LOCUS       NM_018235               4975 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens carnosine dipeptidase 2 (CNDP2), transcript variant 1,
            mRNA.
ACCESSION   NM_018235
VERSION     NM_018235.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4975)
  AUTHORS   Tancharoen,C., Tovivek,B., Niramitranon,J., Kityakarn,S.,
            Luksirikul,P., Gorinstein,S. and Pongprayoon,P.
  TITLE     Exploring the structural and dynamic differences between human
            carnosinase I (CN1) and II (CN2)
  JOURNAL   Proteins 91 (6), 822-830 (2023)
   PUBMED   36637795
  REMARK    GeneRIF: Exploring the structural and dynamic differences between
            human carnosinase I (CN1) and II (CN2).
REFERENCE   2  (bases 1 to 4975)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4975)
  AUTHORS   Zhang,L.Q., Yang,H.Q., Yang,S.Q., Wang,Y., Chen,X.J., Lu,H.S. and
            Zhao,L.P.
  TITLE     CNDP2 Acts as an Activator for Human Ovarian Cancer Growth and
            Metastasis via the PI3K/AKT Pathway
  JOURNAL   Technol Cancer Res Treat 18, 1533033819874773 (2019)
   PUBMED   31537175
  REMARK    GeneRIF: Cytosolic nonspecific dipeptidase 2 promotes the
            occurrence and development of ovarian cancer through the PI3K/AKT
            signaling pathway.
REFERENCE   4  (bases 1 to 4975)
  AUTHORS   Okumura,N. and Takao,T.
  TITLE     The zinc form of carnosine dipeptidase 2 (CN2) has dipeptidase
            activity but its substrate specificity is different from that of
            the manganese form
  JOURNAL   Biochem Biophys Res Commun 494 (3-4), 484-490 (2017)
   PUBMED   29056506
  REMARK    GeneRIF: These results suggest that the zinc form of CN2 is an
            active enzyme, but with a different substrate specificity from that
            of the manganese form.
REFERENCE   5  (bases 1 to 4975)
  AUTHORS   Yamakawa-Kobayashi,K., Otagi,E., Ohhara,Y., Goda,T., Kasezawa,N.
            and Kayashima,Y.
  TITLE     The Combined Effects of Genetic Variation in the CNDP1 and CNDP2
            Genes and Dietary Carbohydrate and Carotene Intake on Obesity Risk
  JOURNAL   J Nutrigenet Nutrigenomics 10 (5-6), 146-154 (2017)
   PUBMED   29402779
  REMARK    GeneRIF: 2 SNPs (rs7244647 in CNDP1 and rs4891558 in CNDP2) were
            associated with obesity risk. In addition, these associations were
            observed only in the group with high carbohydrate and low carotene
            intake but not in the group with low carbohydrate and high carotene
            intake.
REFERENCE   6  (bases 1 to 4975)
  AUTHORS   McDonough,C.W., Hicks,P.J., Lu,L., Langefeld,C.D., Freedman,B.I.
            and Bowden,D.W.
  TITLE     The influence of carnosinase gene polymorphisms on diabetic
            nephropathy risk in African-Americans
  JOURNAL   Hum Genet 126 (2), 265-275 (2009)
   PUBMED   19373489
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4975)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 4975)
  AUTHORS   Wanic,K., Placha,G., Dunn,J., Smiles,A., Warram,J.H. and
            Krolewski,A.S.
  TITLE     Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2)
            as a cause of diabetic nephropathy in type 1 diabetes: results of
            large case-control and follow-up studies
  JOURNAL   Diabetes 57 (9), 2547-2551 (2008)
   PUBMED   18753673
  REMARK    GeneRIF: Our large, comprehensive study did not find an association
            between the D18S880 microsatellite or any other polymorphisms in
            the CNDP2-CNDP1 genomic region and susceptibility for diabetic
            nephropathy in type 1 diabetes
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4975)
  AUTHORS   Tu,L.C., Yan,X., Hood,L. and Lin,B.
  TITLE     Proteomics analysis of the interactome of N-myc downstream
            regulated gene 1 and its interactions with the androgen response
            program in prostate cancer cells
  JOURNAL   Mol Cell Proteomics 6 (4), 575-588 (2007)
   PUBMED   17220478
REFERENCE   10 (bases 1 to 4975)
  AUTHORS   Teufel,M., Saudek,V., Ledig,J.P., Bernhardt,A., Boularand,S.,
            Carreau,A., Cairns,N.J., Carter,C., Cowley,D.J., Duverger,D.,
            Ganzhorn,A.J., Guenet,C., Heintzelmann,B., Laucher,V., Sauvage,C.
            and Smirnova,T.
