3541 agagccgaaa tctcctactc caaaatgccc tttctcatac caccggaatt gttgagtttg
     3601 ctgaactgcc tggaattcag cccatgaaaa tcactggagt taggaaacat cttcccttta
     3661 aaatgcttct ggtgtggtta aaggaactag caaccactca tgtataatta ctgtgactga
     3721 attcagtcag gctggttttt tttgtttgtt tgtttgtttt tgagatggag tctcaatctg
     3781 tcacccaggc tggagtgcag tggcgcaatc tcagctcact gcaacctcca ccttccaggt
     3841 tcaagcgatt ctcctgcctc agcctcccat gtagctggga ttataggtgc ccgccaccat
     3901 gcctggctaa tttttgtatt tttagtggag acggggtttc actacgttgg ccaggctggt
     3961 ctcaaactcc caacctcaac tgatctgccg gcctcagcct cccaaagtgc tgggattaca
     4021 ggcatgagcc accacacccg gctcagtctg gctgttttct tctctacctc taagacaact
     4081 gccatgaaga tctggtattt cggcctggcg cagtggctca tgcctgtaat tccagaactt
     4141 tggggggcca aggtgggtgg attacctggg gtcaggagtt caagaccagc ctggccaaca
     4201 tggtgaaacc ctgtctctac taaaaatcag cttcgcatgg tggtgggcac ctgtagtccc
     4261 agctactcgg gaggctgagg caggagaatc acttgaaccc tggaggcgga ggttgtagtg
     4321 agccaagatc aggccactgc actccagcct gggtgacaga aggagactct gtctcaaaaa
     4381 aaaaacaaaa agaaaaagat ctggtatttc atggagacat ggagacccaa gggtgtttgg
     4441 cagatggaga gaagaggctt gcagtgtgtg accacagggt gttcaacaca ctaggagggt
     4501 ggggtgtggg ctggggaggt ctcgtgtagg gcactggtga tgaggaggga gctgtgtacg
     4561 aggggcgagc cagccctgcc tgttttactc ttgtcttgag ctggctttat gcccaggaag
     4621 tgggtggcaa catctcctct tactccccag attgtgggga gaactctaag agctgtagtt
     4681 ccactggatg atgagttaaa tcactctgga ggccttagct ggctggtgag ctctttttct
     4741 gtggggaaaa tgccacttgt gaattgaaca gccatccttt aagtgaatat tcggcagtca
     4801 gtcttcatta taggcagtgg ccaaccagat tggtgctttt cagcctttgt tccctggagt
     4861 cccaggaccc gcgagagaag ttcctggctc ctctacttgc agtcaccctc cacagcttca
     4921 tctttctttt tatttgaggt tttctcctga attgtgtttg aaaaatatat tgctgctaaa
     4981 aaaaaaaaac ctttgtaaac ctctactatg gacatacata aataatagtt taatatggat
     5041 ttcttagaaa ttaatggaaa ctgcttgcct cagtagtaat ccaggtttaa ttgtggacgt
     5101 gtgttcacat atgaagttgc ttgatgatgc tttttgacag gattctttat ttttatttct
     5161 ttaaaaaaaa tttttttttt tttctgagac agattctcac tctgtcaccc aggctagagt
     5221 gcagtggtac aatctcaact cactgcagcc tctgcctccc aggttcaggc aattctcctg
     5281 cctcagcctc ccaagtagct gggattacag gtgcccgcca ccacacctgg ctaatttttg
     5341 tatttttagt agagatggag tttcaccatg ttggccaggc tgatcttgaa ctccttgaca
     5401 ggatacttta caagagtgat tgttaaaact ctcccagaca caactcaaca cctaccccta
     5461 ttataatatt ttatagcatc acttttcaat cttcaaatga aaatcatgga tgatgaagct
     5521 taccttcact cataaaaaca tcactccatt tactattctg aaatgaaact agcaggtaat
     5581 ataactagcc tctaaaacat acccatcagt gacgttctaa ctgaaacaga taagatattt
     5641 tataatgaaa taattatttt catatgtaca tattctagca tggttatatt acaagatgta
     5701 attaaactac taagcagggc acatactttg tatgtgtgtg tataaatata aatatgtgaa
