LOCUS       NM_153610              12888 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens cardiomyopathy associated 5 (CMYA5), mRNA.
ACCESSION   NM_153610
VERSION     NM_153610.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12888)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   2  (bases 1 to 12888)
  AUTHORS   Hoya,S., Watanabe,Y., Shibuya,M. and Someya,T.
  TITLE     Updated meta-analysis of CMYA5 rs3828611 and rs4704591 with
            schizophrenia in Asian populations
  JOURNAL   Early Interv Psychiatry 12 (5), 938-941 (2018)
   PUBMED   28776924
  REMARK    GeneRIF: meta-analysis did not provide evidence supporting a
            contribution of CMYA5 rs3828611 and rs4704591 to schizophrenia
            susceptibility in Asian populations.
REFERENCE   3  (bases 1 to 12888)
  AUTHORS   Han,S., An,Z., Luo,X., Zhang,L., Zhong,X., Du,W., Yi,Q. and Shi,Y.
  TITLE     Association between CMYA5 gene polymorphisms and risk of
            schizophrenia in Uygur population and a meta-analysis
  JOURNAL   Early Interv Psychiatry 12 (1), 15-21 (2018)
   PUBMED   26403435
  REMARK    GeneRIF: association between CMYA5 gene polymorphisms and
            schizophrenia was confirmed in Asian population.
REFERENCE   4  (bases 1 to 12888)
  AUTHORS   Kumar,S., Mishra,A., Srivastava,A., Bhatt,M., Garg,N.,
            Agarwal,S.K., Pande,S. and Mittal,B.
  TITLE     Role of common sarcomeric gene polymorphisms in genetic
            susceptibility to left ventricular dysfunction
  JOURNAL   J Genet 95 (2), 263-272 (2016)
   PUBMED   27350668
  REMARK    GeneRIF: The results showed that MYBPC3 25-bp deletion polymorphism
            was significantly associated with elevated risk of left ventricular
            dysfunction (LVD), while TTN 18 bp I/D, TNNT2 5 bp I/D and myospryn
            K2906N polymorphisms did not show any significant association with
            LVD.
REFERENCE   5  (bases 1 to 12888)
  AUTHORS   Cornelis,M.C., Fornage,M., Foy,M., Xun,P., Gladyshev,V.N.,
            Morris,S., Chasman,D.I., Hu,F.B., Rimm,E.B., Kraft,P., Jordan,J.M.,
            Mozaffarian,D. and He,K.
  TITLE     Genome-wide association study of selenium concentrations
  JOURNAL   Hum Mol Genet 24 (5), 1469-1477 (2015)
   PUBMED   25343990
REFERENCE   6  (bases 1 to 12888)
  AUTHORS   Sarparanta,J.
  TITLE     Biology of myospryn: what's known?
  JOURNAL   J Muscle Res Cell Motil 29 (6-8), 177-180 (2008)
   PUBMED   19140017
  REMARK    GeneRIF: Review discusses interactions that suggest myospryn is
            involved in two seemingly distinct processes, protein kinase A
            signalling and vesicular trafficking.
            Review article
REFERENCE   7  (bases 1 to 12888)
  AUTHORS   Nakagami,H., Kikuchi,Y., Katsuya,T., Morishita,R., Akasaka,H.,
            Saitoh,S., Rakugi,H., Kaneda,Y., Shimamoto,K. and Ogihara,T.
  TITLE     Gene polymorphism of myospryn (cardiomyopathy-associated 5) is
            associated with left ventricular wall thickness in patients with
            hypertension
  JOURNAL   Hypertens Res 30 (12), 1239-1246 (2007)
   PUBMED   18344630
  REMARK    GeneRIF: Polymorphism of myospryn is associated with left
            ventricular hypertrophy, and an association between a Z-disc
            protein and cardiac adaptation in response to pressure overload.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 12888)
  AUTHORS   Kouloumenta,A., Mavroidis,M. and Capetanaki,Y.
  TITLE     Proper perinuclear localization of the TRIM-like protein myospryn
            requires its binding partner desmin
  JOURNAL   J Biol Chem 282 (48), 35211-35221 (2007)
   PUBMED   17872945
  REMARK    GeneRIF: perinuclear localization of the TRIM-like protein myospryn
            requires its binding partner desmin
REFERENCE   9  (bases 1 to 12888)
  AUTHORS   Durham,J.T., Brand,O.M., Arnold,M., Reynolds,J.G., Muthukumar,L.,
            Weiler,H., Richardson,J.A. and Naya,F.J.
  TITLE     Myospryn is a direct transcriptional target for MEF2A that encodes
            a striated muscle, alpha-actinin-interacting, costamere-localized
            protein
  JOURNAL   J Biol Chem 281 (10), 6841-6849 (2006)
   PUBMED   16407236
  REMARK    GeneRIF: Functions directly downstream of MEF2A at the costamere in
            striated muscle potentially playing a role in myofibrillogenesis.
REFERENCE   10 (bases 1 to 12888)
  AUTHORS   Benson,M.A., Tinsley,C.L. and Blake,D.J.
  TITLE     Myospryn is a novel binding partner for dysbindin in muscle
  JOURNAL   J Biol Chem 279 (11), 10450-10458 (2004)
   PUBMED   14688250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC020856.1, AC109488.3, AL834252.2, AC008496.6 and KF457927.1.
