LOCUS       NM_015050               4034 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens cap methyltransferase 1 (CMTR1), mRNA.
ACCESSION   NM_015050
VERSION     NM_015050.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4034)
  AUTHORS   Lukoszek,R., Inesta-Vaquera,F., Brett,N.J.M., Liang,S.,
            Hepburn,L.A., Hughes,D.J., Pirillo,C., Roberts,E.W. and
            Cowling,V.H.
  TITLE     CK2 phosphorylation of CMTR1 promotes RNA cap formation and
            influenza virus infection
  JOURNAL   Cell Rep 43 (7), 114405 (2024)
   PUBMED   38923463
  REMARK    GeneRIF: CK2 phosphorylation of CMTR1 promotes RNA cap formation
            and influenza virus infection.
REFERENCE   2  (bases 1 to 4034)
  AUTHORS   You,A.B., Yang,H., Lai,C.P., Lei,W., Yang,L., Lin,J.L., Liu,S.C.,
            Ding,N. and Ye,F.
  TITLE     CMTR1 promotes colorectal cancer cell growth and immune evasion by
            transcriptionally regulating STAT3
  JOURNAL   Cell Death Dis 14 (4), 245 (2023)
   PUBMED   37024465
  REMARK    GeneRIF: CMTR1 promotes colorectal cancer cell growth and immune
            evasion by transcriptionally regulating STAT3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4034)
  AUTHORS   Williams,G.D., Gokhale,N.S., Snider,D.L. and Horner,S.M.
  TITLE     The mRNA Cap 2'-O-Methyltransferase CMTR1 Regulates the Expression
            of Certain Interferon-Stimulated Genes
  JOURNAL   mSphere 5 (3), e00202-20 (2020)
   PUBMED   32404510
  REMARK    GeneRIF: The mRNA Cap 2'-O-Methyltransferase CMTR1 Regulates the
            Expression of Certain Interferon-Stimulated Genes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4034)
  AUTHORS   Simabuco,F.M., Pavan,I.C.B., Pestana,N.F., Carvalho,P.C.,
            Basei,F.L., Campos Granato,D., Paes Leme,A.F. and Zanchin,N.I.T.
  TITLE     Interactome analysis of the human Cap-specific mRNA
            (nucleoside-2'-O-)-methyltransferase 1 (hMTr1) protein
  JOURNAL   J Cell Biochem 120 (4), 5597-5611 (2019)
   PUBMED   30320910
  REMARK    GeneRIF: The data presented here are consistent with the important
            role played by hMTr1 in pre-mRNA synthesis.
REFERENCE   5  (bases 1 to 4034)
  AUTHORS   Toczydlowska-Socha,D., Zielinska,M.M., Kurkowska,M., Astha,
            Almeida,C.F., Stefaniak,F., Purta,E. and Bujnicki,J.M.
  TITLE     Human RNA cap1 methyltransferase CMTr1 cooperates with RNA helicase
            DHX15 to modify RNAs with highly structured 5' termini
  JOURNAL   Philos Trans R Soc Lond B Biol Sci 373 (1762), 20180161 (2018)
   PUBMED   30397098
  REMARK    GeneRIF: CMTr1 binds ATP-dependent RNA DHX15 helicase and that this
            interaction, mediated by the G-patch domain of CMTr1, has an
            advantageous effect on CMTr1 activity towards highly structured RNA
            substrates.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4034)
  AUTHORS   Smietanski,M., Werner,M., Purta,E., Kaminska,K.H., Stepinski,J.,
            Darzynkiewicz,E., Nowotny,M. and Bujnicki,J.M.
  TITLE     Structural analysis of human 2'-O-ribose methyltransferases
            involved in mRNA cap structure formation
  JOURNAL   Nat Commun 5, 3004 (2014)
   PUBMED   24402442
  REMARK    GeneRIF: Crystal structures of the active CMTr1 catalytic domain in
            complex with a methyl group donor and a capped oligoribonucleotide
            are examined, thereby revealing the mechanism of specific
            recognition of capped RNA.
REFERENCE   7  (bases 1 to 4034)
  AUTHORS   Werner,M., Purta,E., Kaminska,K.H., Cymerman,I.A., Campbell,D.A.,
            Mittra,B., Zamudio,J.R., Sturm,N.R., Jaworski,J. and Bujnicki,J.M.