     5761 aaatcaccat gaatgtggta gttaccaatt cagacctgct gcattggcag ttcaatacca
     5821 ggaaaggggt cgatgtcagc agtatgattt tctaaaatgt ggccaattct ttagataaag
     5881 ttctaggcat acctagtctg taatggcttc actcatatag tgcttgctgt gtgcctggca
     5941 ttgttctaat acctttctaa taaatctatg aggtgagtac tgctgttagt cccgttttgc
     6001 atatgaggga gttacccagg ttatgtgcta gtcatcctgg ttatgtgcta ataatggcag
     6061 agctgggatt aaaatgaaag cagcctggct ctggctttct tgctcataat cactcagtat
     6121 ataggcttcc ttccatttat agaattctct cattgcattc ttgaaaaatc caaagcatat
     6181 taaaactggg ctgaaaattc tgtgtgttta tatataaaat gaaatgagat catagatttg
     6241 ttattgtaaa ctgagttccc atctatatga atattgggcg gggcaattga aagttgtgtt
     6301 gatgagtcag ctctttgttg tgagggctgt aagctgcagg gcttgtgtat cacgcatgct
     6361 ccaacaggtt aaatctcagt agtggccgcc catcagtggc acccctaaca tgctcacatt
     6421 tccagaactg cctcttgggc ggaggtgggg gagggtacca tctctttcag aacaagtatt
     6481 ttaaaagaaa tcctgtatcc tccttaagta gtatttcagt ctatatattt gtccatttcc
     6541 tatctctgct tctctctcag ttctttcccc accaaacctg aaatttcaga atctattttg
     6601 tgggctttct ttttttaatt ttttccctgg aagaccatga acattcctct ttaggttgtt
     6661 agtattgcag caaaccctga ggtattgaca caaaactttt catccgccaa agagctcgag
     6721 taagtaaatc tgtctgacat ttgaatgtca ccagcaaagc atgagactca tgctgccttt
     6781 tgccaccata ggcatgaatg gtatggagaa gtaggcctga cttgttttct tctattgtag
     6841 atgagattag ttttgtagac cattagttca cattttgctc ctacccttgt gcataaaatc
     6901 actgcatcat ttccgtgggg atgagactac tgcaagctac ttccttggag attctgtgga
     6961 agatggacat cttaaaagta aactactttt ggtatgactg ctcattggct tggccagtga
     7021 tacttgatgt tatttatttt gtgagttact ctgtgtctta atcagctcag gctgcaataa
     7081 caaaatacca tacactgggt agcttaaatg acagaaattt ctcaccgttc tggaggctgg
     7141 gaagtccaag atcaaggtga gttcctggtg agcaccctta ccctggtttg ctgatagcca
     7201 tcatcttccc attgcatcct tacatggcag agagagagaa aggaagcaag caagctctcc
     7261 tttcccttct tgtgagggcg ctaatattca tgagggctcc accctcagga cctactcact
     7321 tcccaaaggc ccacttatgg tattagctcc gcctcctaat accattgctt tggagattag
     7381 ggtttcaaca gatgaatttt gggaggacat aaacatgcaa tccatagcac tctgcttttg
     7441 tatatttttc aaacctttca tgctaatcag ctggaaggtg aatattttaa aatctatttt
     7501 aaaactggct taaggagcac acaaaagctg atttctgatg tttcttccaa tacgtggaaa
     7561 attttgcatg atgtattaac ccctagttag ggtccctcaa ccccagttga ggacctcaac
     7621 acacatttgg taatacctaa gggaatttaa atatatattt tgtagcctat agcatatgga
     7681 attagaaaaa aattagtctc tttactgtaa aatttacctt ttaattattt ggaaatttca
     7741 caattgccaa gtttcaactt aaagtttcta tttatttggg gccagaatta ttgccagaag
     7801 tgtgctaatt tgacaaaggg taccttttac ataagtaaag gaaaaagtga ttacatcatg
     7861 ttcagacctg ctagagggcc ttgtttttcc tctagtttta ggggtgtgga gtctgtccca