            
            On Nov 22, 2018 this sequence version replaced NM_153610.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2151741,
                              SAMEA2154361 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000446378.3/ ENSP00000394770.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-922               BC020856.1         1-922
            923-8434            AC109488.3         16188-23699
            8435-12259          AL834252.2         152-3976
            12260-12833         AC008496.6         87793-88366         c
            12834-12834         KF457927.1         139-139
            12835-12888         AC008496.6         87738-87791         c
FEATURES             Location/Qualifiers
     source          1..12888
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.1"
     gene            1..12888
                     /gene="CMYA5"
                     /gene_synonym="C5orf10; SPRYD2; TRIM76"
                     /note="cardiomyopathy associated 5"
                     /db_xref="GeneID:202333"
                     /db_xref="HGNC:HGNC:14305"
                     /db_xref="MIM:612193"
     exon            1..221
                     /gene="CMYA5"
                     /gene_synonym="C5orf10; SPRYD2; TRIM76"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..12282
                     /gene="CMYA5"
                     /gene_synonym="C5orf10; SPRYD2; TRIM76"
                     /note="2310076E16Rik; tripartite motif-containing 76;
                     genethonin-3; myospryn; dystrobrevin-binding protein 2;
                     SPRY domain-containing protein 2; tripartite
                     motif-containing protein 76"
                     /codon_start=1
                     /product="cardiomyopathy-associated protein 5"
                     /protein_id="NP_705838.3"
                     /db_xref="CCDS:CCDS47238.1"
                     /db_xref="GeneID:202333"
                     /db_xref="HGNC:HGNC:14305"
                     /db_xref="MIM:612193"
                     /translation="MASRDSNHAGESFLGSDGDEEATRELETEEESEGEEDETAAESE
                     EEPDSRLSDQDEEGKIKQEYIISDPSFSMVTVQREDSGITWETNSSRSSTPWASEESQ
                     TSGVCSREGSTVNSPPGNVSFIVDEVKKVRKRTHKSKHGSPSLRRKGNRKRNSFESQD
                     VPTNKKGSPLTSASQVLTTEKEKSYTGIYDKARKKKTTSNTPPITGAIYKEHKPLVLR
                     PVYIGTVQYKIKMFNSVKEELIPLQFYGTLPKGYVIKEIHYRKGKDASISLEPDLDNS
                     GSNTVSKTRKLVAQSIEDKVKEVFPPWRGALSKGSESLTLMFSHEDQKKIYADSPLNA
                     TSALEHTVPSYSSSGRAEQGIQLRHSQSVPQQPEDEAKPHEVEPPSVTPDTPATMFLR
                     TTKEECELASPGTAASENDSSVSPSFANEVKKEDVYSAHHSISLEAASPGLAASTQDG
                     LDPDQEQPDLTSIERAEPVSAKLTPTHPSVKGEKEENMLEPSISLSEPLMLEEPEKEE
                     IETSLPIAITPEPEDSNLVEEEIVELDYPESPLVSEKPFPPHMSPEVEHKEEELILPL
                     LAASSPEHVALSEEEREEIASVSTGSAFVSEYSVPQDLNHELQEQEGEPVPPSNVEAI
                     AEHAVLSEEENEEFEAYSPAAAPTSESSLSPSTTEKTSENQSPLFSTVTPEYMVLSGD
                     EASESGCYTPDSTSASEYSVPSLATKESLKKTIDRKSPLILKGVSEYMIPSEEKEDTG
                     SFTPAVAPASEPSLSPSTTEKTSECQSPLPSTATSEHVVPSEGEDLGSERFTPDSKLI
                     SKYAAPLNATQESQKKIINEASQFKPKGISEHTVLSVDGKEVIGPSSPDLVVASEHSF
                     PPHTTEMTSECQAPPLSATPSEYVVLSDEEAVELERYTPSSTSASEFSVPPYATPEAQ
                     EEEIVHRSLNLKGASSPMNLSEEDQEDIGPFSPDSAFVSEFSFPPYATQEAEKREFEC
                     DSPICLTSPSEHTILSDEDTEEAELFSPDSASQVSIPPFRISETEKNELEPDSLLTAV
                     SASGYSCFSEADEEDIGSTAATPVSEQFSSSQKQKAETFPLMSPLEDLSLPPSTDKSE
                     KAEIKPEIPTTSTSVSEYLILAQKQKTQAYLEPESEDLIPSHLTSEVEKGEREASSSV
                     AAIPAALPAQSSIVKEETKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALSKV
                     RKEEIVPDSQEATAHVSQDQKMEPQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVLNV
                     TSELEQRKLSKNEPEVIKPYSPLKETSLSGPEALSAVKMEMKHDSKITTTPIVLHSAS
                     SGVEKQVEHGPPALAFSALSEEIKKEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSS
                     LITPVDRPVLTKVGKGELGSGLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLAW
                     SEAEKEIKFDSLPSVSSIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARVEDK
                     QDLLFSTVCDSERLVSSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSP
                     ASKHIIPKGKDEETASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEK
                     QDVALAELSLEPEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSV
                     LEKGPAELRSREGKEENRELCASSTMPAISELSSLLREESQNEEIKPFSPKIISLESK
                     EPPASVAEGGNPEEFQPFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKAQVMG
                     DILDKLSEETGHPNSSQVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTS
                     SEDKQDLGIKQFSLMRENLPLEQSKSFMTTKPADVKETKMEEFFISPKDENWMLGKPE
                     NVASQHEQRIAGSVQLDSSSSNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSS
                     QEAVSALDTSSGNTETLSSKSYSSEEVKLAEEPKSLVLAGNVERNIAEGKEIHSLMES
                     ESLLLEKANTELSWPSKEDSQEKIKLPPERFFQKPVSGLSVEQVKSETISSSVKTAHF
                     PAEGVEPALGNEKEAHRSTPPFPEEKPLEESKMVQSKVIDDADEGKKPSPEVKIPTQR
                     KPISSIHAREPQSPESPEVTQNPPTQPKVAKPDLPEEKGKKGISSFKSWMSSLFFGSS
                     TPDNKVAEQEDLETQPSPSVEKAVTVIDPEGTIPTNFNVAEKPADHSLSEVKLKTADE
                     PRGTLVKSGDGQNVKEKSMILSNVEDLQQPKFISEVSREDYGKKEISGDSEEMNINSV
                     VTSADGENLEIQSYSLIGEKLVMEEAKTIVPPHVTDSKRVQKPAIAPPSKWNISIFKE
                     EPRSDQKQKSLLSFDVVDKVPQQPKSASSNFASKNITKESEKPESIILPVEESKGSLI
                     DFSEDRLKKEMQNPTSLKISEEETKLRSVSPTEKKDNLENRSYTLAEKKVLAEKQNSV
                     APLELRDSNEIGKTQITLGSRSTELKESKADAMPQHFYQNEDYNERPKIIVGSEKEKG
                     EEKENQVYVLSEGKKQQEHQPYSVNVAESMSRESDISLGHSLGETQSFSLVKATSVTE
                     KSEAMLAEAHPEIREAKAVGTQPHPLEESKVLVEKTKTFLPVALSCRDEIENHSLSQE
                     GNLVLEKSSRDMPDHSEEKEQFRESELSKGGSVDITKETVKQGFQEKAVGTQPRPLEE
                     SKVLVEKTKTFLPVVLSCHDEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQFKESELW
                     KGGSVDITKESMKEGFPSKESERTLARPFDETKSSETPPYLLSPVKPQTLASGASPEI
                     NAVKKKEMPRSELTPERHTVHTIQTSKDDTSDVPKQSVLVSKHHLEAAEDTRVKEPLS
                     SAKSNYAQFISNTSASNADKMVSNKEMPKEPEDTYAKGEDFTVTSKPAGLSEDQKTAF
                     SIISEGCEILNIHAPAFISSIDQEESEQMQDKLEYLEEKASFKTIPLPDDSETVACHK
                     TLKSRLEDEKVTPLKENKQKETHKTKEEISTDSETDLSFIQPTIPSEEDYFEKYTLID
                     YNISPDPEKQKAPQKLNVEEKLSKEVTEETISFPVSSVESALEHEYDLVKLDESFYGP
                     EKGHNILSHPETQSQNSADRNVSKDTKRDVDSKSPGMPLFEAEEGVLSRTQIFPTTIK
                     VIDPEFLEEPPALAFLYKDLYEEAVGEKKKEEETASEGDSVNSEASFPSRNSDTDDGT
                     GIYFEKYILKDDILHDTSLTQKDQGQGLEEKRVGKDDSYQPIAAEGEIWGKFGTICRE
                     KSLEEQKGVYGEGESVDHVETVGNVAMQKKAPITEDVRVATQKISYAVPFEDTHHVLE
                     RADEAGSHGNEVGNASPEVNLNVPVQVSFPEEEFASGATHVQETSLEEPKILVPPEPS
                     EERLRNSPVQDEYEFTESLHNEVVPQDILSEELSSESTPEDVLSQGKESFEHISENEF
                     ASEAEQSTPAEQKELGSERKEEDQLSSEVVTEKAQKELKKSQIDTYCYTCKCPISATD
                     KVFGTHKDHEVSTLDTAISAVKVQLAEFLENLQEKSLRIEAFVSEIESFFNTIEENCS
                     KNEKRLEEQNEEMMKKVLAQYDEKAQSFEEVKKKKMEFLHEQMVHFLQSMDTAKDTLE
                     TIVREAEELDEAVFLTSFEEINERLLSAMESTASLEKMPAAFSLFEHYDDSSARSDQM
                     LKQVAVPQPPRLEPQEPNSATSTTIAVYWSMNKEDVIDSFQVYCMEEPQDDQEVNELV
                     EEYRLTVKESYCIFEDLEPDRCYQVWVMAVNFTGCSLPSERAIFRTAPSTPVIRAEDC
                     TVCWNTATIRWRPTTPEATETYTLEYCRQHSPEGEGLRSFSGIKGLQLKVNLQPNDNY
                     FFYVRAINAFGTSEQSEAALISTRGTRFLLLRETAHPALHISSSGTVISFGERRRLTE
