LOCUS       NM_003418               3295 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens CCHC-type zinc finger nucleic acid binding protein
            (CNBP), transcript variant 3, mRNA.
ACCESSION   NM_003418
VERSION     NM_003418.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3295)
  AUTHORS   Liu,X., Chen,Y., Li,Y., Bai,J., Zeng,Z., Wang,M., Dong,Y. and
            Zhou,Y.
  TITLE     STAU1-mediated CNBP mRNA degradation by LINC00665 alters stem cell
            characteristics in ovarian cancer
  JOURNAL   Biol Direct 19 (1), 59 (2024)
   PUBMED   39080743
  REMARK    GeneRIF: STAU1-mediated CNBP mRNA degradation by LINC00665 alters
            stem cell characteristics in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3295)
  AUTHORS   Liu,Y., Jiang,H., Hu,K., Zou,H., Zhang,W., Liu,J. and Jian,X.
  TITLE     CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP
            to regulate the translation and stability of CDK6 mRNA
  JOURNAL   PLoS One 19 (4), e0298947 (2024)
   PUBMED   38626179
  REMARK    GeneRIF: CircPRMT5 promotes progression of osteosarcoma by
            recruiting CNBP to regulate the translation and stability of CDK6
            mRNA.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3295)
  AUTHORS   Gil Rosas,M., Centola,C., Torres,M., Mouguelar,V.S., David,A.P.,
            Piga,E.J., Gomez,D., Calcaterra,N.B., Armas,P. and Coux,G.
  TITLE     The transcription of the main gene associated with Treacher-Collins
            syndrome (TCOF1) is regulated by G-quadruplexes and cellular
            nucleic acid binding protein (CNBP)
  JOURNAL   Sci Rep 14 (1), 7472 (2024)
   PUBMED   38553547
  REMARK    GeneRIF: The transcription of the main gene associated with
            Treacher-Collins syndrome (TCOF1) is regulated by G-quadruplexes
            and cellular nucleic acid binding protein (CNBP).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3295)
  AUTHORS   Chen,Y., Lei,X., Jiang,Z., Humphries,F., Parsi,K.M., Mustone,N.J.,
            Ramos,I., Mutetwa,T., Fernandez-Sesma,A., Maehr,R., Caffrey,D.R.
            and Fitzgerald,K.A.
  TITLE     Cellular nucleic acid-binding protein restricts SARS-CoV-2 by
            regulating interferon and disrupting RNA-protein condensates
  JOURNAL   Proc Natl Acad Sci U S A 120 (47), e2308355120 (2023)
   PUBMED   37963251
  REMARK    GeneRIF: Cellular nucleic acid-binding protein restricts SARS-CoV-2
            by regulating interferon and disrupting RNA-protein condensates.
REFERENCE   5  (bases 1 to 3295)
  AUTHORS   Liu,H., Fang,Y., Hou,B., Lin,Q., Zhang,W., Wang,X., Hu,Y., Xu,G.
            and He,Z.
  TITLE     CircPACRGL promoted cell proliferation, migration and invasion as
            well as inhibited cell apoptosis in colorectal cancer via
            regulation of the miR-330-3p/CNBP axis
  JOURNAL   Mol Cell Biochem 478 (7), 1633-1644 (2023)
   PUBMED   36459268
  REMARK    GeneRIF: CircPACRGL promoted cell proliferation, migration and
            invasion as well as inhibited cell apoptosis in colorectal cancer
            via regulation of the miR-330-3p/CNBP axis.
REFERENCE   6  (bases 1 to 3295)
  AUTHORS   Flink,I.L. and Morkin,E.
  TITLE     Organization of the gene encoding cellular nucleic acid-binding
            protein
  JOURNAL   Gene 163 (2), 279-282 (1995)
   PUBMED   7590281
REFERENCE   7  (bases 1 to 3295)
  AUTHORS   Warden,C.H., Krisans,S.K., Purcell-Huynh,D., Leete,L.M.,
            Daluiski,A., Diep,A., Taylor,B.A. and Lusis,A.J.
  TITLE     Mouse cellular nucleic acid binding proteins: a highly conserved
            family identified by genetic mapping and sequencing
  JOURNAL   Genomics 24 (1), 14-19 (1994)
   PUBMED   7896269
REFERENCE   8  (bases 1 to 3295)
  AUTHORS   Schoser,B.
  TITLE     Myotonic Dystrophy Type 2
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301639
REFERENCE   9  (bases 1 to 3295)
  AUTHORS   Lusis,A.J., Rajavashisth,T.B., Klisak,I., Heinzmann,C., Mohandas,T.
            and Sparkes,R.S.
  TITLE     Mapping of the gene for CNBP, a finger protein, to human chromosome
            3q13.3-q24
  JOURNAL   Genomics 8 (2), 411-414 (1990)
   PUBMED   2249857
  REMARK    Erratum:[Genomics 1991 Mar;9(3):564]
REFERENCE   10 (bases 1 to 3295)
  AUTHORS   Rajavashisth,T.B., Taylor,A.K., Andalibi,A., Svenson,K.L. and
            Lusis,A.J.