     7921 aaccctatat atgtgtgcat ttgtgtatgt aaaagacaaa ttttttatac tcaaaagttt
     7981 gtcttaaata atggcctatg gcctactgat ttggatagag gagagaaatt ttgtctataa
     8041 gcaacaaaaa atgctacaca gccaggagac tgtcacacac agtttttcag aacctttggg
     8101 ccacatactg cactcccctt ccatagaaat acacatgggg tcagtgatta aggactcaat
     8161 tctggttgtg acttggccat ccataggcat attctaaagt tctatggcaa cctttatgaa
     8221 gctcgtcttc tgagttgatc acctgttcat gcgctgccca tttacaacat acctcaggga
     8281 ttaaaacgtg aggctacacc taaggaaagt cggtcctaat cctgcgtttc ctcctgcatg
     8341 tcactgacca ttggagtcac tgctctctga ggaagacagt ttacagcctg agcattcatg
     8401 tcacgctcac agccaacctg ttacttgctg gcctccttta ccaagctcct tgtttcatga
     8461 agaagttgtg aaactgaagt tggaggaaaa aaattaagaa ataaacctca aaggtattta
     8521 aaagggcagt agagtaatta ctcctcacac ccagggataa ggatattctc atcattttct
     8581 ctcctcttgc ctggagcata aacattcaga tgtttgtgaa gaaatgatta aaaggagaga
     8641 aaatatcagg agaaaaatga ttaaaatgag agaaatgttc ttccactgac tagacccatt
     8701 aaaggggagg atttaacttt attgttagag gggtgaaaac tggattttaa gatatttctt
     8761 caccattttg acatatcttg ggctgaacat tttgattatt ttagagaatc agggagcttc
     8821 agaaatgaag tttaatataa agtaagattg tctctgaagg aagaaattgt ccttttaact
     8881 cagtgtcagg ttccgttttc ttactcatat ctaaacttcc tgtcactcca actgaggctg
     8941 caccaggata agaggaggga tttgaggaat tagcgcgaat ttagaagcct ttgacttttg
     9001 ggaatttgca tcaagcagat agaagcaggc gggggctcag cttttgaagt tggatcatcc
     9061 agctgtctca ctttgccact tatgggatct gtgacttgaa gcaggtgact gacctctcca
     9121 ctcctcagtt atctatgaaa tggggataat actagcatct acttcgaagg cttatggtga
     9181 ttaaatgaga taatgttttt aaggcccttt cttcgcatag tctggcacac agcatttaag
     9241 agatgttgac tcgtgttcct gtagtagcag tactgactcc atctcagcct ctagtgaata
     9301 aggtattcag agctggccaa caggaaattg ctcattcttt tgtccataag cagcaaaata
     9361 atgccagtgt gacactgtca gagggctgca gtgtggtcag tggcctagag atgcagcttt
     9421 tactgttaga aaactcactc ggatgtttta gccgattcag aactcaagaa atgacaaaag
     9481 tctgtgattg gacacacttt tttttttttt tttgagacgg agtttcagtc ttgttgccca
     9541 ggctggagtg caatggtacg atcttggctc accgcaactt ccgcctactg ggttcaagtg
     9601 attctcctgc ctcagactcc caagtagctg ggattacagg catgtgccac cacacccggc
     9661 taattttgta tttttagtag atggggtttc ttcgtgttgg tcaggctggt ctcgaactcc
     9721 cgacctcagg tgatccgctc acctcagcct cccaaagtgt tgggattaca ggcgtgagcc
     9781 actgcgcccc gcctagagta ttctttcaat attgacttga tttgtcatca tcatatcttt
     9841 tctattaaat cccttccact tccttcaatg aaatcgtata tgaaaacaaa gggaatcgga
     9901 gcattttgcc cacctcctag ttggctgaat tatttttgcc tcccattccc atcttgaagt
     9961 ggtattcctc aaactcgttt ctatgtttcc tgtggtttta aataaaggaa taatgtagaa
    10021 tggtatctat tttggacatt ctcatcgtga aaaggaactc ttacacaaat acaaagccaa
    10081 gagattgtgt tgccattgtt gaagctgaaa aggacagtca ctggatgcct ccccacccaa