                     IPSVLGEELPSCGQHYWETTVTDCPAYRLGICSSSAVQAGALGQGETSWYMHCSEPQR
                     YTFFYSGIVSDVHVTERPARVGILLDYNNQRLIFINAESEQLLFIIRHRFNEGVHPAF
                     ALEKPGKCTLHLGIEPPDSVRHK"
     exon            222..10710
                     /gene="CMYA5"
                     /gene_synonym="C5orf10; SPRYD2; TRIM76"
                     /inference="alignment:Splign:2.1.0"
     exon            10711..10806
                     /gene="CMYA5"
                     /gene_synonym="C5orf10; SPRYD2; TRIM76"
                     /inference="alignment:Splign:2.1.0"
     exon            10807..11040
                     /gene="CMYA5"
                     /gene_synonym="C5orf10; SPRYD2; TRIM76"
                     /inference="alignment:Splign:2.1.0"
     exon            11041..11063
                     /gene="CMYA5"
                     /gene_synonym="C5orf10; SPRYD2; TRIM76"
                     /inference="alignment:Splign:2.1.0"
     exon            11064..11182
                     /gene="CMYA5"
                     /gene_synonym="C5orf10; SPRYD2; TRIM76"
                     /inference="alignment:Splign:2.1.0"
     exon            11183..11332
                     /gene="CMYA5"
                     /gene_synonym="C5orf10; SPRYD2; TRIM76"
                     /inference="alignment:Splign:2.1.0"
     exon            11333..11479
                     /gene="CMYA5"
                     /gene_synonym="C5orf10; SPRYD2; TRIM76"
                     /inference="alignment:Splign:2.1.0"
     exon            11480..11627
                     /gene="CMYA5"
                     /gene_synonym="C5orf10; SPRYD2; TRIM76"
                     /inference="alignment:Splign:2.1.0"
     exon            11628..11761
                     /gene="CMYA5"
                     /gene_synonym="C5orf10; SPRYD2; TRIM76"
                     /inference="alignment:Splign:2.1.0"
     exon            11762..11861
                     /gene="CMYA5"
                     /gene_synonym="C5orf10; SPRYD2; TRIM76"
                     /inference="alignment:Splign:2.1.0"
     exon            11862..12035
                     /gene="CMYA5"
                     /gene_synonym="C5orf10; SPRYD2; TRIM76"
                     /inference="alignment:Splign:2.1.0"
     exon            12036..12888
                     /gene="CMYA5"
                     /gene_synonym="C5orf10; SPRYD2; TRIM76"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12866..12871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMYA5"
                     /gene_synonym="C5orf10; SPRYD2; TRIM76"
                     /note="hexamer: AATAAA"
     polyA_site      12888
                     /gene="CMYA5"
                     /gene_synonym="C5orf10; SPRYD2; TRIM76"
                     /note="major polyA site"
ORIGIN      
        1 agtcggaggg agaacaccag gcgcggcgcg ggcggctccg gctccggccc cggcccaggc
       61 ccgggagagg cgatggcgag ccgcgatagc aaccacgctg gcgagagctt tctcggctcc
      121 gacggggacg aggaggcgac ccgggagctg gagaccgagg aggagtcgga gggcgaggag
      181 gacgagacgg cggcggagtc ggaggaggag ccggactcca ggttatcaga ccaggatgaa
      241 gagggaaaga tcaagcagga gtatatcata tctgacccct ccttttccat ggtgacagtc
      301 caaagggaag atagtgggat aacctgggaa accaattcaa gtagatcttc tactccttgg
      361 gcttcagaag aaagtcagac ttctggtgtg tgtagtcggg aagggtcaac tgtgaattct
      421 cctcctggaa atgtttcctt tattgtggat gaagtgaaaa aggttcggaa aaggactcat
      481 aagtcaaagc atggttcacc atcattacgc cggaaaggca acagaaaaag aaattctttt
      541 gaatcccaag atgttccaac aaacaaaaaa ggcagtcctt taacttcagc aagccaggta
      601 ctaaccacgg agaaagagaa gtcatatact ggcatttatg ataaagcaag aaaaaagaag
      661 accacttcaa atacacctcc gattactggg gcaatataca aagaacacaa gccattagtg
      721 ttaagaccag tctacatagg aacagtacaa tataaaatta agatgtttaa ttcggttaaa