  TITLE     Sequence identification and characterization of human carnosinase
            and a closely related non-specific dipeptidase
  JOURNAL   J Biol Chem 278 (8), 6521-6531 (2003)
   PUBMED   12473676
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC313148.1, BC001375.2, AC009704.8 and BM675304.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018235.2.
            
            Summary: CNDP2, also known as tissue carnosinase and peptidase A
            (EC 3.4.13.18), is a nonspecific dipeptidase rather than a
            selective carnosinase (Teufel et al., 2003 [PubMed
            12473676]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1, 3, 4, and 5 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.150920.1,
                                           SRR1803613.127698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324262.9/ ENSP00000325548.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DC313148.1         99-127
            30-1897             BC001375.2         1-1868
            1898-2538           AC009704.8         134284-134924
            2539-2646           BC001375.2         2510-2617
            2647-4315           AC009704.8         135033-136701
            4316-4975           BM675304.1         17-676              c
FEATURES             Location/Qualifiers
     source          1..4975
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.3"
     gene            1..4975
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
                     /note="carnosine dipeptidase 2"
                     /db_xref="GeneID:55748"
                     /db_xref="HGNC:HGNC:24437"
                     /db_xref="MIM:169800"
     exon            1..69
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
                     /inference="alignment:Splign:2.1.0"
     exon            70..221
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1589
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
                     /EC_number="3.4.13.18"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peptidase A; glutamate carboxypeptidase-like protein 1;
                     epididymis secretory protein Li 13; cytosolic non-specific
                     dipeptidase; CNDP dipeptidase 2 (metallopeptidase M20
                     family); carnosinase-2; carnosine dipeptidase II;
                     cytosolic nonspecific dipeptidase; threonyl dipeptidase"
                     /codon_start=1
                     /product="cytosolic non-specific dipeptidase isoform 1"
                     /protein_id="NP_060705.2"
                     /db_xref="CCDS:CCDS12006.1"
                     /db_xref="GeneID:55748"
                     /db_xref="HGNC:HGNC:24437"
                     /db_xref="MIM:169800"
                     /translation="MAALTTLFKYIDENQDRYIKKLAKWVAIQSVSAWPEKRGEIRRM
                     MEVAAADVKQLGGSVELVDIGKQKLPDGSEIPLPPILLGRLGSDPQKKTVCIYGHLDV
                     QPAALEDGWDSEPFTLVERDGKLYGRGSTDDKGPVAGWINALEAYQKTGQEIPVNVRF
                     CLEGMEESGSEGLDELIFARKDTFFKDVDYVCISDNYWLGKKKPCITYGLRGICYFFI
                     EVECSNKDLHSGVYGGSVHEAMTDLILLMGSLVDKRGNILIPGINEAVAAVTEEEHKL
                     YDDIDFDIEEFAKDVGAQILLHSHKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPR
                     KVVGKFSIRLVPNMTPEVVGEQVTSYLTKKFAELRSPNEFKVYMGHGGKPWVSDFSHP
                     HYLAGRRAMKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEK
                     LNRYNYIEGTKMLAAYLYEVSQLKD"
     exon            222..365
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
                     /inference="alignment:Splign:2.1.0"
     exon            366..528
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
                     /inference="alignment:Splign:2.1.0"