  TITLE     2'-O-ribose methylation of cap2 in human: function and evolution in
            a horizontally mobile family
  JOURNAL   Nucleic Acids Res 39 (11), 4756-4768 (2011)
   PUBMED   21310715
REFERENCE   8  (bases 1 to 4034)
  AUTHORS   Belanger,F., Stepinski,J., Darzynkiewicz,E. and Pelletier,J.
  TITLE     Characterization of hMTr1, a human Cap1 2'-O-ribose
            methyltransferase
  JOURNAL   J Biol Chem 285 (43), 33037-33044 (2010)
   PUBMED   20713356
  REMARK    GeneRIF: hMTr1 catalyzes specific methylation of the 2'-O-ribose of
            the first nucleotide of a capped RNA transcript.
REFERENCE   9  (bases 1 to 4034)
  AUTHORS   Haline-Vaz,T., Silva,T.C. and Zanchin,N.I.
  TITLE     The human interferon-regulated ISG95 protein interacts with RNA
            polymerase II and shows methyltransferase activity
  JOURNAL   Biochem Biophys Res Commun 372 (4), 719-724 (2008)
   PUBMED   18533109
  REMARK    GeneRIF: The results presented in this work indicate that ISG95 is
            part of the interferon response pathway and functions in the
            pre-mRNA processing events mediated by the C-terminal domain of the
            RNA polymerase II.
REFERENCE   10 (bases 1 to 4034)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA508836.1, BC031890.1 and BC010731.2.
            
            On Nov 22, 2018 this sequence version replaced NM_015050.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031890.1, D43949.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373451.9/ ENSP00000362550.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DA508836.1         93-108
            17-2917             BC031890.1         1-2901
            2918-3825           BC010731.2         1135-2042
            3826-4034           BC031890.1         3809-4017
FEATURES             Location/Qualifiers
     source          1..4034
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.2"
     gene            1..4034
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /note="cap methyltransferase 1"
                     /db_xref="GeneID:23070"
                     /db_xref="HGNC:HGNC:21077"
                     /db_xref="MIM:616189"
     exon            1..157
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            158..296
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..2671
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /EC_number="2.1.1.57"
                     /note="ISG95; S-adenosyl-L-methionine-dependent
                     methyltransferase FTSJD2; cap1 2'O-ribose
                     methyltransferase 1; interferon-stimulated gene 95 kDa
                     protein; ftsJ methyltransferase domain-containing protein
                     2; FtsJ methyltransferase domain containing 2"
                     /codon_start=1
                     /product="cap-specific mRNA
                     (nucleoside-2'-O-)-methyltransferase 1"
                     /protein_id="NP_055865.1"
                     /db_xref="CCDS:CCDS4835.1"
                     /db_xref="GeneID:23070"
                     /db_xref="HGNC:HGNC:21077"
                     /db_xref="MIM:616189"
                     /translation="MKRRTDPECTAPIKKQKKRVAELALSLSSTSDDEPPSSVSHGAK
                     ASTTSLSGSDSETEGKQHSSDSFDDAFKADSLVEGTSSRYSMYNSVSQKLMAKMGFRE
                     GEGLGKYSQGRKDIVEASSQKGRRGLGLTLRGFDQELNVDWRDEPEPSACEQVSWFPE
                     CTTEIPDTQEMSDWMVVGKRKMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRAR
                     TRANPYEMIRGVFFLNRAAMKMANMDFVFDRMFTNPRDSYGKPLVKDREAELLYFADV
                     CAGPGGFSEYVLWRKKWHAKGFGMTLKGPNDFKLEDFYSASSELFEPYYGEGGIDGDG