      781 gaagaattaa ttcctctaca attttatgga acattgccaa agggttatgt aattaaagaa
      841 atacattata ggaaagggaa agatgcatcc attagtctag agccagattt ggacaatagt
      901 ggttctaata cagtgtccaa aacacgcaaa ttagtagccc aaagcataga ggataaagta
      961 aaagaggttt ttccaccctg gagaggcgca ctctccaaag gatcagagtc cctaacctta
     1021 atgttcagtc atgaagatca aaagaaaatt tatgctgatt ctcccctaaa tgccacatct
     1081 gcattggagc acacagttcc ctcttattca agtagtggca gagcagaaca aggaatacag
     1141 ctcaggcatt cacagtcagt gccacaacag ccagaagatg aagcaaaacc acatgaagtg
     1201 gaacctccat ctgtgacacc cgacacacct gcaactatgt tcctgagaac aacaaaggaa
     1261 gaatgtgagc ttgcttcacc aggaactgca gcttcagaga atgactcttc agtctcacca
     1321 tcatttgcta atgaggtaaa gaaggaagat gtgtattctg ctcaccattc catttctctg
     1381 gaggcagcgt caccaggtct ggcagcatct acccaggatg gtttggaccc agaccaagaa
     1441 cagccggacc tgacttcaat agaaagggca gaaccagtct ccgcaaaact gacccctacc
     1501 catcccagtg tcaaaggaga gaaggaggaa aacatgcttg agccatccat ttctctttct
     1561 gaacctctaa tgttagaaga accagagaaa gaagaaatag aaacttccct acccatagct
     1621 attacccctg aacctgaaga ttctaattta gtagaagaag agatcgtaga acttgattac
     1681 ccagaaagcc cattggtttc cgagaagccc ttcccaccac atatgtcccc tgaagtggag
     1741 cacaaagaag aagagcttat tctaccatta ttggcagcat catctcctga acatgttgct
     1801 ttgtctgagg aagaaagaga ggaaattgca tctgtttcta ctggttctgc ttttgtatca
     1861 gagtattcag taccacagga tttgaaccat gaattacagg agcaagaagg tgagccagtt
     1921 cccccatcca atgtagaagc tatagctgaa catgcagttt tgtcagaaga agagaatgag
     1981 gaatttgagg cttattcccc agctgcagcc cctacatctg agagctctct ctcaccatcc
     2041 acaactgaga agacttcaga gaaccagtct ccactgtttt caacagttac accagaatac
     2101 atggtcctat caggagacga ggcctcagaa agtgggtgtt acacaccaga ctccacatct
     2161 gcttctgaat attcagttcc atcactggca acaaaagagt cactgaagaa aacaattgac
     2221 cgtaagtccc cgttaatatt gaaaggtgtt tctgagtaca tgattccatc agaagagaag
     2281 gaagacactg gatcgtttac tccagctgtg gcccctgctt ctgagccctc tctctcacca
     2341 tccacaaccg aaaagacttc tgaatgccag tcaccactgc cttctactgc cacatcagaa
     2401 cacgtggtcc catcagaagg agaggaccta ggaagtgaac gtttcacacc ggattcaaag
     2461 ttgatctcca aatatgcagc cccactcaat gcaacacagg aatctcaaaa gaaaataatc
     2521 aatgaggcat cccaattcaa accaaaaggt atttctgagc acacagttct gtcagtagac
     2581 ggcaaggagg tcattggacc atcttcccca gatttggttg ttgcatctga acactctttc
     2641 ccaccacaca caaccgagat gacttctgaa tgccaggccc caccactttc agccacccca
     2701 tctgaatatg ttgttctatc agacgaagag gcagtcgagt tggaacgata cacaccctct
     2761 tctacatctg cttctgaatt ttcagtacca ccatatgcaa caccggaggc acaggaggaa
     2821 gaaattgtcc atagatctct aaatctaaaa ggtgcatcct cacccatgaa tttatcagaa
     2881 gaagatcaag aagacattgg acctttttct ccagattctg catttgtgtc agaattctca
     2941 tttccaccgt atgcaaccca ggaagcagag aaaagagaat ttgagtgcga ttctccaata
     3001 tgtttaacat caccatctga gcacactatt ttgtcagatg aagacactga agaagcggaa
     3061 ctgttctctc cagactcagc atcacaagtt tcaatccctc cctttagaat ctcagaaaca
     3121 gagaaaaatg aacttgagcc tgattcacta ttaactgcag tgtctgcttc aggttattcc
     3181 tgcttttcag aagcagatga ggaagacatt ggatccacag ctgctacacc tgtatctgag
     3241 cagttcagtt catcacagaa gcaaaaagct gaaactttcc ctttgatgtc tccgcttgaa
     3301 gacttaagtc tgccgccttc aacagataaa tcagagaaag cagaaattaa gccagagatt
     3361 ccaacaacct caacatctgt atctgaatat ctcattttgg cacagaagca gaaaactcaa
     3421 gcatatttag agcctgagtc tgaagacttg attccttcac atttaaccag tgaagtggag
     3481 aagggagaaa gggaggcaag ttcatcagta gctgcaatac ctgctgcttt acctgcacaa
     3541 tcatctatag taaaggaaga aaccaaacct gcatctccac attcagtttt acctgattca
     3601 gtccctgcaa tcaagaaaga acaggaaccc acagcagcac tcactctaaa agctgcagat
     3661 gaacagatgg ctttgtcaaa agtcagaaag gaagaaattg tgcctgattc tcaagaagct
     3721 acagcacatg tatcacagga tcaaaaaatg gagcctcagc ctccaaatgt tccagagtct
     3781 gagatgaaat attcagtttt gcctgacatg gtagatgagc caaagaaggg tgtcaagccc