    10141 ggccaaggct ttggtaggtc caggaagtga aaaggaaaga gaagctatgg gagagacaaa
    10201 gggaagtaaa aaatggttgt tcggctcagc ataacaatca cttttgtggg gcttattggt
    10261 tgtgcataaa tttcatccat ttgggcacac acacagatgt gacacccaga ccactcagac
    10321 acttggctaa cactgatgcc gtcatcctga atgttgtttc tggaaggact ttcatgaata
    10381 gaatctattt cagattggcc gtaagtctcg atttattgat ccgcaccact ggactggggt
    10441 ggggttgtgt ccactttttc cctgcccctt ccctgctttg gctcttgtga ttgtgtcctc
    10501 cgtgtgtcag gcagagccct gtgaaggtgt ggatatgtgg ccatatttta cctgcataat
    10561 ctgcagttca tatgattcag cctaatgggt tgcaatgccc tgaggacaga gaccatactt
    10621 tttcttcctt tgtcttttta gcgaaattca atcctgttct gcgcctgcgc cacagttgca
    10681 ggctgtactg tctgccctgt gcatctcaca cacccccact gcactgtgca cctagtgatg
    10741 gccgcagatt tgcttttact catcttccag ggcctaccct gttaattcca tcacagttgc
    10801 aggctgtact gtctgccctg tgcatctcac acacccccac tgcactgtgc acctagtgat
    10861 ggccgcagat ttgcttttac tcatctgttt gcagggccta ccctgttaat tccatcacag
    10921 ttgcaggctc tactgtctgc cctgtgcatg catctcacac acccactgga ctgtgcacct
    10981 agttgatgac cacagatttg ctcttaccca tctatttcca gggcctgcca ctgttaattc
    11041 ctaggaaaaa agaaaaaaca agcatggtgg attggttaaa ttggcatttt atattgtttg
    11101 tgttcatggc catgccaatg ataaacaaga gctggtcatg ggcattcaga tcagatgagc
    11161 aattaaatcc cctccaaaaa acagaaacct acttttagag aagaaaagaa ttaaaccaag
    11221 atctttcagg gttttgcttc tccttttgtt tttaaggcac ttaaataaat ggaagaacat
    11281 gtaagctaac cgtgtttaga gtactatgtt ttactagaaa gtgctaccct tctgcagatt
    11341 tctcctcaat gaaagaatgc cactgaagca cctttaatgg tgcctttatc ctatagtctt
    11401 attgaatcat tctctttagc caacataaaa tacaaagcca gggtataaga cttcatgtag
    11461 gtggtaattt aaactaacaa ttagtgaggc cgggcgcggt gggtcacgcc tgtaatccca
    11521 gcactttggg aggctgaggc aggtggatca caaggtcagg agatcgagac catcctggct
    11581 aacacggtga aaccccgtct ctactaaaaa tataaaaaaa aaaaaattag ccgggcgtgg
    11641 tggcgggcgc ctgtagtccc agctactcgg gaggttgagg caggagaatg gcgtgaaccc
    11701 gggaggcgca acttgcagtg agccgagatt gcgccactgc actccagcct gggagacaga
    11761 gcgagactcc gtctcaaaaa aaaaaaaaaa agaaaacaat tagtgaattt ttgctgatgc
    11821 tttccttaaa ccccttactt agcacttagt tctggattct taaatcctga taatggactc
    11881 atccttctcg gtctagttac cccagtaagt cccaaggtca tccatatgag gtcctccttg
    11941 atcttactct gaatagaatt aactggtctc ttctgttttt ccatagcatt gactcatcgt
    12001 gttagaccag cttgaattgt gagcctttct aaagcagggt ctgtataatt tacccttata
    12061 tttgctctgt aggcagagaa aatattattg aagtaactag atggtaaaat taactgtgca
    12121 atcagaaaag aagttagaaa aaattattaa aattttctgt gaaaattgtt ttaattttat
    12181 taatatatta aagcattttg cagactattc cataaagaat tttattacat tggctctcat
    12241 tttaaagaaa acattatacc aggtgtcaga actcaatcat atttgtagga agaataagcc