     exon            529..617
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
                     /inference="alignment:Splign:2.1.0"
     exon            618..818
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
                     /inference="alignment:Splign:2.1.0"
     exon            819..903
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1064
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1229
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1371
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1519
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..4975
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2625..2630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
                     /note="hexamer: AGTAAA"
     polyA_site      2646
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
                     /note="major polyA site"
     regulatory      4947..4952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
                     /note="hexamer: AATAAA"
     polyA_site      4975
                     /gene="CNDP2"
                     /gene_synonym="CN2; CPGL; HEL-S-13; HsT2298; PEPA"
ORIGIN      
        1 cgtggtacgg aaccggcgcc gcgcttgctg ctggtaacag ggccttgcct agtgggcctt
       61 ccttcccagg tcgcccctca gtctccacta gagacaggac tgaccagttg ctcttccttc
      121 caagaacctt cgagatctgc ggtctggggt ctggttgaaa gatggcggcc ctcactaccc
      181 tgtttaagta catagatgaa aatcaggatc gctacattaa gaaactcgca aaatgggtgg
      241 ctatccagag tgtgtctgcg tggccggaga agagaggcga aatcaggagg atgatggaag
      301 ttgctgctgc agatgttaag cagttggggg gctctgtgga actggtggat atcggaaaac
      361 aaaagctccc tgatggctcg gagatcccgc tccctcctat tctgctcggc aggctgggct
      421 ccgacccaca gaagaagacc gtgtgcattt acgggcacct ggatgtgcag cctgcagccc
      481 tggaggacgg ctgggacagc gagcccttca ccctggtgga gcgagacggc aagctgtatg
      541 ggagaggttc gactgatgat aagggcccgg tggccggctg gataaacgcc ctggaagcgt
      601 atcagaaaac aggccaggag attcctgtca acgtccgatt ctgcctcgaa ggcatggagg
      661 agtcaggctc tgagggccta gacgagctga tttttgcccg gaaagacaca ttctttaagg
      721 atgtggacta tgtctgcatt tctgacaatt actggctggg aaagaagaag ccctgcatca
      781 cctacggcct caggggcatt tgctactttt tcatcgaggt ggagtgcagc aacaaagacc
      841 tccattctgg ggtgtacggg ggctcggtgc atgaggccat gactgatctc attttgctga
      901 tgggctcttt ggtggacaag agggggaaca tcctgatccc cggcattaac gaggccgtgg
      961 ccgccgtcac ggaagaggag cacaagctgt acgacgacat cgactttgac atagaggagt
     1021 ttgccaagga tgtgggggcg cagatcctcc tgcacagcca caagaaagac atcctcatgc
     1081 accgatggcg gtacccgtct ctgtccctcc atggcatcga aggcgccttc tctgggtctg
     1141 gggccaagac cgtgattccc aggaaggtgg ttggcaagtt ctccatcagg ctcgtgccga
     1201 acatgactcc tgaagtcgtc ggcgagcagg tcacaagcta cctaactaag aagtttgctg
     1261 aactacgcag ccccaatgag ttcaaggtgt acatgggcca cggtgggaag ccctgggtct
     1321 ccgacttcag tcaccctcat tacctggctg ggagaagagc catgaagaca gtttttggtg
     1381 ttgagccaga cttgaccagg gaaggcggca gtattcccgt gaccttgacc tttcaggagg
     1441 ccacgggcaa gaacgtcatg ctgctgcctg tggggtcagc ggatgacgga gcccactccc
     1501 agaatgaaaa gctcaacagg tataactaca tagagggaac caagatgctg gccgcgtacc
     1561 tgtatgaggt ctcccagctg aaggactagg ccaagccctc tgtgtgccat ctccaatgag
     1621 aaggaatcct gccctcacct cacccttttc caacttgccc agggaagtgg aggttccctc
     1681 tttcctttcc ctcttgtcag gtcatccatg actttagaga acagacacaa gtgtatccag
     1741 ctgtccacgg gtggagctac ccgttgggct tatgagtgac ctggagtgac agctgagtca
     1801 ccctgggtaa gttctcagag tggtcaggat ggcttgacct gcagaagata cccaaggtcc
     1861 aaaagcacaa ggtctgcgga aagttctggt tgtcggccgg gcaccacggc tcacacctat
     1921 aatcgagcac tttgggaggc caagacagga ggatcacttg aggccaggag tctgagacaa
     1981 gcctaggcaa caaaacaaga ctctgtctct acaaaaagtt taagaaatga gccagacatg