     3841 aaattagttc taaatgtgac ttctgaacta gaacagagaa agttgtccaa gaatgagcct
     3901 gaagtaataa aaccatattc acctctaaag gaaacatctt tatctggacc tgaggcttta
     3961 tcagcagtga aaatggagat gaaacatgat tccaaaataa caactacacc tatagtgctt
     4021 cattcagctt cctcaggagt ggaaaagcaa gttgaacatg gtccacctgc actagcattt
     4081 tcagctttgt cagaagaaat taaaaaagaa attgaaccca gttcctcaac aactacagca
     4141 tctgtaacta agcttgattc aaacttaacc agagcagtaa aagaagaaat cccaacagat
     4201 tcatctctta tcactcctgt agatcgtcca gtcttaacaa aagtaggaaa gggtgaatta
     4261 ggaagtggtt tgccaccact ggtaacatct gcagatgaac attcagttct tgcagaagaa
     4321 gacaaggtgg caattaaagg tgcttctccc attgaaactt catccaaaca tttagcttgg
     4381 tcagaagcag agaaggaaat taaatttgat tcacttccaa gtgtctcctc tatagcagag
     4441 cattctgttt tgtcagaagt agaagccaaa gaagttaaag ctgggttgcc agtaatcaaa
     4501 acatcatctt ctcagcattc agataaatct gaggaagcaa gggtagaaga caaacaagat
     4561 cttttatttt ctacagtctg tgactctgaa cgtttggttt catcacagaa gaagagcttg
     4621 atgtctacct cagaggtgtt agagcctgaa catgagcttc cactcagcct atggggtgag
     4681 ataaagaaga aagaaactga acttccttca tcacaaaatg tgtcacctgc atccaaacat
     4741 ataatcccaa aaggcaaaga tgaggaaaca gcaagttcat ctcctgagtt ggaaaattta
     4801 gcatcaggtt tagccccaac attactgctc ctcagtgatg ataagaacaa accggcagtg
     4861 gaggtatctt ctacagctca gggagacttc ccatcagaaa aacaagatgt tgctttggca
     4921 gagctgtctt tggaacctga gaagaaagac aagccacacc aaccgttgga attaccaaat
     4981 gctgggtcag aattttctag tgatttaggt agacaaagtg gatccatagg tacaaaacaa
     5041 gcaaagtctc ccataactga aacagaggat tctgttttag aaaaaggccc agctgagctt
     5101 aggagcagag aaggaaaaga agaaaataga gagctttgtg catcttctac gatgcctgca
     5161 atttcagagc tttcatcatt gcttagggag gaatctcaga atgaagaaat taaacctttc
     5221 tctcccaaga tcatcagcct agagtcgaaa gaaccacctg cctctgtagc tgaaggaggc
     5281 aacccagaag aatttcagcc atttactttt tctttaaaag gattatcaga ggaggttagc
     5341 catccagccg actttaaaaa gggaggaaat caagaaatag gcccattacc accaactgga
     5401 aatttgaagg cacaagtcat gggagatatt ttagataagc taagtgaaga aacaggccac
     5461 ccaaattcat cccaggtact ccagagtata acagaaccat caaagattgc tccttctgac
     5521 ctccttgtag aacaaaaaaa gacagaaaaa gcacttcatt cagatcaaac tgttaaatta
     5581 cctgatgtaa gcacctcttc tgaagataaa caagatctgg gtattaagca gttttcactt
     5641 atgagagaga atttgccttt ggaacaatca aaatcattta tgacaaccaa gcctgcggat
     5701 gtcaaagaaa caaaaatgga agaattcttt atttctccaa aggatgaaaa ctggatgttg
     5761 ggaaagccag aaaatgtggc tagtcaacac gaacagagaa tagcaggatc tgtgcagctg
     5821 gattcctcta gcagcaatga gctgaggcca gggcagctca aggctgctgt gtccagtaag
     5881 gaccatacat gtgaagtgag aaagcaggtc ctgccgcatt ctgctgaaga atctcatttg
     5941 tcatcacaag aagcagtatc tgctcttgat acttccagtg gtaatacaga gaccttatca
     6001 agtaaaagtt actcttctga agaagtaaag ctggctgaag aaccaaagtc tttagtccta
     6061 gctggaaatg tagagagaaa catagcagag gggaaggaga ttcattcttt gatggagagt
     6121 gaaagtttgc tattggagaa agcaaacaca gagctttcct ggccttccaa agaagatagc
     6181 caggaaaaaa ttaaactacc tcctgaaaga ttcttccaga aaccagtgtc tggcctatca
     6241 gtggaacagg tgaagtcaga aacaatctcc tcttctgtca aaacagccca tttcccggca
     6301 gaaggtgtgg aacctgcatt gggcaatgaa aaagaagcac acaggagcac acctcctttt
     6361 cctgaagaga agccattgga agaatcaaaa atggttcagt caaaggttat tgatgatgct
     6421 gatgagggaa agaaaccatc acctgaagta aaaataccca cacaaagaaa acccatctcc
     6481 tcaatccatg caagagagcc tcaatcccca gagtcacctg aggtgacaca aaatccacct
     6541 acacaaccaa aggtggctaa gccggacctt cctgaggaaa agggaaagaa aggaatttca
     6601 tctttcaaat cgtggatgtc cagcttgttt tttggatcga gcactccaga taacaaagtt
     6661 gctgaacaag aagacttaga aacacagcca agtccatccg tagaaaaagc agtgactgtg
     6721 atagatcctg aaggtacaat tcccaccaat tttaatgtag ctgagaaacc agctgatcat
     6781 tcattatcag aggtaaaact taaaactgct gatgaaccca gaggtacttt agtaaaatct