    12301 ttggccatca acaacgcttc tttggttaca ggattacagg aactgctgag aatgtaagca
    12361 ctttccgaag tccacaaaga actcatttaa agctcgtaca ggcagtttca aattagccag
    12421 ggaaaagtta atggtgggga ggtaaggtca tagaatgctc tataaatgga ggcgacgtgg
    12481 aggacagttg cagttgtata acatttgatt gaaggagagg gatttggacc tgaggaaacc
    12541 aggtctataa atactaaggc tggctgggca cagttggctc atgcctgtaa tctcagcatt
    12601 ttgggaggct gaggccggtg gattgcttga gcccaggagt ttgagaccag cctggacaac
    12661 atggtgaaac cctgcctcca aacaaacaaa attaaccgag tgtggtggtg tgcacctgta
    12721 gtcccagcta ctcaggaggc tgagatggga ggatctcttg agcctgagag gtagaggctg
    12781 cagtaagccc agattgcacc actgcactcc agcctggtga cagagtgaga ctccatctca
    12841 aacaaacaaa acgtacatgc atatataggc tgtagactaa atagtgaaat attactaaga
    12901 accttcatcc caaggggttg agtggtagaa ccactgagaa tattgttgct gctcttttgg
    12961 agacaacaaa ctgcattaat aaaagtctga gaacaagaaa gttgagtttt caagtaatgt
    13021 cctttgcata ttgctacata gggctcatct gagtctgtga tgttctactt tgttgatgaa
    13081 agaaaacaag tggaaattct gctcccccac acatcctgca ctgcaaaaag ataacaagta
    13141 gcaggagata ctcaattatg atgcagttca acaaagaaaa caaattaaaa taaagagatc
    13201 ctgggtggtt aaatacagag tctcctttgt aaacagcaat ggatgatgat gatgactgtt
    13261 accagggctc tgtatgatca ttttcccaat tctttggagt acttttttca aaagcactct
    13321 tgtagaatta actggaaaca tagactaccc ttcactcatt acatgggaaa tgggattgaa
    13381 ttctcttctt ggcaatggaa aatacttgat gcatgcaaat aagaaaactc ttactttttc
    13441 cttctctcct tgcaggggga gcacgcgtcc taagcttgcc aggaagccct gctctcctgc
    13501 cctgggcacc tccgttccac ttgacctttt ccacctgtac tccctgcatt ttggtctctt
    13561 gctctggtct ttagccttcg cattttcctg atgcagccca aaccagtcac ctctctccta
    13621 gattcattct ctgtgctcag accatctctt tcctttagtt cctgtgacga aagaaaatgt
    13681 atttggccat tggaggtata agcaacaaag aatccaaccc acacagcttt atatatgcag
    13741 gttctctata tgctcttctt gtgaacagcg tggggagagg aaaatagact tggcaagagg
    13801 actaagaaca gaatcggaca gttatctgat ggctttccta aggttcagga aagaacagtg
    13861 gtccctttgt tgggcctttc tgttgtttct ttgttttcaa tttcactgat ttctgctttt
    13921 tattttctat tttcttctgt ttcctttgga attcttcttt tttttttttt ttttttttac
    13981 ttcttgtatt aggctcatgc tataacaaac aacccccaaa tctcagtgac tttacacact
    14041 aagagtttac attttcctca tcaacgtcca ctttggatgt tccaggttgg gtaatgctct
    14101 gtggctgtcc tctagctagt gactcaggga cttgggttgc tcctggtgtc tccagcgtgg
    14161 ttatggtgtc tccaattttg gacttcaagg tgacccaggc attatccacc tggtaaattg
    14221 ggagatgggt cccaggaaag tgaatactca accaacctgg cctagaagtg acaataataa
    14281 ggccatgtgt ggtggctaac agtcagaaac ccaacaattg ggagattgag ctgggaggat
    14341 tgcttgagac cagaagttca agaccagctg ggcaccatag tgagacccta tctttcaaaa
    14401 aaatataaca accaggcttg gtggtgtaca cctgtggtcc cagctatttg ggaggctgag
    14461 gtgggataat cgctggagcc caggagtttg aggttacagt aaaccaggtt tacaccactg
