LOCUS       NM_152495               2539 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens cornichon family AMPA receptor auxiliary protein 3
            (CNIH3), transcript variant 1, mRNA.
ACCESSION   NM_152495
VERSION     NM_152495.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2539)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2539)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2539)
  AUTHORS   Nelson,E.C., Agrawal,A., Heath,A.C., Bogdan,R., Sherva,R.,
            Zhang,B., Al-Hasani,R., Bruchas,M.R., Chou,Y.L., Demers,C.H.,
            Carey,C.E., Conley,E.D., Fakira,A.K., Farrer,L.A., Goate,A.,
            Gordon,S., Henders,A.K., Hesselbrock,V., Kapoor,M., Lynskey,M.T.,
            Madden,P.A., Moron,J.A., Rice,J.P., Saccone,N.L., Schwab,S.G.,
            Shand,F.L., Todorov,A.A., Wallace,L., Wang,T., Wray,N.R., Zhou,X.,
            Degenhardt,L., Martin,N.G., Hariri,A.R., Kranzler,H.R.,
            Gelernter,J., Bierut,L.J., Clark,D.J. and Montgomery,G.W.
  TITLE     Evidence of CNIH3 involvement in opioid dependence
  JOURNAL   Mol Psychiatry 21 (5), 608-614 (2016)
   PUBMED   26239289
  REMARK    GeneRIF: Study's convergent findings in humans and mice support
            CNIH3 involvement in the pathophysiology of opioid dependence,
            complementing prior studies implicating the
            alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
            glutamate system
REFERENCE   4  (bases 1 to 2539)
  AUTHORS   Drummond,J.B., Simmons,M., Haroutunian,V. and Meador-Woodruff,J.H.
  TITLE     Upregulation of cornichon transcripts in the dorsolateral
            prefrontal cortex in schizophrenia
  JOURNAL   Neuroreport 23 (17), 1031-1034 (2012)
   PUBMED   23103966
  REMARK    GeneRIF: Significant upregulation of CNIH-3 mRNA expression was
            found in schizophrenia.
REFERENCE   5  (bases 1 to 2539)
  AUTHORS   Shi,Y., Suh,Y.H., Milstein,A.D., Isozaki,K., Schmid,S.M.,
            Roche,K.W. and Nicoll,R.A.
  TITLE     Functional comparison of the effects of TARPs and cornichons on
            AMPA receptor trafficking and gating
  JOURNAL   Proc Natl Acad Sci U S A 107 (37), 16315-16319 (2010)
   PUBMED   20805473
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC096537.3, AK096312.1 and AL596330.6.
            
            On Nov 22, 2018 this sequence version replaced NM_152495.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.16408.1,
                                           SRR1803611.109465.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272133.4/ ENSP00000272133.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AC096537.3         107896-108055
            161-2532            AK096312.1         1-2372
            2533-2539           AL596330.6         70725-70731
FEATURES             Location/Qualifiers
     source          1..2539
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.12"
     gene            1..2539
                     /gene="CNIH3"
                     /gene_synonym="CNIH-3"
                     /note="cornichon family AMPA receptor auxiliary protein 3"
                     /db_xref="GeneID:149111"
                     /db_xref="HGNC:HGNC:26802"
     exon            1..939
                     /gene="CNIH3"
                     /gene_synonym="CNIH-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             859..1341
                     /gene="CNIH3"
                     /gene_synonym="CNIH-3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein cornichon homolog 3"
                     /codon_start=1
                     /product="protein cornichon homolog 3 isoform 1"
                     /protein_id="NP_689708.1"
                     /db_xref="CCDS:CCDS1544.1"
                     /db_xref="GeneID:149111"
                     /db_xref="HGNC:HGNC:26802"
                     /translation="MAFTFAAFCYMLSLVLCAALIFFAIWHIIAFDELRTDFKSPIDQ
                     CNPVHARERLRNIERICFLLRKLVLPEYSIHSLFCIMFLCAQEWLTLGLNVPLLFYHF
                     WRYFHCPADSSELAYDPPVVMNADTLSYCQKEAWCKLAFYLLSFFYYLYCMIYTLVSS
                     "
     exon            940..1008
                     /gene="CNIH3"
