LOCUS       NM_138410               1856 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens CKLF like MARVEL transmembrane domain containing 7
            (CMTM7), transcript variant 1, mRNA.
ACCESSION   NM_138410
VERSION     NM_138410.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1856)
  AUTHORS   Chen,Z.H., Tian,Y., Zhou,G.L., Yue,H.R., Zhou,X.J., Ma,H.Y., Ge,J.,
            Wang,X., Cao,X.C. and Yu,Y.
  TITLE     CMTM7 inhibits breast cancer progression by regulating
            Wnt/beta-catenin signaling
  JOURNAL   Breast Cancer Res 25 (1), 22 (2023)
   PUBMED   36829181
  REMARK    GeneRIF: CMTM7 inhibits breast cancer progression by regulating
            Wnt/beta-catenin signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1856)
  AUTHORS   Liu,B., Lu,Y., Zhang,T., Yu,X., Wang,Q., Chi,Y., Jin,S. and
            Cheng,G.
  TITLE     CMTM7 as a novel molecule of ATG14L-Beclin1-VPS34 complex enhances
            autophagy by Rab5 to regulate tumorigenicity
  JOURNAL   Cell Commun Signal 19 (1), 77 (2021)
   PUBMED   34281589
  REMARK    GeneRIF: CMTM7 as a novel molecule of ATG14L-Beclin1-VPS34 complex
            enhances autophagy by Rab5 to regulate tumorigenicity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1856)
  AUTHORS   Lu,C., Zhao,Y., Wang,J., Shi,W., Dong,F., Xin,Y., Zhao,X. and
            Liu,C.
  TITLE     Breast cancer cell-derived extracellular vesicles transfer
            miR-182-5p and promote breast carcinogenesis via the CMTM7/EGFR/AKT
            axis
  JOURNAL   Mol Med 27 (1), 78 (2021)
   PUBMED   34294040
  REMARK    GeneRIF: Breast cancer cell-derived extracellular vesicles transfer
            miR-182-5p and promote breast carcinogenesis via the CMTM7/EGFR/AKT
            axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1856)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1856)
  AUTHORS   Wu,J.
  TITLE     CMTM5/7 are biomarkers and prognostic factors in human breast
            carcinoma
  JOURNAL   Cancer Biomark 29 (1), 89-99 (2020)
   PUBMED   32568178
  REMARK    GeneRIF: CMTM5/7 are biomarkers and prognostic factors in human
            breast carcinoma.
REFERENCE   6  (bases 1 to 1856)
  AUTHORS   Li,H., Li,J., Su,Y., Fan,Y., Guo,X., Li,L., Su,X., Rong,R.,
            Ying,J., Mo,X., Liu,K., Zhang,Z., Yang,F., Jiang,G., Wang,J.,
            Zhang,Y., Ma,D., Tao,Q. and Han,W.
  TITLE     A novel 3p22.3 gene CMTM7 represses oncogenic EGFR signaling and
            inhibits cancer cell growth
  JOURNAL   Oncogene 33 (24), 3109-3118 (2014)
   PUBMED   23893243
  REMARK    GeneRIF: Loss of CMTM7 by promoter CpG methylation is associated
            with neoplasms.
REFERENCE   7  (bases 1 to 1856)
  AUTHORS   Miyazaki,A., Yogosawa,S., Murakami,A. and Kitamura,D.
  TITLE     Identification of CMTM7 as a transmembrane linker of BLNK and the
            B-cell receptor
  JOURNAL   PLoS One 7 (2), e31829 (2012)
   PUBMED   22363743
  REMARK    GeneRIF: CMTM7 functions to link sIgM and BLNK in the plasma
            membrane.
REFERENCE   8  (bases 1 to 1856)
  AUTHORS   Morrison,A.C., Felix,J.F., Cupples,L.A., Glazer,N.L., Loehr,L.R.,
            Dehghan,A., Demissie,S., Bis,J.C., Rosamond,W.D., Aulchenko,Y.S.,
            Wang,Y.A., Haritunians,T., Folsom,A.R., Rivadeneira,F.,
            Benjamin,E.J., Lumley,T., Couper,D., Stricker,B.H., O'Donnell,C.J.,
            Rice,K.M., Chang,P.P., Hofman,A., Levy,D., Rotter,J.I., Fox,E.R.,
            Uitterlinden,A.G., Wang,T.J., Psaty,B.M., Willerson,J.T., van
            Duijn,C.M., Boerwinkle,E., Witteman,J.C., Vasan,R.S. and Smith,N.L.