     6841 ggtgacggtc aaaacgttaa agaaaaatcc atgattttat caaatgtaga agatttacaa
     6901 cagccaaaat tcatttctga ggtgtctagg gaagattatg gaaaaaaaga aatctcaggc
     6961 gattcagagg aaatgaacat aaactcagta gttacttctg ctgatggtga gaaccttgaa
     7021 attcaatctt attcactaat cggtgagaaa ttggttatgg aagaagccaa aactattgtt
     7081 cctcctcatg ttactgatag taaaagagtc cagaagccag caatcgctcc tccatctaaa
     7141 tggaatattt ctatttttaa ggaagagcca agaagtgatc aaaaacaaaa atcactcctt
     7201 tcatttgatg tagtagataa ggtgccacaa cagccaaaat cagcttcctc caactttgca
     7261 agtaaaaata tcacaaagga atcagagaaa ccagagtcaa ttattttgcc agtagaagaa
     7321 tcaaaaggca gtttaattga tttcagtgaa gacagactca agaaagaaat gcaaaatcct
     7381 acttccttga aaatttctga agaggaaaca aaactcaggt ctgttagtcc aactgagaag
     7441 aaagataatt tggaaaacag atcatatacc ttggcagaaa agaaggtgct ggcagaaaaa
     7501 caaaactctg tggccccatt agagcttaga gatagtaatg aaatagggaa gacacaaatt
     7561 acacttggat ctagatctac tgaactgaaa gaatcaaaag ccgatgctat gccacagcac
     7621 ttctatcaaa atgaagacta caatgaaaga cccaaaatca ttgttggttc tgaaaaggag
     7681 aaaggtgaag aaaaagaaaa tcaggtatat gtgctttcag aaggaaagaa gcagcaggaa
     7741 catcagcctt attctgtgaa tgtagccgag tctatgagta gagaatcaga tatctcttta
     7801 ggtcattctt tgggtgaaac tcaatcattt tcattagtta aagctacatc agttactgaa
     7861 aaatcagaag ccatgctcgc agaggctcac ccagaaatca gagaagcaaa ggcagtagga
     7921 acccaaccac atcctttaga agaaagtaaa gttttggtgg agaaaaccaa gactttcctg
     7981 ccggtggctc tttcttgtcg tgatgaaata gagaaccact ctttatctca ggaaggaaat
     8041 ctagtattag aaaagtcaag cagagatatg ccagatcaca gtgaagaaaa agaacagttc
     8101 agagagtcag agctatcgaa aggcggttca gtagatatca caaaagaaac tgtgaaacaa
     8161 ggatttcaag aaaaggcagt aggaacccaa ccacgtcctt tagaagaaag taaagttttg
     8221 gtggagaaaa ctaagacttt cctgccagtg gttctttctt gtcatgatga aatagagaac
     8281 cactctttgt ctcaggaagg aaatctagtg ttagaaaagt caagcagaga tatgccagat
     8341 cacagtgaag aaaaagaaca gttcaaagag tcagagctat ggaaaggtgg ttcagtagat
     8401 atcacaaaag aaagtatgaa agaaggattt ccatctaaag aatccgaaag gactttagct
     8461 cgtccttttg atgaaactaa gagctcagaa acaccgccat atttgctgtc acctgtaaaa
     8521 ccacaaactc ttgcttcagg agcttctcca gaaattaacg cagtgaagaa aaaagaaatg
     8581 ccacgatcag aattgactcc agaaaggcat acagttcata ctattcagac atctaaagat
     8641 gacacatccg atgtgcctaa acaatctgtt cttgtttcaa agcaccactt ggaggctgcg
     8701 gaagataccc gtgtaaagga accactgtct tcagcaaaaa gcaactatgc tcaatttata
     8761 tctaatacat cagcaagcaa tgctgataaa atggtttcta ataaagaaat gcccaaggaa
     8821 cctgaagaca catatgcaaa aggtgaagac tttacagtga ctagtaagcc agccggactt
     8881 tcagaagatc agaagactgc ctttagtatc atttctgaag gctgtgagat attgaatatt
     8941 catgctccgg cctttatttc ttcaatcgat caggaagaaa gtgaacaaat gcaagataaa
     9001 ttagaatatt tggaagagaa agcctcattt aaaaccatac cactccctga tgatagtgaa
     9061 acagttgctt gtcataaaac attaaagagc aggttagaag atgaaaaagt taccccattg
     9121 aaagaaaata aacaaaagga aactcataag acaaaagaag agatatccac agattcagaa
     9181 actgatttat catttattca gcccacaatt cccagtgaag aggattattt tgaaaaatat
     9241 actttgattg attataacat ctccccagac ccagaaaaac agaaagctcc acagaaatta
     9301 aatgttgaag agaaactctc aaaggaagtt acagaagaaa ctatctcttt cccagtaagt
     9361 tcagtggaaa gtgcactaga acatgaatat gacttggtga aattagatga aagtttttat
     9421 ggaccagaaa agggccacaa catattatct catccagaga cccaaagcca aaactcagct
     9481 gacaggaatg tttcaaagga cacaaagaga gatgtggact caaagtcacc ggggatgcct
     9541 ttatttgaag cagaggaagg agttctatca cgaacccaga tatttcctac cactattaaa
     9601 gtcattgatc cagaatttct ggaggagcca cctgcacttg catttttata taaggatctg
     9661 tatgaagaag cagttggaga gaaaaagaag gaagaggaga cagcttctga aggtgacagt
     9721 gtgaattctg aggcatcatt tcccagcaga aattctgaca ctgatgatgg aacaggaata
     9781 tattttgaga agtacatact caaagatgac attctccatg acacatctct aactcaaaag
