LOCUS       NM_182553               1374 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens cornichon family AMPA receptor auxiliary protein 2
            (CNIH2), transcript variant 1, mRNA.
ACCESSION   NM_182553 XM_938838
VERSION     NM_182553.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1374)
  AUTHORS   Zhang,Y., Liu,D., Guo,D., Lin,W., Lu,W., Hu,L., Chen,S. and Chen,C.
  TITLE     CPSF3 regulates alternative polyadenylation of CNIH2 to promote
            esophageal squamous cell carcinoma progression
  JOURNAL   Cancer Lett 593, 216925 (2024)
   PUBMED   38718887
  REMARK    GeneRIF: CPSF3 regulates alternative polyadenylation of CNIH2 to
            promote esophageal squamous cell carcinoma progression.
REFERENCE   2  (bases 1 to 1374)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1374)
  AUTHORS   Boudkkazi,S., Brechet,A., Schwenk,J. and Fakler,B.
  TITLE     Cornichon2 dictates the time course of excitatory transmission at
            individual hippocampal synapses
  JOURNAL   Neuron 82 (4), 848-858 (2014)
   PUBMED   24853943
REFERENCE   4  (bases 1 to 1374)
  AUTHORS   Drummond,J.B., Simmons,M., Haroutunian,V. and Meador-Woodruff,J.H.
  TITLE     Upregulation of cornichon transcripts in the dorsolateral
            prefrontal cortex in schizophrenia
  JOURNAL   Neuroreport 23 (17), 1031-1034 (2012)
   PUBMED   23103966
  REMARK    GeneRIF: Significant upregulation of CNIH-2 mRNA expression was
            found in schizophrenia.
REFERENCE   5  (bases 1 to 1374)
  AUTHORS   Gill,M.B., Kato,A.S., Wang,H. and Bredt,D.S.
  TITLE     AMPA receptor modulation by cornichon-2 dictated by transmembrane
            AMPA receptor regulatory protein isoform
  JOURNAL   Eur J Neurosci 35 (2), 182-194 (2012)
   PUBMED   22211840
REFERENCE   6  (bases 1 to 1374)
  AUTHORS   Gill,M.B., Kato,A.S., Roberts,M.F., Yu,H., Wang,H., Tomita,S. and
            Bredt,D.S.
  TITLE     Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor
            regulatory protein assembly to dictate gating and pharmacology
  JOURNAL   J Neurosci 31 (18), 6928-6938 (2011)
   PUBMED   21543622
REFERENCE   7  (bases 1 to 1374)
  AUTHORS   Schober,D.A., Gill,M.B., Yu,H., Gernert,D.L., Jeffries,M.W.,
            Ornstein,P.L., Kato,A.S., Felder,C.C. and Bredt,D.S.
  TITLE     Transmembrane AMPA receptor regulatory proteins and cornichon-2
            allosterically regulate AMPA receptor antagonists and potentiators
  JOURNAL   J Biol Chem 286 (15), 13134-13142 (2011)
   PUBMED   21343286
REFERENCE   8  (bases 1 to 1374)
  AUTHORS   Kato,A.S., Gill,M.B., Ho,M.T., Yu,H., Tu,Y., Siuda,E.R., Wang,H.,
            Qian,Y.W., Nisenbaum,E.S., Tomita,S. and Bredt,D.S.
  TITLE     Hippocampal AMPA receptor gating controlled by both TARP and
            cornichon proteins
  JOURNAL   Neuron 68 (6), 1082-1096 (2010)
   PUBMED   21172611
REFERENCE   9  (bases 1 to 1374)
  AUTHORS   Shi,Y., Suh,Y.H., Milstein,A.D., Isozaki,K., Schmid,S.M.,
            Roche,K.W. and Nicoll,R.A.
  TITLE     Functional comparison of the effects of TARPs and cornichons on
            AMPA receptor trafficking and gating
  JOURNAL   Proc Natl Acad Sci U S A 107 (37), 16315-16319 (2010)
   PUBMED   20805473
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001107.5, BM547951.1 and
            BC047953.1.
            
            On Nov 23, 2018 this sequence version replaced NM_182553.2.