                     /gene_synonym="CNIH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1056
                     /gene="CNIH3"
                     /gene_synonym="CNIH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1169
                     /gene="CNIH3"
                     /gene_synonym="CNIH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1313
                     /gene="CNIH3"
                     /gene_synonym="CNIH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..2539
                     /gene="CNIH3"
                     /gene_synonym="CNIH-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2517..2522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNIH3"
                     /gene_synonym="CNIH-3"
                     /note="hexamer: ATTAAA"
     polyA_site      2539
                     /gene="CNIH3"
                     /gene_synonym="CNIH-3"
                     /note="major polyA site"
ORIGIN      
        1 gcagtggcaa aggcggcggc ggcggcggcg gcagcggcag cagcaggtgg agcgagctac
       61 agcgtttggc ctgaaaccca ctgctgcagc cacccgggct ggagttggcc cgttgggtgg
      121 agccagtgct cgccccggtc cgacccccgg tttccgggac acttgggttg cggaggccgg
      181 ctggccggag tcacggttgg ggacgggcgc gcctcggagc gcacggctgc gctggaagcc
      241 gcgtctgggg cgcaggacca acgggaccta cctcctcccg gctacctaaa gactccttct
      301 ctcgggaaag agcgctgccc ggctctggga tttgggagga gctcggaggc cgctcgggca
      361 cctcgctgga cactatccgt ttgcgccccg gtggcgcggg agggtccgga gcggagcgct
      421 cgtctctcct cagcggttta gtggagaaaa gcagagagct cttcctgggg cgaatgggac
      481 ctcctccctc ggtcctccgt ggagtcgtcg catcgcttgt cgtgttggtc tcgaggggct
      541 cacagcttgg cactaatttg caggtgttcg ctgctgattt ggtttcttct tcgatttgcg
      601 gacggttccc tccagcgact ctcgacacac gttttcctgt cttcgccgga gggccgggtc
      661 tggggtcgcc ggagcctgcg ggaatccagc gcttattcgc tgaccctcga gtcgcttcgc
      721 tagctgtgcg ccctcctggg cactagcctg gagaggagcg tgcagacgcg gctccttgga
      781 gggagtgcgg tcctctaggg aggcatcggg ctcctagggg cttcttggcg tgtgtggtgg
      841 gattggggtc cgccggccat ggccttcact ttcgctgcgt tctgctacat gctgtctctg
      901 gtgctgtgcg ctgcgctcat cttcttcgcc atctggcaca taattgcctt tgatgagtta
      961 aggacagatt ttaagagccc catagaccag tgcaatcctg ttcatgcgag ggaacggttg
     1021 aggaacatcg agcgcatctg cttccttctg cgaaagctgg tgctgccaga atactccatc
     1081 catagcctct tctgcattat gttcctgtgt gcgcaagagt ggctcacgct ggggctgaat
     1141 gtccctctac ttttctatca cttctggagg tatttccact gtccagcaga tagctcagaa
     1201 ctagcctacg acccaccggt ggtcatgaat gccgacactt tgagttactg tcagaaggag
     1261 gcctggtgta agctggcctt ctatctcctc tccttcttct actaccttta ctgcatgatc
     1321 tacactttag tgagctctta acgcaaagac catgcacatc atcagagact gagatgggag
     1381 aggcctgaga cggagaggtg catttctgct ggtgactgga ggagggacca gaatgaggat
     1441 acgtgagaaa tagacccggc aggcagtcag actgaatggg agctggaatc acgcagcagc
     1501 tgggagccga gttaaccctg cgtgtctgtg tcaccctgtt tgtcaatctt tggcattcga
     1561 attccacaca cggggtccta gagcccttct gagcatcagt ggtgtggggg agtaggtgac
     1621 gaaacactag acctctcctg agagagaatt gctgcttcct gaatccactt cattgaacag
     1681 caccttgcaa gttcaaatga gttcctggga gcggaggctg gaaggccaca aggtgcttgc
     1741 taaggaacag aatgacccag agtcaaggcc aagtctgcag ggacctgttg aaagcctcga
     1801 gaatgtcttg gctgcccaag actcttgttg cctttcttcc aagccatggc catgcccttt
     1861 ttctcaaatg ggaggggctg gagggtgtgt gggatttgtc ttcagctgca accagccttg
     1921 agcctgctgg gctattttca gctgaggagg ggtgaatata ggaaaaatgc atttttgaaa
     1981 cgtttgcaac atgatcaagg tgttagttct ccaccacaca agttgtattc ttcttttgcc
     2041 acctcaaacc atcacagagt ctttaaatgc aaatcaattg gtcaatgcta gtcaaagcta
     2101 tgttcttaca aaaaccccag acagctcaga gctcagaaaa tcctgtggag tggctgctct
     2161 gtaccgtggg catccggcag ccaggaagtg agacaacata attataactt tgttttatga
     2221 tgctgcatca tttgtactgt ttaggtcgac gtgaggacat catcttattt agaattttcc
     2281 gtttggcatt ctcttttggg tgggagttat gctgggggtt gtaaataatg acaaggctga
     2341 gatttttatg atgtttaaat tgggcacaat gattttgacc ttattcccca aacttctttt
     2401 cttttctact gtttaacata cacaggctat ttatacacgt ccccagctcc catctgaaac
     2461 ctgtgactca ggtttatgaa tggtgtttgt gtagcaacac attgtgtgct atgtttatta
     2521 aaatgcagcg acaacttga
//