    14521 cactccagtc tggatgacaa agcaaaaccc tcatctcaca aaagaaaaga aatgacaatc
    14581 acagccactg caacttcaag gaaggttggg agagtgatat tggtcaggat gagtggtctc
    14641 tgacatgttt cttaagttgg atatttagct tattaattta caactctttt ctaatattaa
    14701 tactcaagac tacattttcc ccaaaacatt tattttgcca tgttttgcaa ggcttggtat
    14761 atggcatttt cattactctt taattctaac taatttttaa tttctattat gatttattat
    14821 ttgatctatg aatcattttg aaatttgttt ttgtaacctt ggatagggaa agatttctta
    14881 tagaagacag taaaagggct gagtacaaaa gaaaagacta ataaattcag ctacgctaaa
    14941 gcttagaact tttcctcatc ataggacacc ttaaagaaaa tttttaaaaa gttacaaatt
    15001 gggagaagat taaaaagtcc taagggttag cagtaagaat atatacatat aattattaca
    15061 aattggcaag agaatgacaa atcaacacaa aaacgagcga aaaggcattt tgcaaaagag
    15121 aatcagatgg tccatatgca tgtgaagcga ttttcactag cgagcaggga aagtgaagtc
    15181 aaaatcacag ggagatgctg ctctctacct gactggcaaa actgaaatga ttagaaaata
    15241 cttggaggat atcctagaac gatcagtggg atctggtata ttatgtgtat gaggttaaat
    15301 tagcagtgag tattcacata ccctatgact cagcagtttc attcctagat atatatcctg
    15361 gggattagaa acactaagta ggtgggtgca gtggctcaca cctacaatcc cagcactttg
    15421 ggaggccaag gcaggtggat cacttgaggt caggggttcg agaccagact ggccaacatg
    15481 gtgaaacccc atctctacta aaaatacaaa aattagccag gcgtggtggc gggcacctgt
    15541 aatcccagct acttgggagg ctgaggtggg agaatcgctt gaaccccgga ggtggaggtt
    15601 gcagtgagct gagattgtgc cactgtactc cagcctgggc gacagaatga gactccatct
    15661 ccaaacaaac aaacaaacaa acaaaccact aactacctca gaggacaatg ctaacatttc
    15721 aaagtgttct agaagttggt ttcccagaaa agaagtcagg ctcttgtgga gctccatgga
    15781 aactggcaat gacccatgac ttagggcagt gaagtctcat caaatgcaag gcttagaccc
    15841 cattctgctg ctgccgtcag gggaggcaag ggctccttgt tccccaaaca tcgatgctaa
    15901 tgaagcaaat cctgctgcta gtttgcagtg ttgcctagct gcaaacacaa cctctgatga
    15961 tgccaataga gaggctggtg cctccttcat catagagctt acaatcccca caaggtttcg
    16021 ggaccctctt ttggattctg agggtgggct cctttagcca tctgtttagt gccccagatg
    16081 aaattgacag caggggacct gcactccttc tactgctttt tctcaaggca tccccagcag
    16141 agggtctcta gggtgcctgt tatgtgtgct gtttggccat ctgcctttgt agaacacagc
    16201 ccaatgtctg ttggcaaaaa aaggtttaca tgtggtatat tcttaccatg gaatattctg
    16261 cagcaagtaa aaatgaataa attacagcta ttcatatcaa agagatggat tttattaata
    16321 tagtgctgag tgggaaaaag catcagaaga caacatataa tggtacactc tttttttttt
    16381 tttgagatgg agtctctctc tgttgcccag gctggagtgc agtggctcca tctcggctca
    16441 ctgcaacctc cacctcccag gttcgagcga ttctcctgcc tcagctgccc gagtagctgg
    16501 gactacaggt gcgcaccacc acaccaagct aatttttgta tttttaatag tgacggggtt
    16561 tcaccatgtt ggccaggatg gtctctgtct cttgacctca tgatccgcct gcctcagcct
    16621 tccaaagtgc tgggattaca ggcatgagcc accatgccca gctacattct ttttaaacat
