LOCUS       NM_014927               5753 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens connector enhancer of kinase suppressor of Ras 2
            (CNKSR2), transcript variant 1, mRNA.
ACCESSION   NM_014927
VERSION     NM_014927.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5753)
  AUTHORS   Ito,H. and Nagata,K.I.
  TITLE     Functions of CNKSR2 and Its Association with Neurodevelopmental
            Disorders
  JOURNAL   Cells 11 (2), 303 (2022)
   PUBMED   35053419
  REMARK    GeneRIF: Functions of CNKSR2 and Its Association with
            Neurodevelopmental Disorders.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5753)
  AUTHORS   Toraman,B., Bilginer,S.C., Hesapcioglu,S.T., Goker,Z., Soykam,H.O.,
            Erguner,B., Dincer,T., Yildiz,G., Unsal,S., Kasap,B.K., Kandil,S.
            and Kalay,E.
  TITLE     Finding underlying genetic mechanisms of two patients with autism
            spectrum disorder carrying familial apparently balanced chromosomal
            translocations
  JOURNAL   J Gene Med 23 (4), e3322 (2021)
   PUBMED   33591602
  REMARK    GeneRIF: Finding underlying genetic mechanisms of two patients with
            autism spectrum disorder carrying familial apparently balanced
            chromosomal translocations.
REFERENCE   3  (bases 1 to 5753)
  AUTHORS   Zhang,Y., Yu,T., Li,N., Wang,J., Wang,J., Ge,Y. and Yao,R.
  TITLE     Psychomotor development and attention problems caused by a splicing
            variant of CNKSR2
  JOURNAL   BMC Med Genomics 13 (1), 182 (2020)
   PUBMED   33298018
  REMARK    GeneRIF: Psychomotor development and attention problems caused by a
            splicing variant of CNKSR2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5753)
  AUTHORS   Bonardi,C.M., Mignot,C., Serratosa,J.M., Giraldez,B.G., Moretti,R.,
            Rudolf,G., Reale,C., Gellert,P.M., Johannesen,K.M., Lesca,G.,
            Tassinari,C.A., Gardella,E., Moller,R.S. and Rubboli,G.
  TITLE     Expanding the clinical and EEG spectrum of CNKSR2-related
            encephalopathy with status epilepticus during slow sleep (ESES)
  JOURNAL   Clin Neurophysiol 131 (5), 1030-1039 (2020)
   PUBMED   32197126
  REMARK    GeneRIF: Expanding the clinical and EEG spectrum of CNKSR2-related
            encephalopathy with status epilepticus during slow sleep (ESES).
REFERENCE   5  (bases 1 to 5753)
  AUTHORS   Daoqi,M., Guohong,C., Yuan,W., Zhixiao,Y., Kaili,X. and Shiyue,M.
  TITLE     Exons deletion of CNKSR2 gene identified in X-linked syndromic
            intellectual disability
  JOURNAL   BMC Med Genet 21 (1), 69 (2020)
   PUBMED   32245427
  REMARK    GeneRIF: This study enhances our knowledge of the CNKSR2 gene
            mutation spectrum and provides further information about the
            phenotypic characteristics of X-linked syndromic intellectual
            disability.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5753)
  AUTHORS   Wang,X., Patel,R. and Studzinski,G.P.
  TITLE     hKSR-2, a vitamin D-regulated gene, inhibits apoptosis in
            arabinocytosine-treated HL60 leukemia cells
  JOURNAL   Mol Cancer Ther 7 (9), 2798-2806 (2008)
   PUBMED   18790760
REFERENCE   7  (bases 1 to 5753)
  AUTHORS   Rajakulendran,T., Sahmi,M., Kurinov,I., Tyers,M., Therrien,M. and
            Sicheri,F.
  TITLE     CNK and HYP form a discrete dimer by their SAM domains to mediate
            RAF kinase signaling
  JOURNAL   Proc Natl Acad Sci U S A 105 (8), 2836-2841 (2008)
   PUBMED   18287031
  REMARK    GeneRIF: CNK and HYP form a discrete dimer by their SAM domains to
            mediate RAF kinase signaling.
REFERENCE   8  (bases 1 to 5753)
  AUTHORS   Bumeister,R., Rosse,C., Anselmo,A., Camonis,J. and White,M.A.
  TITLE     CNK2 couples NGF signal propagation to multiple regulatory cascades
            driving cell differentiation
  JOURNAL   Curr Biol 14 (5), 439-445 (2004)
   PUBMED   15028221
REFERENCE   9  (bases 1 to 5753)
  AUTHORS   Lanigan,T.M., Liu,A., Huang,Y.Z., Mei,L., Margolis,B. and Guan,K.L.