                     DITRPENISAFRNFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQLLLCQFLMAL
                     SIVRTGGHFICKTFDLFTPFSVGLVYLLYCCFERVCLFKPITSRPANSERYVVCKGLK
                     VGIDDVRDYLFAVNIKLNQLRNTDSDVNLVVPLEVIKGDHEFTDYMIRSNESHCSLQI
                     KALAKIHAFVQDTTLSEPRQAEIRKECLRLWGIPDQARVAPSSSDPKSKFFELIQGTE
                     IDIFSYKPTLLTSKTLEKIRPVFDYRCMVSGSEQKFLIGLGKSQIYTWDGRQSDRWIK
                     LDLKTELPRDTLLSVEIVHELKGEGKAQRKISAIHILDVLVLNGTDVREQHFNQRIQL
                     AEKFVKAVSKPSRPDMNPIRVKEVYRLEEMEKIFVRLEMKIIKGSSGTPKLSYTGRDD
                     RHFVPMGLYIVRTVNEPWTMGFSKSFKKKFFYNKKTKDSTFDLPADSIAPFHICYYGR
                     LFWEWGDGIRVHDSQKPQDQDKLSKEDVLSFIQMHRA"
     exon            297..448
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..607
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..700
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..772
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            773..867
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..940
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1139
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1258
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1355
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1488
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1668
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1725
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1783
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1852
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1984
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2107
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2199
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2268
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2316
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2429
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2538
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..4034
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4018..4023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /note="hexamer: GATAAA"
     polyA_site      4034
                     /gene="CMTR1"
                     /gene_synonym="FTSJD2; hMTr1; KIAA0082; MTr1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtactgg acccgagcgc gacggtgcgg ctggcggacc cgggctggct tgtggggaaa
       61 cgaaactgag ggaggaggcg gcggctctgg cagcggcggc gacagtgtcg gcctgacccc
      121 ccctccgctc cccggcagct cgctctctcc cctcagctta acgatgaaga ggagaactga
      181 cccagaatgc actgccccca tcaagaaaca gaaaaaaaga gttgcagagc ttgccctgag
      241 cctcagctcc acgtccgatg atgaacctcc ctcctctgtc agtcatggag caaaagcatc
      301 tactacaagc cttagtgggt ctgatagtga gaccgagggg aaacaacaca gctctgactc
      361 ttttgacgat gcattcaaag cagactctct tgtggaagga acttcttctc gctattccat
      421 gtataatagc gtctcccaga agcttatggc caagatgggc ttcagggaag gtgaaggatt
      481 gggtaaatac agccagggtc ggaaggacat cgttgaggct tccagtcaga aaggtcgaag
      541 aggcttgggt ctgacactcc ggggctttga ccaggagctg aacgtggact ggcgagatga
      601 gccagagccc agtgcttgtg agcaggtgtc atggtttcca gaatgtacca ctgaaattcc
      661 tgacactcag gaaatgagcg attggatggt ggtgggaaag agaaagatga ttattgaaga
      721 tgaaacagag ttttgtgggg aagagctgct tcacagtgtg ttgcagtgta agagcgtgtt
      781 tgatgtcttg gatggggaag agatgcggcg agctcggact cgggccaatc cctatgagat
      841 gatccgagga gtcttctttc taaacagggc agcaatgaag atggctaaca tggattttgt
      901 atttgatcgc atgttcacaa atccgcggga ctcttatggg aagccactgg tgaaggaccg
      961 ggaagctgag cttctgtact ttgctgatgt ctgcgcaggc ccaggtggct tctcagagta
     1021 tgtgctgtgg aggaagaagt ggcatgcaaa gggctttgga atgactttga agggccctaa
     1081 tgacttcaag ctggaggact tctactctgc ttccagtgaa ctcttcgaac cctactatgg
