LOCUS       NM_005776               4735 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens cornichon family member 1 (CNIH1), mRNA.
ACCESSION   NM_005776
VERSION     NM_005776.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4735)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4735)
  AUTHORS   Drummond,J.B., Simmons,M., Haroutunian,V. and Meador-Woodruff,J.H.
  TITLE     Upregulation of cornichon transcripts in the dorsolateral
            prefrontal cortex in schizophrenia
  JOURNAL   Neuroreport 23 (17), 1031-1034 (2012)
   PUBMED   23103966
  REMARK    GeneRIF: Significant upregulation of CNIH-1 mRNA expression was
            found in schizophrenia.
REFERENCE   3  (bases 1 to 4735)
  AUTHORS   Gill,M.B., Kato,A.S., Wang,H. and Bredt,D.S.
  TITLE     AMPA receptor modulation by cornichon-2 dictated by transmembrane
            AMPA receptor regulatory protein isoform
  JOURNAL   Eur J Neurosci 35 (2), 182-194 (2012)
   PUBMED   22211840
  REMARK    GeneRIF: the modulation of AMPA receptors by CNIH-2 depends upon
            the Transmembrane AMPA receptor regulatory protein isoform
            composition within the receptor complex
REFERENCE   4  (bases 1 to 4735)
  AUTHORS   Castro,C.P., Piscopo,D., Nakagawa,T. and Derynck,R.
  TITLE     Cornichon regulates transport and secretion of TGFalpha-related
            proteins in metazoan cells
  JOURNAL   J Cell Sci 120 (Pt 14), 2454-2466 (2007)
   PUBMED   17607000
  REMARK    GeneRIF: human CNIH and Drosophila Cni are primarily localized in
            the endoplasmic reticulum and associate with immature TGFalpha
            family proteins; alterations of cornichon expression result in
            changes in transport, processing and secretion of TGFalpha proteins
REFERENCE   5  (bases 1 to 4735)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   6  (bases 1 to 4735)
  AUTHORS   Utku,N., Bulwin,G.C., Beinke,S., Heinemann,T., Beato,F.,
            Randall,J., Schnieders,B., Sandhoff,K., Volk,H.D., Milford,E. and
            Gullans,S.R.
  TITLE     The human homolog of Drosophila cornichon protein is differentially
            expressed in alloactivated T-cells
  JOURNAL   Biochim Biophys Acta 1449 (3), 203-210 (1999)
   PUBMED   10209299
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF104398.1, AY358635.1 and AL359792.3.
            
            On Nov 23, 2018 this sequence version replaced NM_005776.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.202148.1,
                                           SRR1803611.13196.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216416.9/ ENSP00000216416.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-659               AF104398.1         10-668
            660-1367            AY358635.1         626-1333
            1368-4735           AL359792.3         173506-176873
FEATURES             Location/Qualifiers
     source          1..4735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.2"
     gene            1..4735
                     /gene="CNIH1"
                     /gene_synonym="CNIH; CNIH-1; CNIL; TGAM77"
                     /note="cornichon family member 1"
                     /db_xref="GeneID:10175"
                     /db_xref="HGNC:HGNC:19431"
                     /db_xref="MIM:611287"
     exon            1..128
                     /gene="CNIH1"
                     /gene_synonym="CNIH; CNIH-1; CNIL; TGAM77"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..482
                     /gene="CNIH1"
                     /gene_synonym="CNIH; CNIH-1; CNIL; TGAM77"
                     /note="T-cell growth-associated molecule 77; cornichon
                     homolog; cornichon family AMPA receptor auxiliary protein
                     1"
                     /codon_start=1
                     /product="protein cornichon homolog 1"
                     /protein_id="NP_005767.1"