  TITLE     Genomic variation associated with mortality among adults of
            European and African ancestry with heart failure: the cohorts for
            heart and aging research in genomic epidemiology consortium
  JOURNAL   Circ Cardiovasc Genet 3 (3), 248-255 (2010)
   PUBMED   20400778
  REMARK    GeneRIF: Meta-analysis and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 1856)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   10 (bases 1 to 1856)
  AUTHORS   Han,W., Ding,P., Xu,M., Wang,L., Rui,M., Shi,S., Liu,Y., Zheng,Y.,
            Chen,Y., Yang,T. and Ma,D.
  TITLE     Identification of eight genes encoding chemokine-like factor
            superfamily members 1-8 (CKLFSF1-8) by in silico cloning and
            experimental validation
  JOURNAL   Genomics 81 (6), 609-617 (2003)
   PUBMED   12782130
  REMARK    GeneRIF: Bioinformatics based on CKLF2 cDNA and protein sequences
            in combination with experimental validation identified CKLFSF1-8
            gene clusters, between the SCY and the TM4SF gene families. The 8
            family members were cloned and characterized.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF479263.2, CD366110.1 and
            AC098475.2.
            
            On May 17, 2019 this sequence version replaced NM_138410.3.
            
            Summary: This gene belongs to the chemokine-like factor gene
            superfamily, a novel family that is similar to the chemokine and
            transmembrane 4 superfamilies. This gene is one of several
            chemokine-like factor genes located in a cluster on chromosome 3.
            This gene acts as a tumor suppressor that regulates G1/S transition
            in the cell cycle, and epidermal growth factor receptor/protein
            kinase B signaling during tumor pathogenesis. Alternative splicing
            results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM764608.1, DRR138512.122023.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334983.10/ ENSP00000335605.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1169              AF479263.2         183-1351
            1170-1172           CD366110.1         18-20               c
            1173-1856           AC098475.2         151547-152230
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.3"
     gene            1..1856
                     /gene="CMTM7"
                     /gene_synonym="CKLFSF7"
                     /note="CKLF like MARVEL transmembrane domain containing 7"
                     /db_xref="GeneID:112616"
                     /db_xref="HGNC:HGNC:19178"
                     /db_xref="MIM:607890"
     exon            1..213
                     /gene="CMTM7"
                     /gene_synonym="CKLFSF7"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..582
                     /gene="CMTM7"
                     /gene_synonym="CKLFSF7"
                     /note="isoform a is encoded by transcript variant 1;
                     chemokine-like factor super family 7; chemokine-like
                     factor superfamily 7; CKLF-like MARVEL transmembrane
                     domain-containing protein 7; chemokine-like factor
                     superfamily member 7"
                     /codon_start=1
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 7 isoform a"
                     /protein_id="NP_612419.1"
                     /db_xref="CCDS:CCDS33730.1"
                     /db_xref="GeneID:112616"
                     /db_xref="HGNC:HGNC:19178"
                     /db_xref="MIM:607890"
                     /translation="MSHGAGLVRTTCSSGSALGPGAGAAQPSASPLEGLLDLSYPRTH