  TITLE     Identification of a zinc finger protein that binds to the sterol
            regulatory element
  JOURNAL   Science 245 (4918), 640-643 (1989)
   PUBMED   2562787
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB027227.1, BC093058.1,
            AC108673.11 and BU616793.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_003418.4.
            
            Summary: This gene encodes a nucleic-acid binding protein with
            seven zinc-finger domains. The protein has a preference for binding
            single stranded DNA and RNA. The protein functions in
            cap-independent translation of ornithine decarboxylase mRNA, and
            may also function in sterol-mediated transcriptional regulation. A
            CCTG expansion from <30 repeats to 75-11000 repeats in the first
            intron of this gene results in myotonic dystrophy type 2. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant uses an alternate in-frame splice
            site in the central coding region, compared to variant 1, resulting
            in a shorter protein (isoform 3).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.84667.1,
                                           SRR1803615.2291.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000422453.7/ ENSP00000410619.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DB027227.1         72-81
            11-290              BC093058.1         1-280
            291-291             AC108673.11        133247-133247       c
            292-1545            BC093058.1         282-1535
            1546-2818           AC108673.11        130044-131316       c
            2819-3295           BU616793.1         28-504              c
FEATURES             Location/Qualifiers
     source          1..3295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.3"
     gene            1..3295
                     /gene="CNBP"
                     /gene_synonym="CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9"
                     /note="CCHC-type zinc finger nucleic acid binding protein"
                     /db_xref="GeneID:7555"
                     /db_xref="HGNC:HGNC:13164"
                     /db_xref="MIM:116955"
     exon            1..121
                     /gene="CNBP"
                     /gene_synonym="CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9"
                     /inference="alignment:Splign:2.1.0"
     exon            122..259
                     /gene="CNBP"
                     /gene_synonym="CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..669
                     /gene="CNBP"
                     /gene_synonym="CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9"
                     /note="isoform 3 is encoded by transcript variant 3; zinc
                     finger protein 273; cellular nucleic acid-binding protein;
                     erythroid differentiation-related; zinc finger protein 9
                     (a cellular retroviral nucleic acid binding protein);
                     sterol regulatory element-binding protein"
                     /codon_start=1
                     /product="CCHC-type zinc finger nucleic acid binding
                     protein isoform 3"
                     /protein_id="NP_003409.1"
                     /db_xref="CCDS:CCDS3056.1"
                     /db_xref="GeneID:7555"
                     /db_xref="HGNC:HGNC:13164"
                     /db_xref="MIM:116955"
                     /translation="MSSNECFKCGRSGHWARECPTGGGRGRGMRSRGRGGFTSDRGFQ
                     FVSSSLPDICYRCGESGHLAKDCDLQEDACYNCGRGGHIAKDCKEPKREREQCCYNCG
                     KPGHLARDCDHADEQKCYSCGEFGHIQKDCTKVKCYRCGETGHVAINCSKTSEVNCYR
                     CGESGHLARECTIEATA"
     exon            260..352
                     /gene="CNBP"
                     /gene_synonym="CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9"
                     /inference="alignment:Splign:2.1.0"
     exon            353..551
                     /gene="CNBP"
                     /gene_synonym="CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9"
                     /inference="alignment:Splign:2.1.0"
     exon            552..3295
                     /gene="CNBP"
                     /gene_synonym="CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1522..1527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNBP"
                     /gene_synonym="CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9"
                     /note="hexamer: AATAAA"
     polyA_site      1556
                     /gene="CNBP"
                     /gene_synonym="CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9"
     regulatory      1610..1615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNBP"
                     /gene_synonym="CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9"
