LOCUS       NM_032649               4342 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens carnosine dipeptidase 1 (CNDP1), mRNA.
ACCESSION   NM_032649
VERSION     NM_032649.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4342)
  AUTHORS   Tancharoen,C., Tovivek,B., Niramitranon,J., Kityakarn,S.,
            Luksirikul,P., Gorinstein,S. and Pongprayoon,P.
  TITLE     Exploring the structural and dynamic differences between human
            carnosinase I (CN1) and II (CN2)
  JOURNAL   Proteins 91 (6), 822-830 (2023)
   PUBMED   36637795
  REMARK    GeneRIF: Exploring the structural and dynamic differences between
            human carnosinase I (CN1) and II (CN2).
REFERENCE   2  (bases 1 to 4342)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4342)
  AUTHORS   Zhou,Z., Liu,X.Q., Zhang,S.Q., Qi,X.M., Zhang,Q., Yard,B. and
            Wu,Y.G.
  TITLE     Correlation between serum carnosinase concentration and renal
            damage in diabetic nephropathy patients
  JOURNAL   Amino Acids 53 (5), 687-700 (2021)
   PUBMED   33811534
  REMARK    GeneRIF: Correlation between serum carnosinase concentration and
            renal damage in diabetic nephropathy patients.
REFERENCE   4  (bases 1 to 4342)
  AUTHORS   Qiu,J., Albrecht,T., Zhang,S., Hauske,S.J., Rodriguez-Nino,A.,
            Zhang,X., Nosan,D., Pastene,D.O., Sticht,C., Delatorre,C., van
            Goor,H., Porubsky,S., Kramer,B.K. and Yard,B.A.
  TITLE     Human carnosinase 1 overexpression aggravates diabetes and renal
            impairment in BTBROb/Ob mice
  JOURNAL   J Mol Med (Berl) 98 (9), 1333-1346 (2020)
   PUBMED   32803273
  REMARK    GeneRIF: Human carnosinase 1 overexpression aggravates diabetes and
            renal impairment in BTBR(Ob/Ob) mice.
REFERENCE   5  (bases 1 to 4342)
  AUTHORS   Zhang,S., Xu,J., Cui,D., Jiang,S., Xu,X., Zhang,Y., Zhu,D., Xia,L.,
            Yard,B., Wu,Y. and Zhang,Q.
  TITLE     Genotype Distribution of CNDP1 Polymorphisms in the Healthy Chinese
            Han Population: Association with HbA1c and Fasting Blood Glucose
  JOURNAL   J Diabetes Res 2020, 3838505 (2020)
   PUBMED   32733966
  REMARK    GeneRIF: Genotype Distribution of CNDP1 Polymorphisms in the
            Healthy Chinese Han Population: Association with HbA1c and Fasting
            Blood Glucose.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4342)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 4342)
  AUTHORS   Teufel,M., Saudek,V., Ledig,J.P., Bernhardt,A., Boularand,S.,
            Carreau,A., Cairns,N.J., Carter,C., Cowley,D.J., Duverger,D.,
            Ganzhorn,A.J., Guenet,C., Heintzelmann,B., Laucher,V., Sauvage,C.
            and Smirnova,T.
  TITLE     Sequence identification and characterization of human carnosinase
            and a closely related non-specific dipeptidase
  JOURNAL   J Biol Chem 278 (8), 6521-6531 (2003)
   PUBMED   12473676
REFERENCE   8  (bases 1 to 4342)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   9  (bases 1 to 4342)
  AUTHORS   Lenney,J.F., Peppers,S.C., Kucera,C.M. and Sjaastad,O.
  TITLE     Homocarnosinosis: lack of serum carnosinase is the defect probably
            responsible for elevated brain and CSF homocarnosine
  JOURNAL   Clin Chim Acta 132 (2), 157-165 (1983)
   PUBMED   6616870
REFERENCE   10 (bases 1 to 4342)
  AUTHORS   Lenney,J.F., George,R.P., Weiss,A.M., Kucera,C.M., Chan,P.W. and
            Rinzler,G.S.
