LOCUS       NM_178868               1169 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens CKLF like MARVEL transmembrane domain containing 8
            (CMTM8), transcript variant 1, mRNA.
ACCESSION   NM_178868
VERSION     NM_178868.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1169)
  AUTHORS   Kang,N., Xie,X., Zhou,X., Wang,Y., Chen,S., Qi,R., Liu,T. and
            Jiang,H.
  TITLE     Identification and validation of EMT-immune-related prognostic
            biomarkers CDKN2A, CMTM8 and ILK in colon cancer
  JOURNAL   BMC Gastroenterol 22 (1), 190 (2022)
   PUBMED   35429970
  REMARK    GeneRIF: Identification and validation of EMT-immune-related
            prognostic biomarkers CDKN2A, CMTM8 and ILK in colon cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1169)
  AUTHORS   Zeng,X., Ma,X., Guo,H., Wei,L., Zhang,Y., Sun,C., Han,N., Sun,S.
            and Zhang,N.
  TITLE     MicroRNA-582-5p promotes triple-negative breast cancer invasion and
            metastasis by antagonizing CMTM8
  JOURNAL   Bioengineered 12 (2), 10126-10135 (2021)
   PUBMED   34978519
  REMARK    GeneRIF: MicroRNA-582-5p promotes triple-negative breast cancer
            invasion and metastasis by antagonizing CMTM8.
REFERENCE   3  (bases 1 to 1169)
  AUTHORS   Wu,J., Sun,Y., Xiong,Z., Niu,F., Liu,Y., Li,H., Liu,J., Wu,J.,
            Liu,Q. and Jin,T.
  TITLE     Influence of CMTM8 polymorphisms on lung cancer susceptibility in
            the Chinese Han population
  JOURNAL   Pharmacogenet Genomics 31 (4), 89-95 (2021)
   PUBMED   33395025
  REMARK    GeneRIF: Influence of CMTM8 polymorphisms on lung cancer
            susceptibility in the Chinese Han population.
REFERENCE   4  (bases 1 to 1169)
  AUTHORS   Yan,M., Zhu,X., Qiao,H., Zhang,H., Xie,W. and Cai,J.
  TITLE     Downregulated CMTM8 Correlates with Poor Prognosis in Gastric
            Cancer Patients
  JOURNAL   DNA Cell Biol 40 (6), 791-797 (2021)
   PUBMED   33978454
  REMARK    GeneRIF: Downregulated CMTM8 Correlates with Poor Prognosis in
            Gastric Cancer Patients.
REFERENCE   5  (bases 1 to 1169)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1169)
  AUTHORS   Jin,C., Wang,Y., Han,W., Zhang,Y., He,Q., Li,D., Yin,C., Tian,L.,
            Liu,D., Song,Q. and Ma,D.
  TITLE     CMTM8 induces caspase-dependent and -independent apoptosis through
            a mitochondria-mediated pathway
  JOURNAL   J Cell Physiol 211 (1), 112-120 (2007)
   PUBMED   17149703
  REMARK    GeneRIF: These data implicate CMTM8 as a negative regulator of
            epidermal growth factor (EGF)-induced signaling.
REFERENCE   7  (bases 1 to 1169)
  AUTHORS   Li,D., Jin,C., Yin,C., Zhang,Y., Pang,B., Tian,L., Han,W., Ma,D.
            and Wang,Y.
  TITLE     An alternative splice form of CMTM8 induces apoptosis
  JOURNAL   Int J Biochem Cell Biol 39 (11), 2107-2119 (2007)
   PUBMED   17681841
  REMARK    GeneRIF: The cloning and sequencing of an alternative splice form
            of CMTM8, obtained from a human blood cDNA library, that utilizes
            apoptotic pathways distinct from CMTM8, is reported.
REFERENCE   8  (bases 1 to 1169)
  AUTHORS   Huang,Y.M. and Du,Y.
  TITLE     [Effect of novel human chemokine-like factor superfamily 8 on
            proliferation and EGFR expression of tumor cells]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 22 (4), 466-468 (2006)
   PUBMED   16806010
  REMARK    GeneRIF: Cell proliferation and expression of EGFR of tumor cells
            can be inhibited by transfection of CKLFSF8.
REFERENCE   9  (bases 1 to 1169)
  AUTHORS   Jin,C., Ding,P., Wang,Y. and Ma,D.
  TITLE     Regulation of EGF receptor signaling by the MARVEL
            domain-containing protein CKLFSF8
  JOURNAL   FEBS Lett 579 (28), 6375-6382 (2005)
   PUBMED   16263120
  REMARK    GeneRIF: These results identify CKLFSF8 as a novel regulator of
            EGF-induced signaling and indicate that the association of EGFR
            with four transmembrane proteins is critical for EGFR
            desensitization.
REFERENCE   10 (bases 1 to 1169)
  AUTHORS   Han,W., Ding,P., Xu,M., Wang,L., Rui,M., Shi,S., Liu,Y., Zheng,Y.,
            Chen,Y., Yang,T. and Ma,D.
  TITLE     Identification of eight genes encoding chemokine-like factor
            superfamily members 1-8 (CKLFSF1-8) by in silico cloning and
            experimental validation
  JOURNAL   Genomics 81 (6), 609-617 (2003)
   PUBMED   12782130
  REMARK    GeneRIF: Bioinformatics based on CKLF2 cDNA and protein sequences
            in combination with experimental validation identified CKLFSF1-8
            gene clusters, between the SCY and the TM4SF gene families. The 8
            family members were cloned and characterized.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY598783.1 and AF474370.2.