                     /note="hexamer: ATTAAA"
     polyA_site      1638
                     /gene="CNBP"
                     /gene_synonym="CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9"
                     /note="major polyA site"
     regulatory      3274..3279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNBP"
                     /gene_synonym="CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9"
                     /note="hexamer: AATAAA"
     polyA_site      3295
                     /gene="CNBP"
                     /gene_synonym="CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9"
ORIGIN      
        1 gtgcagaccc gcgtgtggcg caggcaagga ccctcaaaat aaacagcctc taccttgcga
       61 gccgtcttcc ccaggcctgc gtccgagtct ccgccgctgc gggcccgctc cgacgcggaa
      121 gatctgactg cagccatgag cagcaatgag tgcttcaagt gtggacgatc tggccactgg
      181 gcccgggaat gtcctactgg tggaggccgt ggtcgtggaa tgagaagccg tggcagaggt
      241 ggttttacct cggatagagg tttccagttt gtttcctcgt ctcttccaga catttgttat
      301 cgctgtggtg agtctggtca tcttgccaag gattgtgatc ttcaggagga tgcctgctat
      361 aactgcggta gaggtggcca cattgccaag gactgcaagg agcccaagag agagcgagag
      421 caatgctgct acaactgtgg caaaccaggc catctggctc gtgactgcga ccatgcagat
      481 gagcagaaat gctattcttg tggagaattc ggacacattc aaaaagactg caccaaagtg
      541 aagtgctata ggtgtggtga aactggtcat gtagccatca actgcagcaa gacaagtgaa
      601 gtcaactgtt accgctgtgg cgagtcaggg caccttgcac gggaatgcac aattgaggct
      661 acagcctaat tattttcctt tgtcgcccct cctttttctg attgatggtt gtattatttt
      721 ctctgaatcc tcttcactgg ccaaaggttg gcagatagag gcaactccca ggccagtgag
      781 ctttacttgc cgtgtaaaag gaggaaaggg gtggaaaaaa accgactttc tgcatttaac
      841 tacaaaaaaa gtttatgttt agtttggtag aggtgttatg tataatgctt tgttaaagaa
      901 ccccctttcc gtgccactgg tgaataggga ttgatgaatg ggaagagttg agtcagacca
      961 gtaagcccgt cctgggttcc ttgaacatgt tcccatgtag gaggtaaaac caattctgga
     1021 agtgtctatg aacttccata aataacttta attttagtat aatgatggtc ttggattgtc
     1081 tgacctcagt agctattaaa taacatcaag taacatctgt atcaggccct acatagaaca
     1141 tacagttgag tgggagtaaa caaaaagata aacatgcgtg ttaatggctg ttcgagagaa
     1201 atcggaataa aagcctaaac aggaacaact tcatcacagt gttgatgttg gacacataga
     1261 tggtgatggc aaaggtttag aacacattat tttcaaagac taaatctaaa acccagagta
     1321 aacatcaatg ctcagagtta gcataatttg gagctattca ggaattgcag agaaatgcat
     1381 tttcacagaa atcaagatgt tatttttgta tactatatca cttagacaac tgtgtttcat
     1441 ttgctgtaat cagtttttaa aagtcagatg gaaagagcaa ctgaagtcct agaaaataga
     1501 aatgtaattt taaactattc caataaagct ggaggaggaa ggggagtttg actaaagttc
     1561 tttttgtttg tttcaaattt tcattaatgt atatagtgca aaataccata ttaaagaggg
     1621 gaatgtggag gactgaaagc tgacagtttg gacttttctt tttgtactta agtcatgtct
     1681 tcaataatga aaattgctgt taaaaggatg tatgggattt agatactttt gcaaagctat
     1741 agaaaattca ctttgtaatc tgttataata atgcccttga gttctgtgtt cagtctgaac
     1801 aggttttttg gtggtggtgg ttttgttttg ttttggagac ggagtctcac tcttgtcgcc
     1861 caggctggag tgcaggcttg gctcactgca acctccacct cccgggttca agcaattctc
     1921 ctgcctcagc ctcctgagta gctgggatta caggcacccg ccaccacccc ccgctaattt
     1981 tttgtatttt tatttttatt ttattttttt attttttttt gagacagagt gtcgctctgt
     2041 tgcccaggct ggagtgtagt ggtgcgatct cggctcactg caagctccgc ctcctgggtt
     2101 cgtgccattc tcctgcctca gcctcctgag tagctggggc tacaggtacc cgccaccgcg
     2161 cccagctaat tttttttttt tgtattttta gtaaagacgg ggtttcacgg tgttagccag
     2221 gatggtctca atctcctgac ctcgtgatcc gcccgccttg gcctcccaaa gtgctgggat
     2281 cacaggcgtg agccaccgcg cccggcctat tttttgtatt tttagtagag actgggtttc
     2341 atcatgttgg tcgggctggt ctccaactcc tgacctcagg tgatccacct gccccgcccc
     2401 ccaaagtgct agtgttacag gtgcgagcca ccgtgtctgg ccgattctga acagttttaa
     2461 taccattgct atttttgtgt ttttcctggg cctttttttt tttttttttt ttttttgaga
     2521 cagtctcgct ctgttgccca ggctagagtg caatggtgca atctcagctc actgcaacct
     2581 ccacccccca cccccacacc ccgttcaagt aattctcctg cctcagcctc ccaaatagct
     2641 gggattacag gtgtccgcca ccacacccag ctaatttttg ttatttttag tagagatggg
     2701 gtttcactgt gttggtcagg ctggtctcca actgttgccc tcaggtgagc cactgtgccc
     2761 caccttttcc tgggtttcat aaggatctga agtggtggat tccttgtttt tgctagtgtc
     2821 tcatttagag ttgagatgga ccttaaaact catctgtttt aactcacttt ttaatagatg
     2881 agttaaactt aatttactta aggatgtaca gttagagcct ggaacttcaa ccattattca
     2941 ctccccatgc cctgtttccc cccacttcga aattaaatgc ggttagcatc atatagttca
     3001 ttttccccct ccatgctgct gtgtgattct tgactttggg tatgagtttt tcatccttca
     3061 tgcagggttc tgtcagttca tggtatagtg attcagtgtt aaaatggtgg tgtctcagct
     3121 gtgctgtgca cattccaacc ttgtcaaatt aatagtcctg agcaagcaag aaaaagaggt
     3181 aataacatac ccatttcttt atgaatataa gcttataata ttttttcatg tgctattttt
     3241 actgagcaaa ttgtatgtct cacatgttaa cacaataaat atcttgacaa tttta
//