     1141 tgagggtggg attgatggag atggagatat cacccgccca gagaacatct ctgcttttcg
     1201 gaattttgtc ctggataaca cagatcgcaa gggtgtccat tttctgatgg ctgatggggg
     1261 tttctcggtg gaggggcagg agaacctgca ggagatcctc agcaagcagc tgcttctgtg
     1321 tcagttcctc atggcgctgt ccattgtccg gacaggaggc cacttcatct gtaaaacctt
     1381 tgacctgttc acaccgttta gtgtggggct tgtctacctg ctgtactgct gctttgaacg
     1441 agtttgtctc ttcaagccta ttaccagccg tcctgccaac tcagagaggt atgtggtgtg
     1501 caagggcctg aaggtgggca tagatgatgt tcgggattac ctcttcgcag tgaatattaa
     1561 actcaatcag ctgcggaaca cggattccga cgtcaacttg gtggtccccc tggaggtgat
     1621 caagggagac catgaattta ctgactacat gatacggtcc aatgagagcc actgtagtct
     1681 gcagatcaaa gctctggcga aaatccatgc ctttgttcaa gacacgacac tgagtgagcc
     1741 tcgacaggca gagatacgga aggagtgcct ccgactctgg gggatcccag accaggctcg
     1801 tgtggctcct tcttcctccg accctaaatc gaagttcttt gagctaatcc agggcactga
     1861 gattgacatc ttcagctaca agcccacact gctcacctct aaaaccctgg agaagatccg
     1921 ccctgtgttt gactaccgct gcatggtatc tggcagtgag cagaagttcc tcatcggcct
     1981 ggggaaatcc cagatctaca catgggatgg ccgccagtca gaccgctgga tcaagctaga
     2041 cctgaagaca gagctgcccc gggacactct gctatctgtg gaaattgtgc atgagctgaa
     2101 aggggagggg aaggcccaga ggaagatcag tgccatccac atcctcgatg tccttgtgct
     2161 gaatggcacc gacgttcggg agcagcactt taaccagcga attcagcttg ccgagaaatt
     2221 tgtgaaagcc gtttccaagc ctagtcggcc cgacatgaat cccatcaggg tgaaggaggt
     2281 gtacagactg gaagagatgg agaagatttt tgtcaggttg gagatgaaga tcatcaaggg
     2341 ctccagtggc accccaaagc tcagctacac agggcgtgat gaccggcact ttgtacccat
     2401 gggcctctac atcgtcagga cagtgaatga gccctggact atgggattca gcaaaagctt
     2461 caagaagaag ttcttctaca acaagaaaac caaggactct acttttgacc tccctgcaga
     2521 ctccattgcc ccatttcaca tttgctacta tggccggctc ttctgggagt ggggggatgg
     2581 cattcgtgtg catgactccc agaagcccca ggaccaggac aagctgtcca aggaggacgt
     2641 cctctccttc atccagatgc acagggccta agagcctcag aatgtgccac ccctgcagaa
     2701 tgccctgtca ttcctgagat ggggccacct ggggcccaca gtgctggctt cttccccctc
     2761 ttgaaaaggg actggggagc attgcacctg gcatgaggag tgggtggcct cctctccatc
     2821 ccctgaagag ctcaggcagg gccctgcaga gaacactcat gttccttctg ggacacctgc
     2881 ctgggaactt tcccctgcca ggactcagcc tgaaggaagc tgctcctgag gcaggtatga
     2941 ggtcagtgcc tagggcacgt gggactgatg gaggacatat cagagtggca gagctgtggg
     3001 ctctgctgtt ctctcctgca tcctgtagac tcacttttct gagttccatg cactgccctg
     3061 agggtagcca tgcccttgct ttgcccaact ttttattggg ccatccctga gtgggtggag
     3121 acctgctgtc atgagctggc caggagaacc tgctataaaa aaatcaaggt tttgtttctt
     3181 tgaacttact ctgttttgat gccaaattgg agaccatttt cttgtctcct tcccccactc
     3241 atcctggcct tccctggagt tcttcctagc ccagagctct gacagtccag cagggtggga
     3301 aggagggagt ttgggcaaac tctcatccct gataccacat tgagatcctg ggagccctct
     3361 tttcgtactg agtatggagt tgtagagcca tcctaggtgc catccccttt tggtccaaac
     3421 attgggcagc gctagatggc aggaagcagc cttgaagacc cgtctttccc ccacagcagc
     3481 aggggcccca gcagtaacaa agggtacctc caggggtttg ggtagcgctg ccctctggca
     3541 gtcatgcacc gctgtctgcc atagccgctc tagggtcttg gcagaattct gagcttgaag
     3601 tgcagctccc ttactaccct ttcccttcct ttttcttccc taataggagg tacaatctgc
     3661 ttttgtttgt cgttaagtgg tcactcccat ttcctttatc ttggccgaca acacagagag
     3721 gagggggagc tgggcagtag cttggggtgg gggtgggcac ctgtggttgt ttttaatggg
     3781 aaatacctct cagagatgtt catgcaggct ccctagggcc ccatcccagt gccaggctgg
     3841 tttccatgga gatagggcac tgaggctccc gtgaggttgg aatcgacttc accatggggg
     3901 tccttcagcc agcatccagc tccccacccc caggctggca gtagcactgc tgagatgctg
     3961 tatttccacc caattctggg tatatcagtg tgtcttgcag aatcttggat cattaaagat
     4021 aaacatattt ttaa
//