  TITLE     Human homologue of Drosophila CNK interacts with Ras effector
            proteins Raf and Rlf
  JOURNAL   FASEB J 17 (14), 2048-2060 (2003)
   PUBMED   14597674
  REMARK    GeneRIF: CNK2 through interaction with Raf and Rlf may function as
            a regulator of Ras signaling.
REFERENCE   10 (bases 1 to 5753)
  AUTHORS   Ohtakara,K., Nishizawa,M., Izawa,I., Hata,Y., Matsushima,S.,
            Taki,W., Inada,H., Takai,Y. and Inagaki,M.
  TITLE     Densin-180, a synaptic protein, links to PSD-95 through its direct
            interaction with MAGUIN-1
  JOURNAL   Genes Cells 7 (11), 1149-1160 (2002)
   PUBMED   12390249
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL807781.6, BC136289.1 and
            AL772392.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014927.4.
            
            Summary: This gene encodes a multidomain protein that functions as
            a scaffold protein to mediate the mitogen-activated protein kinase
            pathways downstream from Ras. This gene product is induced by
            vitamin D and inhibits apoptosis in certain cancer cells. It may
            also play a role in ternary complex assembly of synaptic proteins
            at the postsynaptic membrane and coupling of signal transduction to
            membrane/cytoskeletal remodeling. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2009].
            
            Transcript Variant: This variant (1, also known as CNK2A and
            MAGUIN-1) represents the longest transcript and encodes the longest
            isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.36477.1,
                                           SRR1803611.255113.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA2144333 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379510.5/ ENSP00000368824.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               AL807781.6         102685-103129       c
            446-3680            BC136289.1         1-3235
            3681-5753           AL772392.4         46872-48944
FEATURES             Location/Qualifiers
     source          1..5753
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.12"
     gene            1..5753
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /note="connector enhancer of kinase suppressor of Ras 2"
                     /db_xref="GeneID:22866"
                     /db_xref="HGNC:HGNC:19701"
                     /db_xref="MIM:300724"
     exon            1..544
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     CDS             481..3585
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /note="isoform 1 is encoded by transcript variant 1;
                     connector enhancer of KSR2; membrane-associated guanylate
                     kinase-interacting protein; CNK homolog protein 2"
                     /codon_start=1
                     /product="connector enhancer of kinase suppressor of ras 2
                     isoform 1"
                     /protein_id="NP_055742.2"
                     /db_xref="CCDS:CCDS14198.1"
                     /db_xref="GeneID:22866"
                     /db_xref="HGNC:HGNC:19701"
                     /db_xref="MIM:300724"
                     /translation="MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQL
                     LRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNF
                     ITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNV
                     IQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQL
                     ANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLK
                     NLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPS
                     STISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPN
                     SFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVG
                     DYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTH
                     YSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCK
                     DLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFK
                     IDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQD
                     YWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQS
                     SHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSA
                     AISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHC
                     CLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLGDSLQDLYR
                     ALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAII
                     DKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLAHTHSYI
                     ETHV"
     exon            545..708
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            709..911
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            912..999
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1041
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1161
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1221
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1290
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1437
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1571
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1783
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1873
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2088
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2137
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2310
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2384
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2456
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2524
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2625
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..3172
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3369
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..5753
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5732..5737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /note="hexamer: AATAAA"
     polyA_site      5753
                     /gene="CNKSR2"
                     /gene_synonym="CNK2; KSR2; MAGUIN; MRXSHG"
                     /note="major polyA site"
ORIGIN      
        1 gtcatttccg ccgggcagct agtcgtgctc ggggcttcac tcccgcgcgt gaggcgagcg
       61 ggcaagttgg ctgagggcgt gcggcagagg ctgcttccct cggcgacgcg acccctcagc
      121 aactcaagct atgaactgaa gctccctagg gacggagacc ggagcggagc ggcggaggca
      181 gcagcagcag cagcagcagc agcagcagca gcagccgccg ccgccgccgc cttagcggga
      241 actgagcaga cccggcgcgg agccacgact cctgcacgtt tacctccctg tcgccgttcc
      301 tgccggcggt tggctaaaag acgttacagc cgcgagaccc gacacacaaa agccgctttc
      361 tccgcgccgc ccgcccaggg aggctgcggc cagcaaggga ccccacctga gagcagctcg
      421 ggctgctgag ttcgttttgt gtctgagctc tgcgctctgc acggaaccga ccccgtaccc
      481 atggctctga taatggaacc ggtgagcaaa tggtctccga gtcaagtagt ggactggatg
      541 aaaggtcttg atgactgttt gcagcagtat attaagaact ttgagaggga gaagatcagt
      601 ggggaccagc tgctgcgcat tacacatcag gagctagaag atctgggggt cagccgcatt
      661 ggccatcagg aactgatctt ggaagcagtt gaccttctgt gtgcattgaa ttatggcttg
      721 gaaacagaaa atctaaaaac cctttctcac aagttgaatg catctgccaa aaatctgcag
      781 aattttataa caggaaggag aaggagtggc cattatgatg ggaggaccag ccgaaaattg
      841 ccaaacgact ttctgacctc agttgtggat ctgattggag cagccaagag tctgcttgcc
      901 tggttggaca ggtcaccatt tgctgctgtg acagactatt cagttacaag aaataatgtc
      961 atacaactct gcctggagtt aacaacaatt gtgcaacagg attgtactgt atatgaaaca
     1021 gagaataaaa ttcttcacgt gtgtaaaact ctttctggag tctgtgacca catcatatcc
     1081 ctgtcgtcag atcctctggt ttcacagtct gctcacctgg aagtgattca actggcaaac
     1141 attaaaccaa gcgaagggct gggtatgtat attaaatcta catatgatgg cctccatgta
     1201 attactggaa ccacagaaaa ttcacctgca gatcggtgca agaaaatcca tgctggcgat
     1261 gaagtgattc aagttaatca tcagactgtg gtggggtggc agttgaaaaa tttggtgaat
     1321 gcactacgag aggacccgag tggtgttatc ttaactttga aaaagcgacc tcagagcatg
     1381 cttacctcag caccagcttt actgaaaaat atgagatgga agccccttgc tctgcagcct
     1441 cttataccta gaagtcccac aagcagcgtt gccacgcctt ccagcaccat cagtacaccc
     1501 accaaaagag acagttctgc cctccaggat ctctacattc cccctcctcc tgcagaacca
     1561 tatattccca gggatgaaaa aggaaacctt ccttgtgaag acctcagagg acatatggtg
     1621 ggcaagccag tgcataaggg atctgaatca ccaaattcat ttctggatca ggaatatcga
     1681 aagagattta atattgtcga agaagatact gtcttatatt gctatgaata tgaaaaagga
     1741 agatcaagta gtcaaggaag acgagaaagc accccaactt atggcaagct acgacctata
     1801 tctatgccag tggaatataa ttgggtgggg gactatgaag atccaaataa gatgaagaga
     1861 gatagtagaa gagaaaactc tctacttcgg tatatgagca atgaaaagat tgctcaagaa
     1921 gaatacatgt ttcagagaaa cagcaaaaag gacacaggga agaagtcaaa aaagaagggt
     1981 gataagagta atagcccaac tcactattca ttgctaccta gtttacaaat ggatgcactg
     2041 agacaagaca tcatgggcac tcctgtgcca gagaccacac tataccatac atttcagcag
     2101 tcctcactgc agcacaaatc aaagaagaaa aacaaaggtc ctatagcagg caagagcaaa
     2161 agacgaattt cttgcaaaga tcttggccgt ggtgactgtg agggctggct ttggaaaaag
