LOCUS       NM_001037329            1916 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens cyclic nucleotide gated channel subunit alpha 4
            (CNGA4), mRNA.
ACCESSION   NM_001037329 XM_290552
VERSION     NM_001037329.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1916)
  AUTHORS   Hofmann,F., Biel,M. and Kaupp,U.B.
  TITLE     International Union of Pharmacology. LI. Nomenclature and
            structure-function relationships of cyclic nucleotide-regulated
            channels
  JOURNAL   Pharmacol Rev 57 (4), 455-462 (2005)
   PUBMED   16382102
  REMARK    Review article
REFERENCE   2  (bases 1 to 1916)
  AUTHORS   Kelliher,K.R., Ziesmann,J., Munger,S.D., Reed,R.R. and Zufall,F.
  TITLE     Importance of the CNGA4 channel gene for odor discrimination and
            adaptation in behaving mice
  JOURNAL   Proc Natl Acad Sci U S A 100 (7), 4299-4304 (2003)
   PUBMED   12649326
REFERENCE   3  (bases 1 to 1916)
  AUTHORS   Bradley,J., Frings,S., Yau,K.W. and Reed,R.
  TITLE     Nomenclature for ion channel subunits
  JOURNAL   Science 294 (5549), 2095-2096 (2001)
   PUBMED   11764791
REFERENCE   4  (bases 1 to 1916)
  AUTHORS   Munger,S.D., Lane,A.P., Zhong,H., Leinders-Zufall,T., Yau,K.W.,
            Zufall,F. and Reed,R.R.
  TITLE     Central role of the CNGA4 channel subunit in
            Ca2+-calmodulin-dependent odor adaptation
  JOURNAL   Science 294 (5549), 2172-2175 (2001)
   PUBMED   11739959
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022762.8, DB238337.1 and AK122736.1.
            
            On May 17, 2019 this sequence version replaced NM_001037329.3.
            
            Summary: CNGA4 is a modulatory subunit of vertebrate cyclic
            nucleotide-gated membrane channels that transduce odorant signals
            (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar
            2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122736.1, SRR1803612.256359.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379936.3/ ENSP00000369268.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC022762.8         155324-155326
            4-308               DB238337.1         1-305
            309-580             AK122736.1         299-570
            581-582             AC022762.8         156492-156493
            583-1914            AK122736.1         572-1903
            1915-1916           AC022762.8         160713-160714
FEATURES             Location/Qualifiers
     source          1..1916
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..1916
                     /gene="CNGA4"
                     /gene_synonym="CNCA2; CNG-4; CNG4; CNG5; CNGB2; OCNC2;
                     OCNCb; OCNCBETA"
                     /note="cyclic nucleotide gated channel subunit alpha 4"
                     /db_xref="GeneID:1262"
                     /db_xref="HGNC:HGNC:2152"
                     /db_xref="MIM:609472"
     exon            1..180
                     /gene="CNGA4"
                     /gene_synonym="CNCA2; CNG-4; CNG4; CNG5; CNGB2; OCNC2;
                     OCNCb; OCNCBETA"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1846
                     /gene="CNGA4"
                     /gene_synonym="CNCA2; CNG-4; CNG4; CNG5; CNGB2; OCNC2;
                     OCNCb; OCNCBETA"
                     /note="cyclic nucleotide gated channel beta 2; cyclic
                     nucleotide-gated cation channel alpha-4; CNG channel
                     alpha-4; cyclic nucleotide gated channel alpha 4;
                     olfactory cyclic nucleotide-gated channel subunit 2"
                     /codon_start=1
                     /product="cyclic nucleotide-gated channel alpha-4"
                     /protein_id="NP_001032406.1"
                     /db_xref="CCDS:CCDS31408.1"
                     /db_xref="GeneID:1262"
                     /db_xref="HGNC:HGNC:2152"
                     /db_xref="MIM:609472"
                     /translation="MSQDTKVKTTESSPPAPSKARKLLPVLDPSGDYYYWWLNTMVFP
                     VMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMVVRFHTGFLEQGILVVDK
                     GRISSRYVRTWSFFLDLASLMPTDVVYVRLGPHTPTLRLNRFLRAPRLFEAFDRTETR
                     TAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQY
                     LYSFYFSTLILTTVGDTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTAD
                     AAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEV
                     AVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQ
                     LAVVADDGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDL
                     REVLSEYPQAQTIMEEKGREILLKMNKLDVNAEAAEIALQEATESRLRGLDQQLDDLQ
                     TKFARLLAELESSALKIAYRIERLEWQTREWPMPEDLAEADDEGEPEEGTSKDEEGRA
                     SQEGPPGPE"
     exon            181..282
                     /gene="CNGA4"
                     /gene_synonym="CNCA2; CNG-4; CNG4; CNG5; CNGB2; OCNC2;
                     OCNCb; OCNCBETA"
                     /inference="alignment:Splign:2.1.0"
     exon            283..389
                     /gene="CNGA4"
                     /gene_synonym="CNCA2; CNG-4; CNG4; CNG5; CNGB2; OCNC2;
                     OCNCb; OCNCBETA"
                     /inference="alignment:Splign:2.1.0"
     exon            390..1035
                     /gene="CNGA4"
                     /gene_synonym="CNCA2; CNG-4; CNG4; CNG5; CNGB2; OCNC2;
                     OCNCb; OCNCBETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1385
                     /gene="CNGA4"
                     /gene_synonym="CNCA2; CNG-4; CNG4; CNG5; CNGB2; OCNC2;
                     OCNCb; OCNCBETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1916
                     /gene="CNGA4"
                     /gene_synonym="CNCA2; CNG-4; CNG4; CNG5; CNGB2; OCNC2;
                     OCNCb; OCNCBETA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1896..1901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNGA4"
                     /gene_synonym="CNCA2; CNG-4; CNG4; CNG5; CNGB2; OCNC2;
                     OCNCb; OCNCBETA"
                     /note="hexamer: AGTAAA"
     polyA_site      1916
                     /gene="CNGA4"
                     /gene_synonym="CNCA2; CNG-4; CNG4; CNG5; CNGB2; OCNC2;
                     OCNCb; OCNCBETA"
                     /note="major polyA site"
ORIGIN      
        1 agcagaagcc caacagcagc ctccttcagg cagtcaggca ctagtgccca actccagaag
       61 tcccctacag gcagagaggg tgtggacatc tcacacccca gcaccagacc acagaaccat
      121 gagccaggac accaaagtga agacaacaga gtccagtccc ccagccccat ccaaggccag
      181 gaagttgctg cctgtcctgg acccatctgg ggattactac tactggtggc tgaacacaat
      241 ggtcttccca gtcatgtata acctcatcat cctcgtgtgc agagcctgct tccccgactt
      301 gcagcacggt tatctggtgg cctggttggt gctggactac acgagtgacc tgctatacct
      361 actagacatg gtggtgcgct tccacacagg attcttggaa cagggcatcc tggtggtgga
      421 caagggtagg atctcgagtc gctacgttcg cacctggagt ttcttcttgg acctggcttc
      481 cctgatgccc acagatgtgg tctacgtgcg gctgggcccg cacacaccca ccctgaggct
      541 gaaccgcttt ctccgcgcgc cccgcctctt cgaggccttc gaccgcacag agacccgcac
      601 agcttaccca aatgcctttc gcattgccaa gctgatgctt tacatttttg tcgtcatcca
      661 ttggaacagc tgcctatact ttgccctatc ccggtacctg ggcttcgggc gtgacgcatg
      721 ggtgtacccg gaccccgcgc agcctggctt tgagcgcctg cggcgccagt acctctatag
      781 cttttacttc tccacgctga tactgactac agtgggcgat acaccgccgc cagccaggga
      841 agaagagtac ctcttcatgg tgggcgactt cctgctggcc gtcatgggtt tcgccaccat
      901 catgggtagc atgagctctg tcatctacaa catgaacact gcagatgcgg ctttctaccc
      961 agatcatgca ctggtgaaga agtacatgaa gctgcagcac gtcaaccgca agctggagcg
     1021 gcgagttatt gactggtatc agcacctgca gatcaacaag aagatgacca acgaggtagc
     1081 catcttacag cacttgcctg agcggctgcg ggcagaagtg gctgtgtctg tgcacctgtc
     1141 cactctgagc cgggtgcaga tctttcagaa ctgtgaggcc agcctgctgg aggagctggt
     1201 gctgaagctg cagccccaga cctactcacc aggtgaatat gtatgccgca aaggagacat
     1261 tggccaagag atgtacatca tccgagaggg tcaactggcc gtggtggcag atgatggtat
     1321 cacacagtat gctgtgctcg gtgcagggct ctactttggg gagatcagca tcatcaacat
     1381 caaagggaac atgtctggga accgccgcac agccaacatc aagagcctag gttattcaga
     1441 cctattctgc ctgagcaagg aggacctgcg ggaggtgctg agcgagtatc cacaagcaca
     1501 gaccatcatg gaggagaaag gacgtgagat cctgctgaaa atgaacaagt tggacgtgaa
     1561 tgctgaggca gctgagatcg ccctgcagga ggccacagag tcccggctac gaggcctaga
     1621 ccagcagctg gatgatctac agaccaagtt tgctcgcctc ctggctgagc tggagtccag
     1681 cgcacttaag attgcttacc gcattgaacg gctggagtgg cagactcgag agtggccaat
     1741 gcccgaggac ctggctgagg ctgatgacga gggtgagcct gaggagggaa cttccaaaga
     1801 tgaagagggc agggccagcc aggagggacc cccaggtcca gagtgacccc atccccatcc
     1861 ccaggattcc cacctcctag tgaatccaga gttgtagtaa agcctaactg ctgcaa
//