    16681 tcagaaacag gtaaaactga aaaatatata atttagacac aacacttatg tgaaaagacc
    16741 aagtttagga tgttggttac ctgtgacggg gcagcaagat tgtgggaaag gaaggaagct
    16801 acaggtatgt gacagagagt tgcattagcc caaatctcta cagagctggt gtcaaggatg
    16861 aaactattgg tgttttattt ggaagataca agcccaaggc gaggtgagaa aaaagagaag
    16921 ggaagcaaaa gaagacacaa agtgacacaa aatggcatga actaaattac gttctctcca
    16981 aattcacata ttgaagtcct aaccccagta cctcagaatg taactgtatt tggagattcg
    17041 gtctttaaag aagtgattca ggctgggcct gattgctcac gcctgtaatc ccagcacttt
    17101 gggaggccga ggcaggcgga tcatgaggtc aggagattga gactatcctg gctaacacga
    17161 tgaaaccctg tctctactaa aaatacaaaa aattagccag ttgtggtggc aggcgcctgt
    17221 agtctcagct acttgggaag ttgagggagg agaatggtgt gaacccagga ggtggagctt
    17281 gcagtgagcc gagattgtgc cactgcactc cagcctgggt gacagagtga gaccccgtct
    17341 caaaaaaaga aaaaaagtga ttcagttaaa atgcagtcat tatggtgggc tcaatcaagg
    17401 acatgtggac acagatatgt atgcacatgg aggaaagacc atgtgaagtc ggggagaaga
    17461 aaaccagcta cacactaaag aaagaggcgt caggccgggc gcgatggctc ccgcttgtaa
    17521 tcctagcagt ttgggaggcc aaggtgggca aatcacttga ggtcaggagt tcgagaccag
    17581 cctggccaga atggtgaaac cctctctcta ctaaaaatat aaaaattagc tgggcgtggt
    17641 ggcatgtgcc tgtaatccca gctacttggg aggctgaggc aggagaatca cttgaacccg
    17701 ggaggtggag gttgcagtga gccgagatgg agccactgca ctccagcctg ggcaacagag
    17761 tgagactcca tctcaaaaaa aaaaaaaaaa aaaagcctca gaagaaacca gtgctgctga
    17821 caccttgatc agtcttccac ctgcagagct gtgagaagac acatttctgt tgtttaagct
    17881 acccagtctg tggtattttg ttatggcagc cccaacaaac taatacacaa aatgatgcac
    17941 agccttgctg actatcactt caaaatgagc caaacagaga cacaacgggg cactaggcaa
    18001 ttgtgtccca ctcagtgaaa cttctctgga aagctgtaag gtatagtcca gagacgagag
    18061 gaagggaaga agaaatttat cctctgggag cctcccattt cctgtctcct aatagtgaga
    18121 atttttccat gagaagttaa tgtccctata ctttcacaat gtgttacctt cttttgttgc
    18181 tgttcaagat gccaagccta tgccctgcag tgtggccttt tgtcagagtc cataaagggc
    18241 aggaggaact aggaactctg ggtgtgtatg gttggcccag ctgcagagtt gacagtcaag
    18301 gggataacca actctaatca gcctagaagg gaacttggta gcctaggtga gttggtcagg
    18361 cacaggctgg ggctaaggca aggcaaatgg ctgaggtcta agacgtaggt ggtgctgaga
    18421 aaatgtgggg aagcatacaa gatttgtgac tgatgagtaa tattctagtt cttggttagg
    18481 ataatgggta catggggtgt tccttttatt attttcaaaa tgaaatgaaa taaaagaggg
    18541 atatgtgtgg actgatgatg atgtataatg aatcaaagat tatgattaac ttaactctgc
    18601 atacttgagt ttgtttattt ttctataaaa ggagaatagc aatattaagt cttacagccc
    18661 aggaatgaaa tgtctttcca tttgtttgtg tcttctttaa tttatttcat cagtattttg
    18721 tagttttcag tatacaagtc tttcacctcc ttagttaagt ttattcccaa gtattttatt
    18781 attttgggtg ctattatata tgggattgtt tcgctaattt cctttttaga tagttctgtg
    18841 ttaatgtata gaaatcgcaa ctgatttttg tatgttgatt ttgtattatg caactttatt