            
            Summary: The protein encoded by this gene is an auxiliary subunit
            of the ionotropic glutamate receptor of the AMPA subtype. AMPA
            receptors mediate fast synaptic neurotransmission in the central
            nervous system. This protein has been reported to interact with the
            Type I AMPA receptor regulatory protein isoform gamma-8 to control
            assembly of hippocampal AMPA receptor complexes, thereby modulating
            receptor gating and pharmacology. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047953.1, ERR279864.1518.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311445.7/ ENSP00000310003.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AP001107.5         18431-18456
            27-50               BM547951.1         1-24
            51-1374             BC047953.1         1-1324
FEATURES             Location/Qualifiers
     source          1..1374
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..1374
                     /gene="CNIH2"
                     /gene_synonym="CNIH-2; Cnil"
                     /note="cornichon family AMPA receptor auxiliary protein 2"
                     /db_xref="GeneID:254263"
                     /db_xref="HGNC:HGNC:28744"
                     /db_xref="MIM:611288"
     exon            1..363
                     /gene="CNIH2"
                     /gene_synonym="CNIH-2; Cnil"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..765
                     /gene="CNIH2"
                     /gene_synonym="CNIH-2; Cnil"
                     /note="cornichon homolog 2"
                     /codon_start=1
                     /product="protein cornichon homolog 2"
                     /protein_id="NP_872359.1"
                     /db_xref="CCDS:CCDS8131.1"
                     /db_xref="GeneID:254263"
                     /db_xref="HGNC:HGNC:28744"
                     /db_xref="MIM:611288"
                     /translation="MAFTFAAFCYMLTLVLCASLIFFVIWHIIAFDELRTDFKNPIDQ
                     GNPARARERLKNIERICCLLRKLVVPEYSIHGLFCLMFLCAAEWVTLGLNIPLLFYHL
                     WRYFHRPADGSEVMYDAVSIMNADILNYCQKESWCKLAFYLLSFFYYLYSMVYTLVSF
                     "
     exon            364..432
                     /gene="CNIH2"
                     /gene_synonym="CNIH-2; Cnil"
                     /inference="alignment:Splign:2.1.0"
     exon            433..480
                     /gene="CNIH2"
                     /gene_synonym="CNIH-2; Cnil"
                     /inference="alignment:Splign:2.1.0"
     exon            481..593
                     /gene="CNIH2"
                     /gene_synonym="CNIH-2; Cnil"
                     /inference="alignment:Splign:2.1.0"
     exon            594..737
                     /gene="CNIH2"
                     /gene_synonym="CNIH-2; Cnil"
                     /inference="alignment:Splign:2.1.0"
     exon            738..1374
                     /gene="CNIH2"
                     /gene_synonym="CNIH-2; Cnil"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1357..1362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNIH2"
                     /gene_synonym="CNIH-2; Cnil"
                     /note="hexamer: AATAAA"
     polyA_site      1374
                     /gene="CNIH2"
                     /gene_synonym="CNIH-2; Cnil"
                     /note="major polyA site"
ORIGIN      
        1 gccccgccgg cttcgcgggc tggagagcga gggagccgcg ggcgagggat cgcaggatga
       61 gcgatcgggg cccgggcagc cggcagcgga cgcgcccccc gagcccaccg gcccgcgccc
      121 cgcgcccccc acggccccgc ggtcccggtc ccggccgcat cacccacgtc ccccgagccc
      181 cacgggccat gcccggccgg ccctaagcgc gggccggggg gcgtcccctt gcgcccgggc
      241 cccgcgctgg cgccccccgg gccgccgccc ggcgcggggg ccatggcgtt caccttcgcc
      301 gcgttctgct acatgctcac cctggtgctg tgcgcctccc tcatcttctt tgtcatctgg
      361 cacatcatag cctttgatga gctgcggacc gacttcaaga accccatcga ccaggggaac
      421 cctgcgcggg cacgcgagcg tttaaaaaac atcgaacgca tctgctgcct cctgaggaag
      481 ctggtggtcc cagaatactc catccacggc ctcttctgtc tgatgtttct gtgtgcagca
      541 gagtgggtga ccctgggcct caacatcccc ctcctcttct accacctctg gaggtacttc
      601 caccgtcctg cagatggctc tgaggtcatg tatgatgcgg tctccatcat gaatgctgac
      661 attctcaact actgccagaa ggagtcctgg tgcaaacttg ccttctacct gctctccttc
      721 ttctattacc tgtacagtat ggtttatacg ttggtgagtt tctaaggggg aagccggcca
      781 gggagcgagc ccagaacgga ccggacgcct gtgcaccccc agccctgccc cttggccgca
      841 gaggcctcag ccctggggag ggagggggca ctggtgcccc cagcctctcc aacccccaaa
      901 ctgctgctgc ggggaacccc ccccaccccg ccttcagagc cctccccctt ggactagagc
      961 ggctgggcag agctctaaac aggggcaggg gctcctctgc cagcctgtgg gcatggcagt
     1021 cattcctgga aggggcagga cctccggcct tgtccatttc gggggaaact tgggccctgc
     1081 caaggggcag agcttgaccc tggaaattct gggccatccc cctccacccc caccctgagg
     1141 ctccccctgc aggtgggggg gtacccgcac cgggaatgag caggctcagc aggggggcag
     1201 ccccacccct agtctgccct cccctctccc ccaggctctt tctccagccc tgtctccatc
     1261 tgccccaacc tcagcccacc ttgtctcttg gacctatttt ctatgtcgcc tggaggagtc
     1321 cggcaccccc tccccggcca tttgtgacaa aatatgaata aactactgca aata
//