     2221 aaagatgcga agagttactt ttcacagaaa tggaaaaaat attggtttgt cctaaaggat
     2281 gcatcccttt attggtatat taatgaggag gatgaaaaag cagaaggatt cattagcctg
     2341 cctgaattta aaattgatag agccagtgaa tgccgcaaaa aatatgcatt caaagcctgt
     2401 catcctaaaa tcaaaagctt ttattttgct gctgaacatc ttgatgatat gaacaggtgg
     2461 cttaacagaa ttaatatgct gactgcagga tatgcagaaa gagagaggat taagcaggaa
     2521 caagattact ggagtgagag tgacaaggaa gaagcagata ctccatcaac accaaaacaa
     2581 gatagccctc cacccccata tgatacatac ccacgacctc cctcgatgag ttgcgccagt
     2641 ccttatgtgg aagcaaaaca tagccgactt tcctccacgg agacttctca gtctcagtct
     2701 tctcatgagg agtttcgcca ggaagtaact gggagcagtg cagtgtctcc cattcgcaag
     2761 acagccagtc agcgccgctc ctggcaggat ttaattgaga cgccactgac aagttcaggc
     2821 ttacactatc ttcagactct gcccctggag gattctgtct tctctgactc cgcggccatc
     2881 tccccagagc acaggcggca gtctaccctg ccaactcaga aatgccacct gcaggatcac
     2941 tatgggccat accccttagc tgagagtgag aggatgcaag tgctaaatgg aaatgggggc
     3001 aagcctcgaa gttttactct gcctcgagat agcgggttca accattgctg tctgaatgct
     3061 ccagttagtg cctgtgaccc acaggatgac gtgcaacccc cagaggtgga ggaagaggag
     3121 gaggaggagg aggaggaagg ggaggcagca ggggaaaaca taggagaaaa aagtgaaagc
     3181 agagaagaaa agttaggaga ctcattgcaa gatttataca gggcactgga gcaggccagt
     3241 ctgtcaccac taggagaaca tcgtatttca accaagatgg aatacaagct atcatttata
     3301 aaaagatgta atgatcctgt aatgaatgaa aaactacacc ggctgagaat tctcaaaagc
     3361 actttaaagg ccagagaagg ggaagtagcc attatcgata aagtcctaga caatccagac
     3421 ttgacatcta aagaattcca acaatggaag cagatgtacc tcgacctttt cttggatatc
     3481 tgtcaaaata ccacctcaaa tgacccactg agtatttctt ctgaagtaga tgtaatcact
     3541 tcctctctag cacacactca ttcatacatt gaaacgcatg tctaaatgta ttctgccttc
     3601 agaccatcta gtacctgctg gtactctgaa caagtatata aggtagtttt tatatcaatg
     3661 tgtggaacac ttgacaagct atactttaat gttaccaaac tatatgaaac aaaccatata
     3721 tggtcacaat accactatct ttaatgagca tttgtatatt ttatatgcaa cagtgctcag
     3781 cttatgttta ccatgtgcaa aatcaactgt ctttaatgac ttaaaattaa cttttgcaaa
     3841 caattctaaa tacaggtggt cttcaagtag taaaaccaca aaaggcagtt ttctatctat
     3901 ggtcatcttt tctcccttta agttaatttt atataaacaa gacttcaaaa gtaaatcaca
     3961 ttttttcagg tgcagacatc cttgtgggtg ggaaagaatt taaacctttt ttatatttat
     4021 taaaatgttc taagaatttt cttaaacatt gcacaaagtt taatgctgta gttttatttt
     4081 tgtgaaatgt agatgcgcat acaagagcta agcaaaatag aagagcatcg acataagaaa
     4141 agttcaggta tctaatattc gtcttaatag tctattaact tgtgaaagct aagttaatgg
     4201 aaatattatt ccaaatctat gagaacactt ggtgtatcag ggcaaagctt tgtaagatgt
     4261 ttttgtaact aagaccaaaa ttgaagatag agctgcttta ttttcttggt ttaaatcttc
     4321 ctttattttt gtagtgatga gatgctgatt gtgtacagaa gaatttgaga ggggattttt
     4381 aaaaactgac ttaacacacc cagaaaggca gctaacagct atatatatat ataaatttca
     4441 gcccaaactc atgtttttaa actccaactc ttaaaagaca acaaggtata aactgaaatg
     4501 aatcaacttt ccacttagtt tccaattttc ccctagtcca ctaattaaac ttaggtaatt
     4561 atacttcagg tagggaagta caatatgttt agtttcaggc tgatgtgtgt tataaaaaac
     4621 aacactgaaa aataaaaatg tacttccctt ctaaggagca agcaggtgat ggtcattcaa
     4681 agagatgtca cattgaatta tgagagaaac aatttagagg tttttttcct ggcttcatga
     4741 attgttctat agagtggatg aagtctaagg aaaagtcctc ttcatatatt tccatttata
     4801 agcgtcttgt ttttgaaagt gatcacagca tgaaaatgac tgtgctgctt tttagtgtct
     4861 ggctgcataa tgtacaagtc acaatttgct gtttttttca ggaggagaaa gggaacctcc
     4921 tttactattc tatatcctaa aatctacttc taatcagctt tatactgttg cctgtacagc
     4981 tcagtgaatg tactttcatc tttaagagtt cagatatatg ccagtgaata tttttgctgt
     5041 agaggagaaa gtaaaaactc cacagcgggg atctttttct ttgcttttga aaccaccatt
     5101 gaatcactat cgttttgcag actttgcaca actgtacagg agagtggcct ttctacagca
     5161 cattttcagt aatcctatat ttagtcaaaa tggatgagaa atcatgtatt aatgtttgta
     5221 tggaattttg ggtccagtgt aatattttta tcatttaaaa agaactctat ttgtaaaaac
     5281 atttatttac tgcatggata ttgacgcaca ttaaatttgt gggattttgt atatgtaaaa
     5341 aaaaaaaaaa aaaaaaaaca aaaaacctct tgtcctaaaa tgaagtgtgc ttgttaacag
     5401 gtgtttagac ttattgatgt ttactagacc aaatgtgtat gttcacttaa aaatatatgt
     5461 acctgatgga tgtgtcatgt ttacagtggc caggttgtgg cctgtaaaca gcaagcagtt
     5521 gacgggaaga ctagctctgt tgctactaag cagcttttac ttttgtaaag tcagctctgt
     5581 tgttttaaat ggtaaaaatt aaactaatga atttgacaag actcgtggct agcctagcat
     5641 gaaagagacc ttttaacact atataatatc tgtacatttt attgcattcg tttcaaatct
     5701 aggagagagg cagcactgta aactgaagtc aaataaattc agctcttaat gaa
//