     9841 gaccagggcc aaggtctgga agaaaaacga gttggtaagg atgattcata ccaaccgata
     9901 gctgcagaag gggaaatttg gggaaagttt ggaactattt gcagggagaa gagtctggaa
     9961 gaacagaaag gtgtttatgg ggaaggagaa tcagtagacc atgtggagac cgttggtaac
    10021 gtagcgatgc agaagaaagc tcccatcaca gaggacgtca gagtggctac ccagaaaata
    10081 agttatgcgg ttccatttga agacacccat catgttctgg agcgtgcaga tgaagcaggc
    10141 agtcacggta atgaagtcgg aaatgcaagt ccagaggtca atctgaatgt cccagtacaa
    10201 gtgtccttcc cggaggaaga atttgcatct ggtgcaactc atgttcaaga aacatcacta
    10261 gaagaaccta aaatcctggt cccacctgag ccaagtgaag agaggctccg taatagccct
    10321 gttcaggatg agtatgaatt tacagaatcc ctgcataatg aagtggttcc tcaagacata
    10381 ttatcagaag aactgtcttc agaatccaca cctgaagatg tcttatctca aggaaaggaa
    10441 tcctttgagc acatcagtga aaatgaattt gcgagtgagg cagaacaaag tacacctgct
    10501 gaacaaaaag agttgggcag cgagaggaaa gaagaagacc aattatcatc tgaggtagta
    10561 actgaaaagg cacaaaaaga gctgaaaaag tcccagattg acacatactg ttacacctgc
    10621 aaatgtccaa tttctgccac tgacaaggtg tttggcaccc acaaagacca tgaagtttca
    10681 acgcttgaca cagctataag tgctgtaaag gttcaattag cagaatttct agaaaattta
    10741 caagaaaagt ccttgaggat tgaagccttt gttagtgaga tagaatcctt ttttaatacc
    10801 attgaggaaa actgtagtaa aaatgagaaa aggctagaag aacagaatga ggaaatgatg
    10861 aagaaggttt tagcacagta tgatgagaaa gcccagagct ttgaggaagt gaagaagaag
    10921 aagatggagt tcctgcatga gcagatggtc cactttctgc agagcatgga cactgccaaa
    10981 gacaccctgg agaccatcgt gagagaagca gaggagcttg atgaggccgt cttcctgact
    11041 tcgtttgagg aaatcaatga aaggttgctt tctgcaatgg agagcactgc ttctttagag
    11101 aaaatgcctg ctgcgttttc ccttttcgaa cattatgatg acagctcggc aagaagtgac
    11161 cagatgttaa aacaagtggc tgttccacag cctcctagat tagaacctca ggaaccaaat
    11221 tctgccacca gcacaacaat tgcagtttac tggagcatga acaaggaaga tgtcattgat
    11281 tcatttcagg tttactgcat ggaggagcca caagatgatc aagaagtaaa tgagttggta
    11341 gaagaataca gactgacagt gaaagaaagc tactgcattt ttgaagatct ggaacctgac
    11401 cgatgctatc aagtgtgggt gatggctgtg aacttcactg gatgtagcct gcccagtgaa
    11461 agggccatct ttaggacagc accctccacc cctgtgatcc gcgctgagga ctgtactgtg
    11521 tgttggaaca cagccactat ccgatggcgg cccaccaccc cagaggccac ggagacctac
    11581 actctggagt actgcagaca gcactctcct gagggagagg gcctcagatc tttctctgga
    11641 atcaaaggac tccagctgaa agttaacctc caacccaatg ataactactt tttctatgtg
    11701 agggccatca atgcatttgg gacaagtgaa cagagtgaag ctgctctcat ctccaccaga
    11761 ggaaccagat ttctcttgtt gagagaaaca gctcatcctg ctctacacat ttcctcaagt
    11821 gggacagtga tcagctttgg tgagaggaga cggctgacgg aaatcccgtc agtgctgggt
    11881 gaggagctgc cttcctgtgg ccagcattac tgggaaacca cagtcacaga ctgcccagca
    11941 tatcgactcg gcatctgctc cagctcggct gtgcaggcag gtgccctagg acaaggggag
    12001 acctcatggt acatgcactg ctctgagcca cagagataca catttttcta cagtggtatt
    12061 gtgagtgatg ttcatgtgac tgagcgtcca gccagagtgg gcatcctgct ggactacaac
    12121 aaccagagac ttatcttcat caacgcagag agcgagcagt tgctcttcat catcaggcac
    12181 aggtttaatg agggtgtcca ccctgccttt gccctggaga aacctggaaa atgtactttg
    12241 cacctgggga tagagccccc ggattctgta aggcacaagt gatccttggc tttcagaatt
    12301 tgcaagaaca gcgatttgaa ttttgggggg gtctgctgtt cattccttta ggtgctatac
    12361 attattcaaa aagtctcccg cgcatttgca ctaatgatgg ctgcatgcat agcaatcagc
    12421 atgtgagcaa aatcgacaag aaaaccttga ctttacagag cagtgtgtga gtaaacagaa
    12481 tgaaaacaac aacctccact ctttagttta tataagtttg agttctttcc taaattaaaa
    12541 gatctacact tgagttggga accgaaagag aaaaatggac ttccatctgt tttactggta
    12601 aaggaaatcc tctgatggac aggtcagagt gaaggaaggt tgtgctggta agacatctct
    12661 gacgaagagc catggatgct ttccacaaaa tgtcacctcg ctgcactaaa ggatgatgaa
    12721 tcctaatcat taaaggaatt gtttcagctg atttaaattt ataatgaact cttttgtaat
    12781 aatgtatact gtagaacatg agtctctcct ccctaaaatt ttaaatgtag aaaagtgcta
    12841 tatattagaa atttccattt tgttaaataa atggttagag tctataaa
//