  TITLE     Human serum carnosinase: characterization, distinction from
            cellular carnosinase, and activation by cadmium
  JOURNAL   Clin Chim Acta 123 (3), 221-231 (1982)
   PUBMED   7116644
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358756.1, AK098369.1,
            H41544.1, BG202268.1, BM662490.1 and FP565322.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_032649.5.
            
            Summary: This gene encodes a member of the M20 metalloprotease
            family. The encoded protein is specifically expressed in the brain,
            is a homodimeric dipeptidase which was identified as human
            carnosinase. This gene contains trinucleotide (CTG) repeat length
            polymorphism in the coding region. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.121274.1,
                                           SRR1803615.275435.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358821.8/ ENSP00000351682.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-890               AY358756.1         33-922
            891-1183            AK098369.1         713-1005
            1184-1979           AY358756.1         1216-2011
            1980-1980           H41544.1           153-153             c
            1981-2030           AY358756.1         2013-2062
            2031-2126           BG202268.1         561-656
            2127-2148           AY358756.1         2159-2180
            2149-2155           BM662490.1         14-20               c
            2156-4342           FP565322.5         22242-24428
FEATURES             Location/Qualifiers
     source          1..4342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.3"
     gene            1..4342
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /note="carnosine dipeptidase 1"
                     /db_xref="GeneID:84735"
                     /db_xref="HGNC:HGNC:20675"
                     /db_xref="MIM:609064"
     exon            1..192
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1692
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /EC_number="3.4.13.20"
                     /note="glutamate carboxypeptidase-like protein 2;
                     carnosinase 1; beta-Ala-His dipeptidase; serum
                     carnosinase; carnosine dipeptidase 1 (metallopeptidase M20
                     family); CNDP dipeptidase 1"
                     /codon_start=1
                     /product="beta-Ala-His dipeptidase precursor"
                     /protein_id="NP_116038.4"
                     /db_xref="CCDS:CCDS12007.1"
                     /db_xref="GeneID:84735"
                     /db_xref="HGNC:HGNC:20675"
                     /db_xref="MIM:609064"
                     /translation="MDPKLGRMAASLLAVLLLLLERGMFSSPSPPPALLEKVFQYIDL
                     HQDEFVQTLKEWVAIESDSVQPVPRFRQELFRMMAVAADTLQRLGARVASVDMGPQQL
                     PDGQSLPIPPVILAELGSDPTKGTVCFYGHLDVQPADRGDGWLTDPYVLTEVDGKLYG
                     RGATDNKGPVLAWINAVSAFRALEQDLPVNIKFIIEGMEEAGSVALEELVEKEKDRFF
                     SGVDYIVISDNLWISQRKPAITYGTRGNSYFMVEVKCRDQDFHSGTFGGILHEPMADL
                     VALLGSLVDSSGHILVPGIYDEVVPLTEEEINTYKAIHLDLEEYRNSSRVEKFLFDTK
                     EEILMHLWRYPSLSIHGIEGAFDEPGTKTVIPGRVIGKFSIRLVPHMNVSAVEKQVTR
                     HLEDVFSKRNSSNKMVVSMTLGLHPWIANIDDTQYLAAKRAIRTVFGTEPDMIRDGST
                     IPIAKMFQEIVHKSVVLIPLGAVDDGEHSQNEKINRWNYIEGTKLFAAFFLEMAQLH"
     exon            193..321