                     /db_xref="CCDS:CCDS9717.1"
                     /db_xref="GeneID:10175"
                     /db_xref="HGNC:HGNC:19431"
                     /db_xref="MIM:611287"
                     /translation="MAFTFAAFCYMLALLLTAALIFFAIWHIIAFDELKTDYKNPIDQ
                     CNTLNPLVLPEYLIHAFFCVMFLCAAEWLTLGLNMPLLAYHIWRYMSRPVMSGPGLYD
                     PTTIMNADILAYCQKEGWCKLAFYLLAFFYYLYGMIYVLVSS"
     exon            129..197
                     /gene="CNIH1"
                     /gene_synonym="CNIH; CNIH-1; CNIL; TGAM77"
                     /inference="alignment:Splign:2.1.0"
     exon            198..310
                     /gene="CNIH1"
                     /gene_synonym="CNIH; CNIH-1; CNIL; TGAM77"
                     /inference="alignment:Splign:2.1.0"
     exon            311..454
                     /gene="CNIH1"
                     /gene_synonym="CNIH; CNIH-1; CNIL; TGAM77"
                     /inference="alignment:Splign:2.1.0"
     exon            455..4735
                     /gene="CNIH1"
                     /gene_synonym="CNIH; CNIH-1; CNIL; TGAM77"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1344..1349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNIH1"
                     /gene_synonym="CNIH; CNIH-1; CNIL; TGAM77"
                     /note="hexamer: AATAAA"
     polyA_site      1368
                     /gene="CNIH1"
                     /gene_synonym="CNIH; CNIH-1; CNIL; TGAM77"
                     /note="major polyA site"
     regulatory      4714..4719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNIH1"
                     /gene_synonym="CNIH; CNIH-1; CNIL; TGAM77"
                     /note="hexamer: AATAAA"
     polyA_site      4735
                     /gene="CNIH1"
                     /gene_synonym="CNIH; CNIH-1; CNIL; TGAM77"
ORIGIN      
        1 ctttctccgc tggcaacggc gccgctcccc gctcctcctc cccagccatg gcgttcacgt
       61 tcgcggcctt ctgctacatg ctggcgctgc tgctcactgc cgcgctcatc ttcttcgcca
      121 tttggcacat tatagcattt gatgagctga agactgatta caagaatcct atagaccagt
      181 gtaataccct gaatcccctt gtactcccag agtacctcat ccacgctttc ttctgtgtca
      241 tgtttctttg tgcagcagag tggcttacac tgggtctcaa tatgcccctc ttggcatatc
      301 atatttggag gtatatgagt agaccagtga tgagtggccc aggactctat gaccctacaa
      361 ccatcatgaa tgcagatatt ctagcatatt gtcagaagga aggatggtgc aaattagctt
      421 tttatcttct agcatttttt tactacctat atggcatgat ctatgttttg gtgagctctt
      481 agaacaacac acagaagaat tggtccagtt aagtgcatgc aaaaagccac caaatgaagg
      541 gattctatcc agcaagatcc tgtccaagag tagcctgtgg aatctgatca gttactttaa
      601 aaaatgactc cttatttttt aaatgtttcc acatttttgc ttgtggaaag actgttttca
      661 tatgttatac tcagataaag attttaaatg gtattacgta taaattaata taaaatgatt
      721 acctctggtg ttgacaggtt tgaacttgca cttcttaagg aacagccata atcctctgaa
      781 tgatgcatta attactgact gtcctagtac attggaagct tttgtttata ggaacttgta
      841 gggctcattt tggtttcatt gaaacagtat ctaattataa attagctgta gatatcaggt
      901 gcttctgatg aagtgaaaat gtatatctga ctagtgggaa acttcatggg tttcctcatc
      961 tgtcatgtcg atgattatat atggatacat ttacaaaaat aaaaagcggg aattttccct
     1021 tcgcttgaat attatccctg tatattgcat gaatgagaga tttcccatat ttccatcaga
     1081 gtaataaata tacttgcttt aattcttaag cataagtaaa catgatataa aaatatatgc
     1141 tgaattactt gtgaagaatg catttaaagc tattttaaat gtgtttttat ttgtaagaca
     1201 ttacttatta agaaattggt tattatgctt actgttctaa tctggtggta aaggtattct
     1261 taagaatttg caggtactac agattttcaa aactgaatga gagaaaattg tataaccatc
     1321 ctgctgttcc tttagtgcaa tacaataaaa ctctgaaatt aagactcact ttcagtgcat
     1381 tgtttgagat taaaaatagt atttcttaaa cttgcttaat ccatgataaa gacatgttgc
     1441 tgtcattttt aaaaagtgac gtactacatt atgggttttc tgaaaaatac catgcctaga
     1501 tctaaaaagg aaaattttta aatgccgagc acattaacct cttttgtcat ttgacaagat
     1561 tcataaacgt ggatggcata gcatcatcat ttctcttacc aattaagaaa aattatggtg