            
            On Nov 22, 2018 this sequence version replaced NM_178868.4.
            
            Summary: This gene belongs to the chemokine-like factor gene
            superfamily, a novel family that is similar to the chemokine and
            the transmembrane 4 superfamilies. This gene is one of several
            chemokine-like factor genes located in a cluster on chromosome 3.
            This gene acts as a tumor suppressor, and plays a role in
            regulating the migration of tumor cells. The encoded protein is
            thought to function as a a negative regulator of epidermal growth
            factor-induced signaling. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF474370.2, BC041390.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307526.4/ ENSP00000307741.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-364               AY598783.1         2-365
            365-1169            AF474370.2         366-1170
FEATURES             Location/Qualifiers
     source          1..1169
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.3"
     gene            1..1169
                     /gene="CMTM8"
                     /gene_synonym="CKLFSF8; CKLFSF8-V2"
                     /note="CKLF like MARVEL transmembrane domain containing 8"
                     /db_xref="GeneID:152189"
                     /db_xref="HGNC:HGNC:19179"
                     /db_xref="MIM:607891"
     exon            1..440
                     /gene="CMTM8"
                     /gene_synonym="CKLFSF8; CKLFSF8-V2"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..815
                     /gene="CMTM8"
                     /gene_synonym="CKLFSF8; CKLFSF8-V2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CKLF-like MARVEL transmembrane domain-containing protein
                     8; chemokine-like factor superfamily member 8"
                     /codon_start=1
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 8 isoform 1"
                     /protein_id="NP_849199.2"
                     /db_xref="CCDS:CCDS2652.1"
                     /db_xref="GeneID:152189"
                     /db_xref="HGNC:HGNC:19179"
                     /db_xref="MIM:607891"
                     /translation="MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLPGFL
                     IVAEIVLGLLVWTLIAGTEYFRVPAFGWVMFVAVFYWVLTVFFLIIYITMTYTRIPQV
                     PWTTVGLCFNGSAFVLYLSAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNT
                     YFSFIAWRSRTIQ"
     exon            441..614
                     /gene="CMTM8"
                     /gene_synonym="CKLFSF8; CKLFSF8-V2"
                     /inference="alignment:Splign:2.1.0"
     exon            615..731
                     /gene="CMTM8"
                     /gene_synonym="CKLFSF8; CKLFSF8-V2"
                     /inference="alignment:Splign:2.1.0"
     exon            732..1169
                     /gene="CMTM8"
                     /gene_synonym="CKLFSF8; CKLFSF8-V2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1148..1153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMTM8"
                     /gene_synonym="CKLFSF8; CKLFSF8-V2"
                     /note="hexamer: ATTAAA"
     polyA_site      1169
                     /gene="CMTM8"
                     /gene_synonym="CKLFSF8; CKLFSF8-V2"
                     /note="major polyA site"
ORIGIN      
        1 gcctccaccg ccttccccgg ctgcccggca gcctcccctc gctcgctctc ctcttcctct
       61 agggccccag cgcagctcgg gagcccgcgc accgaggcgc taggggcacc gcgcactaga
      121 gggacacccg ccgcgcctgg acagcccccg gcgggcgccc ccctcgcacc tcctgccccg
      181 cgcgggccgc gctcccctcc cccgcgcctg tgtccccagg gcgcagggcc gcgcgtccag
      241 ccccagaccc gccggggtcc ctggggacgc gccagcccgg cagtggctcg acgatggagg
      301 agccgcagcg cgcccgctcg cacacagtca ccaccaccgc cagctccttc gcagagaact
      361 tctccaccag cagcagcagc ttcgcctacg accgggagtt cctccgcacc ctgcccggct
      421 tcctcatcgt ggccgagatc gttctggggc tgctggtatg gacgcttatt gctggaactg
      481 agtacttccg ggtccccgca tttggctggg tcatgtttgt agctgtattt tactgggtcc
      541 tcaccgtctt cttcctcatt atctacataa caatgaccta caccaggatt ccccaggtgc
      601 cctggacaac agtgggcctg tgctttaacg gcagtgcctt cgtcttgtac ctctctgccg
      661 ctgttgtaga tgcatcttcc gtctcccctg agagggacag tcacaacttc aacagctggg
      721 cggcctcatc gttctttgcc ttcctggtca ccatctgcta cgctggaaat acatatttca
      781 gttttatagc atggagatcc aggaccatac agtgatttac cattttgata attaaaagga
      841 aaaaaaaagg aagactctca ctgtaaaaac agctgtaggt ataatgtata ttcccagaga
      901 attgtattta actaattaat gttttttata ttcttaaatt tgctcacaaa ttgtggtttg
      961 ttacaattaa actggatact tatttgcaaa gtgttgtagc ttataatgaa ctcttaagta
     1021 tcttattaat gtattaatgt cttcatagat catattttct tagacaatgt ttaaatagat
     1081 aaattgctaa tattgagaat gtgtcaagtt tgtaaaccta acttttaaga tgccagattc
     1141 ttttttgatt aaatgttgca aaatcccaa
//