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /inference="alignment:Splign:2.1.0"
     exon            322..471
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /inference="alignment:Splign:2.1.0"
     exon            472..634
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /inference="alignment:Splign:2.1.0"
     exon            635..723
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /inference="alignment:Splign:2.1.0"
     exon            724..924
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1009
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1170
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1335
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1477
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1625
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..4342
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1845..1850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /note="hexamer: AATAAA"
     polyA_site      1864
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
     regulatory      2123..2128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /note="hexamer: AATAAA"
     polyA_site      2142
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /note="major polyA site"
     regulatory      4320..4325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
                     /note="hexamer: AATAAA"
     polyA_site      4342
                     /gene="CNDP1"
                     /gene_synonym="CN1; CPGL2; HsT2308"
ORIGIN      
        1 agatgtgaat agctccacta taccagcctc gtcttccttc cgggggacaa cgtgggtcag
       61 ggcacagaga gatatttaat gtcaccctct tggggctttc atgggactcc ctctgccaca
      121 ttttttggag gttgggaaag ttgctagagg cttcagaact ccagcctaat ggatcccaaa
      181 ctcgggagaa tggctgcgtc cctgctggct gtgctgctgc tgctgctgga gcgcggcatg
      241 ttctcctcac cctccccgcc cccggcgctg ttagagaaag tcttccagta cattgacctc
      301 catcaggatg aatttgtgca gacgctgaag gagtgggtgg ccatcgagag cgactctgtc
      361 cagcctgtgc ctcgcttcag acaagagctc ttcagaatga tggccgtggc tgcggacacg
      421 ctgcagcgcc tgggggcccg tgtggcctcg gtggacatgg gtcctcagca gctgcccgat
      481 ggtcagagtc ttccaatacc tcccgtcatc ctggccgaac tggggagcga tcccacgaaa
      541 ggcaccgtgt gcttctacgg ccacttggac gtgcagcctg ctgaccgggg cgatgggtgg
      601 ctcacggacc cctatgtgct gacggaggta gacgggaaac tttatggacg aggagcgacc
      661 gacaacaaag gccctgtctt ggcttggatc aatgctgtga gcgccttcag agccctggag
      721 caagatcttc ctgtgaatat caaattcatc attgagggga tggaagaggc tggctctgtt
      781 gccctggagg aacttgtgga aaaagaaaag gaccgattct tctctggtgt ggactacatt
      841 gtaatttcag ataacctgtg gatcagccaa aggaagccag caatcactta cggaacccgg
      901 gggaacagct acttcatggt ggaggtgaaa tgcagagacc aggattttca ctcaggaacc
      961 tttggtggca tccttcatga accaatggct gatctggttg ctcttctcgg tagcctggta
     1021 gactcgtctg gtcatatcct ggtccctgga atctatgatg aagtggttcc tcttacagaa
     1081 gaggaaataa atacatacaa agccatccat ctagacctag aagaataccg gaatagcagc
     1141 cgggttgaga aatttctgtt cgatactaag gaggagattc taatgcacct ctggaggtac
     1201 ccatctcttt ctattcatgg gatcgagggc gcgtttgatg agcctggaac taaaacagtc
     1261 atacctggcc gagttatagg aaaattttca atccgtctag tccctcacat gaatgtgtct
     1321 gcggtggaaa aacaggtgac acgacatctt gaagatgtgt tctccaaaag aaatagttcc
     1381 aacaagatgg ttgtttccat gactctagga ctacacccgt ggattgcaaa tattgatgac
     1441 acccagtatc tcgcagcaaa aagagcgatc agaacagtgt ttggaacaga accagatatg
     1501 atccgggatg gatccaccat tccaattgcc aaaatgttcc aggagatcgt ccacaagagc