     1621 gcacttaaaa tattttactt tgatttttcc tttttggaac agtcagtttt aaggtaaaat
     1681 ggcttgtaaa tttgagtttt tgctgctgct tgtaaggcag gtaaattatg gcttgcatgt
     1741 tttcataagc ataaataaat cttgtgcttt atttgggatg aggaagttaa ggcagttgaa
     1801 aataaaataa gtggtttgga agtttcttga gaagaggatc aaaagaaaga gaaccaatat
     1861 atagaaattt cacatgatca aggaagttta tggatgcgtt tgtggaaatc ttactctatg
     1921 aacttgttgg attagatgct gttttattct ctactaagtg aaaagtgctt tatttcagtg
     1981 ctttcccatg gttgggagag agtagctgtt aactattctg ggtaatgggg gtgagtatgt
     2041 tgaggaagag atttagaacc agaagagtga agagactcaa actgttccat aacaaggaaa
     2101 gctttaaaga ccttgtattt cacagtctgg agaactagag ggatctgact cttggtcagt
     2161 tcatgtaaca aattatttat tgagtacttg ctgggctctc aagattcatg ctttgagcac
     2221 aggcagtcat tcagtttcca gtccacctga ttacatcagc atgcacttag ttttctttct
     2281 tgttcacaag gacttttgat catgcaagac ctggccaagt cttctataat ccagatgggt
     2341 ttcctggggc tgttacttga gtattcctgt caaaatattt tcgtgaaccc tgcctctctt
     2401 agcaaacact acttcataag tgttaacaaa catcctttta ataatctatt ccagaatatt
     2461 ctccaggagt aagtttactg gttgggattt gtggaagcca ttttctcatg tttcccaaat
     2521 aagatatgta gtcttcagct gattcctcaa agatgattga cagggagttt cacccatctt
     2581 tgtggtagtt tgtgagttcc taggcatgta agtgattaaa agattgagta cctgctctcc
     2641 taatatctac ccacttttac catgtcagtg ttttatgaat tagatcactt accaagagaa
     2701 agcagaaacg aaatacttga atctgacaat atccgactgg ctcttttcat tgctctggat
     2761 ttattttcca catcaatctc tttggggtgg ccctagccta ttattcctgt gggttcagct
     2821 gaggcatggt tagcctgggt ttataattca gtttacgtta aacattccct gtgcagcaac
     2881 agctgttcat ttaggtactc tttttttttt tctccttatt acagttactt ttggtattat
     2941 gtgctttatc tttaaaagct ttctagctct aggaaattgt tttccctgtt tgtgtctatt
     3001 ttattgcatc ttgtgtaaca ctgtggttat atctatacca acaacttttt gttgctatgg
     3061 ataccacaga ttgtcctgaa ttaaaaccct aacataataa atgtctgttt agccgttact
     3121 ttactgagta ataatactat attgtggcag tatggccctt taatactaag gaggtatggt
     3181 gtagaaatta tttgaacact catatccaaa tgttattaat gatgtttgac agttttctca
     3241 atgcttaatg atattcctca ctcctcattc cagggtagag gagggtttgg tcccaggcta
     3301 tggacaaact gctaatttgt ttgaagtttg aattattttt catgggaaag ggaagtgata
     3361 ggaaatgacc aagaccatcc acttttgact tgagtatgga tcgagtataa gtaatagttt
     3421 cctagcctca ctgattgtac catgaactga cagacctacc agtcaaattc atgtacccag
     3481 ataatggtct ctcacatggc aacaaagtac acagcagttt gcagtatgtg tctcttttaa
     3541 agccagttca gtgttttcac cttgacgacc actcctgcaa acagttctca tagagctctt
     3601 ctctgctccc caaatcaata tattttgaag ctatgtcaaa tatttacata gaaaggaaat
     3661 aaagttgtat gtgctttgaa accagcaaaa tcctttgtac aacacctctc ttctccttct
     3721 atgtttatga atagagttcg tggaatattg ccatagtgca aataatgact tccgtgtatc
     3781 acttataccc tgtaggggtg agctttcacc ttaggtgtgg ttatatccta gcagtgtatc
     3841 aagcccactc aaataatggt ctatatttaa aagtatgtgt ctagtttact tatttatgtc
     3901 atttaacatc cataaatgta catctctcag ttgtatatca tgattgtaaa tcagaaattt
     3961 tgatggcaaa aatattctaa aacaacattc ttcaggggaa agaaaaacat ggatacctta
     4021 tctagcattg ctcataaaag tactcatgtt catccttttt ggaaactatt aatcatgcta
     4081 gccttagatc attttaagct cctttgctca aaccaatcat tgatgtgcag tatgaccagc
     4141 agctagtaag tctgtggtgc taccagtata gcttggaaga tggttctgaa ttaatacctc
     4201 agaatgatat caaaagtaaa agagtggttc tattgctaaa tatattgact agctttctta
     4261 taacaatttt actttgaaat tcaaagttcc aaagctaaat gtctaaaaga agtaactgca
     4321 gcttgttctg ctgattttgg aaaatagtat taaccatgta agatctttgg ggttggagtg
     4381 aaggtcttat ctgcattaat tttgttaatg cacattgtag atgtggagaa catcttgacc
     4441 tgcataagga ttgcgtctca ttttattgtg tagtgctttt tcgaaatatt tacatttctt
     4501 tggttcccat gttcatgtat tctggagaag taaaatttct tgattactgg gcagacccta
     4561 aaactactaa gagaaacata acatgtagtt agctgtctgc tcatggtttg ttcaaatcta
     4621 agctaacctt aatggtgctg tgtccgctgt ccacagaaaa cgcccttaag tagccctacc
     4681 ttactcctta gagcttattt tgcttttgta tttaataaaa gctgtcttaa atgtt
//