                     AALLKVAQMVTLLIAFICVRSSLWTNYSAYSYFEVVTICDLIMILAFYLVHLFRFYRV
                     LTCISWPLSELLHYLIGTLLLLIASIVAASKSYNQSGLVAGAIFGFMATFLCMASIWL
                     SYKISCVTQSTDAAV"
     exon            214..387
                     /gene="CMTM7"
                     /gene_synonym="CKLFSF7"
                     /inference="alignment:Splign:2.1.0"
     exon            388..486
                     /gene="CMTM7"
                     /gene_synonym="CKLFSF7"
                     /inference="alignment:Splign:2.1.0"
     exon            487..568
                     /gene="CMTM7"
                     /gene_synonym="CKLFSF7"
                     /inference="alignment:Splign:2.1.0"
     exon            569..1856
                     /gene="CMTM7"
                     /gene_synonym="CKLFSF7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1146..1151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMTM7"
                     /gene_synonym="CKLFSF7"
                     /note="hexamer: AATAAA"
     polyA_site      1169
                     /gene="CMTM7"
                     /gene_synonym="CKLFSF7"
                     /note="major polyA site"
     polyA_site      1221
                     /gene="CMTM7"
                     /gene_synonym="CKLFSF7"
ORIGIN      
        1 atctggcccc tgggcagctg cccggggagg cggccagcga gctggggccg cgcaatgtcg
       61 cacggagccg ggctcgtccg caccacgtgc agcagcggca gcgcgctcgg acccggggcc
      121 ggcgcggccc agcccagcgc gagccccttg gaggggctgc tggacctcag ctacccccgc
      181 acccacgcgg ccctgctgaa agtggcgcaa atggtcaccc tgctgattgc cttcatctgt
      241 gtgcggagct ccctgtggac caactacagc gcctacagct actttgaagt ggtcaccatt
      301 tgcgacttga taatgatcct cgccttttac ctggtccacc tcttccgctt ctaccgcgtg
      361 ctcacctgta tcagctggcc cctgtcggaa cttctgcact atttaatcgg taccctgctc
      421 ctcctcatcg cctccattgt ggcagcttcc aagagttaca accagagcgg actggtagcc
      481 ggagcgatct ttggtttcat ggccaccttc ctctgcatgg caagcatatg gctgtcctat
      541 aagatctcgt gtgtaaccca gtccacagat gcagccgtct gatgaggcca caacccctag
      601 gcccctcagg agctttgcag agaggaggac gtgtactcca ggcgaggcct ctggacctgt
      661 gttcctgtgc caaagtcctg tcaggctggt gggcaccagg aaaggcctgc accctcttcc
      721 tgctctccca ggaagccagc tccctgagct cctgagccag ccggaaactc ttcctccagc
      781 cttccgggga gaacatccct cccattctgg gaaaggaaag cagcctccag ggaaatgttt
      841 tctgccttcc tgcttctaga accacctcag gtactgatga accccactta gcacagctga
      901 aggggtttgt gaatactccc gcctaaatcc cttctacttc actcctcagg ggagtgaagt
      961 gccttaagaa acaaagccct gtcctaattt atctagcttg tcagtccggt cttagagata
     1021 ccctctttcc tgaagtgagg cgtgcctgta gaaacactat gtggtcagcc tgtccccaag
     1081 gagatcttgt gtctcctctc catctctgcc tttgttacca gtgtgcatgt gtttgtgtgt
     1141 tttttaataa aatattgact cggccagttg cacaaggatt tcttattgaa ccagatgaag
     1201 gctgtaaaac ctggcctgaa acagtttcca ttcgagcttg tgtctggccc atggccctcc
     1261 acccgtgctc tgtgtgtgcc ccttgctgaa ctgctggact tcaggttttc tctccatctt
     1321 gggggatagt atagcagggc agagttttag gtaaacatgt gcaggttctc aattatattc
     1381 acgtcctcct tctcctgcaa taccaatctt ctcattttgg aaagagcttt agagcaagct
     1441 aagggttgtg tttacactat gatgattaat gatctcggcc taaatgtgct gtttcgctga
     1501 tcttgagctg ctcagttggc tagaaaaagg agggatggaa caatgtttga gcaaccccgt
     1561 gtgcaaggac ctacattcac aaccacatct aatagcgatg gtagtgactg caagggggca
     1621 ggttatagga ccacattttt agaaatgaaa tcggggctcc atccccaggc acagggcaag
     1681 ccagtgagga gctgggctca ggatctaggt ctgcctgact cccagcccca tccttgcctc
     1741 tgctgagtgt tgccggaaat ggaagcagcc cctgtgggct ttgagctgga gctctggggc
     1801 tactcttgtg gctgctggcc agctcggggc atcgggttct gtctgggatg atctaa
//