     1561 gtggtgctaa ttccgctggg agctgttgat gatggagaac attcgcagaa tgagaaaatc
     1621 aacaggtgga actacataga gggaaccaaa ttatttgctg cctttttctt agagatggcc
     1681 cagctccatt aatcacaaga accttctagt ctgatctgat ccactgacag attcacctcc
     1741 cccacatccc tagacaggga tggaatgtaa atatccagag aatttgggtc tagtatagta
     1801 cattttccct tccatttaaa atgtcttggg atatctggat cagtaataaa atatttcaaa
     1861 ggcacagatg ttggaaatgg tttaaggtcc cccactgcac accttcctca agtcatagct
     1921 gcttgcagca acttgatttc cccaagtcct gtgcaatagc cccaggattg gattccttca
     1981 aaccttttag catatctcca accttgcaat ttgattggca taatcactcc agtttgcttt
     2041 ctaggtcctc aagtgctcgt gacacataat cattccatcc aatgatcgcc tttgctttac
     2101 cactctttcc ttttatctta ttaataaaaa tgttggtctc caccactgac tacaatgatt
     2161 tccccatgga ttcattttca gaggagttac taaggcatgg tactatatta acctcttgcc
     2221 tccccttcat ttattttttc ccacttcttg aaaagttccg aagctgaaat gatcaatatt
     2281 catacccata tgccatttgg gagtccttgt gcaaagatga gtattttttt ttttattcca
     2341 agcttcttta cctttcctga gatcgatgcc accttgtcag cttctctgcc tcccgttcct
     2401 tcttcctgtc ccatcagaaa aggcccactc tctctctatc caacatctgt gcacaggttg
     2461 caccagagca gaatttatcc tgatagaatt tctctcaccc cattgaagtt ttactcaatg
     2521 acaacatcta aattgctcaa agcttttaat agcatcagtt ttagatagag aactaatcaa
     2581 ccctgacatc agtaacacac gctaaattta aagccatcag ctaatgctgc attcattaat
     2641 cattttagtt aaccatcatg tttggcttga ttggatttga cggtgtaaac aacaaaaaaa
     2701 gacagtcatt tttctacagt tgagtgtata taaacaaaat caatctttat gaatttatta
     2761 tttaaatcac attaatggag aatcatttag gggcttatta aaattttttt ctattatgac
     2821 tccaaataaa aacaaagcag agggccaggc gcggtggctc atgcccataa tcccagcact
     2881 ttcggaggcc gaggtgggcg gatcacctga ggtcgggagt tcgagatcag cctggctaac
     2941 atggtgaaac cctgtctcta ctgaatatac aaaattaact gggcatggtg gtgcatgcct
     3001 gtagtcccag ctactcggga ggctgaggca ggagaatcgc ttgaacccag gaggcggaag
     3061 ttgcagtgaa ctgggatcat gccactgcac tccagcctgg gcgacagagt gagactccgt
     3121 ctccaaaaaa aaaaaaaaaa aaaaaaaaag cagaacacat ttgcgttcaa cttttttcca
     3181 tcactctgtt ggttcttgag atgtcagtgt cagtttaaaa acgtgctgta ccacctttaa
     3241 aaggactgga gcaggcaggc agtgattcag ttcaccttga ctctagtcat agaagtggac
     3301 ccaactgaga gctcaaccta gttgtgggca tttgtgaagg attccagtta gtgttttctt
     3361 tggaagcagg aggcttcaag ccatcacatc tccaattcta tagaatatca agtcatcgtt
     3421 aaagaacagc agcaggtgtt tgatattttg tgctattaag tgtagtttgc gctcatctaa
     3481 ttatgcagag tttcgtggtg tttctcgatt ttgttgaacc tacctgatgc atttggcact
     3541 gtagataagg actaacagta agagagattt agagtcttca tgttagtcca ttaacataag
     3601 tttattataa aatacactgt aagcatttct ggctaatgta ccatcagatt taagaagtta
     3661 cccaacaata tgtattcgct gatcttcatt cctgctgaat ctgagaccag cagtgtctca
     3721 attattacgt tgctgccagg agagaagggg aggagaatga atagttatgg aagttgtaga
     3781 atctaggata ttccaaccct ggattgccag agttcagagt ccatgttttt ctgtcaccca
     3841 gggtcacgac tggtctcccc agctcttccc tcctgttttt ccacccaatt ctaagccctg
     3901 tggtgatcca gaccctaccc tgacgtggga gtcagaaagg agtatcttcc aagctccttg
     3961 tactcaaagg gataaaagaa agctactcag ttgttattca gatatattaa ccagccatat
     4021 ggaggcaaaa aagggagaaa tttaaatatt tgttttttaa cattttaatg atgaaatata
     4081 tgcacttgga caaaaatgat cacccagtaa agttgggcgt acattgtggc atgcccatca
     4141 gggggacttt gttgtattgg aggagggcaa tgtatctggc tttgttagta gacgtagcgc
     4201 attaaagcgt aactattgtg ataagtttag gggttaggaa tatcatttga gtttggtaga
     4261 tgcttttctg gaaaacaatg aggctgggaa tgtttctggc tttatgttgt attcataaaa
     4321 ataaaatgta ctggcttgga aa
//