     2041 gtggtgtatg cctgtagtcc cagccactca gaaggctgag gcaggaggat cgcttgagac
     2101 caagagtttg agcctgcggt gagctgtgaa tgcaccacgg cactcaagcc tgggcaatgt
     2161 agcaagatcc tgtctctaca agaaattttt taaaaatgag ccaagtgtgg tggtgcatgc
     2221 ctgtagttcc agctactcag gacactgacg taggagggtt gcttgagact gagagttgga
     2281 ggctgcgatg agccatgaat gccccactgc actccagcct gggcgacaga acgagacccc
     2341 atctcaaaaa aaataagttc tggttgtcat tgaattggga taaacagaga gcttgatgct
     2401 ttctgccttc tgtctcaggt gatgcattgc acatttggga tatttggaaa ggaaatgagg
     2461 aaagaaatta gggcctcctc tgatctctcg ctatctgcgg gtcctgtcct tttctcaaga
     2521 ccttcaccat tactggcatt ttcctgtctt ctctttagta tgatccctca aaacctcact
     2581 aactggaagg atgattttgt ctcagtttgt actcctaaat aaaaagtaaa catgacacct
     2641 ctaaaagaat cgctccatct cagttgctcg tcgcgtgcac accatgctta ttgagtggtg
     2701 tctggttggt ggtgtcagct cagggcaggg gacagcaggc aggacccgga aaacagaacc
     2761 caggtcttcc caggcgagca ctccctccct cgtccacaca agtggaggct cactcgtggc
     2821 cccctgcatg ttccgagaag tgtccctgtc tctgctcctt aacggctgtg gggccacagg
     2881 aagtccagct ggcttaaaca aagaattgat tggcccactt gacataaaag aacagagtaa
     2941 actcaatgaa aggaaaaggc tccttgaagt ggttggttcc agggctgggc agggaagatg
     3001 caagatgagt ctggaccctc tcacatcgga acgtaaggat gcgctcctga gggcgtgggg
     3061 ctgcgtccaa ggacacagga gccagcctgg aagagtttgc aggggcccag gggagcaatt
     3121 ggagtgagaa aatagcagta gtgttggatt tttaccatgg aataaacaac aatccatgag
     3181 tccatactaa tataaataaa gtgacaaagt gggtgagaag gaccagtgcc cctggatgaa
     3241 gaatctctgc tcatgtggga ggaaggtggg agatcaaagc tggagcactt gctgctgcag
     3301 gtgagacccc tgacacactc tcaaattggt aggcaaaggt ttaaagaacg ggatatttgc
     3361 ttagcttaaa agcacctccc aaggggaaaa cagtaacttc acagtggaga gacctggcag
     3421 gcaccaccct cagatcaaaa tgaacctcag cagtaatgac acgtccacat cagcaccccc
     3481 aacaccactc cctgaggagg acatgccagt tctgggaaca tcacactcat cgtgacaaaa
     3541 catcagacaa acccaaacgg atgaaatgtg aggaaaatct gtagttggtt ttacgtggat
     3601 gttaatctct tagttttgat cattgtgctg tagctgcata agaggttagc tgggtgaagt
     3661 gtatctgggg accctctatg gcttttgcat cttttctcta agtctcctgt catttcaaag
     3721 taaaaacaaa aaaagaagac aagggtagcg gcttcaggta cagctggacc cagcactcag
     3781 tgctatctgg gcttgtggct ccaactcaac tcctccatca gaactgtgag aaatgcattc
     3841 tttcagcttc taatcctgca aaaagaactg catggtcttc ccccagaaat cctaagagta
     3901 gctgctggtg tctcatgcat gcgagctgca tatgggcccc cgttagtcag gaacccatgc
     3961 tgagaggtgc tatgctttga atgtttggct cctcccaaac tcgtgttgaa acttaatagc
     4021 cattgtaaca gtattaagag gcagggcctt caagagctgg tcaggccatg agggccctgt
     4081 cctcctgact gagtgaatgc tgttattgta ggagtgggct tgtttggcct cctcttgctc
     4141 tctctacccc tctctgagcc cttgtgttgt gggatgacac agccagaagg cccttgccag
     4201 gttccggtcc ctccaccttg gacctcccag cctcccgaac gttgagccaa tacatctctg
     4261 ctcattgtaa attacctagt cttgggcatt gtgttacagc agcaaaaagc agcctacggc
     4321 agtcaccgtg ctaacacctg cagcagcctg cggcggtcac cgtgctaaca cgtgcagcag
     4381 cctgtgtggc tcaggccagt cagcttcccc tggaagcaag tgtgaggtcg tcgcctctgg
     4441 aagtgctagc ggagggtgat ctcccggagg aaatcagagt ggtgttctac tagaaggccg
     4501 atgactcctg ggtaaagtgc caatgctcac ctccatctct gcaagctcag tccctcgtgg
     4561 aatttccagg agcacaaggg caatctcgac agctccacgt tcccagtgcc cgacccaagc
     4621 ctggcccatg atcagataaa tgcctaagtg gggtggcatg gacatttgca cacgtccaga
     4681 ctgctttatg ttagaagctg agctggcatg ccactagctg gttttgatgt aaacaacaat
     4741 tttgtaaaac cctggactga atgggtctga ctaacggctg gttctgtgaa cttgagcctc
     4801 agcgtcctgt gtcagaagag cacaaaccac tttcccagag aggttatgaa gacagaaatg
     4861 accctgtgac ccctttgcaa agtatgaaga acggttccca ctcatgcatg gagctggatc
     4921 ttctcaagtg ggaaacaggc gtggtaaata aatactgttg tttcagctgg tgtaa
//