    18901 gaattccttt attctaacat gtttaaaaaa tggagtctta gggcgttcta tatatgagac
    18961 gatgtcatct gaagacaggg acaaaacaat tctacagtcc atatgaaacc acaaaagacc
    19021 atgaatagcc atatcaatct tgagaaagaa gaacaaagat agaggcatca cattgcttga
    19081 tttcagaatg tataacaaaa ctacagtaat caaaacagta tgttactggc caacagatag
    19141 acatatatgt gaatggaaca gaatagagag tccagaaata gattcacatg tatattgtca
    19201 actgatcttc aacaatggtg ccaagaatac ataatgggga aaggatagtc tcttcaacac
    19261 atggtattga gaaaatcaga tatccatgtg caaaaggggg aaactggact tttatcttac
    19321 atcacataca aaacccaact caaaatggat taaagattta aacataaaat ctgaagctgt
    19381 aaaactccta gaagaaaaca taggcgaaaa gctctttgac attggtcttg tcaatgattt
    19441 catggatatg acccccaaaa cacaggcaac aaaaacaaaa ataagcaaag ttacatcaaa
    19501 tcacaaagct tctcacagca aaggcaacaa tcaacagagt gaaaagaaaa cctatgaaat
    19561 gggagaaagt atttgcaagc gatgtatgtg ataagggttg acatctaaaa tatgtaagga
    19621 attcataact caatagcaaa aaaaaaaaaa cccaattttt acaaatgggc caaggatctg
    19681 aatagcatgg gctctggcat cttgaacagc aatgaaagaa gctagttgac acattgcgag
    19741 agtataggga tattaacctc tcatgggcaa attctcatca atgagaggaa atgggaggct
    19801 cccagaggat aaaaggtgct catcatcact gatcatcagg gcaatgcaaa tcaaaaccac
    19861 cgtgagatat caactctcac ctgtcaggat ggctatcatt gaagaaccaa aacacaacaa
    19921 atattggtga agaagtggac aaattggaac ccttgcatac tgttgatggg aatgcaaaat
    19981 ggtgcagcca ctaaggaaaa cagtatgggt gttcctaaaa aatgtaaaaa tagaactgcc
    20041 atgtgaccta gcaaccctat ttctggatat ttatccaaaa aaattgaaat caggatccca
    20101 aagaggtatt agcatttgca ggttcattgc cgcattattc acaatatcca agatacacaa
    20161 acaatctaag cgtccatcgg cggagaaatg aataaagaaa atgtatatac acatacaatg
    20221 gaatactatt tagcttttaa aaagaaggaa attctgcaat tattcaacaa catggataaa
    20281 tcttaaggac attacgctaa gtgaaataaa ctattaacag aaagactaat atggcaggat
    20341 tcaatttatg tgggatattt aaaatagtca acttcataga accaaagagt gaaatgatgg
    20401 tggccagggg ctgaggggag tggggagtta ctaatcaata ggcataaagt ttcagtgaag
    20461 tcaggtgaat aagctctaga gatttgtggt acaatattgc acctatagtc aacaatactg
    20521 cagtgtacac tgaacaattt gttaagatag atctcacctt gtgttcttac tgaaaaaaaa
    20581 aaagaaagaa aatagaacag aaaagcaatt ggattttaat tctggaaact cctttctctt
    20641 ccttacatcc aggaaatttg ctgtttattt tgaaaagcaa atttaaacct atttaaggga
    20701 gagagagctc ttgtaaaaat tcatttatta gttctggacc aatgttattt ataagctatt
    20761 atttcaaatg ataaaaaata aatgcataat acatttgatg atagaacatt tttcttttta
    20821 aataaggcct gatttttcaa aaagcattga atatgtttgt ttctaatttc caaagcttga
    20881 cagtttctta tgtttcatta aaagcagaag aattgttatg tatgcatgtt catatcactt
    20941 ttgaatgact catgtggcta caaatgcagc aatctgtggt tatcatggac catgaactag
    21001 ataaacattc ctgcttttct taacattcct ttcctgtgcc tcattaacta atgtacataa
    21061 taaaacatct ttatttca
//
